scholarly journals Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2254 ◽  
Author(s):  
Nan Shang ◽  
Jianping Wu
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Egg White ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Raw 264.7 Cells ◽  
Nuclear Factor ◽  
Prevention Of Osteoporosis

Ovotransferrin, a member of the transferrin family, is the second main protein found in egg white. Ovotransferrin was reported to have antimicrobial, antioxidant, and immunomodulating activities. The aim of this work was to characterize the cellular and molecular functions of egg white ovotransferrin on osteoclasts differentiation and function. Osteoclasts were prepared from mouse macrophage RAW 264.7 cells stimulated with receptor activator of nuclear factor κB ligand (RANKL). Ovotransferrin inhibited osteoclasts differentiation and the calcium–phosphate resorptive ability via the suppression of RANKL-induced nuclear factor κ-light chain-enhancer of activated B cells (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. Ovotransferrin induced apoptosis of matured osteoclasts, accompanied by increased expression of Bcl-2-like protein 11 (Bim) and Bcl-2-assoicated death promoter (Bad), but decreased expression of B-cell lymphoma 2 (Bcl-2) and B-cell lymphoma-extra-large (Bcl-xl). We established a novel role of egg white ovotransferrin as an inhibitor of osteoclastogenesis, which may be used for the prevention of osteoporosis.

scholarly journals Nuclear Factor-κB Pathway–Activating Gene Aberrancies in Primary Cutaneous Large B-Cell Lymphoma, Leg Type

2014 ◽  
Vol 134 (1) ◽  
pp. 290-292 ◽  
Author(s):  
Lianne Koens ◽  
Willem H. Zoutman ◽  
Passorn Ngarmlertsirichai ◽  
Grzegorz K. Przybylski ◽  
Piotr Grabarczyk ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma

2012 ◽  
Vol 53 (10) ◽  
pp. 1971-1977 ◽  
Author(s):  
Rong Bu ◽  
Prashant Bavi ◽  
Jehad Abubaker ◽  
Zeenath Jehan ◽  
Wael Al-Haqawi ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Middle Eastern ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-κB pathways in subtypes of diffuse large B-cell lymphoma

Blood ◽  
2008 ◽  
Vol 111 (7) ◽  
pp. 3701-3713 ◽  
Author(s):  
Lloyd T. Lam ◽  
George Wright ◽  
R. Eric Davis ◽  
Georg Lenz ◽  
Pedro Farinha ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
Gene Expression Signature ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Janus Kinase ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Abstract The activated B cell–like (ABC) subgroup of diffuse large B-cell lymphoma (DLBCL) is characterized by constitutive activation of the nuclear factor-κB (NF-κB) pathway. In this study, we showed that the NF-κB pathway induced the expression of the cytokines interleukin (IL)-6 and IL-10 in ABC DLBCL cell lines, which also have high levels of total and phosphorylated signal transducer and activator of transcription (STAT) 3 protein, suggesting autocrine signaling. Using RNA interference for STAT3, we defined a gene expression signature of IL-6 and IL-10 signaling through STAT3. Based on this signature, we constructed a molecular predictor of STAT3 signaling that defined a subset of ABC DLBCL tumors with high expression of STAT3, IL-6, and/or IL-10 and their downstream targets. Although the STAT3-high and STAT3-low subsets had equivalent expression of genes that distinguish ABC DLBCL from germinal center B cell–like DLBCL, STAT3-high ABC DLBCLs had higher expression of signatures that reflected NF-κB activity, proliferation, and glycolysis. A small-molecule inhibitor of Janus kinase signaling, which blocked STAT3 signature expression, was toxic only for ABC DLBCL lines and synergized with an inhibitor of NF-κB signaling. These findings suggest that the biological interplay between the STAT3 and NF-κB pathways may be exploited for the treatments of a subset of ABC DLBCLs.

Clinicopathological implications of nuclear factor κB signal pathway activation in diffuse large B-cell lymphoma

2015 ◽  
Vol 46 (4) ◽  
pp. 524-531 ◽  
Author(s):  
Qian Zhao ◽  
Weijun Fu ◽  
Hua Jiang ◽  
Juan Du ◽  
Chunyang Zhang ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Nuclear Factor Κb ◽  
Signal Pathway ◽  
Nuclear Factor ◽  
Large B Cell Lymphoma ◽  
Pathway Activation ◽  
Large B Cell

Role of nuclear factor κB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation

2007 ◽  
Vol 32 (5) ◽  
pp. 930-935 ◽  
Author(s):  
Li Li Ji ◽  
Maria-Carmen Gomez-Cabrera ◽  
Jose Vina
Keyword(s):  
Protein Kinase ◽  
Nuclear Factor Κb ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Ros Generation ◽  
Nuclear Factor ◽  
Adaptive Responses ◽  
Wide Range ◽  
Mitogen Activated Protein ◽  
Exercise Induced

Activation of nuclear factor (NF) κB and mitogen-activated protein kinase (MAPK) pathways in skeletal muscle has been shown to enhance the gene expression of several enzymes that play an important role in maintaining oxidant–antioxidant homeostasis, such as mitochondrial superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS). While an acute bout of exercise activates NFκB and MAPK signaling and upregulates MnSOD and iNOS, administration of chemical agents that suppress reactive oxygen species (ROS) production can cause attenuation of exercise-induced MnSOD and iNOS expression. Thus, ROS generation during exercise may have duel effects: the infliction of oxidative stress and damage, and the stimulation of adaptive responses favoring long-term protection. This scenario explains why animals and humans involved in exercise training have demonstrated increased resistance to oxidative damage under a wide range of physiological and pathological stresses.

Sign in / Sign up

Export Citation Format

Share Document