scholarly journals The Effect of Surgeon Expertise on the Outcome of Patients with Adrenocortical Carcinoma

2022 ◽  
Vol 12 (1) ◽  
pp. 100
Author(s):  
Anja Barac Nekic ◽  
Nikola Knezevic ◽  
Karin Zibar Tomsic ◽  
Ivana Kraljevic ◽  
Annemarie Balasko ◽  
...  
Keyword(s):  
Adrenocortical Carcinoma ◽  
High Volume ◽  
Adrenal Tumors ◽  
Surgical Removal ◽  
Adrenal Surgery ◽  
European Network ◽  
Long Term Outcomes ◽  
Ki 67 ◽  
The Difference

Complete surgical removal of adrenocortical carcinoma (ACC) represents the only chance of long-term cure. In this study, we compared the long-term outcomes of ACC patients depending on whether they had adrenal surgery performed in a high-volume (HVC) or in a low-volume (LVC) center. This retrospective study included 49 patients from the Croatian ACC Registry with the European Network for the Study of Adrenal Tumors (ENSAT) stage I–III ACC, of which 35 underwent surgery in a HVC whereas 14 of them were operated in one of the LVCs. Patients operated in the LVCs had a significantly higher rate of ACC recurrence (57.1% vs. 22.9%; p = 0.02). Accordingly, RFS was significantly longer in patients operated on in HVC (p = 0.04). The difference in RFS remained significant after controlling for age, gender, tumor size, Ki-67 index, Weiss score, and type of surgery (HR 4.55; 95% CI 1.16–17.88; p = 0.03). In addition, there is a tendency towards longer DSS in patients in the HVC group compared to those in the LVC group (p = 0.05). These results point to the centralization of adrenal surgery as a key prerequisite for improving the outcomes of ACC patients.

1002: Long Term Outcomes for Patients with High Volume Retroperitoneal Teratoma Undergoing Post Chemotherapy Surgery

2007 ◽  
Vol 177 (4S) ◽  
pp. 331-331 ◽  
Author(s):  
Stephen D.W. Beck ◽  
Richard S. Foster ◽  
Richard Bihrle ◽  
John P. Donohue
Keyword(s):  
High Volume ◽  
Long Term Outcomes ◽  
Retroperitoneal Teratoma

23: High Volume Hospitals do not have Better Long Term Outcomes Following Cystectomy for Bladder Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 8-9 ◽  
Author(s):  
Brent K. Hollenbeck ◽  
Yongliang Wei ◽  
John D. Birkmeyer
Keyword(s):  
Bladder Cancer ◽  
High Volume ◽  
Long Term Outcomes

scholarly journals Total pancreatectomy: short- and long-term outcomes at a high-volume pancreas center

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S752
Author(s):  
H. Zakaria ◽  
J. Stauffer ◽  
M. Raimondo ◽  
T. Woodward ◽  
M. Wallace ◽  
...  
Keyword(s):  
Total Pancreatectomy ◽  
High Volume ◽  
Long Term Outcomes ◽  
Short And Long Term

scholarly journals Hemostatic Changes in Patients with COVID-19: A Meta-Analysis with Meta-Regressions

2020 ◽  
Vol 9 (7) ◽  
pp. 2244 ◽  
Author(s):  
Matteo Nicola Dario Di Minno ◽  
Ilenia Calcaterra ◽  
Roberta Lupoli ◽  
Antonio Storino ◽  
Giorgio Alfredo Spedicato ◽  
...  
Keyword(s):  
Regression Models ◽  
Meta Analysis ◽  
C Reactive Protein ◽  
Long Term Outcomes ◽  
Chronic Disability ◽  
Reactive Protein ◽  
The Difference ◽  
D Dimer

Background: Complications of coronavirus disease 2019 (COVID-19) include coagulopathy. We performed a meta-analysis on the association of COVID-19 severity with changes in hemostatic parameters. Methods: Data on prothrombin time (PT), activated partial thromboplastin time (aPTT), D-Dimer, platelets (PLT), or fibrinogen in severe versus mild COVID-19 patients, and/or in non-survivors to COVID-19 versus survivors were systematically searched. The standardized mean difference (SMD) was calculated. Results: Sixty studies comparing 5487 subjects with severe and 9670 subjects with mild COVID-19 documented higher PT (SMD: 0.41; 95%CI: 0.21, 0.60), D-Dimer (SMD: 0.67; 95%CI: 0.52, 0.82), and fibrinogen values (SMD: 1.84; 95%CI: 1.21, 2.47), with lower PLT count (SMD: −0.74; 95%CI: −1.01, −0.47) among severe patients. Twenty-five studies on 1511 COVID-19 non-survivors and 6287 survivors showed higher PT (SMD: 0.67; 95%CI: 0.39, 0.96) and D-Dimer values (SMD: 3.88; 95%CI: 2.70, 5.07), with lower PLT count (SMD: −0.60, 95%CI: −0.82, −0.38) among non-survivors. Regression models showed that C-reactive protein values were directly correlated with the difference in PT and fibrinogen. Conclusions: Significant hemostatic changes are associated with COVID-19 severity. Considering the risk of fatal complications with residual chronic disability and poor long-term outcomes, further studies should investigate the prognostic role of hemostatic parameters in COVID-19 patients.

scholarly journals Favorable long-term outcomes of one-year adjuvant S-1 monotherapy for pathological stage II or III gastric cancer treated at a high-volume center

2018 ◽  
Vol 21 (6) ◽  
pp. 1024-1030 ◽  
Author(s):  
Yosuke Kano ◽  
Manabu Ohashi ◽  
Naoki Hiki ◽  
Daisuke Takahari ◽  
Keisho Chin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Volume ◽  
Stage Ii ◽  
Pathological Stage ◽  
Long Term Outcomes ◽  
High Volume Center ◽  
One Year

scholarly journals Long-Term Outcomes of Coronary and Carotid Artery Disease Revascularization in the FRIENDS Study

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Fabrizio Tomai ◽  
Anna Piccoli ◽  
Fausto Castriota ◽  
Luca Weltert ◽  
Bernhard Reimers ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cumulative Incidence ◽  
Carotid Artery Disease ◽  
High Volume ◽  
Cardiovascular Death ◽  
Long Term Outcomes ◽  
Major Cardiovascular Events ◽  
Long Term Follow Up ◽  
Artery Disease

Objectives. The aim of this study is to assess long-term-outcomes of patients with concomitant CAD and COD treated with different revascularization strategies. Background. Multisite artery disease is common and patients with combined disease have poor prognosis. The best therapeutic strategy for patients with concomitant carotid obstructive disease (COD) and coronary artery disease (CAD) remains controversial. Methods. This observational registry enrolled, between January 2006 and December 2012, 1022 consecutive patients from high volume institutions with concomitant CAD and COD suitable for endovascular, surgical, or hybrid revascularization in both territories selected by consensus of a multidisciplinary team. Results. The cumulative incidence of 5-year major cardiovascular events (MACCE) including cardiovascular death, myocardial infarction (MI), or stroke in the overall population was 12%. The incidence of 5-year MACCE was not statistically different in the surgical, endovascular, or hybrid patients group (10.1% vs. 13.0% vs. 13.2%, P = .257, respectively). However, the hybrid group exhibited rates of myocardial infarction, chronic kidney disease, and cumulative incidence of all clinical events higher than the surgical group. After propensity score matching, the incidence of 5-year MACCE was similar in the three groups (13.0% vs. 15.0% vs. 16.0%, p = .947, respectively). Conclusions. An individualized revascularization approach of patients with combined CAD and COD yields very good results at long-term follow-up, despite the high risk of this multilevel population even when the baseline clinical features are equalized.

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