scholarly journals Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

2020 ◽  
Vol 9 (11) ◽  
pp. 3435
Author(s):  
Suk Kyun Hong ◽  
Nam-Joon Yi ◽  
Kyung Chul Yoon ◽  
Myoung Soo Kim ◽  
Jae Geun Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Overall Survival ◽  
Survival Rates ◽  
High Volume ◽  
National Registry ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Significant Difference ◽  
Poor Outcomes

Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY). Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed. Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database. Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.

scholarly journals Diaphragmatic hernias after pediatric liver transplantation: Eight cases from a high volume transplant center

2020 ◽  
Vol 75 ◽  
pp. S18
Author(s):  
Serdar Karakas ◽  
Tevfik Tolga Sahin ◽  
Koray Kutluturk ◽  
Cemalettin Aydin ◽  
Cüneyt Kayaalp ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
High Volume ◽  
Pediatric Liver Transplantation ◽  
Pediatric Liver ◽  
Transplant Center ◽  
Diaphragmatic Hernias

Anesthetic Risk Factors Associated With Early Mortality in Pediatric Liver Transplantation

2010 ◽  
Vol 42 (6) ◽  
pp. 2383-2386 ◽  
Author(s):  
P.D. Castañeda-Martínez ◽  
R.I. Alcaide-Ortega ◽  
V.E. Fuentes-García ◽  
J.A. Hernández-Plata ◽  
J. Nieto-Zermeño ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Early Mortality ◽  
Pediatric Liver Transplantation ◽  
Factors Associated ◽  
Pediatric Liver ◽  
Anesthetic Risk

Long-term results of Intergroup RTOG 91–11: A phase III trial to preserve the larynx—Induction cisplatin/5-FU and radiation therapy versus concurrent cisplatin and radiation therapy versus radiation therapy

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 5517-5517 ◽  
Author(s):  
A. A. Forastiere ◽  
M. Maor ◽  
R. S. Weber ◽  
T. Pajak ◽  
B. Glisson ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Survival Rates ◽  
Disease Free Survival ◽  
High Volume ◽  
Phase Iii ◽  
Long Term Results ◽  
Free Survival ◽  
Significant Difference ◽  
Lower Death Rate

5517 Background: The 2-year results of Intergroup RTOG 91–11 were published in 2003 (NEJM 349:2091–8,2003). We now present the 5-year results (after median follow-up for surviving patients of 6.9 years) of 515 eligible pts with resectable stage III or IV (excluding T1 and high volume T4), cancer of the glottic or supraglottic larynx. Methods: Patients were randomized to induction cisplatin/5-FU (CF) with responders then receiving RT (I+RT) (n = 173); or concurrent cisplatin (100 mg/m2 q 21 days × 3) and RT (CRT) (n = 171); or RT alone (R) (n = 171). Laryngectomy was performed for < partial response to induction CF, for persistent/recurrent disease or for laryngeal dysfunction. Results: At 5 years, laryngectomy-free survival (LFS) was significantly better with either I+RT (44.6%, p = 0.011) or CRT (46.6%, p = 0.011) compared to R (33.9%). There was no difference in LFS between I+RT and CRT (p = 0.98). Laryngeal preservation (LP) was significantly better with CRT (83.6%) compared to I+RT (70.5%, p = 0.0029) or R (65.7%, p = 0.00017). Local-regional control (LRC) was significantly better with CRT (68.8%) compared to I+RT (54.9%, p = 0.0018) or R (51%, p = 0.0005). I+RT compared to R for LP and LRC showed no significant difference (p = 0.37 and 0.62, respectively). The distant metastatic rate was low (I+RT 14.3%, CRT 13.2%, R 22.3%) with a trend (p ∼0.06) for benefit from chemotherapy. Disease-free survival (DFS) was significantly better with either I+RT (38.6%, p = 0.016) or CRT (39%, p = 0.0058) compared to R (27.3%). Overall survival rates were similar for the first 5 years (I+RT 59.2%, CRT 54.6%, R 53.5%); thereafter I+RT had a non-significant lower death rate. Compared to CRT, significantly more pts in the R group died of their cancer (34% vs 58.3%, p = 0.0007); the rate for I+RT was 43.8%. Conclusion: These 5-year results differ from the 2-year analysis by a significant improvement in LFS now seen for both I+RT and CRT treatments compared to R. For the endpoints of LP and LRC, CRT is still the superior treatment with no advantage seen to the addition of induction CF to R. There is no significant difference in overall survival. [Table: see text]

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