Solitary Fibrous Tumor of the Prostate: A Case Report and Literature Review

Solitary fibrous tumors (SFTs) usually occur in the pleura and account for two-thirds of all cases; however, SFTs occurring in the prostate are extremely rare. Approximately 25 cases have been reported in the literature to date. This study reports the case of a 43-year-old man referred to our hospital with the chief complaint of a pelvic tumor after careful examination. The tumor marker levels were within normal limits. T2-weighted magnetic resonance imaging revealed a tumor, demonstrating primarily low signal intensity. It showed a capsule-like rim at the left lobe of the prostate, suggesting that the tumor was partially invading the rectal wall. Histopathological examination of needle-core biopsies showed spindle cell neoplasm with small and fusiform cells, strongly expressing signal transducer and activator of transcription 6 (STAT6) with a ramifying vascular network. Therefore, the clinical diagnosis of the patient was SFT of the prostate and robot-assisted radical prostatectomy was performed. Histopathological examination revealed that the tumor was composed of spindle cells with patternless and staghorn patterns. Immunohistochemical analysis showed a strong expression of STAT6. Furthermore, the tumor was partially positive for CD34. Therefore, the patient was diagnosed with SFT of the prostate. Two years after the initial diagnosis, the patient was alive with normal erectile function, continence status, and no evidence of the disease.

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Solitary Fibrous Tumor of the Auditory Canal

Archives of Pathology & Laboratory Medicine ◽

10.5858/2004-128-e169-sftota ◽

2004 ◽

Vol 128 (12) ◽

pp. e169-e171 ◽

Cited By ~ 1

Author(s):

Sherif Rezk ◽

Mohammad Yousef ◽

Marshall Zamansky ◽

Ashraf Khan

Keyword(s):

Salivary Glands ◽

Solitary Fibrous Tumor ◽

Paranasal Sinuses ◽

Spindle Cell ◽

Immunohistochemical Analysis ◽

Spindle Cell Neoplasm ◽

Cell Neoplasm ◽

Fibrous Tumor

Abstract Solitary fibrous tumor (SFT) is an uncommon spindle cell neoplasm of increasing incidence that was originally described to be of pleural origin; however, more recently, SFT has been reported in extrapleural sites, including the orbit, liver, salivary glands, tongue, nose, paranasal sinuses, larynx, retroperitoneum, meninges, and thyroid. The increase in the number of SFTs does not necessarily mean increased incidence of this tumor but rather an increased understanding of this tumor, especially recognition of this tumor in extrapleural locations, which has been aided by immunohistochemical analysis. We report a case of SFT in the auditory canal, which to our knowledge has not been previously reported, as evident by morphologic findings and immunophenotype.

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Perigastric Hyaline-Vascular Variant Castleman’s Disease

Case Reports in Gastroenterology ◽

10.1159/000513175 ◽

2021 ◽

pp. 632-638

Author(s):

Yu Ming Jin ◽

Gui Ying Jing

Keyword(s):

Histopathological Examination ◽

Immunohistochemical Analysis ◽

Lymphoproliferative Disease ◽

Castleman Disease ◽

Unknown Etiology ◽

Mesenchymal Tumors ◽

Imaging Characteristics ◽

Contrast Enhanced ◽

Hyaline Vascular Variant ◽

Vascular Variant

Castleman disease (CD) is a rare chronic lymphoproliferative disease with unknown etiology and pathogenesis disease. When the lesion is located in the mediastinum, the diagnosis of CD is easy. However, if the lesion presents as a perigastric mass mimicking other subserosal gastric mesenchymal tumors, the diagnosis can be challenging. As few sonographic manifestations of hyaline-vascular variant CD, especially contrast-enhanced ultrasound (CEUS) imaging, as well as computed tomography (CT) and histopathological imaging, have been reported in literature, this case may provide a vivid example of a comprehensive CEUS and CT usage in the diagnosis and surgery with regard to CD. This report presents a case of a 50-year-old female diagnosed with hyaline-vascular variant CD in a random physical examination, the ultrasound examination first revealed a 24.3 mm × 15.4 mm hypoechogenic lesion abutting the stomach, esophagus, and liver, which was under the suspicion of gastrointestinal stromal tumor. Following a series of medical examinations, including CEUS, CT, postoperative histopathological examination, and immunohistochemical analysis, the patient was diagnosed with hyaline-vascular variant unicentric CD. After the mass was completely excised through laparoscopic surgery, the woman recovered very well without recurrence during a follow-up period of 15 months. Thus, mastering ultrasound and CT-imaging characteristics of CD and applying ultrasound and CT examination together would do help to preoperative diagnosis.

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Concurrent Bowen’s Disease of the Nipple and Breast Cancer

Case Reports in Oncology ◽

10.1159/000511565 ◽

2020 ◽

Vol 13 (3) ◽

pp. 1410-1414

Author(s):

Kei Yamaguchi ◽

Ryoichi Matsunuma ◽

Toko Kumeta ◽

Sae Imada ◽

Ryosuke Hayami ◽

...

Keyword(s):

Breast Cancer ◽

Squamous Cell Carcinoma ◽

Carcinoma In Situ ◽

Histopathological Examination ◽

Careful Examination ◽

Bowen’S Disease ◽

Ipsilateral Breast ◽

Surgical Specimen ◽

Bowen's Disease

Bowen’s disease is a squamous cell carcinoma in situ that commonly develops on the trunk, arms, or legs and has not spread beyond the top layer of skin. It seldom develops on the nipple. We report a patient who presented with Bowen’s disease of the nipple and had a concurrent breast cancer identified in the ipsilateral breast after careful examination. Histopathological examination of the surgical specimen after mastectomy confirmed the diagnoses.

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Effect of the Total Extract of Averrhoacarambola (Oxalidaceae) Root on the Expression Levels of TLR4 and NF-κB in Streptozotocin-Induced Diabetic Mice

Cellular Physiology and Biochemistry ◽

10.1159/000430194 ◽

2015 ◽

Vol 36 (6) ◽

pp. 2307-2316 ◽

Cited By ~ 9

Author(s):

Xiaohui Xu ◽

Tao Liang ◽

Xing Lin ◽

Qingwei Wen ◽

Xingmei Liang ◽

...

Keyword(s):

Body Weight ◽

Histopathological Examination ◽

Fasting Blood Glucose ◽

Folk Medicine ◽

Immunohistochemical Analysis ◽

Tissue Expression ◽

Pancreatic Tissue ◽

Diabetic Mice ◽

Total Extract ◽

Expression Levels

Background: Averrhoacarambola L., which is a folk medicine used in diabetes mellitus (DM) in ancient China, has been reported to have anti-diabetic efficacy. Aims: The aim of this study was to evaluate the hypoglycemic effect of the extract of Averrhoacarambola L. root (EACR) on the regulation of the Toll-like receptor 4 (TLR4)-Nuclear-factor kappa B (NF-κB) pathway in B) pathway in streptozotocin (STZ)-induced diabetic mice. Methods: the mice were injected with STZ (120 mg/kg body weight) via a tail vein. After 72 h, the mice with FBG = 11.1 mmol/L were confirmed as having diabetes. Subsequently, the mice were treated intragastrically with EACR (300, 600, 1200 mg/kg body weight/d) and metformin (320 mg/kg body weight/d) for 14 days. Results: As a result the serum fasting blood glucose (FBG), interleukin-6 (IL-6) and tumor necrosis factor-a (TNF-a) levels were decreased following EACR administration. Immunohistochemical analysis revealed that the pancreatic tissue expression levels of TLR4 and NF-κB were downregulated after EACR administration. EACR suppressed pancreatic mRNA expression level of TLR4 and blocked the downstream NF-κB pathway in the pancreas. According to Western blot analysis EACR suppressed pancreatic TLR4 and NF-κB protein expression levels. Histopathological examination of the pancreas showed that STZ-induced pancreas lesions were alleviated by the EACR treatment. Conclusion: These findings suggest that the modulation of the IL-6 and TNF-a inflammatory cytokines and the suppression of the TLR4-NF-κB pathway are most likely involved in the anti-hyperglycemic effect of EACR in STZ-induced diabetic mice.

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Oral fibrosarcoma in jararaca (Bothrops pubescens): anatomopathological and immunohistochemical aspects

Pesquisa Veterinária Brasileira ◽

10.1590/s0100-736x2015000700011 ◽

2015 ◽

Vol 35 (7) ◽

pp. 664-670 ◽

Cited By ~ 2

Author(s):

Ezequiel D. Santos ◽

José R. Silva Filho ◽

Tanise P. Machado ◽

Stefano L. Dau ◽

Rubens Rodriguez ◽

...

Keyword(s):

Spindle Cell ◽

Immunohistochemical Analysis ◽

Pathological Examination ◽

Neoplastic Cells ◽

Spindle Cell Neoplasm ◽

Two Samples ◽

Cell Neoplasm ◽

Morphology Characterization ◽

Masson Trichrome Staining ◽

Positive Content

Abstract A 4-year-old female captive-bred snake of the genus Bothrops showed swelling on the left side of the oral cavity, suggesting the development of neoplasia. The mass was removed surgically and sent for pathological examination. Two months later a new increase in volume in the same site was observed, suggesting recurrence. The lesion was completely removed and sent for pathological analysis. Histologically, the two-samples consisted of a mass with highly-cell density composed of spindle-shaped anaplastic cells arranged in interwoven bundles, distributed throughout the tissue extension and, occasionally, polygonal cells arranged in irregular fascicles. The Masson trichrome staining showed modest amount of collagen supporting the neoplastic cells. PAS-positive content was not observed in the cytoplasm of neoplastic cells. Histological and histochemical findings indicated that it was a spindle cell neoplasm, but the classification was not possible. Immunohistochemistry was requested and performed using the streptavidin-biotin-peroxidase method. The markers used were anti-vimentin, anti-PCNA, anti-EMA, anti-melan A and anti-melanosome, anti-desmin, anti-actin, anti-CD68 and anti- S100protein. The neoplastic cells were immunoreactive for vimentin and PCNA and negative for the other antibodies. The morphology characterization, histochemical and immunohistochemical analysis of neoplastic cells allowed the definitive diagnosis of oral fibrosarcoma.

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Calcifying fibrous tumor of the rectum - a case report

Libri Oncologici Croatian Journal of Oncology ◽

10.20471/lo.2020.48.02-03.20 ◽

2020 ◽

Vol 48 (2-3) ◽

pp. 119-123

Author(s):

Tomislav Pavlović ◽

◽

Rosana Troskot-Perić ◽

Sanja Trtica ◽

Keyword(s):

Magnetic Resonance Imaging ◽

Intestinal Tract ◽

Benign Tumor ◽

Rectal Wall ◽

Fibrous Tissue ◽

Unknown Etiology ◽

Dystrophic Calcification ◽

Resonance Imaging ◽

Calcifying Fibrous Tumor ◽

Fibrous Tumor

A calcifying fibrous tumor (CFT) is a benign tumor of unknown etiology. A calcifying fibrous tumor is rare in the intestinal tract. A calcifying fibrous tumor is characterized by hyalinized collagenous fibrous tissue, psammomatous or dystrophic calcification, and focal lymphoplasmacytic infiltrates on histology. Magnetic resonance imaging is the standard method for evaluating the lesions of the rectum, and CFTs should be considered in differentiating the rectal wall tumors. Herein, we report a case of a 68-year-old man with a rectal wall CFT.

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Solitary fibrous tumor of the hard palate: a rare entity in oral cavity

Brazilian Dental Science ◽

10.14295/bds.2016.v19i1.1148 ◽

2016 ◽

Vol 19 (1) ◽

pp. 113

Author(s):

Antonione Santos Bezerra Pinto ◽

Vera Cavalcanti De Araújo ◽

Fabrício Passador Santos ◽

José Ferreira de Menezes Filho ◽

Viviane Siqueira ◽

...

Keyword(s):

Oral Cavity ◽

Solitary Fibrous Tumor ◽

Hard Palate ◽

Salivary Gland Tumor ◽

Immunohistochemical Analysis ◽

Soft Tissue Tumors ◽

Rare Entity ◽

Gland Tumor ◽

Clinical Imaging ◽

Fibrous Tumor

A case of solitary fibrous tumor is reported. Solitary fibrous tumor is a rare neoplasia characterized by the proliferation of fusiform cells of mesenchymal origin accounting for at least 2% of all soft tissue tumors. In this present case, the initial diagnosis was salivary gland tumor because of the location in the hard palate. Histologically, the tumor was composed by conjunctive tissue with proliferation of oval and fusiform cells. The immunohistochemical analysis was positive for CD34 and CD99. The lesion was treated by surgical resection. The clinical, imaging, histological and immunohistochemical data are discussed in this study. KeywordsSolitary fibrous tumor; Oral cavity; Hard palate; Differential diagnosis.

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Solitary Fibrous Tumor of the Kidney. A Propos of a Case

Urologia Journal ◽

10.1177/039156030907600214 ◽

2009 ◽

Vol 76 (2) ◽

pp. 112-114 ◽

Cited By ~ 1

Author(s):

M. Marzi ◽

M. D'Alpaos ◽

P. Piras ◽

A. Paiusco ◽

M.S. Minervini ◽

...

Keyword(s):

Solitary Fibrous Tumor ◽

Renal Pelvis ◽

Spindle Cell ◽

Left Kidney ◽

Clinical Behavior ◽

Spindle Cell Neoplasm ◽

Solitary Fibrous Tumors ◽

Genital Apparatus ◽

Cell Neoplasm ◽

Fibrous Tumor

Solitary Fibrous Tumors (SFT) are rare spindle cell neoplasm that typically originate from the pleura. However, cases of the SFT are described with origin in other organs, including the urinary and genital apparatus. Within the kidney, except from the renal pelvis, only 19 cases of SFT are described and such rarity of localization makes the histogenesis and the prognosis of the tumor rather unknown. We report the case of a 72-year-old lady who attended our Unit for a mass that was clinically palpable at the level of the left hemiabdomen. The tomodensitographic test indicated a 19cm-diameter mass of likely pertinence of the middle bystender of the left kidney. She had undergone left radical nephrectomy. The histological examination highlighted a solitary fibrous tumor (SFT): the presence of hypercellularity, of cellular pleiomorphism and of a high number of mitosis has led to a histological diagnosis of malignancy for the neoplasm analyzed. The SFT are of rare clinical comparison: this does not allow for a deep knowledge of the lesion histogenesis and prognosis; moreover, the clinical behavior should be more precisely defined.

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Ovarian fibrothecoma: An uncommon cause of a large pelvic mass

10.1055/s-0039-1685325 ◽

2016 ◽

Author(s):

Nikita Kumari ◽

Reenu Kanwar ◽

Bindu Bajaj ◽

Garima Kapoor

Keyword(s):

Ovarian Tumor ◽

Histopathological Examination ◽

Wide Spectrum ◽

Pelvic Mass ◽

Mass Effect ◽

Left Ovary ◽

Cystic Tumor ◽

Normal Limits ◽

Malignant Ovarian Tumor ◽

Cystic Changes

Introduction: Ovarian fibrothecomas represent an ovarian stromal neoplasm developing in a wide spectrum of clinical settings. These tumors have been described as rare ovarian neoplasm, accounting for about 4% of all ovarian tumors. We report a case whose clinical presentation was highly deceptive and was clinically and radiologically diagnosed as malignant ovarian tumor. Ascitic fluid cytology revealed absence of malignant cells. On histopathological examination, it was diagnosed as benign fibrothecoma with cystic changes. Postoperative follow-up for about six months was uneventful. Case: A 45 year old female presented to the gynae emergency with large abdominal lump of 20 weeks size with acute pain abdomen. She was admitted for initial management and thorough evaluation. Hematological and biochemical parameters were within normal limits. USG revealed a large multilocular, predominantly cystic lesion 20.9x9.6x11.4 cm in pelvis. CECT revealed ovarian cystadencarcinoma left ovary with locoregional mass effect, mild ascites and suspicious metastasis to internal iliac lymph nodes. Radiological and preoperative clinical diagnosis was malignant ovarian tumor. Panhysterectomy and omentectomy was performed. On gross examination, a well encapsulated, multinodular cystic tumor of left ovary about 17x14x7 cm was identified. Cut surface was mostly solid with few cystic areas. Uterus, cervix, right ovary and both tubes were unremarkable. On microscopic examination, multiple sections showed spindle shaped cells in storiform and palisading pattern. No mitotic activity was identified. On special staining, it was positive for vimentin, which is a characteristic feature of ovarian fibrothecoma. Conclusion: The accurate preoperative diagnosis of ovarian fibrothecoma with cystic changes could have prevented the extensive surgical intervention such as bilateral salpingo- oopherectomy with hysterectomy.

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Eosinophilic Fasciitis Associated with Myositis

Case Reports in Dermatology ◽

10.1159/000381845 ◽

2015 ◽

Vol 7 (1) ◽

pp. 79-83 ◽

Cited By ~ 5

Author(s):

Yuko Adachi ◽

Yoko Mizutani ◽

En Shu ◽

Hiroyuki Kanoh ◽

Tatsuhiko Miyazaki ◽

...

Keyword(s):

Histopathological Examination ◽

Lymphocytic Infiltration ◽

Japanese Woman ◽

Eosinophilic Fasciitis ◽

Old Japanese ◽

Weighted Magnetic Resonance Imaging ◽

Peau D’Orange ◽

Lymphocytic Infiltrates ◽

Immunohistological Study ◽

Fibrinoid Degeneration

Eosinophilic fasciitis is clinically characterized by symmetrical scleroderma-like indurations of the skin with pain. The histological features are fascial inflammation with lymphocytes and eosinophils as well as thickened and fibrotic fascia. Lymphocytic infiltration and degeneration of the underlying muscle are rarely observed. We report a 69-year-old Japanese woman who presented with multiple areas of glossy induration and painful peau d'orange-like lesions on the chest and four extremities. T2-weighted magnetic resonance imaging showed significant hyperintense thickening of the fascia of the lower extremities. Histopathological examination of a biopsy specimen from the induration showed marked fibrinoid degeneration of the fascia and the neighboring muscle with mixed cellular infiltration of lymphocytes and eosinophils. The predominant CD8+ lymphocytic infiltrates were observed by immunohistological study. A diagnosis of eosinophilic fasciitis with myositis was made. Oral administration of prednisolone and discontinuation of exercise significantly improved the lesions and pain.

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