scholarly journals In Silico Studies of Lamiaceae Diterpenes with Bioinsecticide Potential against Aphis gossypii and Drosophila melanogaster

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 766
Author(s):  
Gabriela Cristina Soares Rodrigues ◽  
Mayara dos Santos Maia ◽  
Andreza Barbosa Cavalcanti ◽  
Natália Ferreira de Sousa ◽  
Marcus Tullius Scotti ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Insecticidal Activity ◽  
High Probability ◽  
Aphis Gossypii ◽  
Agricultural Products ◽  
Computer Assisted ◽  
In Silico Studies ◽  
Clerodane Diterpenes ◽  
Low Toxicity ◽  
Plant Compounds

Background: The growing demand for agricultural products has led to the misuse/overuse of insecticides; resulting in the use of higher concentrations and the need for ever more toxic products. Ecologically, bioinsecticides are considered better and safer than synthetic insecticides; they must be toxic to the target organism, yet with low or no toxicity to non-target organisms. Many plant extracts have seen their high insecticide potential confirmed under laboratory conditions, and in the search for plant compounds with bioinsecticidal activity, the Lamiaceae family has yielded satisfactory results. Objective: The aim of our study was to develop computer-assisted predictions for compounds with known insecticidal activity against Aphis gossypii and Drosophila melanogaster. Results and conclusion: Structure analysis revealed ent-kaurane, kaurene, and clerodane diterpenes as the most active, showing excellent results. We also found that the interactions formed by these compounds were more stable, or presented similar stability to the commercialized insecticides tested. Overall, we concluded that the compounds bistenuifolin L (1836) and bistenuifolin K (1931), were potentially active against A. gossypii enzymes; and salvisplendin C (1086) and salvixalapadiene (1195), are potentially active against D. melanogaster. We observed and highlight that the diterpenes bistenuifolin L (1836), bistenuifolin K (1931), salvisplendin C (1086), and salvixalapadiene (1195), present a high probability of activity and low toxicity against the species studied.

Evaluation of Discrepancies in Patients' Results— An Aspect of Computer-Assisted Quality Control

1975 ◽  
Vol 21 (1) ◽  
pp. 87-92 ◽  
Author(s):  
Philip Whitehurst ◽  
Thomas V Di Silvio ◽  
Gaydzag Boyadjian
Keyword(s):  
Quality Control ◽  
Patient Safety ◽  
Computer Program ◽  
High Probability ◽  
Clinical Chemistry ◽  
Computer Assisted ◽  
Probability Of Error ◽  
On Demand

Abstract A computer program has been devised to select those clinical chemistry results that have a high probability of error for inclusion on a discrepancy report, which is printed on demand throughout the day. Each report entry is evaluated by a supervisor, who decides whether to accept the result or to re-assay. With this program, 8.4% of all results were included on the report, 1.9% were re-assayed, and 0.83% were judged to be in error and corrected. Checking results at the time of their release to the computer has led to earlier report delivery and more convenient timing of re-assays without compromise of patient safety.

scholarly journals Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies

2020 ◽  
Vol 143 ◽  
pp. 111549
Author(s):  
Mirley Alves Vasconcelos ◽  
Priscila Capelari Orsolin ◽  
Victor Constante Oliveira ◽  
Paula Marynella Alves Pereira Lima ◽  
Maria Paula Carvalho Naves ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Vitamin D3 ◽  
In Silico ◽  
In Silico Studies

Visualizing Maya Agriculture along the Rio Hondo

2016 ◽  
Author(s):  
Thomas Guderjan ◽  
Sheryl Luzzadder-Beach ◽  
Timothy Beach ◽  
Samantha Krause ◽  
Clifford Brown
Keyword(s):  
Agricultural Landscape ◽  
Agricultural Products ◽  
Computer Assisted ◽  
Contact Period ◽  
Agricultural Systems ◽  
Blue Creek ◽  
Massive Scale ◽  
Maya Agriculture ◽  
Assisted Analysis ◽  
Level Production

Chapter 5 draws on a broad range of evidence to develop a view of what the agricultural landscape of the Rio Hondo basin, now on the Belize-Mexican border, must have looked like in the heavily populated Classic era landscape. The authors use Contact period Spanish accounts to describe trade in agricultural products–especially cacao, but also achiote and vanilla–that were particularly prized from this region. Ten years of research on the drained field agricultural systems, such as the Chan Cahal fields near Blue Creek, identified the timespan for commercial level production, and computer assisted analysis of aerial and satellite photographs are beginning to document the massive scale of this enterprise.

Nano-formulation enhances insecticidal activity of natural pyrethrins against Aphis gossypii (Hemiptera: Aphididae) and retains their harmless effect to non-target predators

2017 ◽  
Vol 25 (11) ◽  
pp. 10243-10249 ◽  
Author(s):  
Nikos E. Papanikolaou ◽  
Argyro Kalaitzaki ◽  
Filitsa Karamaouna ◽  
Antonios Michaelakis ◽  
Vassiliki Papadimitriou ◽  
...  
Keyword(s):  
Insecticidal Activity ◽  
Aphis Gossypii ◽  
Nano Formulation

scholarly journals Assessment of Insecticidal Activity of Benzylisoquinoline Alkaloids from Chilean Rhamnaceae Plants against Fruit-Fly Drosophila melanogaster and the Lepidopteran Crop Pest Cydia pomonella

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5094
Author(s):  
Soledad Quiroz-Carreño ◽  
Edgar Pastene-Navarrete ◽  
Cesar Espinoza-Pinochet ◽  
Evelyn Muñoz-Núñez ◽  
Luis Devotto-Moreno ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Insecticidal Activity ◽  
Cydia Pomonella ◽  
Fruit Fly ◽  
Codling Moth ◽  
Ecdysone Receptor ◽  
Action Mechanism ◽  
Benzylisoquinoline Alkaloids ◽  
Relevant Effect ◽  
Feeding Medium

The Chilean plants Discaria chacaye, Talguenea quinquenervia (Rhamnaceae), Peumus boldus (Monimiaceae), and Cryptocarya alba (Lauraceae) were evaluated against Codling moth: Cydia pomonella L. (Lepidoptera: Tortricidae) and fruit fly Drosophila melanogaster (Diptera: Drosophilidae), which is one of the most widespread and destructive primary pests of Prunus (plums, cherries, peaches, nectarines, apricots, almonds), pear, walnuts, and chestnuts, among other. Four benzylisoquinoline alkaloids (coclaurine, laurolitsine, boldine, and pukateine) were isolated from the above mentioned plant species and evaluated regarding their insecticidal activity against the codling moth and fruit fly. The results showed that these alkaloids possess acute and chronic insecticidal effects. The most relevant effect was observed at 10 µg/mL against D. melanogaster and at 50 µg/mL against C. pomonella, being the alteration of the feeding, deformations, failure in the displacement of the larvae in the feeding medium of D. melanogaster, and mortality visible effects. In addition, the docking results show that these type of alkaloids present a good interaction with octopamine and ecdysone receptor showing a possible action mechanism.

scholarly journals Insecticidal activity and sublethal effects of Beauveria bassiana (Bals.-Criv.) Vuill. isolates and essential oils against Aphis gossypii Glover, 1877 (Hemiptera: Aphididae)

2020 ◽  
Vol 115 (2) ◽  
pp. 463
Author(s):  
Mahdieh MOUSAVI ◽  
Youbert GHOSTA ◽  
Nariman MAROOFPOUR
Keyword(s):  
Essential Oils ◽  
Life Table ◽  
Beauveria Bassiana ◽  
Insecticidal Activity ◽  
Aphis Gossypii ◽  
Population Increase ◽  
Intrinsic Rate Of Increase ◽  
Reproduction Rate ◽  
Net Reproductive Rate ◽  
Rate Of Increase

<p>The cotton aphid, <em>Aphis gossypii</em> Glover, 1877, is a polyphagous species and one of the most important pests of cucumber crops in Iran. In this study, virulence of three <em>Beauveria bassiana </em>(Bals.-Criv.) Vuill isolates, IRAN 108, IRAN 429C and LRC 137, as well as insecticidal activity of two essential oils extracted from <em>Matricaria chamomilla</em> L. and <em>Cuminum cyminum </em>L. were evaluated against adult stage of <em>A. gossypii </em>under laboratory conditions. The data for life table were analyzed using the age-stage, two-sex life table theory. Results showed that all isolates were pathogenic on aphid, but their virulence was varied in different isolates. The lowest calculated LC<sub>50</sub> was belonged to IRAN 429C (3.9 × 10<sup>4</sup>conidia ml<sup>-1</sup>). The lowest LT<sub>50</sub> was obtained at concentration of 10<sup>8</sup> and 10<sup>7</sup> conidia ml<sup>-1</sup> for IRAN 429C (2.9 and 3.55 days, respectively). <em>M. chamomilla</em> essential oil had the lowest LC<sub>50</sub> and LT<sub>50</sub> values (19 µl l<sup>-1</sup> air and 11.4 h), respectively. Longevity and population growth parameters, including the intrinsic rate of increase (<em>r<sub>m</sub></em>), gross reproduction rate (<em>GRR</em>), net reproductive rate (<em>R</em><sub>0</sub>), generation time (<em>T</em>) and finite rate of population increase (<em>λ</em>), were affected negatively by both agents. According to the results obtained in this study, both entomopathogenic fungi and essential oils could be used as an alternative to chemical insecticides in aphid IPM programs.</p>

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