Long-Term Outcome of Epiretinal Membrane Surgery in Patients with Internal Limiting Membrane Dehiscence

Purpose: To identify the effect of internal limiting membrane (ILM) dehiscence on surgical outcomes in eyes that have undergone epiretinal membrane (ERM) removal. Methods: Consecutive eyes with performed vitrectomy for ERM removal were included. Subjects were divided into two groups: patients with ILM dehiscence (group 1) and without ILM dehiscence (group 2). The best-corrected visual acuity (BCVA) and retinal layer thickness before and after surgery were compared between the two groups. Results: A total of 86 eyes were enrolled. Forty-six eyes (53.5%) showed ILM dehiscence before surgery. The baseline BCVAs were 0.46 ± 0.29 and 0.45 ± 0.25 in groups 1 and 2, respectively (p = 0.801). The BCVAs at 3, 6, and 12 months after surgery differed significantly between the two groups. The subfoveal thickness and inner retinal layer thickness (IRLT) of group 1 vs. 2 were 507.4 ± 80.0 vs. 417.6 ± 63.6 μm, and 270.2 ± 74.3 vs. 182.6 ± 60.4 μm, respectively (both p < 0.001). These differences between the groups remained significant until 12 months after surgery. In multivariate analyses, the location of ILM dehiscence (B = −0.105, p = 0.034) and final IRLT (B = 0.001, p = 0.046) were significant factors affecting the final BCVA. Conclusions: ILM dehiscence is a relatively common finding and associated with preoperative and postoperative increased IRLT, which results in worse surgical outcomes compared to the absence of ILM dehiscence in patients with ERM. Additionally, the final BCVA was significantly affected by its location and final IRLT in patients with ILM dehiscence.

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Point of Care Neurosonogram in Neonates - Utility and Prognostic Value

American Journal of Sonography ◽

10.25259/ajs-41-2018 ◽

2019 ◽

Vol 2 ◽

pp. 1

Author(s):

Bhushita Lakhkar ◽

M. M. Patil ◽

Bhavana Lakhkar ◽

Bhushan Lakhkar

Keyword(s):

Neonatal Intensive Care ◽

Point Of Care ◽

Color Doppler ◽

Periventricular Leukomalacia ◽

Birth Asphyxia ◽

Common Finding ◽

Term Outcome ◽

Long Term Outcome ◽

Doppler Study

Objective The study aimed to utilize the neurosonographic findings in neonates in early diagnosis, prediction of their long-term outcome, parental counseling, and early intervention. Methods The study was carried out in neonatal intensive care unit (NICU) of Shri BM Patil Medical College and Hospital. All preterms and term babies with neurological clinical findings were included in the study. Neurosonogram was done within first 7 days in preterms and when indicated in terms. Philips HD11XE ultrasound and color Doppler unit were used with a small footprint probe. Color Doppler images for vessels were performed for screening of vascular changes. Results A total of 215 babies were included, of which 80 (32%) were term and the rest were preterm. Mean weight of term babies was 2.8 kg and that of preterm was 1.2 kg.Among term babies, 78% showed ultrasound abnormality, and among preterm, 42%showed abnormalities. Among term babies, 60% and, among preterms, 30% had birth asphyxia. Periventricular leukomalacia was the most common and earliest finding followed by thalamic hyperechogenicity and intracranial hemorrhage. Intraventricular hemorrhage was more common in preterm babies. Other common finding in NICU was meningitis which was more common in pretrms. Among congenital anomalies, corpus callosal agenesis was more common. Conclusions Point of care ultrasonography along with Doppler study is very useful and safe to use in NICUs. It helps in diagnosis, patient management as well as prediction of many short- and long-term outcomes.

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Association between individual retinal layer thickness and visual acuity in patients with epiretinal membrane: a pilot study

PeerJ ◽

10.7717/peerj.9481 ◽

2020 ◽

Vol 8 ◽

pp. e9481

Author(s):

Jing Zou ◽

Wei Tan ◽

Wenlong Huang ◽

Kangcheng Liu ◽

Fangling Li ◽

...

Keyword(s):

Visual Acuity ◽

Layer Thickness ◽

Epiretinal Membrane ◽

Linear Regression Analysis ◽

Plexiform Layer ◽

Surgical Patients ◽

Retinal Layer ◽

Inner Plexiform Layer ◽

Post Surgery ◽

Visual Improvement

Purpose We investigated the correlation between visual acuity (VA) and individual retinal layer thickness in the foveal, parafoveal, and perifoveal regions of patients with an idiopathic epiretinal membrane (ERM). Methods One hundred and five subjects presenting with unilateral idiopathic ERM were included in this study. We segmented each patient’s optical coherence tomography (OCT) image into seven layers and calculated the mean layer thickness in the foveal, parafoveal, and perifoveal regions using the Iowa Reference Algorithm. In 105 patients with ERM, we detected correlations between their macular regions’ individual retinal layer thickness and their best corrected VA. Thirty-one of the 105 patients with ERM underwent vitrectomy and completed six months of follow-up. We then compared the 31 surgical patients’ preoperative and postoperative individual retinal layer thickness in each macular region. Additionally, the association between preoperative individual retinal layer thickness in each macular region and VA six months post-surgery in patients with ≥ two Snellen lines of visual improvement was determined. Results Multiple linear regression analysis showed that the inner nuclear layer (INL) thickness in the foveal, parafoveal, and perifoveal region were all associated with VA in the 105 patients (R2 = 0.344, P < 0.001; R2 = 0.427, P < 0.001; and R2 = 0.340, P < 0.001, respectively). Thirty-one surgical patients 6 months post-surgery showed significantly decreased thicknesses (P ≤ 0.012) of the foveal INL, inner plexiform layer (IPL), and outer nuclear layer (ONL); the parafoveal retina nerve fiber layer (RNFL), IPL, INL, and ONL; and the perifoveal RNFL, IPL, INL, ganglion cell layer (GCL), outer plexiform layer (OPL), and photoreceptor layer (PRL). We found a weak correlation between postoperative VA and preoperative foveal and perifoveal RNFL thickness (r = 0.404 and r = 0.359, respectively), and a moderate correlation between postoperative VA and preoperative foveal and parafoveal INL thickness (r = 0.529 and r = 0.583, respectively) in the 31 surgical patients (P ≤ 0.047). The preoperative INL thickness in the foveal, parafoveal, and perifoveal regions showed a moderate to strong correlation (r = 0.507, 0.644, and 0.548, respectively), with postoperative VA in patients with ≥ 2 lines of visual improvement (P ≤ 0.038). Conclusion We detected a correlation between retinal damage and VA in the parafoveal, perifoveal, and foveal regions. Our results suggest that INL thickness in all macular regions may be a prognostic factor for postoperative VA in ERM patients.

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The volume of left atrium measured by multi-detector computed tomography can predict of long term outcome in catheter ablation of atrial fibrillation

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeab111.011 ◽

2021 ◽

Vol 22 (Supplement_3) ◽

Author(s):

YR Kim

Keyword(s):

Computed Tomography ◽

Atrial Fibrillation ◽

Catheter Ablation ◽

Left Atrium ◽

Volume Estimation ◽

Term Outcome ◽

Long Term Outcome ◽

Group 2 ◽

Group 1

Abstract Funding Acknowledgements Type of funding sources: None. Background This study aimed to identify the volume left atrium (LA) and left atrial appendage (LAA) calculated by multidetector computed tomography (MDCT) is related to the long term out come of radiofrequency catheter ablation (RFCA) for atrial fibrillation(AF). Methods We analyzed data from 99 consecutive patients who referred for RFCA due to drug-refractory symptomatic AF (age 56 ± 10 years; 74% men; 64% paroxysmal AF). Prior to the procedure, all patients underwent ECG-gated 128 channels MDCT scan for assessment for pulmonary vein anatomy, LA and LAA volume estimation, and electro-anatomical mapping integration. Results The volume of LA and LAA calculated by CT was 142.6 ± 32.2 mL and 14.7 ± 6.0 mL, respectively. LA volume was smaller in paroxysmal AF(PAF) than persistent AF(PeAF) (133.9 ± 29.3 mL vs. 158.0 ± 31.4 mL, p < 0.0001) but LAA volume was not significantly different between PAF and PeAF(13.9 ± 5.0 mL vs. 16.3 ± 7.3 mL, p = 0.09). Patients were classified into 2 groups by the LA volume of 160mL; group 1 (LA volume < 160mL,n = 73) and group 2 (LA volume ≥160mL, n = 26). After a mean follow up 12.6 ± 5.3 months, 78.8% of the patients maintained sinus rhythm after the index ablation. AF free survival was significantly greater in group 1 than group 2 (84.9% vs. 61.5% p = 0.017). No relationship was found between LAA volume and the outcome of RFCA. Multivariate analysis showed that the LA volume >160mL was an independent predictor of arrhythmia-free after ablation (Hazard ration 2.55, 95% confidential interval 1.02-6.35, p = 0.045) Conclusion Higher LA volume is independent risk factor for AF recurrence after RFCA but not LAA volume. The LA volume quickly assessed by MDCT could be a good predictor of long term recurrence after AF ablation.

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Factors affecting the long-term outcome following non-living kidney transplantation

Transplant International Official Journal of the European Society for Organ Transplantation ◽

10.1007/978-3-642-77423-2_43 ◽

1992 ◽

pp. 138-139

Author(s):

J. Thorogood ◽

F. A. Zantvoort ◽

G. G. Persijn ◽

J. J. van Rood ◽

G. M. Th. Schreuder ◽

...

Keyword(s):

Kidney Transplantation ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting

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LONG-TERM OUTCOME OF KIDNEY TRANSPLANT USING NON-HEART BEATING DONOR: MULTIVARIATE ANALYSIS OF PRETRANSPLANT FACTORS AFFECTING THE GRAFT SURVIVAL

Transplantation Journal ◽

10.1097/00007890-199905150-00350 ◽

1999 ◽

Vol 67 (9) ◽

pp. S624

Author(s):

Ryohei Hattori ◽

Shinichi Ohshima ◽

Tamio Fujita ◽

Yoshinari Ono ◽

Tsuneo Kinukawa

Keyword(s):

Multivariate Analysis ◽

Kidney Transplant ◽

Graft Survival ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting ◽

Heart Beating

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Long-term outcome of kidney transplant using non-heart-beating donor: multicenter analysis of factors affecting graft survival

Clinical Transplantation ◽

10.1046/j.1399-0012.2003.00080.x ◽

2003 ◽

Vol 17 (6) ◽

pp. 518-521 ◽

Cited By ~ 15

Author(s):

Ryohei Hattori ◽

Yoshinari Ono ◽

Norio Yoshimura ◽

Kiyotaka Hoshinaga ◽

Tsukasa Nishioka ◽

...

Keyword(s):

Kidney Transplant ◽

Graft Survival ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting ◽

Heart Beating ◽

Multicenter Analysis

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Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin's lymphoma autografted after a first relapse

Annals of Oncology ◽

10.1093/annonc/mdi119 ◽

2005 ◽

Vol 16 (4) ◽

pp. 625-633 ◽

Cited By ~ 142

Author(s):

A. Sureda ◽

M. Constans ◽

A. Iriondo ◽

R. Arranz ◽

M.D. Caballero ◽

...

Keyword(s):

Stem Cell ◽

Prognostic Factors ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Hodgkin's Lymphoma ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting ◽

First Relapse

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Infrainguinal vein bypass graft revision: Factors affecting long-term outcome

Journal of Vascular Surgery ◽

10.1016/j.jvs.2004.08.038 ◽

2004 ◽

Vol 40 (5) ◽

pp. 916-923 ◽

Cited By ~ 83

Author(s):

Louis L. Nguyen ◽

Michael S. Conte ◽

Matthew T. Menard ◽

Edwin C. Gravereaux ◽

David K. Chew ◽

...

Keyword(s):

Bypass Graft ◽

Term Outcome ◽

Long Term Outcome ◽

Factors Affecting ◽

Vein Bypass ◽

Vein Bypass Graft

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Internal retinal layer thickness and macular migration after internal limiting membrane peeling in macular hole surgery

European Journal of Ophthalmology ◽

10.5301/ejo.5001066 ◽

2017 ◽

Vol 28 (3) ◽

pp. 311-316 ◽

Cited By ~ 5

Author(s):

Mun Y. Faria ◽

Nuno P. Ferreira ◽

Sofia Mano ◽

Diana M. Cristóvao ◽

David C. Sousa ◽

...

Keyword(s):

Macular Hole ◽

Layer Thickness ◽

Optic Disc ◽

Internal Limiting Membrane ◽

Retinal Layer ◽

Ilm Peeling ◽

Macular Hole Surgery ◽

Internal Limiting Membrane Peeling ◽

Retinal Layers ◽

Sd Oct

Purpose: To provide a spectral-domain optical coherence tomography (SD-OCT)-based analysis of retinal layers thickness and nasal displacement of closed macular hole after internal limiting membrane peeling in macular hole surgery. Methods: In this nonrandomized prospective interventional study, 36 eyes of 32 patients were subjected to pars plana vitrectomy and 3.5 mm diameter internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH). Nasal and temporal internal retinal layer thickness were assessed with SD-OCT. Each scan included optic disc border so that distance between optic disc border and fovea were measured. Results: Thirty-six eyes had a successful surgery with macular hole closure. Total nasal retinal thickening (p<0.001) and total temporal retinal thinning (p<0.0001) were observed. Outer retinal layers increased thickness after surgery (nasal p<0.05 and temporal p<0.01). Middle part of inner retinal layers (mIRL) had nasal thickening (p<0.001) and temporal thinning (p<0.05). The mIRL was obtained by deducting ganglion cell layer (GCL) and retinal nerve fiber layer (RNFL) thickness from overall thickness of the inner retinal layer. Papillofoveal distance was shorter after ILM peeling in macular hole surgery (3,651 ± 323 μm preoperatively and 3,361 ± 279 μm at 6 months; p<0.0001). Conclusions: Internal limiting membrane peel is associated with important alteration in inner retinal layer architecture, with thickening of mIRL and shortening of papillofoveal distance. These factors may contribute to recovery of disrupted foveal photoreceptor and vision improvement after IMH closure.

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