Smoking and Dental Implants: A Systematic Review and Meta-Analysis

Background and Objectives: Tobacco is today the single most preventable cause of death, being associated with countless diseases, including cancer and neurological, cardiovascular, and respiratory diseases. Smoking also brings negative consequences to oral health, potentially impairing treatment with dental implants. The present review aimed to evaluate the influence of smoking on dental implant failure rates and marginal bone loss (MBL). Materials and Methods: Electronic search was undertaken in three databases, plus a manual search of journals. Meta-analyses were performed, in addition to meta-regressions, in order to verify how the odds ratio (OR) and MBL were associated with follow-up time. Results: The review included 292 publications. Altogether, there were 35,511 and 114,597 implants placed in smokers and in non-smokers, respectively. Pairwise meta-analysis showed that implants in smokers had a higher failure risk in comparison with non-smokers (OR 2.402, p < 0.001). The difference in implant failure between the groups was statistically significant in the maxilla (OR 2.910, p < 0.001), as well as in the mandible (OR 2.866, p < 0.001). The MBL mean difference (MD) between the groups was 0.580 mm (p < 0.001). There was an estimated decrease of 0.001 in OR (p = 0.566) and increase of 0.004 mm (p = 0.279) in the MBL MD between groups for every additional month of follow-up, although without statistical significance. Therefore, there was no clear influence of the follow-up on the effect size (OR) and on MBL MD between groups. Conclusions: Implants placed in smokers present a 140.2% higher risk of failure than implants placed in non-smokers.

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Dental Implants Inserted in Fresh Extraction Sockets versus Healed Sites: A Systematic Review and Meta-Analysis

Materials ◽

10.3390/ma14247903 ◽

2021 ◽

Vol 14 (24) ◽

pp. 7903

Author(s):

Adam Ibrahim ◽

Bruno Ramos Chrcanovic

Keyword(s):

Odds Ratio ◽

Meta Analysis ◽

Implant Failure ◽

Marginal Bone Loss ◽

Manual Search ◽

Failure Risk ◽

Electronic Search ◽

The Difference ◽

Meta Analyses

The present review aimed to evaluate the difference of dental implant failure rates and marginal bone loss (MBL) between implants inserted in fresh extraction sockets or healed sites. Electronic search was undertaken in three databases, plus manual search of journals, including studies randomized or not. Meta-analyses were performed besides meta-regressions, in order to verify how the odds ratio (OR) and MBL were associated with follow-up time. The review included 163 publications. Altogether, there were 17,278 and 38,738 implants placed in fresh extraction sockets and healed sites, respectively. Pairwise meta-analyses showed that implants in sockets had a higher failure risk in comparison to healed sites: OR 1.349, all studies included; OR 2.070, only prospective non-RCTs; OR 2.487, only RCTs (all p < 0.001). The difference in implant failure between the groups was statistically significant in the maxilla (OR 1.616, p = 0.029), but not in the mandible (OR 2.192, p = 0.075). The MBL mean difference (MD) between the groups was −0.053 mm (p = 0.089). There was an estimated decrease of 0.003 in OR (p = 0.284) and an increase of 0.006 mm (p = 0.036) in the MBL MD between groups for every additional month of follow-up. In conclusion, implants placed in fresh extraction sockets present higher risk of failure than implants placed in healed sites.

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The Impact of Dental Implant Length on Failure Rates: A Systematic Review and Meta-Analysis

Materials ◽

10.3390/ma14143972 ◽

2021 ◽

Vol 14 (14) ◽

pp. 3972

Author(s):

Maha Abdel-Halim ◽

Dalia Issa ◽

Bruno Ramos Chrcanovic

Keyword(s):

Treatment Plan ◽

Meta Analysis ◽

Implant Failure ◽

Failure Rates ◽

Manual Search ◽

Short Implants ◽

The Many ◽

The Impact ◽

Implant Length

The present review aimed to evaluate the impact of implant length on failure rates between short (<10 mm) and long (≥10 mm) dental implants. An electronic search was undertaken in three databases, as well as a manual search of journals. Implant failure was the outcome evaluated. Meta-analysis was performed in addition to a meta-regression in order to verify how the risk ratio (RR) was associated with the follow-up time. The review included 353 publications. Altogether, there were 25,490 short and 159,435 long implants. Pairwise meta-analysis showed that short implants had a higher failure risk than long implants (RR 2.437, p < 0.001). There was a decrease in the probability of implant failure with longer implants when implants of different length groups were compared. A sensitivity analysis, which plotted together only studies with follow-up times of 7 years or less, resulted in an estimated increase of 0.6 in RR for every additional month of follow-up. In conclusion, short implants showed a 2.5 times higher risk of failure than long implants. Implant failure is multifactorial, and the implant length is only one of the many factors contributing to the loss of an implant. A good treatment plan and the patient’s general health should be taken into account when planning for an implant treatment.

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Clinical Behavior and Complications of Mandibular Full-Arch Fixed Dental Prostheses Supported by Three Dental Implants. A Systematic Review and Meta-Analysis

Biology ◽

10.3390/biology10040308 ◽

2021 ◽

Vol 10 (4) ◽

pp. 308

Author(s):

Luis Sánchez-Labrador ◽

Pedro Molinero-Mourelle ◽

Jorge Cortés-Bretón Brinkmann ◽

Juan Carlos Prados-Frutos ◽

Miguel Gómez-Polo ◽

...

Keyword(s):

Systematic Review ◽

Survival Rate ◽

Dental Implants ◽

Meta Analysis ◽

Clinical Behavior ◽

Manual Search ◽

Dental Prostheses ◽

Edentulous Mandible ◽

Patient Reported

This systematic review and meta-analysis set out to assess the clinical behavior of mandibular implant-supported fixed complete dental prostheses (ISFCDP) on three dental implants by analyzing implant and prosthetic survival rates, marginal bone loss, biological/technical complications, and patient-reported outcomes. The review was conducted according to PRISMA guidelines. Electronic searches were conducted in the Medline (PubMed), Web of Science, and Cochrane databases, complimented by a manual search in specialist journals for relevant articles published up to February 2021. The Newcastle-Ottawa Quality Assessment Scale tool was used to assess the quality of evidence in the studies reviewed. The study included 13 articles with 728 patients treated with 2184 implants. A mean implant survival rate of 95.9% (95% CI: 94.6–97.3%) and a prosthetic survival rate of 97.0% (95% CI: 95.7–98.3%) were obtained over 1–6-year follow-up periods. Mandibular implant-supported fixed complete dental prostheses on three dental implants would appear to be a viable option for restoring the edentulous mandible in comparison with mandibular ISFCDP on more than three implants. Further comparative studies are needed, with adequate protocols, as well as sufficient sample sizes and follow-up periods to confirm these findings.

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Long-Term Clinical Behavior and Complications of Intentionally Tilted Dental Implants Compared with Straight Implants Supporting Fixed Restorations: A Systematic Review and Meta-Analysis

Biology ◽

10.3390/biology10060509 ◽

2021 ◽

Vol 10 (6) ◽

pp. 509

Author(s):

Jorge Cortés-Bretón Brinkmann ◽

Ignacio García-Gil ◽

Patricia Pedregal ◽

Jesús Peláez ◽

Juan Carlos Prados-Frutos ◽

...

Keyword(s):

Systematic Review ◽

Dental Implants ◽

Meta Analysis ◽

Cochrane Central Register ◽

Success Rates ◽

Implant Survival ◽

Marginal Bone Loss ◽

Clinical Behavior ◽

Manual Search

The aim of this study was to assess the long-term clinical behavior of straight implants in comparison with intentionally tilted dental implants (ITDI) supporting fixed restorations in partial or total edentulous arches, analyzing implant survival and success rates, complications, and marginal bone loss (MBL) after >5 years of function. An electronic search was conducted in five electronic databases (MEDLINE/Pubmed, Embase, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) supplemented by a manual search. The electronic and manual search identified 1853 articles, of which 8 articles were selected for analysis. Out of a total of 3987 dental implants, 2036 were axial dental implants and 1951 tilted. Similar results were found in implant survival or overall implant success rates. Moreover, no statistically significant differences were found in MBL (p = 0.369; MD 0.116 mm (−0.137; 0.369) 95% CI) The prosthodontic/biological complications reported in the articles were very diverse and irregularly distributed. This systematic review suggests that there is no difference between tilted compared with straight dental implants in the medium-long term (>5 years). However, further research is needed to generate long-term data and confirm the present review’s findings.

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The Clinical Performance of Narrow Diameter Implants Versus Regular Diameter Implants: A Meta-Analysis

Journal of Oral Implantology ◽

10.1563/aaid-joi-d-19-00025 ◽

2019 ◽

Vol 45 (6) ◽

pp. 503-508 ◽

Cited By ~ 3

Author(s):

Meng Ma ◽

Mengxing Qi ◽

Dongsheng Zhang ◽

Hongchen Liu

Keyword(s):

Fixed Effects ◽

Meta Analysis ◽

Survival Rates ◽

Success Rates ◽

Implant Survival ◽

Marginal Bone Loss ◽

Manual Search ◽

Meta Regression ◽

Narrow Diameter Implants

The purpose of this study is to analyze 1- and 3-year clinical performances of narrow diameter implants (NDIs) versus regular diameter implants (RDIs). A search of electronic databases and a manual search was performed for the time period January 2000 to April 2018. A meta-regression was used to evaluate the effects of the “fixed effects” model on the implant survival rates, prosthesis success rates and marginal bone loss (MBL) with follow-up time of 1 year and 3 years. Of the 11 studies included, the overall combined 1-year implant survival rates were 98.14% for NDIs and 98.20% for RDIs. The overall combined 3-year implant survival rates were 98.71% for NDIs and 98.84% for RDIs. The corresponding values for 1-year prosthesis success rates were 96.94% for NDIs and 99.25% for RDIs. The corresponding values for 3-year prosthesis success rates were 89.25% for NDIs and 96.55% for RDIs. The meta-regression showed no significant differences between NDIs and RDIs regarding implant survival rates, prosthesis success rates, and MBL in 1-year and 3-year follow-up (P > .05). The results of this meta-analysis concluded that the implant diameter did not affect its survival rates, prosthesis success rates, and MBL in 1 and 3 years. The use of NDIs instead of bone augmentation procedures with RDIs did not affect its survival rates, prosthesis success rates, and MBL in the short-term and middle-term. However, more high-quality randomized controlled trials and long follow-up studies are needed on this topic.

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Immediate loading of short implants: A systematic review

Journal of Advanced Periodontology & Implant Dentistry ◽

10.34172/japid.2021.002 ◽

2021 ◽

Vol 13 (1) ◽

pp. 15-21

Author(s):

Mahdi Hadilou ◽

Pooya Ebrahimi ◽

Behnaz Karimzadeh ◽

Ashkan Ghaffary ◽

Leila Gholami ◽

...

Keyword(s):

Systematic Review ◽

Dental Implants ◽

Randomized Clinical Trials ◽

Meta Analysis ◽

Immediate Loading ◽

Significant Heterogeneity ◽

Marginal Bone Loss ◽

Manual Search ◽

Short Implants ◽

Loading Methods

Background. This systematic review aimed to determine the effectiveness and outcomes of immediate loading methods for short dental implants. Methods. The authors independently conducted an electronic search in the PubMed, Embase, EBSCO, ProQuest, and Cochrane databases for relevant articles published until November 15, 2020. The references of the included studies were assessed, and a manual search was conducted in Google Scholar and PubMed to find additional relevant studies. Results. Finally, three studies were selected and included in this systematic review. Significant heterogeneity existed in the design of the included studies, and due to the low number of the included studies, the authors could not perform a meta-analysis. The studies showed that the survival rate of immediate-loaded short implants is comparable to conventional loading methods. However, more marginal bone loss is expected. Overall, the immediate loading of short dental implants might be clinically successful. Conclusion. Based on the results, immediate loading protocols might be safely used for short implants. However, caution should be exercised in interpreting these results. Future welldesigned randomized clinical trials with more participants and study power are necessary to support the findings of this systematic review.

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Factors Affecting Implant Failure and Marginal Bone Loss of Implants Placed by Post-Graduate Students: A 1-Year Prospective Cohort Study

Materials ◽

10.3390/ma13204511 ◽

2020 ◽

Vol 13 (20) ◽

pp. 4511

Author(s):

Gian Maria Ragucci ◽

Maria Giralt-Hernando ◽

Irene Méndez-Manjón ◽

Oriol Cantó-Navés ◽

Federico Hernández-Alfaro

Keyword(s):

Graduate Students ◽

Dental Implants ◽

Implant Failure ◽

Success Rates ◽

Contributing Factors ◽

Marginal Bone Loss ◽

Post Graduate ◽

One Year ◽

The One

Statement of the problem: Most of the clinical documentation of implant success and survival published in the literature have been issued by either experienced teams from university settings involving strict patient selection criteria or from seasoned private practitioners. By contrast, studies focusing on implants placed and rehabilitated by inexperienced post-graduate students are scarce. Purpose: To record failure rates and identify the contributing factors to implant failure and marginal bone loss (MBL) of implants placed and rehabilitated by inexperienced post-graduate students at the one-year follow-up. Material and Methods: A prospective cohort study was conducted on study participants scheduled for implant therapy at the International University of Catalonia. An experienced mentor determined the treatment plan in accordance with the need of each participant who signed an informed consent. All surgeries and prosthetic rehabilitation were performed by the post-graduate students. Implant failure rate, contributors to implant failure, and MBL were investigated among 24 variables related to patient health, local site, and implant and prosthetic characteristics. The risk of implant failure was analyzed with a simple binary logistic regression model with generalized equation equations (GEE) models, obtaining unadjusted odds ratios (OR). The relationship between MBL and the other independent variables was studied by simple linear regression estimated with GEE models and the Wald chi2 test. Results: One hundred and thirty dental implants have been placed and rehabilitated by post-graduate students. Five implants failed before loading and none after restoration delivery; survival and success rates were 96.15% and 94.62%, respectively. None of the investigated variables significantly affected the implant survival rate. At the one-year follow-up, the mean (SD) MBL was 0.53 (0.39) mm. The following independent variables significantly affected the MBL: Diabetes, implant depth placement. The width of keratinized tissue (KT) and probing depth (PD) above 3 mm were found to be good indicators of MBL, with each additional mm of probing depth resulting in 0.11 mm more MBL. Conclusion: The survival and success rates of dental implants placed and rehabilitated by inexperienced post-graduate students at the one-year follow-up were high. No contributing factor was identified regarding implant failure. However, several factors significantly affected MBL: Diabetes, implant depth placement, PD, and width of KT. Clinical Implications: Survival and success rates of dental implants placed and rehabilitated by inexperienced post-graduate students were high at the one-year follow-up, similar to experienced practitioners. No contributing factors were identified regarding implant failure; however, several factors significantly affected MBL: Diabetes, implant depth placement, PD, and KM.

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Effect of laser-microtexturing on bone and soft tissue attachments to dental implants: A systematic review and meta-analysis

Journal of Dental Research Dental Clinics Dental Prospects ◽

10.34172/joddd.2021.048 ◽

2021 ◽

Vol 15 (4) ◽

pp. 290-296

Author(s):

Roodabeh Koodaryan ◽

Ali Hafezeqoran

Keyword(s):

Dental Implants ◽

Surface Characterization ◽

Meta Analysis ◽

Implant Failure ◽

Failure Rates ◽

Marginal Bone Loss ◽

Osseointegrated Implant ◽

Bone Level ◽

Marginal Bone Level ◽

Mean Differences

Background. It is critical to understand laser-microtextured implant collars’ influence on peri-implant pocket depths and marginal bone levels, especially in crucial areas. The present review investigated the peri-implant marginal bone loss (MBL) and pocket depths and failure rates of dental implants with laser-microtextured collars. Methods. An electronic search was run in the PubMed and Embase databases until September 15, 2019. Randomized and prospective clinical studies comparing peri-implant MBL and pocket depths and failure rates between implants with laser-microtextured and machined collar surfaces were included. Five studies (two cohort studies and three RCTs) were included in the meta-analysis after the inclusion and exclusion criteria and qualitative assessments were applied. The risk ratio of osseointegrated implant failure and mean differences in peri-implant MBL and pocket depths were calculated using the Comprehensive Meta-Analysis (CMA) software. Results. Implants with laser-microtextured collars exhibited significantly better marginal bone level scores (P<0.001; MD: 0.54; 95% CI: 0.489‒0.592) and a significant reduction in peri-implant probing depths than implants with machined collars (P<0.001; MD: 1.01; 95% CI: 0.90‒1.13). The assessed studies showed that 17 out of 516 implants failed (3.29%), comprising nine implants with machined (3.62%) and eight implants with laser-microtextured collars (2.98%). However, no significant differences were detected in the implant neck surface characterization (P=0.695; RR: 1.205; 95% CI: 0.472‒3.076). Conclusion. This study suggests that laser-microtexturing of implant collar significantly affected the peri-implant MBL and probing depths. Although no significant differences were noted in implant failure rates between implants with laser-microtextured and machined collar surfaces, the peri-implant MBL and probing depths with laser-microtextured collars were significantly lower than the machined collars.

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Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis

Gerontology ◽

10.1159/000517099 ◽

2021 ◽

pp. 1-16

Author(s):

Jane Xu ◽

Ching S. Wan ◽

Kiriakos Ktoris ◽

Esmee M. Reijnierse ◽

Andrea B. Maier

Keyword(s):

Systematic Review ◽

Working Group ◽

Meta Analysis ◽

Nursing Home Residents ◽

Community Dwelling ◽

Risk Of Mortality ◽

European Working ◽

Subgroup Analyses ◽

Meta Analyses

Background: Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis. Objective: This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. Methods: A systematic search was conducted in MEDLINE, EMBASE, and Cochrane from 1 January 2010 to 6 April 2020 for articles relating to sarcopenia and mortality. Articles were included if they met the following criteria – cohorts with a mean or median age ≥18 years and either of the following sarcopenia definitions: Asian Working Group for Sarcopenia (AWGS and AWGS2019), European Working Group on Sarcopenia in Older People (EWGSOP and EWGSOP2), Foundation for the National Institutes of Health (FNIH), International Working Group for Sarcopenia (IWGS), or Sarcopenia Definition and Outcomes Consortium (SDOC). Hazard ratios (HR) and odds ratios (OR) were pooled separately in meta-analyses using a random-effects model, stratified by population (community-dwelling adults, outpatients, inpatients, and nursing home residents). Subgroup analyses were performed for sarcopenia definition and follow-up period. Results: Out of 3,025 articles, 57 articles were included in the systematic review and 56 in the meta-analysis (42,108 participants, mean age of 49.4 ± 11.7 to 86.6 ± 1.0 years, 40.3% females). Overall, sarcopenia was associated with a significantly higher risk of mortality (HR: 2.00 [95% CI: 1.71, 2.34]; OR: 2.35 [95% CI: 1.64, 3.37]), which was independent of population, sarcopenia definition, and follow-up period in subgroup analyses. Conclusions: Sarcopenia is associated with a significantly higher risk of mortality, independent of population and sarcopenia definition, which highlights the need for screening and early diagnosis in all populations.

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Long-Term Comparison of Survival and Marginal Bone of Implants with and without Sinus Augmentation in Maxillary Molars within the Same Patients: A 5.8- to 22-Year Retrospective Study

Journal of Clinical Medicine ◽

10.3390/jcm10071360 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1360

Author(s):

Won-Bae Park ◽

Ji-Young Han ◽

Kyung Lhi Kang

Keyword(s):

Statistical Significance ◽

Frailty Model ◽

Implant Failure ◽

Implant Survival ◽

Marginal Bone Loss ◽

Related Factors ◽

Sinus Augmentation ◽

Maxillary Molars ◽

Posterior Maxilla

Maxillary sinus floor augmentation (MSFA) is widely used and considered a predictable procedure for implant placement. However, the influence of MSFA on implant survival and marginal bone loss (MBL) is still inconclusive. The purpose of this retrospective observational study is to evaluate the long-term genuine influence of MSFA on the survival and MBL of implants by comparing those with and without MSFA only in maxillary molars within the same patients. Thirty-eight patients (28 male and 10 female), with a total of 119 implants, received implants with and without MSFA, and were followed up for 5.8 to 22 years. Patient- and implant-related factors were assessed with a frailty model for implant survival and with generalized estimation equations (GEE) for MBL around the implant. No variables showed a statistical significance for implant failure in the frailty model. In GEE analysis for MBL, MSFA did not show any statistical significance. In conclusion, MSFA demonstrated no significant influence on implant failure and MBL in posterior maxilla in this study.

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