scholarly journals Porcine Xenograft and Epidermal Fully Synthetic Skin Substitutes in the Treatment of Partial-Thickness Burns: A Literature Review

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 432
Author(s):  
Herbert L. Haller ◽  
Sigrid E. Blome-Eberwein ◽  
Ludwik K. Branski ◽  
Joshua S. Carson ◽  
Roselle E. Crombie ◽  
...  
Keyword(s):  
Healing Time ◽  
Subsequent Treatment ◽  
Skin Substitute ◽  
Skin Substitutes ◽  
Burn Treatment ◽  
Advantages And Disadvantages ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Partial Thickness Burns ◽  
Porcine Xenograft

Background and Objectives: Porcine xenografts have been used successfully in partial thickness burn treatment for many years. Their disappearance from the market led to the search for effective and efficient alternatives. In this article, we examine the synthetic epidermal skin substitute Suprathel® as a substitute in the treatment of partial thickness burns. Materials and Methods: A systematic review following the PRISMA guidelines has been performed. Sixteen Suprathel® and 12 porcine xenograft studies could be included. Advantages and disadvantages between the treatments and the studies’ primary endpoints have been investigated qualitatively and quantitatively. Results: Although Suprathel had a nearly six times larger TBSA in their studies (p < 0.001), it showed a significantly lower necessity for skin grafts (p < 0.001), and we found a significantly lower infection rate (p < 0.001) than in Porcine Xenografts. Nonetheless, no significant differences in the healing time (p = 0.67) and the number of dressing changes until complete wound healing (p = 0.139) could be found. Both products reduced pain to various degrees with the impression of a better performance of Suprathel® on a qualitative level. Porcine xenograft was not recommended for donor sites or coverage of sheet-transplanted keratinocytes, while Suprathel® was used successfully in both indications. Conclusion: The investigated parameters indicate that Suprathel® to be an effective replacement for porcine xenografts with even lower subsequent treatment rates. Suprathel® appears to be usable in an extended range of indications compared to porcine xenograft. Data heterogeneity limited conclusions from the results.

A Randomized Comparison Study of Lyophilized Nile Tilapia Skin and Silver-Impregnated Sodium Carboxymethylcellulose for the Treatment of Superficial Partial-Thickness Burns

2020 ◽  
Author(s):  
Edmar Maciel Lima Júnior ◽  
Manoel Odorico de Moraes Filho ◽  
Bruno Almeida Costa ◽  
Francisco Vagnaldo Fechine ◽  
Marina Becker Sales Rocha ◽  
...  
Keyword(s):  
Pilot Study ◽  
Nile Tilapia ◽  
Test Group ◽  
Skin Substitute ◽  
Sodium Carboxymethylcellulose ◽  
Open Label ◽  
Burn Treatment ◽  
Partial Thickness ◽  
Patient Reported ◽  
Partial Thickness Burns

Abstract Glycerolized Nile tilapia skin (NTS) showed promising results when used for burn treatment in phases II and III randomized controlled trials. This pilot study aims to evaluate the effectiveness of lyophilized NTS (LNTS) as a temporary skin substitute for superficial partial-thickness burns by comparing it with silver-impregnated sodium carboxymethylcellulose dressing. This was a randomized, prospective, open-label, and controlled pilot study conducted in Fortaleza, Brazil, from April 2019 to December 2019. The 24 participants had ≥18 and ≤70 years of age and superficial partial-thickness burns affecting up to 10% of TBSA. Primary outcomes were the number of dressings performed and pain intensity, assessed via the Visual Analogue Scale and the Electronic von Frey. Secondary outcomes were the level of pain-related anxiety, assessed via the Burns Specific Pain Anxiety Scale, and analgesic consumption. In the test group, the number of dressings and the patient-reported pain after dressing-related procedures were lower. Analgesic intake, pain-related anxiety, and both patient-reported and objectively measured pain before dressing-related procedures were similar for the treatment groups. No adverse effects were detected. LNTS shares the same characteristics of an “‘ideal’” wound dressing demonstrated by glycerolized NTS in previous studies. Also, it demonstrated noninferiority for burn management when compared with silver-impregnated sodium carboxymethylcellulose dressing. The safety and efficacy of LNTS demonstrated in this pilot study may allow the development of larger phases II and III RCTs in a near future.

Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial Partial-Thickness Wounds: A Pilot Study

2019 ◽  
Author(s):  
Edmar Maciel Lima Júnior ◽  
Manoel Odorico de Moraes Filho ◽  
Antonio Jorge Forte ◽  
Bruno Almeida Costa ◽  
Francisco Vagnaldo Fechine ◽  
...  
Keyword(s):  
Pilot Study ◽  
Test Group ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Burn Wound ◽  
Open Label ◽  
Burn Treatment ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Partial Thickness Burns

Abstract This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for the treatment of partial-thickness burn wounds in children. This is an open-label, monocentric, randomized phase II pilot study conducted in Fortaleza, Brazil. The study population consisted of 30 children between the ages of 2 and 12 years with superficial “partial-thickness” burns admitted less than 72 hours from the thermal injury. In the test group, the tilapia skin was applied. In the control group, a thin layer of silver sulfadiazine cream 1% was applied. Tilapia skin showed good adherence to the wound bed, reducing the number of dressing changes required, the amount of anesthetics used, and providing benefits for the patients and also for healthcare professionals, by reducing the overall work load. The number of days to complete burn wound healing, the total amount of analgesics required throughout the treatment, burn improvement on the day of dressing removal, and pain throughout the treatment were similar to the conventional treatment with silver sulfadiazine. Thus, tilapia skin can be considered an effective and low-cost extra resource in the therapeutic arsenal of pediatric superficial partial thickness burns.

scholarly journals Use Of Synthetic Skin Substitute (Biobrane) For Plantar Foot Burn

2018 ◽  
Vol 4 (2) ◽  
pp. 101-104
Author(s):  
Johandi F ◽  
Feng J ◽  
Ruth Lumbun ◽  
Chong J ◽  
Tan B K ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Small Sample Size ◽  
Case Series ◽  
Small Sample ◽  
Skin Substitute ◽  
Repeat Surgery ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Singapore General Hospital ◽  
Partial Thickness Burns

Background : In Singapore, we experience a unique annual surge of burn cases involving sole of foot during the Hindu fire walking festival. Traditionally, superficial partial-thickness burns of the soles were managed expectantly with regular dressings. We conducted a study to evaluate the effectiveness of an alternative approach of using synthetic skin substitute (Biobrane®). Method : A case series of foot burns admitted October 2016 to the Singapore General Hospital Burns Centre. Burn cases with superficial partial-thickness burn of bilateral sole of foot were included in the study. Exclusion criteria included deep dermal burns and burns that required excision and closure with skin grafting. The patient demographics, time to presentation, medical co-morbidities were analyzed. Outcomes such as length of hospital stay, incidence of infection, need for further surgery, return to pre-injury ambulation status and occupation and cost were studied. Result : A total of 6 partial thickness burns of sole of foot in 3 patients with bilateral foot burns which were treated with Biobrane® were included in the study. Patients were able to return pre-injury functional status- return to work and pre-morbid ambulation status. Neither incidence of wound infections nor any needs for repeat surgery were recorded. However, this group required an increased length of stay and incurred high treatment cost. Conclusion: Biobrane® is a viable adjunct in the management of sole of foot burns. The authors believe there is potential for an improved rate of recovery with Biobrane®. However, the higher cost and length of stay are among its drawbacks. In view of the limitations of our study- case series and small sample size, a prospective and double arm assessment will be required to present definite evidence for synthetic skin substitute in these cases

scholarly journals Amnion Membrane Graft Dressing in Superficial Partial Thickness Burn in Pediatric Patients

2015 ◽  
Vol 14 (1) ◽  
pp. 22-25
Author(s):  
Md Saif Ullah ◽  
KMN Ferdous ◽  
Md Mobassar Hussain Mullick ◽  
Md Rashedul Alam ◽  
Md Sazzaduar Rahman ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Pediatric Patients ◽  
Cost Effective ◽  
Skin Substitutes ◽  
Protein Loss ◽  
Change Rate ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Amnion Membrane ◽  
Dressing Change

Objective: The aim of this study was to find out the effectiveness of amniotic membrane graft dressing in the treatment of superficial partial thickness burn in children. Methods: The retrospective study was conducted on the patients admitted with superficial partial thickness burn in the burn unit of Dhaka Shishu Hospital age 0-12 years, during the period from January 1999 to December 2011. All of them treated with amnion membrane graft dressing. Results: Total 370 patients were included in this study. Mean age was 2.76 years. Amnion dressing suppresses bacteria in the wound as well as reduced infection. Amnions have good adherent characteristics, which reduced infection as well as reduction of oozing of plasma from the wound, that become dry early. It has a role on burnt pain reduction, Frequency of dressing change, rate of healing, cost, duration hospital stay. Conclusion: Our experience showed that amniotic membrane is one of the effective biological skin substitutes used in burn wounds, with efficacy of low bacterial counts, has advantageous of reducing protein loss, electrolytes & fluids. Decreasing the risk of infection minimizing pain, accelerate of wound healing and good handling properties. It is ready available does not present immunological problem and allergies response. It is cost effective and very helpful for developing countries. DOI: http://dx.doi.org/10.3329/cmoshmcj.v14i1.22875 Chatt Maa Shi Hosp Med Coll J; Vol.14 (1); Jan 2015; Page 22-25

scholarly journals New Innovations for Deep Partial-Thickness Burn Treatment with ACell MatriStem Matrix

2016 ◽  
Vol 5 (12) ◽  
pp. 546-552 ◽  
Author(s):  
Justine S. Kim ◽  
Alexander J. Kaminsky ◽  
J. Blair Summitt ◽  
Wesley P. Thayer
Keyword(s):  
Burn Treatment ◽  
Partial Thickness ◽  
Partial Thickness Burn

Use of a biosynthetic wound dressing to treat burns: a systematic review

2020 ◽  
Vol 29 (Sup12) ◽  
pp. S16-S22
Author(s):  
Farimah Rahimi ◽  
Reza Rezayatmand
Keyword(s):  
Systematic Review ◽  
Wound Dressing ◽  
Large Scale ◽  
Scientific Evidence ◽  
Ease Of Use ◽  
Wound Dressings ◽  
Split Thickness Skin Graft ◽  
Burn Treatment ◽  
Partial Thickness ◽  
Partial Thickness Burns

Objective: Accelerating the process of wound healing, reducing infection risks, and decreasing pain and discomfort in the burn area are important goals of burn treatment. To achieve these goals, the use of biosynthetic wound dressings has increased in recent years. Suprathel (PolyMedics Innovations, Germany) is a biosynthetic wound dressing used to treat both partial-thickness burns and split-thickness skin graft (STSG) donor sites, full-thickness wounds, large-scale abrasions, and scar revisions. Method: This study is a systematic review of empirical evidence reported on the application of the biosynthetic wound dressing in burns up to 2017. Keywords such as ‘Suprathel’, ‘effectiveness’, ‘safety’, and ‘cost’ were searched in PubMed, Cochrane, Scopus and Embase databases. Results: A total of 14 publications were identified, based on the inclusion and exclusion criteria. The findings reported in the literature reviewed were classified in terms of safety, effectiveness and cost-effectiveness of use of the biosynthetic wound dressing. Regarding safety and effectiveness, the dressing was found to yield desirable results, particularly for partial thickness burns and STSG donor sites. As of 2017 no health economics assessments have been carried out. Conclusion: Despite the desirable advantages of the biosynthetic wound dressing with respect to its effectiveness, safety and ease of use, its major limitation was found to be its cost. However, in the absence of comprehensive studies on the quantification of all factors, there is scant scientific evidence for making reliable conclusions from this systematic review.

scholarly journals Management of facial burns

2020 ◽  
Vol 8 ◽  
Author(s):  
David G Greenhalgh
Keyword(s):  
Skin Grafting ◽  
Healing Time ◽  
The Body ◽  
Full Thickness ◽  
Partial Thickness ◽  
Facial Burns ◽  
The Face ◽  
Partial Thickness Burns

Abstract Burns to the face affect a part of the body that cannot be hidden and thus exposes potentially major changes in appearance to society. Therefore, it is incumbent upon the caregiver to optimize healing and minimize scarring. The goal for partial-thickness burns is to have them heal within 2–3 weeks to minimize healing time. For full-thickness burns there needs to be strategies to optimize the outcomes for skin grafting and minimize scarring. The goal of this review is to discuss the best way to improve the outcomes of these devastating injuries.

A pirfenidone loaded spray dressing based on lyotropic liquid crystals for deep partial thickness burn treatment: healing promotion and scar prophylaxis

2020 ◽  
Vol 8 (13) ◽  
pp. 2573-2588 ◽  
Author(s):  
Jintian Chen ◽  
Hui Wang ◽  
Liling Mei ◽  
Bei Wang ◽  
Ying Huang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Liquid Crystal ◽  
Liquid Crystals ◽  
Lyotropic Liquid Crystals ◽  
Lyotropic Liquid Crystal ◽  
Burn Treatment ◽  
Partial Thickness ◽  
Partial Thickness Burn

This study develops a HA combined lyotropic liquid crystal based spray dressing loaded with pirfenidone for wound healing and scar prophylaxis.

scholarly journals The use of a non-medicated dressing for superficial-partial thickness burns in children: a case series and review

2019 ◽  
Vol 5 ◽  
pp. 205951311989695
Author(s):  
Ter-Er Kusu-Orkar ◽  
Umar Islam ◽  
Benjamin Hall ◽  
Evan Araia ◽  
Nikki Allorto
Keyword(s):  
Antimicrobial Properties ◽  
Case Series ◽  
Length Of Hospital Stay ◽  
Hot Water ◽  
Secondary Outcome ◽  
Wound Complications ◽  
Burn Wounds ◽  
Partial Thickness ◽  
Partial Thickness Burn ◽  
Partial Thickness Burns

Background: Cutimed® Sorbact® is a dressing marketed as having antimicrobial properties and easy application without the threat of antibiotic resistance and difficult accessibility. There is little evidence on the clinical outcomes of the use of Cutimed® Sorbact® in adults and currently no evidence of use of Cutimed® Sorbact® on superficial-partial thickness burn injuries in children. Objective: To summarise the clinical outcome of burn wounds in children with superficial-partial thickness burns in which Cutimed® Sorbact® was used. Method: An observational case series was conducted in Edendale Hospital, Pietermaritzburg, South Africa over the course of four weeks. Patients where included if they were aged < 10 years and had a ⩽ 15% superficial-partial burn. The primary outcome measure was time to 95% re-epithelialisation. Secondary outcome measures included wound complications, adverse healing and number of dressing changes. Results: Ten patients (five girls, five boys; age range = 11 months–8 years) were included in this case series. All participants had a type VI Fitzpatrick skin type and 80% of burns were hot water burns. Of all patients treated with Cutimed® Sorbact®, 50% healed within seven days, 70% within 14 days and 100% within 21 days. There was only one wound complication noted in this study and there was no adverse healing in any burn wounds. The mean number of dressing changes was 1.4 (range = 1–2) and length of hospital stay was in the range of 0–11 days (mean = 5.1 days). Conclusion: Cutimed® Sorbact® is a safe, useful and cost-effective dressing that should be used as an alternative for superficial-partial burns in children.

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