Dyslipidemia: A Trigger for Coronary Heart Disease in Romanian Patients with Diabetes

Previous studies have reported age and gender disparities in the occurrence and therapeutic approach of dyslipidemia and (or) coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM). We aimed to investigate these differences in Romanian patients with T2DM. A cross-sectional, observational, retrospective study was conducted using the medical records of T2DM patients who attended the outpatient facility of the Internal Medicine Clinic of the Clinical Emergency Hospital of Bucharest, Romania for routine check-ups in a six-month period. We analyzed the records of 217 diabetic patients (mean age 69 ± 11 years; 51.15% women). We found no significant gender differences in the occurrence of dyslipidemia, CHD or CHD + dyslipidemia or in terms of statin prescription. However; patients aged 65 years or older were significantly more affected by dyslipidemia, CHD or CHD + dyslipidemia, versus subjects aged <65 years. Further, they were more likely to be prescribed statin therapy (p < 0.0001 for all). Statins were prescribed to 67.24% of the patients with dyslipidemia; 61.01% of the subjects with CHD; and to 91.48% of the patients who had both conditions. e recorded no gender differences in the occurrence of CHD and (or) dyslipidemia in Romanian T2DM patients. Patients aged 65 years or older had a higher prevalence of CHD and/or dyslipidemia, and were more likely to be prescribed statins, versus younger counterparts. However, many T2DM patients with CHD and (or) dyslipidemia were undertreated: Nearly 33% of the subjects with dyslipidemia, and nearly 40% of the ones with CHD were not prescribed statins.

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GAMBARAN KADAR ALBUMINURIA PADA SUBJEK DIABETES MELITUS DENGAN DAN TANPA PENYAKIT JANTUNG KORONER

e-CliniC ◽

10.35790/ecl.2.2.2014.5757 ◽

2014 ◽

Vol 2 (2) ◽

Author(s):

Sandy Cendra ◽

Emma Moeis ◽

Yuanita Langi

Keyword(s):

Diabetes Mellitus ◽

Coronary Heart Disease ◽

Heart Disease ◽

Renal Physiology ◽

Diabetic Patients ◽

Cross Sectional ◽

Female Patients ◽

Patients With Diabetes ◽

Male Patients ◽

Diabetes Melitus

Abstract: Albuminuria is a marker of the decline in renal physiology and function of endothelial. Endothelial dysfunction is an early pathogenesis of coronary heart disease (CHD). High coronary heart disease complications in patients with diabetes mellitus (DM). Objective To know the description and differences in levels of albuminuria in diabetic patients with and without CHD inpoli Metabolic and Endocrine and poli Heart BLU. RSU. Prof. dr. R. D Kandou Manado. Research Method: Cross Sectional descriptive analytic study conducted in patients with diabetes mellitus pieces with and without coronary heart disease in Poli Endocrine Metabolic and poli heart BLU. RSU. Prof. dr. R. D Kandou Manado period November 2012 - November 2013. Results: From 34 patients with diabetes mellitus found the number of diabetic patients with CHD were 17 patients and 17 patients for diabetes without CHD, which consisted of 14 male patients and 20 female patients. The distribution of the sample based on CHD and sex, showed that diabetic patients with CHD were 9 men (26.47%) and 8 women (23.53%). As for diabetic patients without CHD as many as 5 male patients (14.70%) and 12 female patients (35.30%). Distribution of the study sample by CHD and RAKU categories showed diabetic patients with CHD were 7 patients (20.59%) and normal RAKU 10 patients (29.41%) RAKU abnormal. As for diabetic patients without CHD by 16 patients (47.06%) and 1 patient RAKU normal (2.94%) RAKU abnormal. Conclusion: Albuminuria occurs more frequently in patients with diabetes mellitus with coronary heart disease than diabetes mellitus without coronary heart diseaseKeywords: Albuminuria, diabetes mellitus, coronary heart disease. Abstrak: Albuminuria merupakan petanda terjadinya penurunan faal ginjal dan disfungsi endotel. Disfungsi endotel merupakan patogenesis awal penyakit jantung koroner (PJK). Komplikasi penyakit jantung koroner tinggi pada pasien diabetes melitus (DM). Tujuan: Untuk mengetahui gambaran dan perbedaan kadar albuminuria pada pasien DM dengan dan tanpa PJK di Poli Endokrin Metabolik dan Poli Jantung BLU. RSU. Prof. dr. R. D Kandou Manado. Metode Penelitian: Dilakukan penelitian deskriptif analitik lintang potong pada penderita diabetes melitus dengan dan tanpa penyakit jantung koroner di Poli Endokrin Metabolik dan Poli Jantung BLU.RSU. Prof. dr. R. D Kandou Manado periode November 2012 – November 2013. Hasil: Dari 34 pasien Diabetes Melitus ditemukan jumlah pasien DM dengan PJK sebanyak 17 pasien dan 17 pasien untuk DM tanpa PJK, yang terdiri atas 14 orang pasien laki-laki dan 20 pasien wanita. Distribusi sampel berdasarkan PJK dan jenis kelamin, didapatkan hasil pasien DM dengan PJK yaitu sebanyak 9 orang laki-laki (26,47 %) dan 8 orang perempuan (23,53%). Sedangkan untuk pasien DM tanpa PJK yaitu sebanyak 5 orang pasien laki-laki (14,70%) dan 12 orang pasien perempuan (35,30%). Distribusi sampel penelitian berdasarkan PJK dan RAKU Kategori didapatkan hasil pasien DM dengan PJK sebanyak 7 pasien (20,59%) RAKU normal dan 10 pasien (29,41%) RAKU abnormal. Sedangkan untuk pasien DM tanpa PJK sebanyak 16 pasien (47,06%) RAKU normal dan 1 pasien (2,94%) RAKU abnormal. Simpulan: Albuminuria lebih banyak terjadi pada pasien diabetes melitus dengan penyakit jantung koroner dibandingkan diabetes melitus tanpa penyakit jantung koroner Kata kunci: Albuminuria, diabetes melitus, penyakit jantung koroner.

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Ethnic and Gender Differences in 10-Year Coronary Heart Disease Risk: a Cross-Sectional Study in Hawai‘i

Journal of Racial and Ethnic Health Disparities ◽

10.1007/s40615-020-00851-2 ◽

2020 ◽

Author(s):

Claire Townsend Ing ◽

Hyeong Jun Ahn ◽

Rachel Kawakami ◽

Andrew Grandinetti ◽

Todd B. Seto ◽

...

Keyword(s):

Gender Differences ◽

Coronary Heart Disease ◽

Heart Disease ◽

Coronary Heart Disease Risk ◽

Disease Risk ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

And Gender ◽

Heart Disease Risk

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Relationship between childhood secondhand smoke exposure and the occurrence of hyperlipidaemia and coronary heart disease among Chinese non-smoking women: a cross-sectional study

BMJ Open ◽

10.1136/bmjopen-2020-048590 ◽

2021 ◽

Vol 11 (7) ◽

pp. e048590

Author(s):

Kewei Wang ◽

Yuanqi Wang ◽

Ruxing Zhao ◽

Lei Gong ◽

Lingshu Wang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Coronary Heart Disease ◽

Heart Disease ◽

Secondhand Smoke ◽

Chinese Women ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Shs Exposure

ObjectiveThe objective of this study was to evaluate the influence of secondhand smoke (SHS) exposure during childhood on type 2 diabetes mellitus, hypertension, hyperlipidaemia and coronary heart disease among Chinese non-smoking women.MethodsIn this cross-sectional study, the SHS exposure data in childhood were obtained using a questionnaire survey. Self-reported childhood SHS exposure was defined as the presence of at least one parent who smoked during childhood.ResultsOf the 6522 eligible participants, 2120 Chinese women who had never smoked were assessed. The prevalence of SHS exposure in the entire population was 28.1% (596). SHS exposure during childhood was not significant for the standard risk factors of type 2 diabetes mellitus (p=0.628) and hypertension (p=0.691). However, SHS was positively associated with hyperlipidaemia (p=0.037) after adjusting for age, obesity, education status, physical activity, alcohol consumption, current SHS exposure status, diabetes mellitus and hypertension. In addition, childhood SHS increased the occurrence of coronary heart disease (p=0.045) among non-smokers after further adjusting for hyperlipidaemia.ConclusionSHS exposure during childhood is associated with prevalent hyperlipidaemia and coronary heart disease in adulthood among non-smoking Chinese women.

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Peer Review #2 of "Relationship between hemoglobin glycation index and extent of coronary heart disease in individuals with type 2 diabetes mellitus: a cross-sectional study (v0.3)"

10.7287/peerj.3875v0.3/reviews/2 ◽

2017 ◽

Author(s):

HR Freitas

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Heart Disease ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Hemoglobin Glycation

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Myocardial revascularization in diabetic patients presenting with critical limbischemia

Diabetes Mellitus ◽

10.14341/2072-0351-6053 ◽

2010 ◽

Vol 13 (4) ◽

pp. 25-29

Author(s):

Ivan Ivanovich Dedov ◽

Victor Yur'evich Kalashnikov ◽

Konstantin Vladimirovich Melkozerov

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Critical Limb Ischemia ◽

Myocardial Revascularization ◽

Limb Ischemia ◽

Diabetic Patients ◽

Preoperative Risk Assessment ◽

Therapeutic Modalities ◽

Optimal Drug ◽

Patients With Diabetes

The frequency of diabetic complications remains high despite the development of improved therapeutic modalities. Macroangiopathy continues to bethe predominant complication while coronary heart disease is the main cause of mortality.This paper considers clinical features of diabetic patientswith coronary heart disease and critical limb ischemia; various aspects of optimal drug therapy, preoperative examination and diagnostics precedingvascular non-cardiac surgery; preoperative risk assessment; indications for coronary angiography and myocardial revascularization. The authors emphasizethe importance of development of algorithms for the treatment of patients with diabetes, critical limb ischemia, and coronary heart disease.

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