scholarly journals An Injectable Chitosan-Based Self-Healable Hydrogel System as An Antibacterial Wound Dressing

Materials ◽  
2021 ◽  
Vol 14 (20) ◽  
pp. 5956
Author(s):  
Xiaoyu Wang ◽  
Rijian Song ◽  
Melissa Johnson ◽  
Sigen A ◽  
Zhonglei He ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Schiff Base ◽  
Wound Dressing ◽  
Cost Effective ◽  
Hek 293 ◽  
293 Cells ◽  
Good Biocompatibility ◽  
Crosslinking Agents ◽  
Hydrogel System

Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, and genipin. Therefore, we developed a biocompatible yet cost-effective chitosan-based hydrogel system as a candidate biomaterial to prevent infection during wound healing. The hydrogel was fabricated by crosslinking chitosan with dialdehyde chitosan (CTS–CHO) via dynamic Schiff-base reactions, resulting in a self-healable and injectable system. The rheological properties, degradation profile, and self-healable properties of the chitosan-based hydrogel were evaluated. The excellent antibacterial activity of the hydrogel was validated by a spread plate experiment. The use of Live/Dead assay on HEK 293 cells showed that the hydrogel exhibited excellent biocompatibility. The results demonstrate that the newly designed chitosan-based hydrogel is an excellent antibacterial wound dressing candidate with good biocompatibility.

scholarly journals Preparation of Nanofibers with Renewable Polymers and Their Application in Wound Dressing

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Ying Zhao ◽  
Yihui Qiu ◽  
Huanhuan Wang ◽  
Yu Chen ◽  
Shaohua Jin ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Cell Adhesion ◽  
Specific Surface ◽  
Wound Dressing ◽  
Recent Progress ◽  
High Specific Surface Area ◽  
High Porosity ◽  
Renewable Polymers ◽  
Good Biocompatibility

Renewable polymers have attracted considerable attentions in the last two decades, predominantly due to their environmentally friendly properties, renewability, good biocompatibility, biodegradability, bioactivity, and modifiability. The nanofibers prepared from the renewable polymers can combine the excellent properties of the renewable polymer and nanofiber, such as high specific surface area, high porosity, excellent performances in cell adhesion, migration, proliferation, differentiation, and the analogous physical properties of extracellular matrix. They have been widely used in the fields of wound dressing to promote the wound healing, hemostasis, skin regeneration, and treatment of diabetic ulcers. In the present review, the different methods to prepare the nanofibers from the renewable polymers were introduced. Then the recent progress on preparation and properties of the nanofibers from different renewable polymers or their composites were reviewed; the application of them in the fields of wound dressing was emphasized.

Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing

2017 ◽  
Vol 18 (11) ◽  
pp. 3766-3775 ◽  
Author(s):  
Qing Li ◽  
Fei Lu ◽  
Guofang Zhou ◽  
Kun Yu ◽  
Bitao Lu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Gold Nanoparticle ◽  
Wound Dressing

Nitrofurazone-loaded electrospun PLLA/sericin-based dual-layer fiber mats for wound dressing applications

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16940-16949 ◽  
Author(s):  
Rui Zhao ◽  
Xiang Li ◽  
Bolun Sun ◽  
Yan Tong ◽  
Ziqiao Jiang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Fiber Mats ◽  
Good Antibacterial Activity ◽  
Nanofiber Mats ◽  
Layer Fiber

Dual-layer nitrofurazone-loaded nanofiber mats are fabricated by electrospinning with good antibacterial activity and the mats perform well in wound healing.

scholarly journals Study of hydrocellular functional material as microbicidal wound dressing for diabetic wound healing

2021 ◽  
Vol 19 ◽  
pp. 228080002110549
Author(s):  
Michael Rodrigues ◽  
Thilagavati Govindharajan
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Wound Care ◽  
Cost Effective ◽  
Wound Dressings ◽  
Wound Management ◽  
Histopathological Analysis ◽  
Diabetic Wound ◽  
Functional Material ◽  
Diabetic Wound Healing

A hydrocellular functional material as a wound dressing is developed and it is found to be superior in its efficacy as compared to some of the comparator controls in diabetic wound healing studies. A study on wound contraction and Histopathological analysis is done in rats. The efficacy of the dressing is comparable to the established wound dressings like Carboxymethyl cellulose alginate dressings and autolytic enzyme based hydrogel. It is found to be superior to Polyhexamethylene biguanide dressing used as reference controls in this study. The reason for good wound healing performance of the dressing can be attributed to a combined property of effective exudates management and broad spectrum antimicrobial effect. The concept of functional hydro cellular material has shown good results due to the excellent balance of exudates pickup and drying it out. This ensures moist wound healing conditions on the wound. Because of its porous nature it allows good air flow and gaseous exchange in the structure. The cationic sites created on the surface of the dressing ensure a good antimicrobial action on the exudates in the dressing. It reduces the infection load on the wound. The nonleaching property of the dressing also helps in preventing the generation of more resistant and mutant strains of the microbes. The developed dressing can be used as a relatively durable long lasting dressing for wound management in diabetic wounds. The need of repetitive wound dressing changes can be brought down with this concept of dressing. It is not only cost effective in terms of its material cost but also is a cost effective solution when entire wound management cost is considered. Such novel wound dressing material can change the quality of life of diabetic wound patients especially in developing world, where access to functional advanced wound care dressings is limited.

Selective chromo-fluorogenic molecular sensor for dual channel recognition of Cu2+and F−: effect of functional group on selectivity

RSC Advances ◽  
2016 ◽  
Vol 6 (72) ◽  
pp. 67693-67700 ◽  
Author(s):  
Soumen Ghosh ◽  
Aniruddha Ganguly ◽  
Arghyadeep Bhattacharyya ◽  
Md. Akhtarul Alam ◽  
Nikhil Guchhait
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Carboxylic Acid ◽  
Functional Group ◽  
Dual Mode ◽  
Hek 293 ◽  
Hek 293 Cells ◽  
Dual Channel ◽  
Molecular Sensor ◽  
293 Cells

The amido-Schiff base (3-hydroxy-naphthalene-2-carboxylic acid(4-cyano-benzylidene)-hydrazide) shows dual mode sensibility towards Cu2+and F−. It can detect Cu2+in HEK 293 cells and F−in tooth paste and in solid state.

Effectively promoting wound healing with cellulose/gelatin sponges constructed directly from a cellulose solution

2015 ◽  
Vol 3 (38) ◽  
pp. 7518-7528 ◽  
Author(s):  
Ying Pei ◽  
Dongdong Ye ◽  
Qi Zhao ◽  
Xueying Wang ◽  
Chun Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Wound Dressing ◽  
Cost Effective ◽  
Cellulose Solution

The cellulose sponges loading gelatin and bFGF as wound dressing were constructed directly from the cellulose solution via a green and cost-effective pathway, which effectively promoted wound healing.

Novel chitin/chitosan-glucan wound dressing: Isolation, characterization, antibacterial activity and wound healing properties

2016 ◽  
Vol 510 (1) ◽  
pp. 86-99 ◽  
Author(s):  
A.M. Abdel-Mohsen ◽  
J. Jancar ◽  
D. Massoud ◽  
Z. Fohlerova ◽  
H. Elhadidy ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing

Fabrication of bioactive glass-introduced nanofibrous membranes with multifunctions for potential wound dressing

RSC Advances ◽  
2014 ◽  
Vol 4 (104) ◽  
pp. 60114-60122 ◽  
Author(s):  
Weibin Ma ◽  
Xianyan Yang ◽  
Liang Ma ◽  
Xingang Wang ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Bioactive Glass ◽  
Water Uptake ◽  
Wound Dressing ◽  
Chronic Wound ◽  
Uptake Capacity ◽  
Water Uptake Capacity ◽  
Nanofibrous Membranes

Bioactive glass-introduced gelatin/chitosan nanofibrous dressings were developedviaelectrospinning to endow improved antibacterial activity, adjustable bioactivity and water uptake capacity for enhancing chronic wound healing.

scholarly journals Development of wound dressing film using methanolic extracts of freshwater microalgae and determining its wound healing ability

2021 ◽  
pp. 166-173
Author(s):  
S. Soundararajan ◽  
R. Karkuvel Raja ◽  
S. Vishnu Chitthan ◽  
S. Sanjay Prasad ◽  
N. Thajuddin
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Wound Dressing ◽  
Antimicrobial Agents ◽  
Chemical Properties ◽  
Freshwater Microalgae ◽  
Chlorella Sp ◽  
Methanolic Extracts ◽  
Freshwater Habitats ◽  
Pure Cultures

Wound healing is a complex process in which bacterial infection is a major cause for delayed wound healing. Occurrence of drug resistance among bacterial pathogens led to discovery of new antimicrobial agents from new sources. The present study aimed to identify microalgal metabolites with antibacterial activity and to develop a wound dressing film with their potential healing activity. Microalgal samples were collected from three different freshwater habitats, isolated, made them pure cultures and physico-chemical properties of water samples from the respective sampling sites were analzed. Among the three microalgal isolates,  Chlorella sp. NRMC-F-0350 showed antibacterial activity against clinical isolates of  E. coli, Klebsiella pneumoniae and Staphylococcus aureus. Additionally, functional groups present in Chlorella sp. NRMC-F-0350 were identified using FTIR and GC-MS analysis. Several antibacterial compounds viz. benzoxazole, 1,2 Benzene dicarboxylic acid, sistosterol, 9-Octadecanoic acid, eicosane and hexadecane were identified. Wound dressing films were developed and showed evident antibacterial as well as significant wound healing activity (84.5%). Therefore, the developed films can be used as a potential wound dressing material. 

scholarly journals Novel Bis-Ammonium Salts of Pyridoxine: Synthesis and Antimicrobial Properties

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4341
Author(s):  
Nikita V. Shtyrlin ◽  
Mikhail V. Pugachev ◽  
Sergey V. Sapozhnikov ◽  
Marsel R. Garipov ◽  
Rusalia M. Vafina ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Benzalkonium Chloride ◽  
Antimicrobial Properties ◽  
Cellular Membrane ◽  
Ammonium Salts ◽  
Active Compounds ◽  
Hek 293 ◽  
293 Cells ◽  
Antibacterial And Antifungal

A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum inhibitory concentration (MIC) 0.25–16 µg/mL) comparable or superior than miramistin, benzalkonium chloride, and chlorhexidine. A strong correlation between the lipophilicity and antibacterial activity was found. The most active compounds had logP values in the range of 1–3, while compounds with logP > 6 and logP < 0 were almost inactive. All active compounds demonstrated cytotoxicity comparable with miramistin and chlorhexidine on HEK-293 cells and were three-fold less toxic when compared to benzalkonium chloride. The antibacterial activity of leading compound 5c12 on biofilm-embedded Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli or Pseudomonas aeruginosa was comparable or even higher than that of the benzalkonium chloride. In vivo 5c12 was considerably less toxic (LD50 1705 mg/kg) than benzalkonium chloride, miramistine, and chlorhexidine at oral administration on CD-1 mice. An aqueous solution of 5c12 (0.2%) was shown to be comparable to reference drugs efficiency on the rat’s skin model. The molecular target of 5c12 seems to be a cellular membrane as other quaternary ammonium salts. The obtained results make the described quaternary bis-ammonium pyridoxine derivatives promising and lead molecules in the development of the new antiseptics with a broad spectrum of antimicrobial activity.

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