scholarly journals Serum Levels of Glutamate-Pyruvate Transaminase, Glutamate-Oxaloacetate Transaminase and Gamma-Glutamyl Transferase in 1494 Patients with Various Genotypes for the Alpha-1 Antitrypsin Gene

2020 ◽  
Vol 9 (12) ◽  
pp. 3923
Author(s):  
José María Hernández Pérez ◽  
Ignacio Blanco ◽  
Agustín Jesús Sánchez Medina ◽  
Laura Díaz Hernández ◽  
José Antonio Pérez Pérez
Keyword(s):  
Liver Damage ◽  
Serum Levels ◽  
Gamma Glutamyl Transferase ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Gamma Glutamyl ◽  
Glutamate Pyruvate ◽  
Alpha 1 Antitrypsin ◽  
Glutamyl Transferase ◽  
Normal Genotype

Background: Patients with liver disease associated with alpha-1 antitrypsin deficiency (AATD) are homozygous for the Z mutation, leading to chronic liver damage. Objective: To assess the serum levels of glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), and gamma-glutamyl transpeptidase (GGT) in patients with different genotypes for the alpha-1 antitrypsin (AAT) gene. Methods: Patients (n = 1494) underwent genotyping of the SERPINA1 gene, together with a determination of AAT and GOT and GPT and GGT transaminase levels. Patients with a deficient allele (n = 476) and with a normal genotype were compared. Results: A statistically significant association was found between deficient genotypes and GOT (p < 0.0003), GPT (p < 0.002), and GGT (p < 0.006). Comparing GOT levels in patients with PI*Z deficient variant versus those with normal genotype, an odds ratio (OR) of 2.72 (CI: 1.5–4.87) (p < 0.0005) was obtained. This finding was replicated with the PI*Z allele and the GPT values (OR = 2.31; CI: 1.45–3.67; p < 0.0003). In addition, a statistically significant association was found between liver enzymes and AAT values. Conclusion: The PI*Z allele seemed to be a risk factor for the development of liver damage. AAT deficient genotypes were associated with GOT, GPT, and GGT altered values. Low AAT levels were associated with high GPT and GGT levels.

Serum levels of gamma-glutamyl transferase are associated with markers of nocturnal hypoxemia in a general adult population

2009 ◽  
Vol 407 (1-2) ◽  
pp. 67-71 ◽  
Author(s):  
Francisco Gude ◽  
Jesús Rey-Garcia ◽  
Carmen Fernandez-Merino ◽  
Luis Meijide ◽  
Luis García-Ortiz ◽  
...  
Keyword(s):  
Adult Population ◽  
Serum Levels ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Nocturnal Hypoxemia ◽  
General Adult Population ◽  
Glutamyl Transferase

Prevention of acute cadmium toxicity by Picroliv

2005 ◽  
Vol 24 (10) ◽  
pp. 529-536 ◽  
Author(s):  
N Yadav ◽  
R K S Dogra ◽  
M Y Khan ◽  
S Khandelwal
Keyword(s):  
Cadmium Toxicity ◽  
Serum Levels ◽  
Herbal Extract ◽  
Male Rats ◽  
Gamma Glutamyl Transpeptidase ◽  
Glutamate Oxaloacetate Transaminase ◽  
Glutamate Pyruvate Transaminase ◽  
Glutamate Pyruvate ◽  
Glutamyl Transpeptidase ◽  
Marked Suppression

The potential of Picroliv, a herbal extract against acute cadmium (Cd) intoxication, was evaluated in male rats. Biochemical and histopathological profile in rats pretreated with Picroliv (12 mg/kg, oral) followed by a single dose of Cd as cadmium chloride (CdCl2) (3 mg/kg, ip) revealed marked suppression of oxidative stress in liver and testes. The Cd-induced enhanced levels of lipid peroxidation, membrane fluidity and reduced levels of nonprotein sulphydryls and Na+K+ATPase were significantly restored to near normal by Picroliv pretreatment. In addition, the Cd-induced serum levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, gamma glutamyl transpeptidase and lactate dehydrogenase were restored to near basal levels. Hepatic and testicular histopathological damage was also minimized. The results strongly suggest definite hepatoand testicular protection by Picroliv. The antioxidant potential of the herbal extract in the major part, and not its chelating property, seems to be responsible for its ameliorative action.

Fidelity of Gamma-Glutamyl Transferase (GGT) in Differentiating Skeletal Muscle From Liver Damage

2008 ◽  
Vol 23 (7) ◽  
pp. 748-751 ◽  
Author(s):  
Xiomara Q. Rosales ◽  
Mary-Lynn Chu ◽  
Christopher Shilling ◽  
Cheryl Wall ◽  
Gregory M. Pastores ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Liver Damage ◽  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Glutamyl Transferase

scholarly journals Association of severity of depression, paroxetine use and markers of liver damage with QT interval duration in patients with alcohol dependence

2020 ◽  
Vol 77 (7) ◽  
pp. 680-687
Author(s):  
Sanja Vukadinovic-Stojanovic ◽  
Zlatan Stojanovic
Keyword(s):  
Liver Damage ◽  
Qt Interval ◽  
Serum Levels ◽  
Interval Length ◽  
Gamma Glutamyl Transferase ◽  
Qtc Interval ◽  
Chronic Alcoholic ◽  
Number Of Patients ◽  
Severity Of Depression ◽  
Glutamyl Transferase

Background/Aim. Patients suffered from chronic alcoholic disease very often have depression and cardiomyopathy. Treatment with several antidepressants is associated with prolonged QT interval, ventricular arrhythmias and sudden death. The aim of this study was to investigate the relation between the severity of depression, serum levels of gamma-glutamyl transferase (GGT), as a marker of liver damage, and the possible influence of paroxetine use on duration of QT interval in patient who started treatment of chronic alcoholic dependence. Methods. The study included 147 male patients (older than 18 years of age) suffering from alcohol addiction, who were also diagnosed with depressive disorder on the basis of DSM-IV criterion and positive Hamilton Rating Scale for Depression (HRSD) at the beginning of hospitalization. Out of total number of patients, 49 were randomly selected to be treated with antidepressant paroxetine at a dose of 20 mg once daily during 20 days. The global QTc interval was automatically determined. Results. By applying the generalised linear model, the statistically significant positive correlation between the length of QTc interval and serum values of GGT, that is, intensity of alcoholism (p = 0.002) and values of the HRSD score, that is, intensity of depression (p = 0.021) was established in the sample of 147 depressed alcoholic patients before the application of paroxetine. In spite of the vulnerability of patients due to the heart damage and the liver dysfunction arising from alcohol consumption, as well as altered patients' drugs metabolism, no elongation of QTc interval resulting from the application of paroxetine was established. The length of QTc interval 20 days after paroxetine administration was 401.43 ms and before paroxetine administration it was 403.31 ms. The difference in QTc interval length (after and before paroxetine administration) was ?QTc = - 1.88 ms (p = 0.524). Conclusion. The results indicated that the severity of depression and GGT serum levels positively correlated with the length of QT interval. On the other hand, paroxetine after 20 days of usage did not prolong QT interval.

Ameliorative effect of trimetazidine on cisplatin-induced hepatotoxicity in rats

2016 ◽  
Vol 94 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Hayam Ateyya ◽  
Hala Yosef ◽  
Manar A. Nader
Keyword(s):  
Liver Damage ◽  
Antioxidant Defense System ◽  
Serum Levels ◽  
Control Group ◽  
Gamma Glutamyl Transferase ◽  
Protective Effects ◽  
Bax Protein ◽  
Ameliorative Effect ◽  
Glutamyl Transferase ◽  
Per Oral

This study was designed to evaluate the protective effects of trimetazidine (TMZ) against cisplatin (CP) induced liver damage in rats. Animals were distributed among 4 groups as follows: control group; TMZ group (20 mg/kg body mass, per oral), which was treated for 10 days; CP group (6 mg/kg, by intraperitoneal injection), which received a single injection; and the CP + TMZ group (20 mg/kg, per oral), which received TMZ 4 days before and 6 days after CP injection. The extent of hepatic damage was studied by assessing biochemical parameters and histopathological evaluation of the extracted liver tissue. The results revealed that liver enzymes were markedly elevated after injection of CP, as evident from significant increases in the serum levels of alanine transaminase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (γ-GT), and lactate dehydrogenase (LDH), as well as marked changes to the liver architecture, with a significant decrease in serum levels of albumin. There were also marked changes to the antioxidant defense system, as indicated by significant decreases in total antioxidants and hepatic levels of reduced glutathione (GSH) and superoxide dismutase (SOD), together with a significant increase in lipid peroxidation. However, there was a significant increase in the activity of hepatic nuclear factor kappa B (NF-κB) as well as hepatic Bax protein expression. We conclude that TMZ protects against CP-induced liver damage through scavenging free radicals and anti-inflammatory and antiapoptotic effects, as well as through reducing NF-κB activation.

Studies of Gamma-Glutamyl Transferase in Alpha-1 Antitrypsin Deficiency

2010 ◽  
Vol 7 (2) ◽  
pp. 126-132 ◽  
Author(s):  
Jayne Holme ◽  
Paul A. Dawkins ◽  
Ellen K. Stockley ◽  
David G. Parr ◽  
Robert A. Stockley
Keyword(s):  
Gamma Glutamyl Transferase ◽  
Gamma Glutamyl ◽  
Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin Deficiency ◽  
Alpha 1 Antitrypsin ◽  
Glutamyl Transferase

scholarly journals Biochemical adaptations in middle-distance runners: an assessment of blood and anthropometric parameters

2014 ◽  
Vol 87 (2) ◽  
Author(s):  
Danila Di Majo ◽  
Gabriella Schiera ◽  
Valentina Contrò ◽  
Elena Joana Armeli ◽  
Marcello Giaccone ◽  
...  
Keyword(s):  
Hematological Parameters ◽  
Serum Levels ◽  
Antioxidant Defenses ◽  
Physiological Adaptation ◽  
Gamma Glutamyl Transferase ◽  
Distance Runners ◽  
Anthropometric Parameters ◽  
Biological Stress ◽  
Glutamate Pyruvate ◽  
Glutamyl Transferase

In order to understand the mechanism underlying the physiological adaptation of purely aerobic workout, we investigated the effect of 2 months of training on nine males (17-22 year-old) middle distance running agonistic athletes. Blood sample was collected in the morning to analyze: hematological parameters, lipid profile, liver function enzymes [glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, gamma-glutamyl transferase (γ-GT)] and skeletal and myocardial markers of muscle damage [creatin kinase (CK) and creatin kinase MB (CK-MB)]. Endurance training, as it implies high oxygen consumption, should increase reactive oxygen species, but it has been shown that exercise leads to increased activation of antioxidant defenses. In fact, serum levels of γ-GT enzyme and total CK were not increased. On the other hand, a statistical significant reduction of CKMB has been observed. There were not variations in hematological parameters. As far as the anthropometric value is concerned, after two months of training there was a change in weight (P&lt;0.0001). Finally, any oxidative and biological stress was highlighted in the middle distance runners but, since this is a preliminary study, it would be of interest to replicate the study on a larger sample.

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