scholarly journals Effects of Synthetic Anti-Inflammatory Sterol in CB3V-Induced Myocarditis: A Morphological Study on Heart Muscle Tissue

2016 ◽  
Vol 1 (1) ◽  
pp. 69-89 ◽  
Author(s):  
Paola Castrogiovanni ◽  
Francesca Trovato ◽  
Marta Szychlinska ◽  
Carla Loreto ◽  
Salvatore Giunta ◽  
...  
Nature ◽  
1939 ◽  
Vol 143 (3611) ◽  
pp. 76-77 ◽  
Author(s):  
F. B. STRAUB
Keyword(s):  

1939 ◽  
Vol 33 (5) ◽  
pp. 787-792 ◽  
Author(s):  
Ferenc Bruno Straub
Keyword(s):  

2018 ◽  
Vol 4 (1) ◽  
pp. 97-100 ◽  
Author(s):  
Leonie Korn ◽  
Simon Lyra ◽  
Daniel Rüschen ◽  
Alexander Pugovkin ◽  
Dmitry Telyshev ◽  
...  

AbstractThe weakened heart is supported by a left ventricular assist device (LVAD) to supply the heart muscle with oxygenated blood. In case the heart muscle recovers during LVAD therapy, the patient has to be weaned from the device. To date, there is no adequate method to detect heart muscle recovery in LVAD therapy. In order to establish a novel method based on the measurement of electric conductivity, this study presents a silicone model of a ventricle mock-up to simulate the electrical properties of cardiac muscle tissue. Previously, it has been shown that the electrical properties of myocardial tissue change during ischemia, so that these changes are a possible estimate for measuring the condition of myocardial tissue. To this purpose, this study presents a casting process for a ventricle model and describes the materials used to imitate the electrical properties of the heart muscle to obtain conductive material. Initial results showed that the higher the carbon concentration in the silicone, the higher the conductivity of the silicone samples. The measurements were performed at different frequencies and the samples were analyzed for homogenization.


2017 ◽  
Vol 6 (2) ◽  
pp. 29
Author(s):  
Gohar Musheghyan ◽  
Arevik Minasyan ◽  
Gohar Arajyan ◽  
Sinerik Ayrapetyan

In this work the effect of 4Hz 30dB horizontal mechanical vibration (MV) on thermal pain threshold, hydration and [3H]-ouabain binding in brain and heart muscle tissues of rats was studied. It was revealed that 4Hz MV treatment for 10 minutes increased pain threshold, which was accompanied by brain and heart muscle tissue dehydration. In vitro state, hydration of brain and heart muscle tissues of sham animals was increased, while in 4Hz MV-treated animals the increase of brain tissue hydration was more pronounced and heart muscle tissues were dehydrated. The fact that 4Hz MV treatment also impacted heart muscle tissue hydration indicates that 4Hz MV effect on brain and heart muscle tissues is realized through a common messenger circulating in blood. The incubation of brain and heart muscle tissues in PS containing 10-4M and 10-9M ouabain led to tissue hydration in sham and 4Hz MV-treated animals. However, tissues of 4Hz MV-treated animals were less hydrated, and this hydration was accompanied by the decrease and increase of membrane receptors’ affinity at 10-4M and 10-9M ouabain concentrations, respectively. Based on the obtained data, it is suggested that pain-relieving effect of 4Hz MV is due to α3 isoform-dependent brain tissue dehydration.


2017 ◽  
Vol 23 (3) ◽  
pp. 237-240
Author(s):  
André Luiz Silva Davim ◽  
Tereza Neuma de Castro Dantas ◽  
Diego Filgueira Albuquerque ◽  
Márcia Rodrigues Pereira ◽  
Laíse Beatriz Trindade da Silva Queiroz ◽  
...  

ABSTRACT Introduction: Every day science seeks new ways to treat various diseases through drugs that are efficient and viable. Thus, therapeutic alternatives that meet such demand are targets of study. Microemulsions are one of these new alternatives due to their peculiar pharmacodynamic and pharmacokinetic characteristics. Objective: The aim of this study was to analyze the anti-inflammatory potential of microemulsion and pure bullfrog oil using an experimental model of muscle injury. Methods: Male Swiss mice were divided into three groups: control, microemulsion and pure bullfrog oil. After the pre-treatment, a muscle injury was induced in the animals’ leg and subsequently evaluations were carried out in the horizontal extent of edema and compared between the groups at predetermined times. Following evaluation of muscle injury, dissection of the right gastrocnemius muscles was performed for histological analysis. Results: The microemulsion and pure bullfrog oil showed good anti-inflammatory activity, acting similarly in reducing edema during the first two hours, but without statistical significance from the 3rd to the 24th hour after induction. The histological analysis revealed that the muscle tissue of the animals treated with the microemulsion presented mild cellular infiltrate and little wear of muscle fibers when compared with the muscular tissue of animals treated with the pure bullfrog oil. The histological analysis of the hepatic tissue showed signs of injury in the liver lobes of the pure bullfrog oil group, not observed in the microemulsion group. Conclusion: The microemulsion sho-wed good anti-inflammatory potential in the acute phase of the inflammatory response, reducing the formation of edema and preserving muscle tissue against the occurrence of lesions and without inducing injury in hepatic tissue.


1991 ◽  
Vol 24 (9) ◽  
pp. 841-849 ◽  
Author(s):  
Jacques M. Huyghe ◽  
Dick H. van Campen ◽  
Theo Arts ◽  
Robert M. Heethaar

2008 ◽  
Vol 1096 ◽  
Author(s):  
Yoshitake Akiyama ◽  
Kikuo Iwabuchi ◽  
Yuji Furukawa ◽  
Keisume Morishima

AbstractAn insect heart (dorsal vessel) is well suited as an environmentally robust bioactuator since insect tissue is generally robust over culture conditions compared with mammalian tissue. In this paper, the applicability of a caterpillar dorsal vessel to a bioactuator was assessed by fabricating a micropillar actuator driven by dorsal vessel tissue and evaluating the response to electrical pulse stimuli. The actuator worked autonomously for more than 90 days at 25 °C without any maintenance. The average frequency and displacement for 30 s on the 28th day of culturing were 0.83 Hz and 41 μm, respectively. Furthermore, as a regulation method for the dorsal vessel, electrical pulse stimuli were applied to the micropillar actuator. The contractile delay was about 50 ms. A twitch contraction was evoked by electrical pulse stimulus at 20 ms in duration and 10 volts in amplitude. A tetanic contraction was observed when stimuli over 10 Hz were applied.


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