scholarly journals Delineating the Psychic Structure of Substance Use and Addictions, from Neurobiology to Clinical Implications: Ten Years Later

2020 ◽  
Vol 9 (6) ◽  
pp. 1913
Author(s):  
Pier Paolo Pani ◽  
Angelo G. I. Maremmani ◽  
Matteo Pacini ◽  
Emanuela Trogu ◽  
Gian Luigi Gessa ◽  
...  
Keyword(s):  
Substance Use ◽  
Psychiatric Symptoms ◽  
Signs And Symptoms ◽  
Addictive Behavior ◽  
Clinical Implications ◽  
Longitudinal Approach ◽  
Full Picture ◽  
Definition Of ◽  
Neuropsychological Evidence ◽  
Psychiatric Manifestations

The diagnosis of substance use disorder is currently based on the presence of specifically identified behavioral symptoms. In addition, other psychiatric signs and symptoms accompany addictive behavior, contributing to the full picture of patients’ psychopathologic profile. Historically, such symptoms were confined within the framework of “comorbidity”, as comorbid psychiatric disorders or personality traits. However, an alternative unitary view of the psychopathology of addiction, inclusive of related psychiatric symptoms, has been claimed, with the support of epidemiological, neurobiological, and neuropsychological evidence. In the present article, we highlight the research advancements that strengthen this unified perspective. We then give an account of our group’s definition of a specific SCL-90-based construct of the psychopathology of addiction. Lastly, we discuss the benefits that can be expected to be acquired in the evaluation and treatment of patients with a longitudinal approach including psychological/psychiatric predisposing features, addictive behavior, and psychiatric manifestations.

scholarly journals Executive functions and parenting stress in mothers with problematic substance use

2021 ◽  
Author(s):  
Victoria Ingram
Keyword(s):  
Substance Use ◽  
Executive Functions ◽  
Parenting Stress ◽  
Substance Use Treatment ◽  
Future Research ◽  
Clinical Implications ◽  
Household Chaos ◽  
Problematic Substance Use ◽  
Problematic Substance ◽  
Definition Of

A growing body of research has shown that executive functions play an important role in effective and sensitive parenting. No studies have examined this relation in mothers with problematic substance use, who may be at particular risk given biological, psychological, and contextual risks that may undermine executive functions and increase parenting stress. The purpose of this study was to investigate the relation between three executive functions and parenting stress. Sixty-five mothers attending substance use treatment completed tasks assessing updating, inhibition, and shifting executive functions and questionnaires assessing parenting stress, reflecting both relational and household chaos definitions of the construct. Controlling for SES and age of youngest child, lower performance on both inhibition and updating tasks was associated with increased parenting stress, when a relational definition was employed. However, no significant relations were found between executive functions and household chaos definitions of parenting stress, after depression and SES were controlled for. These preliminary results suggest a role for executive functions in parenting stress in mothers with problematic substance use, but highlight the importance of considering the type of executive function assessed and the definition of parenting stress employed. Directions for future research and clinical implications are discussed.

Substance Use and Psychiatric Symptoms Among MCMI-III Cluster Subgroups

2006 ◽  
Author(s):  
Robert C. McMahon ◽  
Robert M. Malow ◽  
Jessy Devieux ◽  
Terri Jennings
Keyword(s):  
Substance Use ◽  
Psychiatric Symptoms

Psychiatric Manifestations of Ehlers-Danlos Syndrome in Adolescents: A Case Report and Literature Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Daisy Vyas Shirk ◽  
Sarah D. Williams
Keyword(s):  
Chronic Pain ◽  
Literature Review ◽  
Literature Search ◽  
Web Search ◽  
Psychiatric Symptoms ◽  
Connective Tissue Disorders ◽  
Ehlers Danlos Syndrome ◽  
Symptoms Of Depression ◽  
Psychiatric Manifestations ◽  
Danlos Syndrome

Background: Ehlers-Danlos Syndromes (EDS) comprise a group of heterogeneous hereditary connective tissue disorders [1, 2]. Psychiatric disorders such as depression, anxiety, panic disorder, agoraphobia, schizophrenia, neurodevelopmental disorders, personality disorder, eating disorders, substance misuse and interpersonal issues have been reported in the literature to be associated with EDS [1-3]. Objectives: The case of a 15-year -old male who was hospitalized after a suicide attempt by gunshot was discovered to have symptoms suggestive of EDS is presented in this paper along with the results of a literature search of psychiatric manifestations of EDS in children and adolescents. Methods: Literature review was conducted on the UpToDate website on March 11, 2020 to review symptoms of EhlersDanlos Syndrome for the purpose of preliminary diagnosis of this patient. Additional literature search was conducted on PubMed on 4/2/20 at 12:10 P.M. and on 4/9/20 at 10:51 P.M. and on the search engine Google on 4/2/20 at 12:25 P.M. On May 11, 2020 at 2 P.M., another web search was conducted with review of 6 different websites pertaining to EhlersDanlos Syndrome. Results: A systematic review of psychiatric manifestations of Ehlers-Danlos Syndromes revealed a strong incidence of psychiatric symptoms. Conclusion: Our patient’s psychiatric symptoms of depression, suicidal ideations, anxiety and social and educational struggles may have been at least partially due to chronic pain- abdominal, headache and musculoskeletal, and social ostracization associated with Ehlers-Danlos Syndrome. Education regarding this illness helped our patient’s recovery as he came to understand why he was so “odd” and the cause of his multisystemic chronic pain.

Substance Use Problems and Associated Psychiatric Symptoms Among Adolescents in Primary Care

PEDIATRICS ◽  
2003 ◽  
Vol 111 (6) ◽  
pp. e699-e705 ◽  
Author(s):  
L. A. Shrier ◽  
S. K. Harris ◽  
M. Kurland ◽  
J. R. Knight
Keyword(s):  
Primary Care ◽  
Substance Use ◽  
Psychiatric Symptoms ◽  
Substance Use Problems

Neurosarcoidosis Presenting as Schizophreniform Disorder

1992 ◽  
Vol 22 (3) ◽  
pp. 269-274 ◽  
Author(s):  
Mohamed Sabaawi ◽  
Jose Gutierrez-Nunez ◽  
M. Richard Fragala
Keyword(s):  
Cognitive Decline ◽  
Mental Status ◽  
Clinical Presentation ◽  
Psychiatric Symptoms ◽  
Steroid Treatment ◽  
Schizophreniform Disorder ◽  
Schizophrenic Psychosis ◽  
Neurologic Involvement ◽  
Mental Status Examination ◽  
Psychiatric Manifestations

A patient whose clinical presentation met criteria for schizophreniform disorder was ultimately found to have neurosarcoidosis, and the psychiatric symptoms responded to steroid treatment. The ongoing search for organic etiology was prompted by the presence of cognitive decline, perseveration and rare bizarre automatisms. This is virtually the first reported association between schizophreniform disorder and sarcoidosis. We reviewed the literature on neurologic involvement and psychiatric manifestations in sarcoidosis as well as the concurrence between organicity and schizophrenic psychosis. The importance of attending to all elements of the mental status examination in a patient with complex atypical findings is underscored.

Frequency and temporal sequence of clinical features in adults with anti-NMDA receptor encephalitis presenting with psychiatric symptoms

2018 ◽  
Vol 49 (16) ◽  
pp. 2709-2716 ◽  
Author(s):  
Ronald J. Gurrera
Keyword(s):  
Nmda Receptor ◽  
Clinical Features ◽  
Psychiatric Symptoms ◽  
Autoimmune Encephalitis ◽  
Signs And Symptoms ◽  
Nmda Receptor Encephalitis ◽  
Nmdar Encephalitis ◽  
Unexplained Fever ◽  
Study Inclusion

AbstractBackgroundAnti-NMDA receptor (NMDAr) encephalitis is the most common autoimmune encephalitis in adults. It mimics psychiatric disorders so often that most patients are initially referred to a psychiatrist, and many are misdiagnosed. Without prompt and effective treatment, patients are likely to suffer a protracted course with significant residual disability, or death. This study focuses on the frequency and chronology of salient clinical features in adults with anti-NMDAr encephalitis who are likely to be first evaluated by a psychiatrist because their presentation suggests a primary psychiatric disorder.MethodsA systematic search of PubMed and EMBASE databases identified published reports of anti-NMDAr encephalitis associated with prominent behavioral or psychiatric symptoms. After eliminating redundancies, the frequencies and relative timing of clinical features were tabulated. Signs and symptoms were assigned temporal ranks based on the timing of their first appearance relative to the first appearance of other signs and symptoms in each patient; median ranks were used to compare temporal sequencing of both individual features and major symptom domains.ResultsTwo hundred thirty unique cases (185 female) met study inclusion criteria. The most common features were seizures (60.4%), disorientation/confusion (42.6%), orofacial dyskinesias (39.1%), and mutism/staring (37.4%). Seizures, fever, and cognitive dysfunction were often the earliest features to emerge, but psychiatric features predominated and sequencing varied greatly between individuals.ConclusionsClinicians should consider anti-NMDAr encephalitis when new psychiatric symptoms are accompanied by a recent viral prodrome, seizures or unexplained fever, or when the quality of the psychiatric symptoms is unusual (e.g. non-verbal auditory hallucinations).

“organic Personality Disorder” as Part of Early Neuropsychiatric Manifestations in Huntington’s Disease - a Case Report

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Maia
Keyword(s):  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Psychiatric Symptoms ◽  
Age Of Onset ◽  
Neuropsychiatric Symptoms ◽  
Personality Change ◽  
Psychotic Symptoms ◽  
Autosomal Dominant Disorder ◽  
Neuropsychiatric Manifestations ◽  
Psychiatric Manifestations

Huntington's Disease (HD) is an inherited autosomal dominant disorder characterized by motor, cognitive and psychiatric symptomatology, being considered a paradigmatic neuropsychiatric disorder that includes all three components of the "Triadic Syndromes": dyskinesia, dementia and depression.Firstly described in 1872 as an "Hereditary Chorea" by George Huntington only in 1993 was its responsible gene identified. A person who inherits the HD gene will sooner or later develop the disease. the age of onset, early signs and rate of disease progression vary greatly from person to person.Neuropsychiatric symptoms are an integral part of HD and have been considered the earliest markers of the disease, presenting sometimes more than 10 years before a formal diagnosis is done. Patients may experience dysphoria, mood swings, agitation, irritability, hostile outbursts, psychotic symptoms and deep bouts of depression with suicidal ideation. Personality change is reported in 48% of the cases, with the paranoid subtype being described as the most prevalent. the clinical case presented illustrates a case of HD which started with insidious psychiatric symptoms and an important personality change.Despite a wide number of medications being prescribed to help control emotional, movement and behaviour problems, there is still no treatment to stop or reverse the course of the disease. Furthermore, psychiatric manifestations are often amenable to treatment, and relief of these symptoms may provide significant improvement in patient's and caregivers quality of life.A greater awarness of psychiatric manifestations of HD is essential to an earlier diagnosis and an optimized therapeutic approach.

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