Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer’s Disease †

Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer’s disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. Here, we aimed to determine whether reactive oxygen species (ROS) reduction by resveratrol in the brain leads to cognitive impairment reduction in rats with angiotensin II (Ang-II)-induced early AD. Male Wistar Kyoto (WKY) rats with Ang-II-induced AD were treated with losartan or resveratrol for two weeks. Our results show decreased blood pressure, increased hippocampal brain-derived neurotrophic factor (BDNF) level, and decreased nucleus tractus solitarius (NTS) ROS production in the Ang-II groups with losartan (10 mg/kg), or resveratrol (10 mg/kg/day) treatment. Furthermore, losartan inhibition of hippocampal TauT231 phosphorylation activated AktS473 phosphorylation, and significantly abolished Ang-II-induced Aβ precursors, active caspase 3, and glycogen synthase kinase 3β (GSK-3β)Y216 expressions. Consistently, resveratrol showed similar effects compared to losartan. Both losartan and resveratrol restored hippocampal-dependent contextual memory by NADPH oxidase 2 (NOX2) deletion and superoxide dismutase 2 (SOD2) elevation. Our results suggest that both losartan and resveratrol exert neuroprotective effects against memory impairment and hippocampal damage by oxidative stress reduction in early stage AD rat model. These novel findings indicate that resveratrol may represent a pharmacological option similar to losartan for patients with hypertension at risk of AD during old age.

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Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer’s Disease

10.20944/preprints201808.0371.v1 ◽

2018 ◽

Author(s):

Yu-Te Lin ◽

Yi-Chung Wu ◽

Gwo-Ching Sun ◽

Chiu-Yi Ho ◽

Tzyy-Yue Wong ◽

...

Keyword(s):

Oxidative Stress ◽

Reactive Oxygen Species ◽

Cognitive Impairment ◽

Angiotensin Ii ◽

Nucleus Tractus Solitarius ◽

Glycogen Synthase ◽

Reactive Oxygen ◽

Hippocampal Damage ◽

Oxygen Species ◽

Ang Ii

Recent studies have indicated that several anti-hypertensive drugs may delay the development and progression of Alzheimer’s disease (AD). However, the relationships among AD, hypertension, and oxidative stress remain to be elucidated. In the present study, we aimed to determine whether treatment with resveratrol reduces reactive oxygen species (ROS) generation in the brain, thereby reducing cognitive impairment in rats with angiotensin II (Ang-II)-induced early AD. Male WKY rats with Ang-II-induced AD were treated with losartan or resveratrol for 2 weeks. Our results revealed that treatment with resveratrol (10 mg/kg/day) decreased blood pressure, increased levels of brain-derived neurotrophic factor (BDNF) in the hippocampus, and decreased ROS production in the nucleus tractus solitarius (NTS) in the Ang-II groups. In addition, inhibition of TauT231 phosphorylation in the hippocampus using resveratrol significantly abolished Ang-II-induced expression of Ab precursors, active caspase 3, and glycogen synthase kinase 3b (GSK-3b)Y216 while increasing AktS473 phosphorylation. Notably, resveratrol reversed impairments in hippocampal-dependent contextual memory induced by deleting NADPH oxidase and NOX2. Overall, our results suggest that resveratrol exerts neuroprotective effects against memory impairment and hippocampal damage in a rat model of early stage AD by reducing oxidative stress. These novel findings indicate that resveratrol may represent a pharmacological option for patients with hypertension at a risk of AD during old age.

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Resveratrol Decrease of Reactive Oxygen Species-Derived Cognitive Impairment in Angiotensin II Induced Rat Model of Early Alzheimer's disease

Proceedings for Annual Meeting of The Japanese Pharmacological Society ◽

10.1254/jpssuppl.wcp2018.0_po1-2-78 ◽

2018 ◽

Vol WCP2018 (0) ◽

pp. PO1-2-78

Author(s):

Peiwen Cheng ◽

Gwo-Ching Sun ◽

Yi-Chung Wu ◽

Ching-Jiunn Tseng

Keyword(s):

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Angiotensin Ii ◽

Rat Model ◽

Reactive Oxygen ◽

Oxygen Species ◽

Early Alzheimer’S Disease

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Influence of Acetylcholinesterase Inhibitors Used in Alzheimer’s Disease Treatment on the Activity of Antioxidant Enzymes and the Concentration of Glutathione in THP-1 Macrophages under Fluoride-Induced Oxidative Stress

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph16010010 ◽

2018 ◽

Vol 16 (1) ◽

pp. 10 ◽

Cited By ~ 3

Author(s):

Marta Goschorska ◽

Izabela Gutowska ◽

Irena Baranowska-Bosiacka ◽

Katarzyna Piotrowska ◽

Emilia Metryka ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Antioxidant Enzymes ◽

Antioxidant Properties ◽

Reactive Oxygen ◽

Acetylcholinesterase Inhibitors ◽

Oxygen Species ◽

Ache Inhibitors

It has been reported that donepezil and rivastigmine, the acetylcholinesterase (AchE) inhibitors commonly used in the treatment of Alzheimer’s disease (AD), do not only inhibit AChE but also have antioxidant properties. As oxidative stress is involved in AD pathogenesis, in our study we attempted to examine the influence of donepezil and rivastigmine on the activity of antioxidant enzymes and glutathione concentration in macrophages—an important source of reactive oxygen species and crucial for oxidative stress progression. The macrophages were exposed to sodium fluoride induced oxidative stress. The antioxidant enzymes activity and concentration of glutathione were measured spectrophotometrically. The generation of reactive oxygen species was visualized by confocal microscopy. The results of our study showed that donepezil and rivastigmine had a stimulating effect on catalase activity. However, when exposed to fluoride-induced oxidative stress, the drugs reduced the activity of some antioxidant enzymes (Cat, SOD, GR). These observations suggest that the fluoride-induced oxidative stress may suppress the antioxidant action of AChE inhibitors. Our results may have significance in the clinical practice of treatment of AD and other dementia diseases.

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PAN-811 Inhibits Oxidative Stress-Induced Cell Death of Human Alzheimer's Disease-Derived and Age-Matched Olfactory Neuroepithelial Cells Via Suppression of Intracellular Reactive Oxygen Species

Journal of Alzheimer s Disease ◽

10.3233/jad-2009-1078 ◽

2009 ◽

Vol 17 (3) ◽

pp. 611-619 ◽

Cited By ~ 10

Author(s):

Valery M. Nelson ◽

Chanteé M. Dancik ◽

Weiying Pan ◽

Zhi-Gang Jiang ◽

Michael S. Lebowitz ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Cell Death ◽

Reactive Oxygen ◽

Intracellular Reactive Oxygen Species ◽

Oxygen Species ◽

Neuroepithelial Cells

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Oxidative stress and its effect on cells functional activity of Alzheimer's disease

Biomeditsinskaya Khimiya ◽

10.18097/pbmc20156101057 ◽

2015 ◽

Vol 61 (1) ◽

pp. 57-69 ◽

Cited By ~ 6

Author(s):

E.E. Dubinina ◽

L.V. Schedrina ◽

N.G. Neznanov ◽

N.M. Zalutskaya ◽

D.V. Zakharchenko

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Functional Activity ◽

Cell Cycle Control ◽

Reactive Oxygen Species Generation ◽

Reactive Oxygen ◽

Regulatory System ◽

Oxygen Species

The paper summarizes literature data on the importance of oxidative stress as one of the pathogenetic mechanisms in Alzheimer's disease. The paper describes the main specific and nonspecific ways of reactive oxygen species generation in the course of the disease development. The effect of reactive oxygen species generated by the functional activity of cells, i.e. apoptosis and mitotic cycle, is shown. The role of the regulatory system of nodal cells is performed by phosphorylation/dephosphorylation process which is associated with intense phosphorylation of tau protein and mitosis-specific proteins. In Alzheimer's disease, the regulating function of peptidyl-prolyl isomerases in particular of Pin1 associated with maintaining a balanced state of phosphorylation/dephosphorylation processes is disturbed. Taking into consideration the multifactorial impairment of the cell cycle control, this process should be considered from the standpoint of the general state of metabolic processes, and oxidative stress has one of the key positions in aging.

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Superoxide-responsive fluorogenic molecular probes for optical bioimaging of neurodegenerative events in Alzheimer’s disease

The Analyst ◽

10.1039/d1an00692d ◽

2021 ◽

Author(s):

Jawon Shin ◽

Dong Min Kang ◽

Jounghyun Yoo ◽

Jeongyun Heo ◽

Keunsoo Jeong ◽

...

Keyword(s):

Oxidative Stress ◽

Alzheimer’S Disease ◽

Reactive Oxygen Species ◽

Alzheimer's Disease ◽

Neurodegenerative Disorder ◽

Reactive Oxygen ◽

Molecular Probes ◽

Oxygen Species

Since oxidative stress has been recognized as a major factor contributing to the progression of several neurodegenerative disorder, reactive oxygen species (ROS) including superoxide have received great attention as a...

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