scholarly journals High-Intensity Interval Training is Associated with Improved Long-Term Survival in Heart Failure Patients

2019 ◽  
Vol 8 (3) ◽  
pp. 409 ◽  
Author(s):  
Chih-Chin Hsu ◽  
Tieh-Cheng Fu ◽  
Shin-Sheng Yuan ◽  
Chao-Hung Wang ◽  
Min-Hui Liu ◽  
...  

This matched-control cohort study explored the effects of high-intensity interval training (HIIT) on left ventricle (LV) dimensions and survival in heart failure (HF) patients between 2009 and 2016. HF patients who underwent the multidisciplinary disease management program (MDP) were enrolled. Non-exercising participants, aged (mean (95% confidence interval)) 62.8 (60.1–65.5) years, were categorized as the MDP group (n = 101). Participants aged 61.5 (58.7–64.2) years who had completed 36 sessions of HIIT were treated as the HIIT group (n = 101). Peak oxygen consumption (VO2peak) and LV geometry were assessed during the 8-year follow-up period. The 5-year all-cause mortality risk factors and overall survival rates were determined in the longitudinal observation. An increased VO2peak of 14–20% was observed in the HIIT group after exercise training. Each 1-mL/kg/min increase in VO2peak conferred a 58% improvement in 5-year mortality. Increased LV end-systolic diameter (LVESD) was significantly (p = 0.0198) associated with increased mortality. The 8-month survival rate was significantly improved (p = 0.044) in HIIT participants compared to non-exercise participants. HF patients with VO2peak ≥14.0 mL/kg/min and LVESD <44 mm had a significantly better 5-year survival rate (98.2%) than those (57.3%) with lower VO2peak and greater LVESD. Both HIIT-induced increased VO2peak and decreased LVESD are associated with improved survival in HF patients.

Author(s):  
Christopher R. J. Fennell ◽  
James G. Hopker

Abstract Purpose The current study sought to investigate the role of recovery intensity on the physiological and perceptual responses during cycling-based aerobic high-intensity interval training. Methods Fourteen well-trained cyclists ($$\dot{V}{\text{O}}_{{{\text{2peak}}}}$$ V ˙ O 2peak : 62 ± 9 mL kg−1 min−1) completed seven laboratory visits. At visit 1, the participants’ peak oxygen consumption ($$\dot{V}{\text{O}}_{{{\text{2peak}}}}$$ V ˙ O 2peak ) and lactate thresholds were determined. At visits 2–7, participants completed either a 6 × 4 min or 3 × 8 min high-intensity interval training (HIIT) protocol with one of three recovery intensity prescriptions: passive (PA) recovery, active recovery at 80% of lactate threshold (80A) or active recovery at 110% of lactate threshold (110A). Results The time spent at > 80%, > 90% and > 95% of maximal minute power during the work intervals was significantly increased with PA recovery, when compared to both 80A and 110A, during both HIIT protocols (all P ≤ 0.001). However, recovery intensity had no effect on the time spent at > 90% $$\dot{V}{\text{O}}_{{{\text{2peak}}}}$$ V ˙ O 2peak (P = 0.11) or > 95% $$\dot{V}{\text{O}}_{{{\text{2peak}}}}$$ V ˙ O 2peak (P = 0.50) during the work intervals of both HIIT protocols. Session RPE was significantly higher following the 110A recovery, when compared to the PA and 80A recovery during both HIIT protocols (P < 0.001). Conclusion Passive recovery facilitates a higher work interval PO and similar internal stress for a lower sRPE when compared to active recovery and therefore may be the efficacious recovery intensity prescription.


2010 ◽  
Vol 35 (3) ◽  
pp. 350-357 ◽  
Author(s):  
Brendon J. Gurd ◽  
Christopher G.R. Perry ◽  
George J.F. Heigenhauser ◽  
Lawrence L. Spriet ◽  
Arend Bonen

The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity and protein in relationship to peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and mitochondrial content were determined in human skeletal muscle. Six weeks of high-intensity interval training (∼1 h of 10 × 4 min intervals at 90% peak oxygen consumption separated by 2 min rest, 3 days per week) increased maximal activities of mitochondrial enzymes in skeletal muscle by 28% to 36% (citrate synthase, β-hydroxyacyl-coenzyme A dehydrogenase, and cytochrome c oxidase subunit IV) and PGC-1α protein (16%) when measured 4 days after training. Interestingly, total muscle SIRT1 activity (31%) and activity per SIRT1 protein (58%) increased despite decreased SIRT1 protein (20%). The present data demonstrate that exercise-induced mitochondrial biogenesis is accompanied by elevated SIRT1 activity in human skeletal muscle.


2018 ◽  
Vol 38 (4) ◽  
pp. 226-233
Author(s):  
Raymond Pranata ◽  
Emir Yonas ◽  
Bambang B. Siswanto ◽  
Budhi S. Purwowiyoto

Heart failure is one of the most common cardiovascular diseases and is a final pathway of various cardiac pathologies. Exercise intolerance and dyspnea accompanied by dete­riorating quality of life are common issues in those suffering from heart failure and may persist despite optimal medical therapy. Exercise training in heart failure theoretically helps to slow down the deterioration of the heart by antagonizing excess neurohormonal activity in heart failure, which translated into better functional capacity and quality of life. Exercise prescription is a mean of assessing and interpreting clinical information and applying the principles of training to develop an appropriate regimen and should be tailored to patient’s clinical condition. Resistance training improves peak VO2, exercise capacity and quality of life in heart failure patients. Both continuous and interval exercise training are linked to better quality of life despite ambiguous results in mortality. The aim of this article is to discuss the benefits of exercise in patients with congestive heart failure, exercise prescription, and exercise program including high-intensity interval training, continuous training and resistance exercise.   Abstrak Gagal jantung adalah salah satu penyakit kardiovaskular yang paling sering ditemui dan merupakan akhir daripada banyak jenis patologi jantung. Intoleransi olahraga dan sesak nafas disertai dengan memburuknya kualitas hidup merupakan beberapa masalah yang sering dihadapi oleh pasien gagal jantung, meskipun telah diberikan pengobatan yang optimal. Latihan olahraga pada gagal jantung secara teoritis dapat memperlambat menurunnya fungsi jantung dengan melawan aktivitas neurohormonal yang meningkat pada kondisi gagal jantung yang dicerminkan dengan kapasitas fungsional dan kualitas hidup yang lebih baik. Preskripsi olahraga meliputi pemeriksaan dan interpretasi dari informasi klinis dan aplikasi dari prinsip latihan untuk membentuk regimen yang sesuai dan harus di sesuaikan dengan keadaan klinis pasien. Latihan beban memperbaiki fungsi VO2 puncak, kapasitas olahraga dan kualitas hidup pada pasien dengan gagal jantung. Kedua metode olahraga baik secara kontinu ataupun interval dihubungkan dengan kualitas hidup yang lebih baik meskipun masih ambigu dalam hal mortalitas. Tujuan artikel ini adalah membahas manfaat latihan fisik pada pasien dengan gagal jantung kongestif, cara peresepan serta membahas program high intensity interval training, continuous training serta latihan beban.


2020 ◽  
Vol 15 (8) ◽  
pp. 1125-1131
Author(s):  
Tomás Chacón Torrealba ◽  
Jaime Aranda Araya ◽  
Nicolas Benoit ◽  
Louise Deldicque

Purpose: To evaluate the effects of a 6-week taekwondo-specific high-intensity interval training (HIIT) in simulated normobaric hypoxia on physical fitness and performance in taekwondoists. Methods: Eighteen male and female black-belt taekwondoists trained twice a week for 6 weeks in normoxia or in hypoxia (FiO2 = 0.143 O2). The HIIT was composed of specific taekwondo movements and simulated fights. Body composition analyses and a frequency speed of kick test during 10 seconds (FSKT10s) and 5 × 10 seconds (FSKTmult), countermovement jump (CMJ) test, Wingate test, and an incremental treadmill test were performed before and after training. Blood lactate concentrations were measured after the FSKTmult and Wingate tests, and a fatigue index during the tests was calculated. Results: A training effect was found for FSKT10s (+35%, P < .001), FSKTmult (+32%, P < .001), and fatigue index (−48%, P = .002). A training effect was found for CMJ height (+5%, P = .003) during the CMJ test. After training, CMJ height increased in hypoxia only (+7%, P = .005). No effect was found for the parameters measured during Wingate test. For the incremental treadmill test, a training effect was found for peak oxygen consumption (P = .002), the latter being 10% lower after than before training in normoxia only (P = .002). Conclusions: In black-belt taekwondoists, hypoxic HIIT twice a week for 6 weeks provides tiny additional gains on key performance parameters compared with normoxic HIIT. Whether the trivial effects reported here might be of physiological relevance to improve performance remains debatable and should be tested individually.


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