scholarly journals Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

Materials ◽  
2021 ◽  
Vol 14 (12) ◽  
pp. 3383
Author(s):  
Damian Krzyzanowski ◽  
Marcin Kruszewski ◽  
Agnieszka Grzelak
Keyword(s):  
Silver Nanoparticles ◽  
Cell Lines ◽  
Atp Binding ◽  
Abc Proteins ◽  
Anticancer Properties ◽  
Antibacterial And Antifungal Activities ◽  
Mammalian Cell Lines ◽  
Nominal Size ◽  
Antibacterial And Antifungal ◽  
Atp Binding Cassette

Silver nanoparticles (AgNPs), due to their unique properties have been receiving immense attention in recent years. In addition to their antibacterial and antifungal activities, AgNPs also cause apoptosis, mitochondria disfunction, nucleic acid damage and show potent anticancer properties in both multidrug resistance (MDR) and sensitive tumors. The MDR phenomenon, caused by the presence of ATP-binding cassette (ABC) proteins, is responsible for the failure of chemotherapy. Thus, investigating the influence of widely used AgNPs on ABC transporters is crucial. In the present study, we have examined the cytotoxicity of silver nanoparticles of a nominal size of 20 nm (Ag20) on the cell lines of different tissue origins. In addition, we have checked the ATP-binding cassette transporters’ activity and expression under AgNP exposure. The results indicate that Ag20 shows a toxic effect on tested cells, as well as modulating the expression and transport activity of ABC proteins.

ATP-Binding Cassette C Transporters in Human Pancreatic Carcinoma Cell Lines

Pancreatology ◽  
2009 ◽  
Vol 9 (1-2) ◽  
pp. 136-144 ◽  
Author(s):  
Wolfgang Hagmann ◽  
Ralf Jesnowski ◽  
Ralf Faissner ◽  
Changqing Guo ◽  
J. Matthias Löhr
Keyword(s):  
Pancreatic Carcinoma ◽  
Cell Lines ◽  
Carcinoma Cell ◽  
Atp Binding ◽  
Carcinoma Cell Lines ◽  
Human Pancreatic Carcinoma Cell ◽  
Atp Binding Cassette

ATP-binding cassette (ABC) proteins in untreated acute myeloid leukemia (AML) in patients 60 years and older (CALGB 9760)

2005 ◽  
Vol 23 (16_suppl) ◽  
pp. 6551-6551
Author(s):  
M. R. Baer ◽  
J. S. Shoemaker ◽  
R. Barrier ◽  
N. W. Cuviello ◽  
K. L. O’Loughlin ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Atp Binding ◽  
Abc Proteins ◽  
Acute Myeloid ◽  
Atp Binding Cassette

scholarly journals Genome-wide analysis of ATP-binding cassette (ABC) proteins in a model legume plant, Lotus japonicus: comparison with Arabidopsis ABC protein family

DNA Research ◽  
2006 ◽  
Vol 13 (5) ◽  
pp. 205-228 ◽  
Author(s):  
Akifumi Sugiyama ◽  
Nobukazu Shitan ◽  
Shusei Sato ◽  
Yasukazu Nakamura ◽  
Satoshi Tabata ◽  
...  
Keyword(s):  
Lotus Japonicus ◽  
Protein Family ◽  
Atp Binding ◽  
Abc Proteins ◽  
Model Legume ◽  
Genome Wide Analysis ◽  
Abc Protein ◽  
Genome Wide ◽  
Legume Plant ◽  
Atp Binding Cassette

scholarly journals The Escherichia coli ATP-binding cassette (ABC) proteins

2002 ◽  
Vol 28 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Kenneth J. Linton ◽  
Christopher F. Higgins
Keyword(s):  
Escherichia Coli ◽  
Atp Binding ◽  
Abc Proteins ◽  
Atp Binding Cassette

scholarly journals Evaluation of the in vitro expression of ATP binding-cassette (ABC) proteins in an Ixodes ricinus cell line exposed to ivermectin

2016 ◽  
Vol 9 (1) ◽  
Author(s):  
Carlo Mangia ◽  
Alice Vismarra ◽  
Laura Kramer ◽  
Lesley Bell-Sakyi ◽  
Daniele Porretta ◽  
...  
Keyword(s):  
Cell Line ◽  
Ixodes Ricinus ◽  
Atp Binding ◽  
Abc Proteins ◽  
In Vitro Expression ◽  
Atp Binding Cassette

scholarly journals ATP Binding Cassette Proteins ABCG37 and ABCG33 are required for potassium-independent cesium uptake in Arabidopsis roots

2019 ◽  
Author(s):  
Mohammad Arif Ashraf ◽  
Sayaka Kumagai ◽  
Keita Ito ◽  
Ryohei Sugita ◽  
Keitaro Tanoi ◽  
...  
Keyword(s):  
Cell Biology ◽  
Environmental Concern ◽  
Chemical Properties ◽  
Root Growth Inhibition ◽  
Atp Binding ◽  
Loss Of Function ◽  
Abc Proteins ◽  
Knock Out ◽  
Group I ◽  
Atp Binding Cassette

AbstractRadiocesium, accumulated in the soil by nuclear accidents is a major environmental concern. The transport process of cesium (Cs+) is tightly linked to the indispensable plant nutrient potassium (K+) as they both belong to the group I alkali metal with similar chemical properties. Most of the transporters that had been characterized to date as Cs+ transporters are directly or indirectly linked to K+. Using a combinatorial approach of physiology, genetics, cell biology and root uptake assay, here we identified two ATP-Binding Cassette (ABC) proteins, ABCG37 and ABCG33 as facilitators of Cs+ influx. The gain-of-function mutant of ABCG37 (abcg37-1) showed hypersensitive response to Cs+-induced root growth inhibition, while the double knock out mutant of ABCG33 and ABCG37 (abcg33-1abcg37-2) showed resistance. Single loss-of-function mutant of ABCG33 and ABCG37 did not show any alteration in Cs+ response. Short term uptake experiment with radioactive Cs+ revealed reduced Cs+ uptake in abcg33-1abgc37-2 compared with wild type in presence or absence of K+. Potassium response and content were unaffected in the double mutant background confirming that Cs+ uptake by ABCG33 and ABCG37 is independent of K+. Collectively, this work identified two ABC proteins as new Cs+ influx carriers, which act redundantly and independent of K+ uptake pathway.

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