scholarly journals Associations between First Trimester Maternal Nutritional Score, Early Markers of Placental Function, and Pregnancy Outcome

Nutrients ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1799 ◽  
Author(s):  
Francesca Parisi ◽  
Valeria M. Savasi ◽  
Ilenia di Bartolo ◽  
Luca Mandia ◽  
Irene Cetin
Keyword(s):  
Pregnancy Outcome ◽  
Gestational Age ◽  
Positive Association ◽  
First Trimester ◽  
Healthy Diet ◽  
Placental Development ◽  
Nutritional Score ◽  
Gestational Age At Birth ◽  
Placental Volume ◽  
Age At Birth

This study investigated the associations between maternal adherence to a healthy diet, first trimester placental markers, and pregnancy outcome. Singleton spontaneous pregnancies were enrolled at 11+0–13+6 gestational weeks in a prospective cohort study. A nutritional score (0–10) measuring the adherence to a healthy diet was calculated. A transabdominal ultrasound scan for placental marker assessment was performed (uterine artery (UtA) doppler, placental volume). Biochemical placental markers were recorded (Pregnancy Associated Plasma Protein A (PAPP-A), free β- Human Chorionic Gonadotropin (HCG)). Birth outcomes were obtained from medical records. Associations between the maternal nutritional score, first trimester placental markers, and pregnancy outcome were investigated by using multi-adjusted general linear models. In total, 112 pregnancies were enrolled with a median nutritional score of 7 (range 3–10). Median gestational age at birth was 277 days (range 203–296). The nutritional score was positively associated with PAPP-A concentrations, whereas a negative association was detected with the UtA mean pulsatility index and placental volume. A positive association was detected between nutritional score and gestational age at birth. This study demonstrates that a first trimester nutritional score as a measure of adherence to a healthy diet is significantly associated with early biochemical and ultrasound markers of placental development, with further association with gestational age at birth.

Treatment of 139 Pregnancies in Antiphospholipid-positive Women Not Fulfilling Criteria for Antiphospholipid Syndrome: A Retrospective Study

2013 ◽  
Vol 40 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Teresa Del Ross ◽  
Amelia Ruffatti ◽  
Maria Serena Visentin ◽  
Marta Tonello ◽  
Antonia Calligaro ◽  
...  
Keyword(s):  
Birth Weight ◽  
Pregnancy Outcome ◽  
Gestational Age ◽  
Pregnancy Loss ◽  
Antiphospholipid Antibody ◽  
Birth Weight Percentile ◽  
Antibody Profile ◽  
Gestational Age At Birth ◽  
Age At Birth ◽  
Weight Percentile

Objective.The effect of low-dose aspirin (LDA) on pregnancy outcome in antiphospholipid (aPL)-positive women not fulfilling the criteria for antiphospholipid antibody syndrome (APS) was evaluated retrospectively.Methods.We evaluated 139 pregnancies of 114 aPL-positive women not fulfilling the Sydney classification criteria for definite APS (104 treated with LDA, 35 untreated). Inclusion criteria consisted of (1) any titer of aPL and no previous pregnancy or no pregnancy losses (defined as aPL carriers); (2) any titer of aPL and 1 or 2 pregnancy losses before the 10th gestational week. No women had previous thrombosis. The rate of pregnancy loss, gestational age at delivery, and birth weight percentile were compared in the treated and untreated patients. Associations between clinical and laboratory characteristics and pregnancy outcomes were investigated.Results.The rate of pregnancy loss was low in both treated and untreated groups (7.7% vs 2.9%, respectively). There were no statistically significant differences in the rate of pregnancy loss, gestational age at birth, or birth weight percentile in the treated and untreated groups. There were significant associations between gestational age at birth ≤ 34th week and positivity for lupus anticoagulant (p = 0.025) and anti-ß2-glycoprotein I IgG antibodies at titers > 99th (p = 0.016).Conclusion.LDA treatment does not appear to improve pregnancy outcome in low-risk women not fulfilling the criteria for APS. Because antibody profile seems to influence pregnancy outcome, further studies of patients stratified according to their antibody profile are warranted.

Comparison of gestational age at birth based on last menstrual period and ultrasound during the first trimester

2008 ◽  
Vol 22 (6) ◽  
pp. 587-596 ◽  
Author(s):  
Caroline S. Hoffman ◽  
Lynne C. Messer ◽  
Pauline Mendola ◽  
David A. Savitz ◽  
Amy H. Herring ◽  
...  
Keyword(s):  
Gestational Age ◽  
First Trimester ◽  
Menstrual Period ◽  
Last Menstrual Period ◽  
Gestational Age At Birth ◽  
Age At Birth

scholarly journals Maternal Hemoglobin Concentration and Pregnancy Outcome: A Study of the Effects of Elevation in El Alto, Bolivia

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Elise M Laflamme
Keyword(s):  
Pregnancy Outcome ◽  
Gestational Age ◽  
Hemoglobin Concentration ◽  
Hemoglobin Level ◽  
Apgar Scores ◽  
El Alto ◽  
Anemia In Pregnancy ◽  
Gestational Age At Birth ◽  
Age At Birth ◽  
In Pregnancy

Iron-defciency anemia is often under-diagnosed in developing coun- tries, specifcally in pregnant populations in regions of high altitude. Hemoglobin  levels are not consistently adjusted for elevation, and therefore many anemic pa- tients are left undiagnosed. The purpose of this study was to incorporate current  parameters for diagnosing anemia in pregnancy at high altitudes, and to evaluate  the effects of appropriately adjusted hemoglobin concentrations on pregnancy out- come. A few studies have examined the effect of elevation on hemoglobin status,  and other studies have considered the effects of anemia of pregnancy; however,  there is a lack of data demonstrating that altitude-adjusted hemoglobin levels ac- curately predict pregnancy outcome. Using the Student t-Test, multiple linear re- gression, and ANOVA statistical analyses, various factors of pregnancy outcome  were compared between anemic and non-anemic groups, as defned by hemoglobin cut-off levels adjusted for trimester of pregnancy and altitude. when appropriate adjustments were used, maternal anemia was associated with lower infant Apgar scores at both one minute and fve minutes after birth, as well as complication of labor, lower gestational age at birth, and higher parity. This study demonstrates the importance of altitude and trimester specifc adjustments to maternal hemoglobin  levels in order to accurately diagnose anemia in pregnancy. In addition, a clear cor- relation is seen between maternal hemoglobin level and pregnancy outcome.

scholarly journals Role of first‐trimester umbilical vein blood flow in predicting large‐for‐gestational age at birth

2020 ◽  
Vol 56 (1) ◽  
pp. 67-72 ◽  
Author(s):  
G. Rizzo ◽  
I. Mappa ◽  
V. Bitsadze ◽  
M. Słodki ◽  
J. Khizroeva ◽  
...  
Keyword(s):  
Blood Flow ◽  
Gestational Age ◽  
Umbilical Vein ◽  
First Trimester ◽  
Large For Gestational Age ◽  
Gestational Age At Birth ◽  
Age At Birth

scholarly journals Preconceptional Cardiovascular Health and Pregnancy Outcomes in Women with Systemic Lupus Erythematosus

2018 ◽  
Vol 46 (1) ◽  
pp. 70-77 ◽  
Author(s):  
Amanda M. Eudy ◽  
Anna Maria Siega-Riz ◽  
Stephanie M. Engel ◽  
Nora Franceschini ◽  
Annie Green Howard ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Preterm Birth ◽  
Total Cholesterol ◽  
Gestational Age ◽  
Lupus Erythematosus ◽  
Pregnancy Outcomes ◽  
First Trimester ◽  
Systemic Lupus ◽  
Gestational Age At Birth ◽  
Age At Birth

Objective.To estimate the effects of preconceptional cardiovascular (CV) health, measured by American Heart Association (AHA) guidelines, on pregnancy outcomes in women with systemic lupus erythematosus (SLE).Methods.The study included patients in the Hopkins Lupus Pregnancy Cohort. Body mass index (BMI), total cholesterol, and blood pressure (BP) in the most recent clinic visit prior to conception or first trimester were used to determine CV health (ideal, intermediate, or poor health) based on AHA definitions. Outcomes included preterm birth, gestational age at birth, and small for gestational age (SGA). Multivariable linear and logistic regression models with generalized estimating equations estimated the association of each CV health factor and outcome.Results.The analysis included 309 live births. There were 95 preterm births (31%), and of the 293 pregnancies with birth weights, 18% were SGA. Ideal BMI, total cholesterol, and BP were reported in 56%, 85%, and 51% of pregnancies, respectively. Intermediate BMI was associated with decreased odds of SGA (OR 0.26, 95% CI 0.11–0.63), adjusted for race and prednisone use. Intermediate/poor total cholesterol was associated with increased odds of preterm birth (OR 2.21, 95% CI 1.06–4.62). Intermediate/poor BP was associated with decreased gestational age at birth (β −0.96, 95% CI −1.62 to −0.29).Conclusion.Poor/intermediate preconception CV health affects pregnancy outcomes of preterm birth and SGA infants among women with SLE. Efforts to maintain BMI, total cholesterol, and BP within the recommended ideal range prior to pregnancy is important to improve pregnancy outcomes in women with SLE.

scholarly journals Prenatal household air pollutant exposure is associated with reduced size and gestational age at birth among a cohort of Ghanaian infants

2021 ◽  
Vol 155 ◽  
pp. 106659
Author(s):  
Ashlinn K. Quinn ◽  
Irene Apewe Adjei ◽  
Kenneth Ayuurebobi Ae-Ngibise ◽  
Oscar Agyei ◽  
Ellen Abrafi Boamah-Kaali ◽  
...  
Keyword(s):  
Gestational Age ◽  
Air Pollutant ◽  
Gestational Age At Birth ◽  
Age At Birth

Coeliac disease presenting atypically: A much wider spectrum

2021 ◽  
pp. 004947552199134
Author(s):  
Avinash Lomash ◽  
Abhinaya Venkatakrishnan ◽  
Meenakshi Bothra ◽  
Bhavna Dhingra ◽  
Praveen Kumar ◽  
...  
Keyword(s):  
Coeliac Disease ◽  
Gestational Age ◽  
Dermatitis Herpetiformis ◽  
Mode Of Delivery ◽  
Gastrointestinal Symptoms ◽  
Stunted Growth ◽  
Significant Difference ◽  
High Index Of Suspicion ◽  
Gestational Age At Birth ◽  
Age At Birth

Atypical coeliac disease in young children is frequently missed when it presents atypically as non-gastrointestinal presentations to different specialties. There was a greater delay (54 months) in establishing the diagnosis in those with atypical coeliac disease (p < 0.001). No difference was observed in the mode of delivery or duration of breast feeding, but significant difference was observed between gestational age at birth (p < 0.001). Most cases showed stunted growth and underweight. Irritability, anaemia, rickets, dermatitis herpetiformis, alopecia and intussusception were other common predictors of atypical coeliac disease. Because of a myriad spectrum of non-gastrointestinal symptoms, at any age with diverse presentation, a high index of suspicion is therefore required.

scholarly journals Maternal biological age assessed in early pregnancy is associated with gestational age at birth

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Eva E. Lancaster ◽  
Dana M. Lapato ◽  
Colleen Jackson-Cook ◽  
Jerome F. Strauss ◽  
Roxann Roberson-Nay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Cellular Aging ◽  
Biological Age ◽  
Potential Candidate ◽  
A Genome ◽  
Gestational Age At Birth ◽  
Age At Birth

AbstractMaternal age is an established predictor of preterm birth independent of other recognized risk factors. The use of chronological age makes the assumption that individuals age at a similar rate. Therefore, it does not capture interindividual differences that may exist due to genetic background and environmental exposures. As a result, there is a need to identify biomarkers that more closely index the rate of cellular aging. One potential candidate is biological age (BA) estimated by the DNA methylome. This study investigated whether maternal BA, estimated in either early and/or late pregnancy, predicts gestational age at birth. BA was estimated from a genome-wide DNA methylation platform using the Horvath algorithm. Linear regression methods assessed the relationship between BA and pregnancy outcomes, including gestational age at birth and prenatal perceived stress, in a primary and replication cohort. Prenatal BA estimates from early pregnancy explained variance in gestational age at birth above and beyond the influence of other recognized preterm birth risk factors. Sensitivity analyses indicated that this signal was driven primarily by self-identified African American participants. This predictive relationship was sensitive to small variations in the BA estimation algorithm. Benefits and limitations of using BA in translational research and clinical applications for preterm birth are considered.

Sign in / Sign up

Export Citation Format

Share Document