A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B
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Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus, to access this compound more efficiently, we herein present a concise and significantly improved total synthesis of the natural product. Our short synthesis relies on two key cyclization steps to assemble the central scaffold: isoquinoline formation via an ethynyl-imino cyclization and an intramolecular Friedel-Crafts reaction to form the furanone.
2019 ◽
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2021 ◽
2019 ◽
2018 ◽
Vol 13
(3)
◽
pp. 1934578X1801300
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