scholarly journals Another Look at Obesity Paradox in Acute Ischemic Stroke: Association Rule Mining

2021 ◽  
Vol 12 (1) ◽  
pp. 16
Author(s):  
Pum-Jun Kim ◽  
Chulho Kim ◽  
Sang-Hwa Lee ◽  
Jong-Hee Shon ◽  
Youngsuk Kwon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Beneficial Effect ◽  
Acute Ischemic Stroke ◽  
Association Rule ◽  
Association Rule Mining ◽  
Obesity Paradox ◽  
Stroke Severity ◽  
Obese Patients ◽  
Rule Mining

Though obesity is generally associated with the development of cardiovascular disease (CVD) risk factors, previous reports have also reported that obesity has a beneficial effect on CVD outcomes. We aimed to verify the existing obesity paradox through binary logistic regression (BLR) and clarify the paradox via association rule mining (ARM). Patients with acute ischemic stroke (AIS) were assessed for their 3-month functional outcome using the modified Rankin Scale (mRS) score. Predictors for poor outcome (mRS 3–6) were analyzed through BLR, and ARM was performed to find out which combination of risk factors was concurrently associated with good outcomes using maximal support, confidence, and lift values. Among 2580 patients with AIS, being obese (OR [odds ratio], 0.78; 95% CI, 0.62–0.99) had beneficial effects on the outcome at 3 months in BLR analysis. In addition, the ARM algorithm showed obese patients with good outcomes were also associated with an age less than 55 years and mild stroke severity. While BLR analysis showed a beneficial effect of obesity on stroke outcome, in ARM analysis, obese patients had a relatively good combination of risk factor profiles compared to normal BMI patients. These results may partially explain the obesity paradox phenomenon in AIS patients.

scholarly journals Prevalence and factors associated with memory disturbance and dementia after acute ischemic stroke

2018 ◽  
Vol 10 (3) ◽  
Author(s):  
Jesada Surawan ◽  
Teabpaluck Sirithanawutichai ◽  
Suchat Areemit ◽  
Somsak Tiamkao ◽  
Suprawita Saensak
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Stroke Severity ◽  
Factors Associated ◽  
Laboratory Test Results ◽  
Khon Kaen ◽  
Memory Disturbance ◽  
State Examination ◽  
With Memory

Prevalence and risk factors associated with memory disturbance and dementia were determined in acute ischemic stroke (AIS) patients in hospitals before discharge, three and six months after stroke. A prospective cohort study was conducted during January-December 2017 with 401 AIS patients admitted to Srinagarind Hospital, Khon Kaen Hospital and Chum Phae Hospital, Khon Kaen, Thailand. The demographics and clinical characteristics, previous illness and past medical history, and laboratory test results of the patients were collected from the medical records, while depression screening, NIH stroke scale (NIHSS) scoring and mini mental state examination (MMSE) were performed using particular medical record forms. The prevalence of memory disturbance and dementia was 56.6, 41.6 and 38.2% before discharge, three and six months after stroke, respectively. Based on logistic regression analysis, age, education and stroke severity were the risk factors associated with the studied disorders before discharge and three months after stroke. Meanwhile, age and education were the risk factors for six months after stroke. Our findings suggested that the prevalence of memory disturbance and dementia remained high at all study periods.

Using association rule mining to identify risk factors for early childhood caries

2015 ◽  
Vol 122 (2) ◽  
pp. 175-181 ◽  
Author(s):  
Vladimir Ivančević ◽  
Ivan Tušek ◽  
Jasmina Tušek ◽  
Marko Knežević ◽  
Salaheddin Elheshk ◽  
...  
Keyword(s):  
Risk Factors ◽  
Early Childhood ◽  
Association Rule ◽  
Association Rule Mining ◽  
Early Childhood Caries ◽  
Rule Mining ◽  
Childhood Caries

scholarly journals Detecting Lifestyle Risk Factors for Chronic Kidney Disease With Comorbidities: Association Rule Mining Analysis of Web-Based Survey Data

10.2196/14204 ◽  
2019 ◽  
Vol 21 (12) ◽  
pp. e14204 ◽  
Author(s):  
Suyuan Peng ◽  
Feichen Shen ◽  
Andrew Wen ◽  
Liwei Wang ◽  
Yadan Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Association Rule ◽  
Chronic Conditions ◽  
Association Rule Mining ◽  
Lifestyle Modification ◽  
Rule Mining ◽  
Web Based ◽  
Lifestyle Risk Factors ◽  
Lifestyle Choices ◽  
Lifestyle Risk

Background The rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal disease necessitating renal replacement therapy has placed a significant strain on health care. The rate of progression of CKD is influenced by both modifiable and unmodifiable risk factors. Identification of modifiable risk factors, such as lifestyle choices, is vital in informing strategies toward renoprotection. Modification of unhealthy lifestyle choices lessens the risk of CKD progression and associated comorbidities, although the lifestyle risk factors and modification strategies may vary with different comorbidities (eg, diabetes, hypertension). However, there are limited studies on suitable lifestyle interventions for CKD patients with comorbidities. Objective The objectives of our study are to (1) identify the lifestyle risk factors for CKD with common comorbid chronic conditions using a US nationwide survey in combination with literature mining, and (2) demonstrate the potential effectiveness of association rule mining (ARM) analysis for the aforementioned task, which can be generalized for similar tasks associated with noncommunicable diseases (NCDs). Methods We applied ARM to identify lifestyle risk factors for CKD progression with comorbidities (cardiovascular disease, chronic pulmonary disease, rheumatoid arthritis, diabetes, and cancer) using questionnaire data for 450,000 participants collected from the Behavioral Risk Factor Surveillance System (BRFSS) 2017. The BRFSS is a Web-based resource, which includes demographic information, chronic health conditions, fruit and vegetable consumption, and sugar- or salt-related behavior. To enrich the BRFSS questionnaire, the Semantic MEDLINE Database was also mined to identify lifestyle risk factors. Results The results suggest that lifestyle modification for CKD varies among different comorbidities. For example, the lifestyle modification of CKD with cardiovascular disease needs to focus on increasing aerobic capacity by improving muscle strength or functional ability. For CKD patients with chronic pulmonary disease or rheumatoid arthritis, lifestyle modification should be high dietary fiber intake and participation in moderate-intensity exercise. Meanwhile, the management of CKD patients with diabetes focuses on exercise and weight loss predominantly. Conclusions We have demonstrated the use of ARM to identify lifestyle risk factors for CKD with common comorbid chronic conditions using data from BRFSS 2017. Our methods can be generalized to advance chronic disease management with more focused and optimized lifestyle modification of NCDs.

scholarly journals Coronary Heart Event Analysis with Association Rule Mining

2013 ◽  
Vol 1 (1) ◽  
pp. 44-48
Author(s):  
B. Gomathy ◽  
S.M. Ramesh ◽  
A. Shanmugam
Keyword(s):  
Risk Factors ◽  
Data Mining ◽  
Blood Pressure ◽  
Family History ◽  
Association Rule ◽  
Association Rule Mining ◽  
Bypass Graft ◽  
Density Lipoprotein ◽  
Rule Mining ◽  
History Of

Coronary heart disease (CHD) is one of the major causes of disability in adults as well as one of the main causes of death in the developed countries. Although significant progress has been made in the diagnosis and treatment of CHD, further investigation is still needed. The objective of this study was to develop the assessment of heart event-risk factors targeting in the reduction of CHD events using Association Rule Mining. The risk factors investigated were: 1) before the event: a) non modifiable—age, sex, and family history for premature CHD, b) modifiable—smoking before the event, history of hypertension, and history of diabetes; and 2) after the event: modifiable—smoking after the event, systolic blood pressure, diastolic blood pressure, total cholesterol, high density lipoprotein, low-density lipoprotein, triglycerides, and glucose. The events investigated were: myocardial infarction (MI), percutaneous coronary intervention (PCI), and coronary artery bypass graft surgery (CABG).Data-mining analysis was carried out using the Association Rule Mining for the afore mentioned three events using five different splitting criteria for larger datasets. The most important risk factors, as extracted from the classification rules analysis were: 1) for MI, age, smoking, and history of hypertension; 2) for PCI, family history, history of hypertension, and history of diabetes; and 3) for CABG, age, history of hypertension, and smoking. It is anticipated that data mining could help in the identification of high and low risk subgroups of subjects, a decisive factor for the selection of therapy, i.e., medical or surgical.

scholarly journals Detecting Lifestyle Risk Factors for Chronic Kidney Disease With Comorbidities: Association Rule Mining Analysis of Web-Based Survey Data (Preprint)

2019 ◽  
Author(s):  
Suyuan Peng ◽  
Feichen Shen ◽  
Andrew Wen ◽  
Liwei Wang ◽  
Yadan Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Association Rule ◽  
Chronic Conditions ◽  
Association Rule Mining ◽  
Lifestyle Modification ◽  
Rule Mining ◽  
Web Based ◽  
Lifestyle Risk Factors ◽  
Lifestyle Choices ◽  
Lifestyle Risk

BACKGROUND The rise in the number of patients with chronic kidney disease (CKD) and consequent end-stage renal disease necessitating renal replacement therapy has placed a significant strain on health care. The rate of progression of CKD is influenced by both modifiable and unmodifiable risk factors. Identification of modifiable risk factors, such as lifestyle choices, is vital in informing strategies toward renoprotection. Modification of unhealthy lifestyle choices lessens the risk of CKD progression and associated comorbidities, although the lifestyle risk factors and modification strategies may vary with different comorbidities (eg, diabetes, hypertension). However, there are limited studies on suitable lifestyle interventions for CKD patients with comorbidities. OBJECTIVE The objectives of our study are to (1) identify the lifestyle risk factors for CKD with common comorbid chronic conditions using a US nationwide survey in combination with literature mining, and (2) demonstrate the potential effectiveness of association rule mining (ARM) analysis for the aforementioned task, which can be generalized for similar tasks associated with noncommunicable diseases (NCDs). METHODS We applied ARM to identify lifestyle risk factors for CKD progression with comorbidities (cardiovascular disease, chronic pulmonary disease, rheumatoid arthritis, diabetes, and cancer) using questionnaire data for 450,000 participants collected from the Behavioral Risk Factor Surveillance System (BRFSS) 2017. The BRFSS is a Web-based resource, which includes demographic information, chronic health conditions, fruit and vegetable consumption, and sugar- or salt-related behavior. To enrich the BRFSS questionnaire, the Semantic MEDLINE Database was also mined to identify lifestyle risk factors. RESULTS The results suggest that lifestyle modification for CKD varies among different comorbidities. For example, the lifestyle modification of CKD with cardiovascular disease needs to focus on increasing aerobic capacity by improving muscle strength or functional ability. For CKD patients with chronic pulmonary disease or rheumatoid arthritis, lifestyle modification should be high dietary fiber intake and participation in moderate-intensity exercise. Meanwhile, the management of CKD patients with diabetes focuses on exercise and weight loss predominantly. CONCLUSIONS We have demonstrated the use of ARM to identify lifestyle risk factors for CKD with common comorbid chronic conditions using data from BRFSS 2017. Our methods can be generalized to advance chronic disease management with more focused and optimized lifestyle modification of NCDs.

Abstract P593: Association Between Troponin and Ischemic Stroke Recurrence in the Greater Cincinnati/Northern Kentucky Stroke Study

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
Alexander E Merkler ◽  
Heidi Sucharew ◽  
Kathleen S Alwell ◽  
Mary Haverbusch ◽  
Florence Rothenberg ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Proportional Hazards Model ◽  
Vascular Risk Factors ◽  
Cox Proportional Hazards Model ◽  
Stroke Recurrence ◽  
Stroke Severity ◽  
Vascular Risk ◽  
Acute Mi

Introduction: Elevations in troponin (cTn) are common in patients with acute ischemic stroke, yet their significance remains uncertain. Hypothesis: Elevated cTn at the time of acute ischemic stroke is associated with ischemic stroke recurrence. Methods: We included all adult patients with acute ischemic stroke who were residents of the Greater Cincinnati/Northern Kentucky region and who presented to an emergency department (ED) in 2015 and who had a cTn measured within 24 hours of ED arrival. Our exposure variable was an elevated cTn, defined as a value exceeding the laboratory’s 99 th percentile. Our primary outcome was ischemic stroke recurrence, defined as a new ischemic stroke with radiographic confirmation in the 3 years following the index ischemic stroke event. Cox proportional hazards model was used to evaluate the association between elevated cTn and ischemic stroke recurrence while adjusting for demographics, vascular risk factors, and stroke severity. In a secondary analysis, we excluded patients with a concomitant adjudicated myocardial infarction (MI) at the time of the index ischemic stroke. Results: Among 2,334 patients with acute ischemic stroke, 1,992 (85%) had a cTn assay within 24 hours of ED arrival and were included in the analysis. 402 (20%) patients had an elevated cTn and 259 (13%) patients had a recurrent ischemic stroke. 66 (3%) patients had an elevated cTn and a concomitant acute MI and 336 (17%) patients had an elevated cTn without a concomitant acute MI. After adjustment for demographics, vascular risk factors, and stroke severity, we found an association between elevated cTn and recurrent ischemic stroke (hazards ratio [HR], 1.5; 95% CI, 1.1-2.0). Our results were unchanged after excluding patients with a concomitant adjudicated MI (HR 1.4; 95% CI, 1.03-2.0). Conclusions: Among patients with acute ischemic stroke, elevated cTn even in the absence of concomitant adjudicated MI, was associated with ischemic stroke recurrence. Further mechanistic studies are necessary to explore the underlying etiology of hypertroponinemia among patients with acute ischemic stroke in order to guide targeted therapies to reduce stroke recurrence.

scholarly journals Association rule mining approach: evaluating pre-purchase risk intentions in the online second-hand goods market

2019 ◽  
Vol 10 (4) ◽  
pp. 669-688
Author(s):  
Abdul Bashiru Jibril ◽  
Michael Adu Kwarteng ◽  
Christina Appiah-Nimo ◽  
Michal Pilik
Keyword(s):  
Risk Factors ◽  
Czech Republic ◽  
Association Rule ◽  
Association Rule Mining ◽  
Value Added ◽  
Data Mining Algorithm ◽  
Rule Mining ◽  
The Czech Republic ◽  
Online Transactions ◽  
Buying Behaviour

Research background: A considerable amount of research has been conducted on the riskiness associated with online transactions in general. However, few studies have paid particular attention to the risk of online second-hand goods transactions. We, therefore, argue in this paper that, while online transactions pose several risks to consumers, the addition of second-hand goods intensifies the risks to the user. As the risk factors brought about by the online second-hand goods transactions persist, the magnitude of such risk inherent in the customer in question has not clearly emerged. Purpose of the article: This paper aims at eliciting the magnitude of risky components aligned with the tendency to connect online in search of second-hand goods. Again, providing insight into demographic variables in relation to the pre-purchasing risk factors; averting customers to connect online in search of second-hand goods stands as one of the key reasons for the present study. Methods: The research adopts a data mining algorithm, notably the Association rule mining to glean relevant patterns in the data accrued from the Czech Republic, premised on risk components governing the online buying behaviour of second-hand goods. To this end, a simple random technique was adopted to gauge the views of e-shoppers in the Czech Republic on online second-hand goods transactions; with 329 out of 411 respondents eligible for our analysis. Findings & Value added: The results of the association rule technique have revealed that respondents within the gender frame are both adamant to hook-up online, in spite of the fact that they have shopped online, yet do not think of looking at second-hand goods sites because of some risky influence inherent in them, even if the respondent is an ordinary personal-user of online transactions. In all these developments, the research concludes that the second-hand industry needs to redesign the websites with much attention to reinforce stringent measures that will give better assurance of the risk factors, which will tend to avert the customer from connecting via the Internet in pursuit of second-hand goods.

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