scholarly journals Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7212
Author(s):  
Hasil Aman ◽  
Yu-Chiao Huang ◽  
Yu-Hao Liu ◽  
Yu-Lin Tsai ◽  
Min Kim ◽  
...  

A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures.

Author(s):  
Reynier Suardíaz ◽  
Emily Lythell ◽  
Philip Hinchliffe ◽  
Marc van der Kamp ◽  
James Spencer ◽  
...  

Elucidation of the catalytic reaction mechanism of MCR-1 enzyme, responsible for the antimicrobial resistance to colistin, using DFT calculations on cluster models.


2010 ◽  
Vol 16 (46) ◽  
pp. 13638-13645 ◽  
Author(s):  
Luis Gómez-Hortigüela ◽  
Furio Corà ◽  
Gopinathan Sankar ◽  
Claudio M. Zicovich-Wilson ◽  
C. Richard A. Catlow

2008 ◽  
Vol 50 (2) ◽  
pp. 138-143
Author(s):  
Masamichi NAGAE ◽  
Atsuko TSUCHIYA ◽  
Kenji YAMAMOTO ◽  
Takane KATAYAMA ◽  
Soichi WAKATSUKI ◽  
...  

Synthesis ◽  
2020 ◽  
Vol 52 (11) ◽  
pp. 1643-1658
Author(s):  
Sergio H. Szajnman ◽  
Juan B. Rodriguez ◽  
María N. Chao ◽  
Mauricio Cattaneo ◽  
Jonathan Sanchez Gonzalez ◽  
...  

An expedient preparation of selenium-containing hetero­cycles via an m-chloroperbenzoic acid-mediated seleno-annulation starting from selenocyanate derivatives is described. In spite of its significance, this cyclization reaction is virtually understudied not only from the point of view of its scope, but also from the mechanistic aspects associated to this remarkable transformation. In this sense, several selenocyanate and thiocyanate derivatives bearing an aromatic ring were evaluated as substrates under different reaction conditions of this interesting cyclization yielding important insights on its scope as well as relevant information on the reaction mechanism.


2013 ◽  
Vol 25 (17) ◽  
pp. 9460-9464
Author(s):  
Dong-Ping Chen ◽  
Ke Gai ◽  
Chao Kong ◽  
Yan-Xia Han ◽  
Li-Jie Hou ◽  
...  

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