scholarly journals Immediate loading of short implants: A systematic review

2021 ◽  
Vol 13 (1) ◽  
pp. 15-21
Author(s):  
Mahdi Hadilou ◽  
Pooya Ebrahimi ◽  
Behnaz Karimzadeh ◽  
Ashkan Ghaffary ◽  
Leila Gholami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Immediate Loading ◽  
Significant Heterogeneity ◽  
Marginal Bone Loss ◽  
Manual Search ◽  
Short Implants ◽  
Loading Methods

Background. This systematic review aimed to determine the effectiveness and outcomes of immediate loading methods for short dental implants. Methods. The authors independently conducted an electronic search in the PubMed, Embase, EBSCO, ProQuest, and Cochrane databases for relevant articles published until November 15, 2020. The references of the included studies were assessed, and a manual search was conducted in Google Scholar and PubMed to find additional relevant studies. Results. Finally, three studies were selected and included in this systematic review. Significant heterogeneity existed in the design of the included studies, and due to the low number of the included studies, the authors could not perform a meta-analysis. The studies showed that the survival rate of immediate-loaded short implants is comparable to conventional loading methods. However, more marginal bone loss is expected. Overall, the immediate loading of short dental implants might be clinically successful. Conclusion. Based on the results, immediate loading protocols might be safely used for short implants. However, caution should be exercised in interpreting these results. Future welldesigned randomized clinical trials with more participants and study power are necessary to support the findings of this systematic review.

scholarly journals Long-Term Clinical Behavior and Complications of Intentionally Tilted Dental Implants Compared with Straight Implants Supporting Fixed Restorations: A Systematic Review and Meta-Analysis

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 509
Author(s):  
Jorge Cortés-Bretón Brinkmann ◽  
Ignacio García-Gil ◽  
Patricia Pedregal ◽  
Jesús Peláez ◽  
Juan Carlos Prados-Frutos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Meta Analysis ◽  
Cochrane Central Register ◽  
Success Rates ◽  
Implant Survival ◽  
Marginal Bone Loss ◽  
Clinical Behavior ◽  
Manual Search

The aim of this study was to assess the long-term clinical behavior of straight implants in comparison with intentionally tilted dental implants (ITDI) supporting fixed restorations in partial or total edentulous arches, analyzing implant survival and success rates, complications, and marginal bone loss (MBL) after >5 years of function. An electronic search was conducted in five electronic databases (MEDLINE/Pubmed, Embase, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials) supplemented by a manual search. The electronic and manual search identified 1853 articles, of which 8 articles were selected for analysis. Out of a total of 3987 dental implants, 2036 were axial dental implants and 1951 tilted. Similar results were found in implant survival or overall implant success rates. Moreover, no statistically significant differences were found in MBL (p = 0.369; MD 0.116 mm (−0.137; 0.369) 95% CI) The prosthodontic/biological complications reported in the articles were very diverse and irregularly distributed. This systematic review suggests that there is no difference between tilted compared with straight dental implants in the medium-long term (>5 years). However, further research is needed to generate long-term data and confirm the present review’s findings.

scholarly journals Hypofractionated radiotherapy for newly diagnosed elderly glioblastoma patients: A systematic review and network meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0257384
Author(s):  
Suely Maymone de Melo ◽  
Gustavo Nader Marta ◽  
Carolina de Oliveira Cruz Latorraca ◽  
Camila Bertini Martins ◽  
Orestis Efthimiou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Progression Free Survival ◽  
Hypofractionated Radiotherapy ◽  
Newly Diagnosed ◽  
Qualitative Synthesis ◽  
Manual Search ◽  
Grade 3

Objective To evaluate different hypofractionated radiotherapy (HRT) regimens for newly diagnosed elderly glioblastoma (GBM) patients. Methods We performed a systematic review with network meta-analysis (NMA), including searches on CENTRAL, Medline, EMBASE, CINAHL, clinical trial databases and manual search. Only randomized clinical trials (RCTs) were included. Primary outcomes: overall survival (OS) and adverse events (AE). Secondary outcomes: progression-free-survival (PFS) and quality of life (QoL). We used the Cochrane Risk of Bias (RoB) table for assessing individual studies and CINeMA for evaluating the certainty of the final body of evidence. Results Four RCTs (499 patients) were included. For OS, the estimates from NMA did not provide strong evidence of a difference between the HRTs: 40 Gray (Gy) versus 45 Gy (HR: 0.89; CI 95%: 0.42, 1.91); 34 Gy versus 45 Gy (HR: 0.85; CI 95% 0.43, 1.70); 25 Gy versus 45 Gy (HR: 0.81; CI 95% 0.32, 2.02); 34 Gy versus 40 Gy (HR: 0.95; CI 95% 0.57, 1.61); and 25 Gy versus 34 Gy (HR: 0.95; CI 95% 0.46, 1.97). We performed qualitative synthesis for AE and QoL due to data scarcity and clinical heterogeneity among studies. The four studies reported a similar QoL (assessed by different methods) between arms. One RCT reported grade ≥ 3 AE, with no evidence of a difference between arms. PFS was reported in one study (25 Gy versus 40 Gy), with no evidence of a difference between arms. Conclusion This review found no evidence of a difference between the evaluated HRTs for efficacy and safety.

scholarly journals Clinical Behavior and Complications of Mandibular Full-Arch Fixed Dental Prostheses Supported by Three Dental Implants. A Systematic Review and Meta-Analysis

Biology ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 308
Author(s):  
Luis Sánchez-Labrador ◽  
Pedro Molinero-Mourelle ◽  
Jorge Cortés-Bretón Brinkmann ◽  
Juan Carlos Prados-Frutos ◽  
Miguel Gómez-Polo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Survival Rate ◽  
Dental Implants ◽  
Meta Analysis ◽  
Clinical Behavior ◽  
Manual Search ◽  
Dental Prostheses ◽  
Edentulous Mandible ◽  
Patient Reported

This systematic review and meta-analysis set out to assess the clinical behavior of mandibular implant-supported fixed complete dental prostheses (ISFCDP) on three dental implants by analyzing implant and prosthetic survival rates, marginal bone loss, biological/technical complications, and patient-reported outcomes. The review was conducted according to PRISMA guidelines. Electronic searches were conducted in the Medline (PubMed), Web of Science, and Cochrane databases, complimented by a manual search in specialist journals for relevant articles published up to February 2021. The Newcastle-Ottawa Quality Assessment Scale tool was used to assess the quality of evidence in the studies reviewed. The study included 13 articles with 728 patients treated with 2184 implants. A mean implant survival rate of 95.9% (95% CI: 94.6–97.3%) and a prosthetic survival rate of 97.0% (95% CI: 95.7–98.3%) were obtained over 1–6-year follow-up periods. Mandibular implant-supported fixed complete dental prostheses on three dental implants would appear to be a viable option for restoring the edentulous mandible in comparison with mandibular ISFCDP on more than three implants. Further comparative studies are needed, with adequate protocols, as well as sufficient sample sizes and follow-up periods to confirm these findings.

scholarly journals Prevalence of Anxiety in Medical Students during the COVID-19 Pandemic: A Rapid Systematic Review with Meta-Analysis

2020 ◽  
Vol 17 (18) ◽  
pp. 6603 ◽  
Author(s):  
Isabel Lasheras ◽  
Patricia Gracia-García ◽  
Darren Lipnicki ◽  
Juan Bueno-Notivol ◽  
Raúl López-Antón ◽  
...  
Keyword(s):  
Systematic Review ◽  
Medical Students ◽  
Meta Analysis ◽  
Total Sample ◽  
Significant Heterogeneity ◽  
The Novel ◽  
Cross Sectional ◽  
Manual Search ◽  
Novel Coronavirus ◽  
Treatment Prognosis

The novel coronavirus disease (COVID-19) pandemic has brought a great deal of pressure for medical students, who typically show elevated anxiety rates. Our aim is to investigate the prevalence of anxiety in medical students during this pandemic. This systematic review and mini meta-analysis has been conducted following the PRISMA guidelines. Two researchers independently searched PubMed on 26 August 2020 for cross-sectional studies on medical students during the COVID-19 outbreak, with no language restrictions applied. We then performed a manual search to detect other potentially eligible investigations. To the 1361 records retrieved in the initial search, 4 more were added by manual search on medRxiv. Finally, eight studies were finally included for qualitative and quantitative analysis, which yielded an estimated prevalence of anxiety of 28% (95% CI: 22–34%), with significant heterogeneity between studies. The prevalence of anxiety in medical students is similar to that prior to the pandemic but correlates with several specific COVID-related stressors. While some preventive and risk factors have been previously identified in a non-pandemic context, knowledge and cognitions on COVID-19 transmission, treatment, prognosis and prevention negatively correlate with anxiety, emerging as a key preventive factor that may provide a rationale for why the levels of anxiety have remained stable in medical students during the pandemic while increasing in their non-medical peers and the general population. Other reasons for the invariability of anxiety rates in this population are discussed. A major limitation of our review is that Chinese students comprised 89% the total sample, which could compromise the external validity of our work

scholarly journals The Clinical Efficacy and Adverse Effects of Entecavir plus Thymosin alpha-1 Combination Therapy versus Entecavir Monotherapy in HBV-related Cirrhosis: A Systematic Review and Meta-analysis

2020 ◽  
Author(s):  
Dan Peng ◽  
Hai-Yan Xing ◽  
Chen Li ◽  
Xian-Feng Wang ◽  
Min Hou ◽  
...  
Keyword(s):  
Systematic Review ◽  
Combination Therapy ◽  
Loss Rate ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Significant Heterogeneity ◽  
Efficacy And Safety ◽  
Significant Difference ◽  
Thymosin Alpha 1

Abstract Background Previous studies have demonstrated the benefits of thymosin alpha-1 (Tα1) in anti-virus, immunological enhancement and anti-inflammation. However, it is controversial about the efficacy and safety of entecavir (ETV) plus T α1 combination therapy versus ETV monotherapy in cirrhotic patients with hepatitis B virus (HBV) infection. Methods The systematic review and meta-analysis of randomized clinical trials (RCTs) were performed to evaluate the efficacy and safety of ETV plus Tα1 combination therapy versus ETV monotherapy in HBV -related patients with cirrhosis. We performed a systematic literature search on seven databases. Relative risk (RR) and standardized mean difference (SMD) with a fixed- or random- effect model were calculated. Heterogeneity was assessed through a Cochrane Q-test and I 2 values. Results Seven RCTs involving 1144 subjects were included in the systematic review and meta-analysis. Compared with ETV monotherapy, ETV plus Tα1 combination therapy led to a higher complete response. In post treatment for 24 weeks, the HBV DNA undetectable rate and HBeAg loss rate were higher in ETV plus Tα1 group than in ETV alone group. However, after 48 and 52 weeks of treatment, there was no significant difference between the combination therapy and ETV monotherapy. At week 52 of treatment, the HBsAg loss rate of ETV plus Tα1 group was no significance with that of ETV alone group. In comparison with ETV alone, the some biochemical parameters and liver fibrosis were obviously improved by ETV plus Tα1 , and there was significant heterogeneity. In addition, the number of adverse events was significantly reduced by ETV plus Tα1, compared to ETV alone. Conclusions ETV plus Tα1 might lead to a higher clinical response and a lower comprehensive adverse reaction rate in HBV-related patients with cirrhosis, compared to ETV alone. However, the whole patients included in this meta-analysis were from Chinese mainland, so that more worldwide RCTs with a larger sample size are needed to verify the current findings.

scholarly journals Evaluation of Implant Collar Surfaces for Marginal Bone Loss: A Systematic Review and Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Roodabeh Koodaryan ◽  
Ali Hafezeqoran
Keyword(s):  
Systematic Review ◽  
Bone Loss ◽  
Dental Implants ◽  
Retrospective Studies ◽  
Meta Analysis ◽  
Survival Rates ◽  
Marginal Bone Loss ◽  
Eligibility Criteria ◽  
Randomized Controlled ◽  
Present Systematic Review

Background. It is important to understand the influence of different collar designs on peri-implant marginal bone loss, especially in the critical area.Objectives. The purpose of the present systematic review and meta-analysis was to compare dental implants with different collar surfaces, evaluating marginal bone loss and survival rates of implants.Methods. Eligibility criteria included clinical human studies, randomized controlled trials, and prospective and retrospective studies, which evaluated dental implants with different collar surface in the same study.Results. Twelve articles were included, with a total of 492 machined, 319 rough-surfaced, and 352 rough-surfaced microthreaded neck implants. There was less marginal bone loss at implants with rough-surfaced and rough-surfaced microthreaded neck than at machined-neck implants (difference in means: 0.321, 95% CI: 0.149 to 0.493;p<0.01).Conclusion. Rough and rough-surfaced microthreaded implants are considered a predictable treatment for preserving early marginal bone loss.

scholarly journals Comparing success of immediate versus delay loading of implants in fresh sockets: A systematic review and meta-analysis

2021 ◽  
Author(s):  
Ebrahim Eyni ◽  
Hojatollah Yousefimanesh ◽  
Alireza Hashemi Ashtiani ◽  
Amal Saki-Malehi ◽  
Amin Olapour ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dental Implants ◽  
Full Text ◽  
Treatment Time ◽  
Clinical Success ◽  
Meta Analysis ◽  
Immediate Loading ◽  
Time Interval ◽  
Level Of Evidence ◽  
Significant Difference

Abstract Background and aims: The replacement of teeth with osseointegrated implants is one of the significant advances in the field of restorative dentistry. The time interval between tooth extraction and the implant can be very short or long. This systematic review and meta-analysis aimed to collect and evaluate articles related to determining the effect of immediate loading of dental implants are placed in the fresh socket initial stability on the clinical success of the implant compared to delay loading procedure. Materials and Methods: In this study, all the available articles indexed in leading databases, including PubMed, ISI Web of Science, Embase, PsycINFO, PROSPERO, and Scopus were searched. The full text of the articles meeting the primary criteria to be included in this research was obtained and appraised. Data of studies were extracted if they were scored as a high or moderate level of evidence. Results: A total of 2,258 published articles were found through electronic database searching. After screening the titles and abstracts, and full-text of articles 16 studies met the inclusion criteria and were included in the analysis. The results of this study revealed that regarding the success rate, although there was no significant difference between immediate and delay loading of dental implants, immediate procedure showed a lower incidence of bone loss in single implants. Conclusion: Based on the results of this study, immediate loading of dental implant, under certain conditions, is a successful treatment process and is effective in reducing treatment time. Thus, immediate loading represents a valid alternative to the traditional delayed loading rehabilitation.

scholarly journals Clinical Comparation of Extra-Short (4 mm) and Long (>8 mm) Dental Implants Placed in Mandibular Bone: A Systematic Review and Metanalysis

Healthcare ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 315
Author(s):  
Vittorio Moraschini ◽  
Carlos Fernando de Almeida Barros Mourão ◽  
Pietro Montemezzi ◽  
Ingrid Chaves Cavalcante Kischinhevsky ◽  
Daniel Costa Ferreira de Almeida ◽  
...  
Keyword(s):  
Systematic Review ◽  
Survival Rate ◽  
Bone Loss ◽  
Dental Implants ◽  
Implant Survival ◽  
Marginal Bone Loss ◽  
Implant Survival Rate ◽  
Short Implants ◽  
Prosthetic Complications

This systematic review (SR) aimed to evaluate implant survival rate, marginal bone loss (MBL), and biological/prosthetic complications of extra-short 4 mm dental implants. An electronic search without language or date restrictions was performed in five databases and in gray literature for articles published until August 2020. Prospective cohort studies and randomized clinical trials (RCTs) that evaluated the clinical performance of extra-short 4 mm dental implants were included. Studies were independently assessed for risk of bias using the Cochrane Collaboration’s tool. The protocol of this SR was registered in the PROSPERO database under number CRD42019139709. Four studies were included in the present SR. There was no significant difference in implant survival rate (p = 0.75) between extra-short 4 mm and long implants. After 12 months of function, the extra-short implants had a significantly (p = 0.003) lower marginal bone loss (MBL) rate when compared to long implants. Extra-short implants had a lower number of biological and prosthetic complications when compared to long implants. After 12 months of follow-up, extra-short 4 mm dental implants placed in the mandible exhibit satisfactory clinical outcomes concerning implant survival rate and MBL when compared to longer implants, with a low number of biological and prosthetic complications. A higher number of RCTs with longer follow-up is necessary for the future.

Sign in / Sign up

Export Citation Format

Share Document