scholarly journals Dietary Fiber, Atherosclerosis, and Cardiovascular Disease

Nutrients ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 1155 ◽  
Author(s):  
Ghada A. Soliman

Observational studies have shown that dietary fiber intake is associated with decreased risk of cardiovascular disease. Dietary fiber is a non-digestible form of carbohydrates, due to the lack of the digestive enzyme in humans required to digest fiber. Dietary fibers and lignin are intrinsic to plants and are classified according to their water solubility properties as either soluble or insoluble fibers. Water-soluble fibers include pectin, gums, mucilage, fructans, and some resistant starches. They are present in some fruits, vegetables, oats, and barley. Soluble fibers have been shown to lower blood cholesterol by several mechanisms. On the other hand, water-insoluble fibers mainly include lignin, cellulose, and hemicellulose; whole-grain foods, bran, nuts, and seeds are rich in these fibers. Water-insoluble fibers have rapid gastric emptying, and as such may decrease the intestinal transit time and increase fecal bulk, thus promoting digestive regularity. In addition to dietary fiber, isolated and extracted fibers are known as functional fiber and have been shown to induce beneficial health effects when added to food during processing. The recommended daily allowances (RDAs) for total fiber intake for men and women aged 19–50 are 38 gram/day and 25 gram/day, respectively. It is worth noting that the RDA recommendations are for healthy people and do not apply to individuals with some chronic diseases. Studies have shown that most Americans do not consume the recommended intake of fiber. This review will summarize the current knowledge regarding dietary fiber, sources of food containing fiber, atherosclerosis, and heart disease risk reduction.

2020 ◽  
Vol 26 (3) ◽  
pp. 243-251 ◽  
Author(s):  
Victor L Fulgoni ◽  
Mary Brauchla ◽  
Lisa Fleige ◽  
YiFang Chu

Background: Diet is known to affect many risk factors of cardiovascular disease (CVD), a leading cause of mortality and morbidity. Aim: The objective of this study was to explore the potential association between whole grain and dietary fiber with CVD risk factors, including metabolic syndrome (MetS) in children and adolescents using National Health and Nutrition Examination Survey (NHANES) 2003–2014. Methods: Two days of 24-hour recall data from 16,507 children and adolescents age 2–18 years were used to estimate dietary intakes. Continuous MetS scores (cMetS) were computed by aggregating age/sex regressed z-scores of waist circumference, mean arterial blood pressure, high-density lipoprotein-cholesterol, triglycerides, and glucose. Regression analyses were used to assess association of fiber and whole grain intake with cardiometabolic markers including MetS after adjusting for demographic factors. Results: Increasing tertiles of fiber intake were significantly associated with 3% lowered risk MetS in adolescents age 13–18 years. Additionally, increasing intake tertiles of fiber were associated with reduced risk elevated cholesterol (5–11% reduction), elevated diastolic blood pressure (10–23% reduction) in adolescents age 13–18 years, and risk of obesity (3–5% reduction) in children and adolescent age 2–18 years. Increasing tertiles of whole grain intake were only associated with reduced risk of elevated triglycerides (52% risk reduction) in adolescents age 13–18 years. Conclusion: The results suggest that intake of dietary fiber was inversely associated with several markers of cardiovascular disease risk including MetS.


2010 ◽  
Vol 140 (8) ◽  
pp. 1445-1453 ◽  
Author(s):  
◽  
Ehab S. Eshak ◽  
Hiroyasu Iso ◽  
Chigusa Date ◽  
Shogo Kikuchi ◽  
...  

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e30
Author(s):  
Niamh Chapman ◽  
Ricardo Fonseca ◽  
Leigh Murfett ◽  
Kevin Beazley ◽  
Rebekah Mcwhirter ◽  
...  

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S503-S504
Author(s):  
Sarah M Michienzi ◽  
Thomas D Chiampas ◽  
Amy Valkovec ◽  
Siria Arzuaga ◽  
Mahesh C Patel ◽  
...  

Abstract Background The 2018 American Heart Association and American College of Cardiology (AHA/ACC) 2018 Guideline on the Management of Blood Cholesterol included human immunodeficiency virus (HIV) as an atherosclerotic cardiovascular disease (ASCVD) risk enhancer for the first time. Our study investigates if patients living with HIV in the Illinois Department of Corrections (IDOC) were prescribed appropriate HMG-CoA reductase inhibitor (statin) therapy following release of these guidelines based on risk. Methods This was a retrospective study of patients with > 1 visit in our multidisciplinary HIV IDOC Telemedicine Clinic from 1/1/19-6/1/19. Our prescriptive authority is limited to HIV and directly related conditions, and we provide recommendations to on-site providers for other comorbidities. Included patients were > 18 years of age, HIV positive, and incarcerated within IDOC. Excluded patients had existing ASCVD. Data from the first visit in the study period were extracted from the electronic medical record and analyzed utilizing descriptive statistics. Primary objectives were to quantify ASCVD risk and appropriate statin use in our population. Results Of the 158 patients included, average age was 42 years. The majority were male (89%), Black (73%), overweight/obese (117/148, 79%), on an integrase single-tablet regimen (78%), with CD4 >200 cells/µL (97%), and HIV RNA < 20 copies/mL (85%). Of the 18 females, 8 were transgender. Within the prior year, 65% had a lipid panel. For the 50 patients meeting criteria for 10-year ASCVD estimation, median (range) risk was 6.6% (0.8% - 31.9%). Only 12 patients were on statins. Of these, all were indicated per AHA/ACC guidelines with 10 prescribed appropriate intensity. An additional 45 patients had indications for statins but were untreated. In total, 47 patients (30%) were not receiving appropriate statin therapy. Conclusion Results of our study suggest ASCVD risk management is an area of improvement for inmates living with HIV, especially as we look towards caring for an aging HIV population. Future directions include comparing these data to data from a later time point to evaluate time for guideline uptake. Disclosures Thomas D. Chiampas, PharmD, BCPS, AAHIVP, Gilead (Employee)


2021 ◽  
pp. 1-25
Author(s):  
Zizhen Lin ◽  
Xianhui Qin ◽  
Yaya Yang ◽  
Yan Huang ◽  
Jieyu Wang ◽  
...  

Abstract High fiber intake is associated with reduced mortality risk in both general and chronic kidney disease populations. However, in dialysis patients such data is limited. Therefore, the association between dietary fiber intake (DFI) and the risk of all-cause and cardiovascular disease (CVD) mortality was examined in this study. A total of 1044 maintenance hemodialysis (MHD) patients from eight outpatient dialysis centers in China were included in this study. Data on DFI was collected using 24-h dietary recalls for three days in a week and was normalized to actual dry weight. The study outcomes included all-cause and CVD mortality. Over a median of 46 months of follow-up, 354 deaths were recorded, of which 210 (59%) were due to CVD. On assessing DFI as tertiles, the CVD mortality risk was significantly lower in patients in tertile 2-3 (≥0.13g/kg/d; hazard ratio [HR]: 0.71; 95% confidence interval [CI]: 0.51-0.97) compared to those in tertile 1 (<0.13g/kg/d). A similar, but non-significant trend was found for the association between DFI (tertile 2-3 vs. tertile 1; HR: 0.83; 95%CI: 0.64-1.07) and all-cause mortality. In summary, higher DFI was associated with lower CVD mortality risk among Chinese patients of MHD. This study emphasized the significance of dietary fiber intake in MHD patients, and provided information that is critical for the improvement of dietary guidelines for dialysis patients.


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