scholarly journals Faster Short-Chain Fatty Acid Absorption from the Cecum Following Polydextrose Ingestion Increases the Salivary Immunoglobulin A Flow Rate in Rats

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1745 ◽  
Author(s):  
Yuko Yamamoto ◽  
Toshiya Morozumi ◽  
Toru Takahashi ◽  
Juri Saruta ◽  
Masahiro To ◽  
...  
Keyword(s):  
Portal Vein ◽  
Flow Rate ◽  
Immunoglobulin A ◽  
Short Chain Fatty Acids ◽  
Vital Role ◽  
Short Chain ◽  
Upper Respiratory Tract ◽  
Salivary Iga ◽  
Tract Infections ◽  
Salivary Immunoglobulin A

Salivary immunoglobulin A (IgA) plays a vital role in preventing upper respiratory tract infections (URTI). In our previous study, we showed that the intake of carbohydrates increases the intestinal levels of short-chain fatty acids (SCFAs), which in turn increase salivary IgA levels. However, the mechanism underlying this phenomenon has not been fully elucidated. In this study, we investigated in rats the effect of polydextrose (PDX) ingestion on salivary IgA level and SCFA concentration in cecal digesta and the portal vein. Five-week-old rats were fed with a fiber-free diet (control) or with 40 g/kg of PDX for 28 days. Compared to the control, ingestion of PDX led to a higher salivary IgA flow rate (p = 0.0013) and a higher concentration of SCFAs in the portal vein (p = 0.004). These two data were positively correlated (rs = 0.88, p = 0.0002, n = 12). In contrast, the concentration of SCFAs in cecal digesta and cecal digesta viscosity were significantly lower following PDX ingestion, compared to the control (p = 0.008 and 0.05, respectively). These findings suggest that the ingestion of PDX increases the absorption rate of SCFAs in the intestine through PDX-induced fermentation, which is accompanied by an increase in SCFA levels in the blood, and ultimately leads to increased salivary IgA levels.

scholarly journals The Salivary IgA Flow Rate Is Increased by High Concentrations of Short-Chain Fatty Acids in the Cecum of Rats Ingesting Fructooligosaccharides

Nutrients ◽  
2016 ◽  
Vol 8 (8) ◽  
pp. 500 ◽  
Author(s):  
Yuko Yamamoto ◽  
Toru Takahahi ◽  
Masahiro To ◽  
Yusuke Nakagawa ◽  
Takashi Hayashi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Flow Rate ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Salivary Iga ◽  
High Concentrations ◽  
Chain Fatty Acids

scholarly journals Evaluation of intestinal microbiota, short-chain fatty acids, and immunoglobulin a in diversion colitis

2021 ◽  
Vol 25 ◽  
pp. 100892
Author(s):  
Kentaro Tominaga ◽  
Atsunori Tsuchiya ◽  
Takeshi Mizusawa ◽  
Asami Matsumoto ◽  
Ayaka Minemura ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Intestinal Microbiota ◽  
Immunoglobulin A ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Diversion Colitis ◽  
Chain Fatty Acids

scholarly journals Correlation of s-IgA and IL-6 Salivary with Caries Disease and Oral Hygiene Parameters in Children

2019 ◽  
Vol 8 (1) ◽  
pp. 3 ◽  
Author(s):  
Giuseppe Lo Giudice ◽  
Fabiana Nicita ◽  
Angela Militi ◽  
Rossella Bertino ◽  
Marco Matarese ◽  
...  
Keyword(s):  
Free Group ◽  
Oral Hygiene ◽  
Interleukin 6 ◽  
Immunoglobulin A ◽  
Tooth Decay ◽  
Salivary Iga ◽  
Group B ◽  
Salivary Immunoglobulin A

This study evaluates salivary immunoglobulin A (s-IgA) and interleukin 6 (IL-6) in saliva of children and its correlation to tooth decay severity. Fifty-nine patients were divided into two groups: caries free (A group) and caries active (B group). B group was investigated according to Mount and Monse indices. Mean salivary IgA rate between two groups (A 16.7 ± 4.5 mg/dL vs. B 21.8 ± 12.9 mg/dL) was not significant, while IL-6 rate (A 19.02 ± 5.3 pg/mL vs. B 30.2 ± 11.8 pg/mL) was statistically different. This study revealed that salivary IL-6 levels were significantly higher in children with active caries when compared with the caries-free group, while the s-IgA rate showed no significant differences between the two groups.

scholarly journals A Comprehensive Analysis of the Colonic Flora Diversity, Short Chain Fatty Acid Metabolism, Transcripts, and Biochemical Indexes in Heat-Stressed Pigs

2021 ◽  
Vol 12 ◽  
Author(s):  
Canying Hu ◽  
Xueting Niu ◽  
Shengwei Chen ◽  
Jiaying Wen ◽  
Minglong Bao ◽  
...  
Keyword(s):  
Immune Response ◽  
Intestinal Microbiota ◽  
Lactobacillus Reuteri ◽  
Immunoglobulin A ◽  
Short Chain Fatty Acids ◽  
Mucosal Damage ◽  
Sensu Stricto ◽  
Short Chain ◽  
Signal Pathways ◽  
Blood Biochemical

Heat stressed pigs show typical characteristics of inflammatory bowel disease (IBD). However, little is known about the pathogenesis of heat stress (HS)-induced IBD in pigs. In this study, we determined the effects of HS on colon morphology, intestinal microbiota diversity, transcriptome genes (transcripts), and short chain fatty acids (SCFAs) metabolism in pigs. In addition, the correlation among these parameters was analyzed by weighted gene co-expression network analysis. Results showed that the liver and kidney functions related to blood biochemical indexes were partially changed in pigs under HS. Furthermore, the levels of diamine oxidase and D-lactic acid were significantly increased, whereas the levels of secretory immunoglobulin A were decreased. The integrity of colonic tissue was damaged under HS, as bleeding, lymphatic infiltration, and villi injury were observed. The concentrations of SCFAs in the colon, such as acetic acid and butyric acid, were decreased significantly. In addition, the composition of colon microbiota, such as decrease in Lactobacillus johnsonii, Lactobacillus reuteri and increase in Clostridium sensu stricto 1 of day 7 and 14 while under HS. These changes were associated with changes in the concentration of SCFAs and biochemical indexes above mentioned. Differentially expressed genes were enriched in the nucleotide-binding oligomerization domain-like receptor signaling pathway, Th17 cell differentiation, and IBD pathway, which were also associated with the changes in SCFAs. Thus, the structure, diversity of intestinal microorganisms, and changes in the levels of SCFAs in colon of heat stressed pigs changed significantly, contributing to the activation of immune response and inflammatory signal pathways and causing abnormal physiological and biochemical indexes and intestinal mucosal damage. These results highlight the interconnections between intestinal microbiota, SCFAs, and immune response and their role in the pathogenesis of stress induced IBD therapy.

Upper respiratory tract symptoms and salivary immunoglobulin A of elite female gymnasts: a full year longitudinal field study

2020 ◽  
Vol 37 (3) ◽  
pp. 285-293
Author(s):  
Jasmien Dumortier ◽  
Nicolette C. Bishop ◽  
Dirk Vogelaers ◽  
Jan Boone ◽  
Liesbeth Delesie ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Field Study ◽  
Immunoglobulin A ◽  
Longitudinal Field ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Female Gymnasts ◽  
Salivary Immunoglobulin A

scholarly journals Salivary IgA as a Useful Biomarker for Dental Caries in Down Syndrome Patients: A Systematic Review and Meta-analysis

2020 ◽  
Vol 14 (04) ◽  
pp. 665-671
Author(s):  
Hiba Hamid ◽  
Necdet Adanir ◽  
Faris Yahya Ibrahim Asiri ◽  
Khadijah Abid ◽  
Muhammad Sohail Zafar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Down Syndrome ◽  
Dental Caries ◽  
Quality Assessment ◽  
Meta Analysis ◽  
Immunoglobulin A ◽  
Salivary Iga ◽  
Mesh Terms ◽  
Quantitative Synthesis ◽  
Salivary Immunoglobulin A

AbstractThe objective of this systematic review and meta-analysis is to critically analyze and summarize studies reporting association of salivary immunoglobulin A (IgA) levels as a biomarker for dental caries in Down syndrome (DS) patients. Using the keywords salivary [All Fields] AND IgA [All Fields] AND (“down syndrome” [MeSH Terms] OR (“down”[All Fields] AND “syndrome” [All Fields]) OR “down syndrome” [All Fields]), an electronic search was conducted via PubMed and Scopus databases by two authors, H. H. and Z. K. independently. Retrieved studies were screened against the predefined exclusion and inclusion criteria. To estimate the risk of bias, quality assessment of included studies was carried using the Newcastle–Ottawa quality assessment scale for observational studies. Primary search resulted in 10 articles from PubMed and 13 articles from Scopus. Ten studies fulfilled the defined selection criteria and evaluated the salivary IgA (sIgA) level in DS patients with dental caries. Five articles were further analyzed in a quantitative synthesis presented in the meta-analysis. Due to a modified lifestyle and compromised oral hygiene in DS patients, understandably, it is still postulated in the literature that the presence of sIgA can have a protective effect on the occurrence of dental caries as compared with healthy counterparts. As indicated by the present meta-analysis, no conclusions can be drawn as to definitively label sIgA as a biomarker for dental caries. Further, well-designed longitudinal clinical studies and translational research are therefore required before the benchmarking of sIgA as a useful biomarker for dental caries in DS patients with preferable molecular insights.

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