Cobalt-Catalyzed Cyclization of 2-Bromobenzamides with Carbodiimides: A New Route for the Synthesis of 3-(Imino)isoindolin-1-ones
Keyword(s):
A novel synthetic pathway to approach 3-(imino)isoindolin-1-ones by the Co-catalyzed cyclization reaction of 2-bromobenzamides with carbodiimides has been developed. This catalytic reaction can tolerate a variety of substituents and provide corresponding products in moderate yields for most cases. According to the literature, the reaction mechanism is proposed through the formation of a five-membered aza-cobalacycle complex, which carries out the following reaction subsequence, including nucleophilic addition and substitution, to furnish the desired structures.
2019 ◽
Vol 27
(11)
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pp. 2696-2704
2010 ◽
Vol 114
(26)
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pp. 8817-8825
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2010 ◽
Vol 16
(46)
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pp. 13638-13645
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Keyword(s):
2020 ◽
Vol 388
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pp. 121779
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