scholarly journals Increased Aluminum Content in Certain Brain Structures is Correlated with Higher Silicon Concentration in Alcoholic Use Disorder

Molecules ◽  
2019 ◽  
Vol 24 (9) ◽  
pp. 1721 ◽  
Author(s):  
Cezary Grochowski ◽  
Eliza Blicharska ◽  
Jacek Bogucki ◽  
Jędrzej Proch ◽  
Aleksandra Mierzwińska ◽  
...  

Introduction: Alcohol overuse may be related to increased aluminum (Al) exposure, the brain accumulation of which contributes to dementia. However, some reports indicate that silicon (Si) may have a protective role over Al-induced toxicity. Still, no study has ever explored the brain content of Al and Si in alcoholic use disorder (AUD). Materials and methods: To fill this gap, the present study employed inductively coupled plasma optical emission spectrometry to investigate levels of Al and Si in 10 brain regions and in the liver of AUD patients (n = 31) and control (n = 32) post-mortem. Results: Al content was detected only in AUD patients at mean ± SD total brain content of 1.59 ± 1.19 mg/kg, with the highest levels in the thalamus (4.05 ± 12.7 mg/kg, FTH), inferior longitudinal fasciculus (3.48 ± 9.67 mg/kg, ILF), insula (2.41 ± 4.10 mg/kg) and superior longitudinal fasciculus (1.08 ± 2.30 mg/kg). Si content displayed no difference between AUD and control, except for FTH. Positive inter-region correlations between the content of both elements were identified in the cingulate cortex, hippocampus, and ILF. Conclusions: The findings of this study suggest that AUD patients may potentially be prone to Al-induced neurodegeneration in their brain—although this hypothesis requires further exploration.

2007 ◽  
Vol 98 (3) ◽  
pp. 571-575 ◽  
Author(s):  
Mehmet Korkmaz ◽  
Uğur Şaylı ◽  
Bekir Sıtkı Şaylı ◽  
Sezgin Bakırdere ◽  
Serap Titretir ◽  
...  

Although, the safe limits of human daily boron (B) exposure are not absolutely clear, there is a growing interest in B and its effects on human health. The aim of the present study was to estimate daily B exposure in 66 males in Turkey living in a B-rich area using water containing at least 2 mg/l boron, with an average age of 38·55 (se 1·66) years and an average number of years of residence in the B-rich area of 35·89 (se 1·73). Another group of males (n 57), living in the city centres of Balıkesir and Ankara, were taken as controls; the average age and number of years of residence for this group were 29·44 (se 1·43) and 10·26 (se 1·83) years, respectively. As it is assumed that the B level in urine reflects daily B exposure, the amount of urinary B of both the study and control groups was analysed by using an inductively coupled plasma optical emission spectrometry (ICP-OES) technique. The average daily B exposure value was calculated as 6·77 (se 0·47) mg in the study group and 1·26 (se 0·1) mg in the controls. The results of this study are expected to contribute to creating a reference value for a safe daily B exposure.


2013 ◽  
Vol 37 (6) ◽  
pp. 1587-1598 ◽  
Author(s):  
Thiago Andrade Bernini ◽  
Marcos Gervasio Pereira ◽  
Lúcia Helena Cunha dos Anjos ◽  
Daniel Vidal Perez ◽  
Ademir Fontana ◽  
...  

The variety of soils in the State of Acre is wide and their chemical profiles are still not fully understood. The nature of the material of origin of these soils is indicated by the high aluminium (Al) content, commonly associated with high calcium (Ca) and magnesium (Mg) contents. The study objective was to use different methods to quantify Al in soils from toposequences formed from material of a sedimentary nature originating from the Solimões Formation, in Acre, Brazil. Trenches were opened at three distinct points in the landscape: shoulder, backslope and footslope positions. Soil samples were collected for physical, chemical, mineralogical analyses. The Al content was quantified using different methods. High Al contents were found in most of these horizons, associated with high Ca and Mg levels, representing the predominant cations in the sum of exchangeable bases. The mineralogy indicates that the soils are still in a low weathering phase, with the presence of significant quantities of 2:1 minerals. Similar Al contents were determined by the methods of NaOH titration, xylenol orange spectrometry and inductively coupled plasma optical emission spectrometry. However, no consistent data were obtained by the pyrocatechol violet method. Extraction with KCl overestimated the exchangeable Al content due to its ability to extract the non-exchangeable Al present in the smectite interlayers. It was observed that high Al contents are related to the instability of the hydroxyl-Al smectite interlayers.


2019 ◽  
Vol 22 (2) ◽  
pp. 64-69 ◽  
Author(s):  
Parisa Ziarati ◽  
Fatemehsadat Mirmohammad Makki ◽  
Sergij Vambol ◽  
Viola Vambol

Abstract Cultural practices and control of diseases and insects are widely used for cultivation of Olea europea L. These are considered potential contaminants. Aim of this investigation lies in determination of concentrations of contaminants in several edible olive oils. All test samples were purchased in three consecutive seasons. They were analysed in compliance with standardized international protocols of wet digestion methods. Ion concentrations were determined in three replicates using method of inductively coupled plasma optical emission spectrometry. We have registered a positive correlation between storage time and heavy metals contents. It was particularly high in Iranian brands and varied significantly. Investigation results show that all obtained heavy metals contents in pepper-flavoured olive oil samples were significantly lower than in other samples. Considering the fungi-flavoured samples, levels of Pb and Cd were prominent and exceeded the maximum permissible level set in the majority of cases. The further monitoring is needed as all these metals are toxic and their detrimental effect becomes obvious only after several years of exposure.


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