Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI

The aim of the study was to assess the volume of the lateral geniculate nucleus (LGN) in patients with open-angle glaucoma in 7Tesla MRI and to evaluate its relation to RNFL thickness and VF indices. Material and methods. The studied group consisted of 20 open-angle glaucoma patients with bilaterally the same stage of glaucoma (11 with early glaucoma and nine with advanced glaucoma) and nine healthy volunteers from the Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Poland. Circumpapillary RNFL-thickness measurements were performed using OCT in all patients and visual fields were performed in the glaucoma group. A 7Tesla MRI was performed to assess the volume of both lateral geniculate bodies. Results. The LGN volume varied significantly between groups from 122.1 ± 14.4 mm3 (right LGN) and 101.6 ± 13.3 mm3 (left LGN) in the control group to 80.2 ± 17.7 mm3 (right LGN) and 71.8 ± 14.2 mm3 (left LGN) in the advanced glaucoma group (right LGN p = 0.003, left LGN p = 0.018). However, volume values from early glaucoma: right LGN = 120.2 ± 26.5 mm3 and left LGN = 103.2 ± 28.0 mm3 differed significantly only from values from the advanced group (right LGN p = 0.006, left LGN p = 0.012), but not from controls (right LGN p = 0.998, left LGN p = 0.986). There were no significant correlations between visual field indices (MD (mean deviation) and VFI (visual field index)) and LGN volumes in both glaucoma groups. Significant correlations between mean RNFL (retinal nerve fiber layers) thickness and corresponding and contralateral LGN were observed for the control group (corresponding LGN: p = 0.064; contralateral LGN: p = 0.031) and early glaucoma (corresponding LGN: p = 0.017; contralateral LGN: p = 0.008), but not advanced glaucoma (corresponding LGN: p = 0.496; contralateral LGN: p = 0.258). Conclusions. The LGN volume decreases in the course of glaucoma. These changes are correlated with RNFL thickness in early stages of glaucoma and are not correlated with visual field indices.

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Comparison of Ocular Biometry between Primary Open Angle Glaucoma Patients and Normal subjects

Nepalese Journal of Ophthalmology ◽

10.3126/nepjoph.v13i2.34048 ◽

2021 ◽

Vol 13 (2) ◽

pp. 62-68

Author(s):

Nisha Manandhar ◽

Chandni Pradhan ◽

Purushottam Joshi ◽

Prabha Subedi ◽

Pranav Shrestha

Keyword(s):

Anterior Chamber ◽

Axial Length ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Anterior Chamber Depth ◽

Control Group ◽

Open Angle ◽

K Value ◽

The Difference ◽

Glaucoma Group

Introduction: Glaucoma is one of the major causes of irreversible blindness. In Nepal, the most common type of Glaucoma seen is Primary Open Angle Glaucoma. There are many risk factors associated with Primary Open Angle Glaucoma. The main objective of the study was to compare ocular biometric parameters in patients diagnosed with Primary Open Angle Glaucoma and age matched controls. Material and methods: This is a hospital based cross sectional study done at Mechi Eye Hospital. The study included 137 cases of Primary Open Angle Glaucoma and 75 normal individuals as control. Axial length (AL), anterior chamber depth (ACD), Keratometry ‘K’ value and Central Corneal Thickness (CCT) were measured. Mann – Whitney U test was used for statistical analysis. Results: Mean age in Primary Open Angle Glaucoma group was (55.25 ± 10.16 years) and in the control group was (60.96 ± 10.91 years). Axial length in the Primary Open Angle Glaucoma group (23.16 ±1.19 mm) was deeper as compared to the control group (22.69 ±0.89 mm), the difference was statistically significant (p<0.001). Anterior chamber depth (ACD) was statistically deeper in the Primary Open Angle Glaucoma group (3.05 ±0.51 mm) as compared to the control group (2.86 ±0.46 mm), (p<0.01). Central corneal thickness (CCT) was thinner in the Primary Open Angle Glaucoma group (519.5 ±36.25 um) as compared to the control group (525.40 ±37.77 um) but the difference was not found to be statistically significant (p<0.19). K value in Primary Open Angle Glaucoma (7.54 ±0.41mm) was higher than age-matched controls (7.58 ± 0.33mm) but the difference was not statistically significant (p<0.79). Conclusion: Patients with Primary Open Angle Glaucoma had longer Axial length (AL) and deeper Anterior chamber depth (ACD) as compared to normal individuals.

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Visual field indices and optic disc parameters in a 24-month follow-up of primary open angle glaucoma patients

Acta Ophthalmologica Scandinavica ◽

10.1111/j.1600-0420.1999.tb01128.x ◽

1999 ◽

Vol 77 (S229) ◽

pp. 20-21

Author(s):

Angelo Macrì ◽

Maurizio Rolando ◽

Guido Corallo ◽

Michele Iester ◽

Giuseppe Verrastro ◽

...

Keyword(s):

Visual Field ◽

Optic Disc ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Open Angle ◽

Visual Field Indices

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Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden.

10.21203/rs.3.rs-34864/v2 ◽

2020 ◽

Author(s):

Marcelo Ayala

Keyword(s):

Visual Field ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

T Test ◽

Open Angle ◽

Visual Field Progression ◽

Exfoliation Glaucoma ◽

The Difference ◽

Glaucoma Group

Abstract Background: The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods: Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for three years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24-2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results: The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (-3.17 dB) than in the primary open-angle (-1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p=<0.001). The difference in VFI was calculated for the three years follow-up period. The difference was higher in the exfoliation (-7.65%) than in the primary open (-1.90%) glaucoma group (t-test, p=<0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p=<0.001). Conclusion: The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

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Comparison of visual field progression in new-diagnosed primary open-angle and exfoliation glaucoma patients in Sweden

BMC Ophthalmology ◽

10.1186/s12886-020-01592-w ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Marcelo Ayala

Keyword(s):

Visual Field ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

T Test ◽

Open Angle ◽

Visual Field Progression ◽

Exfoliation Glaucoma ◽

The Difference ◽

Glaucoma Group

Abstract Background The present study aimed to compare visual field progression in new-diagnosed exfoliation versus open-angle glaucoma patients. Methods Retrospective study. The study included patients with new-diagnosed primary open-angle and exfoliation glaucoma. All patients were followed for 3 years with reliable visual fields. At least five reliable fields were needed for inclusion. Exfoliation and open-angle glaucoma were defined based on the European Glaucoma Society guidelines. Visual field evaluation was performed using the software threshold 24–2 of the Humphrey Field Analysis. Outcomes: Visual field progression. For visual field progression, three different strategies were used: mean deviation (MD), visual field index (VFI), and the guided progression analysis (GPA). Results The study included 128 subjects, of the 54 in the open-angle and 74 in the exfoliation glaucoma group. The MD difference values were higher in the exfoliation (− 3.17 dB) than in the primary open-angle (− 1.25 dB) glaucoma group in the three-year follow-up period. The difference between groups was significant (t-test, p = < 0.001). The difference in VFI was calculated for the 3 years follow-up period. The difference was higher in the exfoliation (− 7.65%) than in the primary open (− 1.90%) glaucoma group (t-test, p = < 0.001). The GPA showed progression in 58% of cases in exfoliation, and 13% in primary open glaucoma group (Chi-square, p = < 0.001). Conclusion The present study found a more frequent and faster visual field progression in exfoliation than in primary open-angle glaucoma patients. New-diagnosed exfoliation glaucoma patients must be controlled and treated more strictly than primary open-angle glaucoma patients to avoid visual field deterioration.

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Comparing the efficacy of trabeculectomy and XEN gel microstent implantation for the treatment of primary open-angle glaucoma: a retrospective monocentric comparative cohort study

Scientific Reports ◽

10.1038/s41598-020-76551-y ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Theresa Theilig ◽

Matus Rehak ◽

Catharina Busch ◽

Caroline Bormann ◽

Marc Schargus ◽

...

Keyword(s):

Visual Field ◽

Open Angle Glaucoma ◽

Statistical Significance ◽

Field Testing ◽

Automated Perimetry ◽

Open Angle ◽

Comparable Group ◽

Comparative Cohort Study ◽

Visual Field Indices

Abstract The aim of this study was to compare the efficacy and safety profile of XEN microstent implantation with trabeculectomy (TET) in a comparable group of open-angle glaucoma cases in a retrospective, monocentric, single-surgeon setting. Each treatment group consisted of 100 eyes of 100 patients. At regular follow-up visits during the first 12 months after surgery, the following assessments were conducted and compared: intraocular pressure (IOP), number of IOP-lowering medications applied, best-corrected visual acuity (BCVA) and visual field testing. In both groups mean IOP was significantly reduced (p < 0.001). Mean IOP dropped from 24.8 ± 7.8 to 14.8 ± 4.0 mmHg in the TET and from 24.5 ± 6.7 to 16.6 ± 4.8 mmHg in the XEN group. The number of active compounds in the prescribed medication dropped from 3.3 ± 1.2 to 1.3 ± 1.4 in the TET and from 3.0 ± 1.1 to 1.4 ± 1.5 in the XEN group. BCVA and mean defect of static automated perimetry did not show a change of statistical significance in either group. Complications were more frequent after TET (p = 0.005) while postoperative needling was more frequent in the XEN group (p = 0.021). TET and XEN led to a significant reduction of IOP and IOP-lowering medication, while BCVA and visual field indices remained mostly unaltered over a 12-month postsurgical follow-up.

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Detection of serum uric acid in primary open angle glaucoma: A pilot study

European Journal of Ophthalmology ◽

10.1177/1120672120944012 ◽

2020 ◽

pp. 112067212094401

Author(s):

Rita Serra ◽

Florence Coscas ◽

Antonio Pinna ◽

Marcella Peri ◽

Ignazio Zucca ◽

...

Keyword(s):

Uric Acid ◽

Pilot Study ◽

Visual Field ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Serum Levels ◽

Mean Deviation ◽

Ophthalmological Examination ◽

Open Angle ◽

Rnfl Thickness

Purpose: To assess the association between the serum levels of uric acid (UA) and primary open-angle glaucoma (POAG). Methods: In this pilot study, 46 eyes of 23 patients with a clinical history of POAG and 30 eyes of 15 healthy subjects were included. All patients underwent a complete ophthalmological examination, including best corrected visual acuity (BCVA), intraocular pressure (IOP), and gonioscopy. Visual field parameters, such as mean deviation (MD) and pattern standard deviation (PSD), and optical coherence tomography (OCT) values of the optic nerve head, including retinal nerve fiber layer (RNFL) thickness and vertical cup/disc ratio (VCDR), were noted. A blood sample was collected from each subject for serum UA measurement. Results: IOP, MD, PSD, RNFL thickness, and VCDR resulted significantly different in POAG patients, when compared with controls ( p < 0.05). POAG patients showed significantly lower levels of mean serum UA than healthy controls (4.00 ± 0.66 mg/dL vs 4.95 ± 0.86 mg/dL, respectively, p < 0.0001). Furthermore, severe POAG patients showed mean serum levels of UA lower than mild POAG patients (3.36 ± 0.70 mg/dL vs 4.22 ± 0.51 mg/dL, respectively, p = 0.01). Visual field and OCT parameters were statistically correlated with the mean serum levels of UA in POAG eyes ( p < 0.05). Conclusion: Results suggest that in POAG patients, serum UA levels may be decreased and correlated with visual field and OCT parameters worsening. Further larger multi-center prospective studies are necessary to confirm our findings and establish the role of UA in glaucoma.

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Progression of Corneal Endothelial Insult by Chronic Elevation of intraocular Pressure: A prospective Observational Comparative Study Among Primary Open Angle Glaucoma Patients

10.21203/rs.3.rs-190994/v1 ◽

2021 ◽

Author(s):

Elshimaa A.Mateen ◽

Hatem Gamal Ammar ◽

Khulood Muhammad Sayed

Keyword(s):

Intraocular Pressure ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Significant Negative Correlation ◽

Control Group ◽

P Value ◽

Open Angle ◽

Advanced Stages ◽

Iop Elevation ◽

Glaucoma Group

Abstract Purpose: To evaluate specular microscopic changes of corneal endothelial cells (CEC) count and morphology in correlation to retinal nerve fiber layer RNFL changes detected by visual field (VF) and OCT in early and advanced primary open-angle glaucoma (POAG).Methods: A prospective observational comparative study was conducted on patients with POAG versus non-glaucomatous patients of the same age group. Specular microscopy, VF test, OCT scans of RNFL, and macular ganglion cell complex (GCC) were performed. Glaucoma group was further subdivided into early and advanced stages.Results: The study included 130 eyes of 130 subjects, 70 were eyes with POAG (glaucoma group), 60 were healthy eyes (control group). Both groups were comparable regarding mean age and sex.In the early glaucoma group, a significant negative correlation was found between the coefficient of variation (CV%) and superior PRNFL thickness (r=-0.5, p-value=0.018). A significant negative correlation was also found between percentage of cellular hexagonality (HEX%) and vertical cup/disc (C/D) ratio (r=-0.43, p-value= 0.035). A significant positive correlation was found between HEX% and (superior, inferior) PRNFL thickness (r=0.53, 0.5 and p-value= 0.008, 0.015) respectively.Mean CEC count was significantly lower in the advanced glaucoma group than in the control group (2958.7±371.2 vs 3085±172.5, p value=0.043). Conclusions: CEC is affected by chronic intraocular pressure (IOP) elevation just like the PRNFL and macular GCC. CEC morphology is insulted in the early stages of POAG while the count can withstand chronic IOP elevation till advanced stages were both are affected.

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The Association Between Primary Open Angle Glaucoma and Clustered Components of Metabolic Syndrome

The Open Ophthalmology Journal ◽

10.2174/1874364101509010149 ◽

2015 ◽

Vol 9 (1) ◽

pp. 149-155 ◽

Cited By ~ 8

Author(s):

Seyed Ahmad Rasoulinejad ◽

Ali Kasiri ◽

Mahdi Montazeri ◽

Negin Rashidi ◽

Maryam Montazeri ◽

...

Keyword(s):

Metabolic Syndrome ◽

Primary Open Angle Glaucoma ◽

Open Angle Glaucoma ◽

Control Group ◽

Open Angle ◽

Mean Values ◽

Conflicting Evidence ◽

The Mean ◽

Spss Software ◽

Glaucoma Group

Purpose : There is conflicting evidence whether components of metabolic syndrome (MetS) increase or decrease the risk of primary open-angle glaucoma (POAG). The aim of the present study was to determine the association between metabolic syndrome and primary open-angle glaucoma. Methods : A total of 200 participants comprising 100 controls and 100 patients with POAG documented by clinical tests and examined by an experienced ophthalmologist using standard ophthalmologic equipment were included in the study. MetS was defined and based on ATP III criteria and POAG was defined by the criteria of the International Society of Geographic and Epidemiological Ophthalmology (ISGEO). The data were entered into the SPSS software and analyzed. Results : The prevalence of MetS in the glaucoma group was 53% in comparison to 38% in the control group (p=0.037). MetS was associated with an increased odds ratio for an IOP higher than 21 mmHg (OR: 1.72; 95% CI 1.03-2.79; p=0.034). The mean IOP was 24.91±4.29 mmHg in the patients without MetS, and 27.23±4.81 mmHg in those with MetS (p=0.027). The mean values of CCT were 603.64±63.16 µm in MetS patients and 579.27±72.87 µm in controls (p=0.018). Conclusion : Data showed an increased prevalence of components of metabolic syndrome in patients with glaucoma. The mechanisms underlying these associations need to be established in future studies. Our results support the recommendation that patients with metabolic syndrome undergo regular ophthalmological exams to monitor for the onset or progression of glaucoma.

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Serum Biomarkers for the Diagnosis of Glaucoma

Diagnostics ◽

10.3390/diagnostics11010020 ◽

2020 ◽

Vol 11 (1) ◽

pp. 20

Author(s):

Young Joo Shin ◽

Eunbi Kim ◽

Bobby Kwanghoon Han ◽

Kayoung Yi

Keyword(s):

Open Angle Glaucoma ◽

Characteristic Curve ◽

Area Under The Curve ◽

Normal Tension Glaucoma ◽

Control Group ◽

Heat Shock Protein 60 ◽

Open Angle ◽

Glaucoma Diagnosis ◽

High Tension ◽

Glaucoma Group

Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups—and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren’s-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group (p < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG.

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COMPARISON OF RETINAL NERVE FIBER LAYER THICKNESS(RNFL) IN NORMAL AND GLAUCOMA PATIENTS WITH OPTICAL COHERENCE TOMOGRAPHY(OCT)

10.36106/gjra/4200420 ◽

2021 ◽

pp. 7-8

Author(s):

Nirav Mehta ◽

Nayana Dhorajiya ◽

Rupam Desai

Keyword(s):

Optical Coherence Tomography ◽

Layer Thickness ◽

Open Angle Glaucoma ◽

Control Group ◽

Optical Coherence ◽

Fiber Layer ◽

Cross Sectional ◽

Glaucoma Suspect ◽

Rnfl Thickness ◽

Glaucoma Group

Optical coherence tomography (OCT) has proved to be valuable in the detection of glaucomatous damage. With its high resolution and proven measurement reproducibility, OCT has the potential to become an important tool for glaucoma detection. This manuscript presents the capabilities of the OCT technology evaluate retinal nerve ber layer thickness in normal and glaucoma patients Method: -A prospective, non-randomized, observational cross-sectional study was done at Rotary eye hospital, Navsari, from September 2019 to March 2020. Groups were divided in Control and glaucoma group and further Glaucoma patients were also subdivided in to Glaucoma Suspect, OHT, NTG and POAG. Patient went under comprehensive examination and selected patient went undergone measuring average retinal nerve ber layer thickness (RNFL) was by using ZEISS CIRRUS HD OCT. Results: - In overall 120 eyes of patients, 60 eyes of control group & 60 eyes of glaucoma groups were analysed. The average RNFL measurement were signicantly thinner in glaucoma group with compared control groups were 80±14 and 89±12, (P<0.01). All four quadrant RNFL thickness were analysed in Glaucoma Suspect, OHT, NTG and POAG which was statistically highly signicant. Superior quadrant RNFL thickness among groups were 105±17, 112±16, 90±17 and 85±18 m respectively (p= < 0.01).Mean RNFL thickness showed a decrease in thickness from Non-Glaucoma to Primary Open angle glaucoma (POAG) shows statistically signicant difference. Conclusions: OCT is important instrument for measuring RNFL thickness. Study shows difference in normal and glaucoma patients and different types of glaucoma patients. OCT measurement will help in early detection of glaucoma as well as in keeping an eye on progression of glaucoma.

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