scholarly journals Mechanobiological Approach to Design and Optimize Bone Tissue Scaffolds 3D Printed with Fused Deposition Modeling: A Feasibility Study

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 648 ◽  
Author(s):  
Gianluca Percoco ◽  
Antonio Emmanuele Uva ◽  
Michele Fiorentino ◽  
Michele Gattullo ◽  
Vito Modesto Manghisi ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Fused Deposition Modeling ◽  
Tissue Scaffolds ◽  
Fused Deposition ◽  
Filament Diameter ◽  
Optimal Distance ◽  
Fabrication Errors ◽  
Deposition Modeling ◽  
3D Printed ◽  
The Difference

In spite of the rather large use of the fused deposition modeling (FDM) technique for the fabrication of scaffolds, no studies are reported in the literature that optimize the geometry of such scaffold types based on mechanobiological criteria. We implemented a mechanobiology-based optimization algorithm to determine the optimal distance between the strands in cylindrical scaffolds subjected to compression. The optimized scaffolds were then 3D printed with the FDM technique and successively measured. We found that the difference between the optimized distances and the average measured ones never exceeded 8.27% of the optimized distance. However, we found that large fabrication errors are made on the filament diameter when the filament diameter to be realized differs significantly with respect to the diameter of the nozzle utilized for the extrusion. This feasibility study demonstrated that the FDM technique is suitable to build accurate scaffold samples only in the cases where the strand diameter is close to the nozzle diameter. Conversely, when a large difference exists, large fabrication errors can be committed on the diameter of the filaments. In general, the scaffolds realized with the FDM technique were predicted to stimulate the formation of amounts of bone smaller than those that can be obtained with other regular beam-based scaffolds.

scholarly journals Feasibility Study for Fused Deposition Modeling (FDM) 3D-Printed Propellers for Unmanned Aerial Vehicles

2020 ◽  
pp. 548-558
Author(s):  
Lorenz R. Toleos ◽  
Niño Jhim Andrew B. Dela Luna ◽  
Mark Christian E. Manuel ◽  
John Marvil R. Chua ◽  
Eldric Marius A. Sangalang ◽  
...  
Keyword(s):  
Unmanned Aerial Vehicles ◽  
Feasibility Study ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Aerial Vehicles ◽  
Deposition Modeling ◽  
3D Printed

Feasibility study into the potential use of fused-deposition modeling to manufacture 3D-printed enteric capsules in compounding pharmacies

2019 ◽  
Vol 569 ◽  
pp. 118581 ◽  
Author(s):  
Christoph Nober ◽  
Giuseppe Manini ◽  
Emeric Carlier ◽  
Jean-Marie Raquez ◽  
Samira Benali ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed ◽  
Potential Use

Biodegradable 3D Printed Polymer Microneedles for Transdermal Drug Delivery

2018 ◽  
Author(s):  
Michael A. Luzuriaga ◽  
Danielle R. Berry ◽  
John C. Reagan ◽  
Ronald A. Smaldone ◽  
Jeremiah J. Gassensmith
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Transdermal Drug Delivery ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Modeling Software ◽  
Deposition Modeling ◽  
3D Printed ◽  
Microfabrication Technique ◽  
Mechanical Strengths

Biodegradable polymer microneedle (MN) arrays are an emerging class of transdermal drug delivery devices that promise a painless and sanitary alternative to syringes; however, prototyping bespoke needle architectures is expensive and requires production of new master templates. Here, we present a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material. We show how this natural degradability can be exploited to overcome a key challenge of FDM 3D printing, in particular the low resolution of these printers. We improved the feature size of the printed parts significantly by developing a post fabrication chemical etching protocol, which allowed us to access tip sizes as small as 1 μm. With 3D modeling software, various MN shapes were designed and printed rapidly with custom needle density, length, and shape. Scanning electron microscopy confirmed that our method resulted in needle tip sizes in the range of 1 – 55 µm, which could successfully penetrate and break off into porcine skin. We have also shown that these MNs have comparable mechanical strengths to currently fabricated MNs and we further demonstrated how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.

scholarly journals Controlling magnetic properties of 3D-printed magnetic elastomer structures via fused deposition modeling

AIP Advances ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 025223
Author(s):  
Thomas M. Calascione ◽  
Nathan A. Fischer ◽  
Thomas J. Lee ◽  
Hannah G. Thatcher ◽  
Brittany B. Nelson-Cheeseman
Keyword(s):  
Magnetic Properties ◽  
Fused Deposition Modeling ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
3D Printed

scholarly journals Pressure Orientation-Dependent Recovery of 3D-Printed PLA Objects with Varying Infill Degree

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1275 ◽  
Author(s):  
Guido Ehrmann ◽  
Andrea Ehrmann
Keyword(s):  
Shape Memory ◽  
Fused Deposition Modeling ◽  
Static Load ◽  
Shape Memory Polymer ◽  
Applied Pressure ◽  
Poly Lactic Acid ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Load Tests ◽  
3D Printed

Poly(lactic acid) is not only one of the most often used materials for 3D printing via fused deposition modeling (FDM), but also a shape-memory polymer. This means that objects printed from PLA can, to a certain extent, be deformed and regenerate their original shape automatically when they are heated to a moderate temperature of about 60–100 °C. It is important to note that pure PLA cannot restore broken bonds, so that it is necessary to find structures which can take up large forces by deformation without full breaks. Here we report on the continuation of previous tests on 3D-printed cubes with different infill patterns and degrees, now investigating the influence of the orientation of the applied pressure on the recovery properties. We find that for the applied gyroid pattern, indentation on the front parallel to the layers gives the worst recovery due to nearly full layer separation, while indentation on the front perpendicular to the layers or diagonal gives significantly better results. Pressing from the top, either diagonal or parallel to an edge, interestingly leads to a different residual strain than pressing from front, with indentation on top always firstly leading to an expansion towards the indenter after the first few quasi-static load tests. To quantitatively evaluate these results, new measures are suggested which could be adopted by other groups working on shape-memory polymers.

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