Early-Life Exposure to Famine and Risk of MetabolicAssociated Fatty Liver Disease in Chinese Adults

Background: Early-life exposure to the Chinese famine has been related to the risk of obesity, type 2 diabetes, and nonalcoholic fatty liver disease later in life. Nevertheless, the long-term impact of famine exposure on metabolic associated fatty liver disease (MAFLD), a recently proposed term to describe liver disease associated with known metabolic dysfunction, remains unknown. The aim of our study was to explore the relationship between early famine exposure and MAFLD in adulthood. Methods: A total of 26,821 participants (10,994 men, 15,827 women) were recruited from a cohort study of Chinese adults in Shanghai. We categorized participants into four famine exposure subgroups based on the birth year as nonexposed (1963–1967), fetal-exposed (1959–1962), childhood-exposed (1949–1958), and adolescence-exposed (1941–1948). MAFLD was defined as liver steatosis detected by ultrasound plus one of the following three criteria: overweight/obesity, type 2 diabetes, or evidence of metabolic dysregulation. Multivariable logistic regression models were performed to examine the association between famine exposure and MAFLD. Results: The mean ± standard deviation age of the participants was 60.8 ± 6.8 years. The age-adjusted prevalence of MAFLD was 38.3, 40.8, 40.1, and 36.5% for the nonexposed, fetal-exposed, childhood-exposed, and adolescence-exposed subgroups, respectively. Compared with nonexposed participants, fetal-exposed participants showed an increased risk of adulthood MAFLD (OR = 1.10, 95% CI 1.00–1.21). The significant association between fetal famine exposure and MAFLD was observed in women (OR = 1.22, 95% CI 1.08–1.37), but not in men (OR = 0.88, 95% CI 0.75–1.03). In age-balanced analyses combining pre-famine and post-famine births as the reference, women exposed to famine in the fetal stage still had an increased risk of MAFLD (OR = 1.15, 95% CI 1.05–1.26). Conclusions: Prenatal exposure to famine showed a sex-specific association with the risk of MAFLD in adulthood.

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Increased Risk of Type 2 Diabetes in Subjects with Both Elevated Liver Enzymes and Ultrasonographically Diagnosed Nonalcoholic Fatty Liver Disease: A 4-year Longitudinal Study

Archives of Medical Research ◽

10.1016/j.arcmed.2013.01.007 ◽

2013 ◽

Vol 44 (2) ◽

pp. 115-120 ◽

Cited By ~ 37

Author(s):

Ji Hun Choi ◽

Eun Jung Rhee ◽

Ji Cheol Bae ◽

Se Eun Park ◽

Cheol Young Park ◽

...

Keyword(s):

Type 2 Diabetes ◽

Liver Disease ◽

Longitudinal Study ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Liver Enzymes ◽

Nonalcoholic Fatty Liver ◽

Elevated Liver Enzymes ◽

Increased Risk

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Connection Between Non-Alcoholic Fatty Liver Disease and Diabetes Mellitus

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.2478/rjdnmd-2014-0017 ◽

2014 ◽

Vol 21 (2) ◽

pp. 121-127 ◽

Cited By ~ 2

Author(s):

Gabriela Oprea-Călin ◽

Petru Aurel Babeș ◽

Dan Valentin Andronescu ◽

Crăița-Isabela Andronescu

Keyword(s):

Type 2 Diabetes ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Metabolic Disorders ◽

Oral Glucose ◽

Alcoholic Fatty Liver ◽

The Metabolic Syndrome ◽

Increased Risk

Abstract Nonalcoholic fatty liver disease (NAFLD) is the commonest liver condition in the world, accounting for 20-30% of the adult population, and encompasses a spectrum of liver disorders characterized by fat accumulation within the liver, associated or not with varying degrees of hepatic inflammation and liver fibrosis through to cirrhosis. The prevalence of NAFLD increases significantly in the presence of obesity (60-80%) and type 2 diabetes (60%). NAFLD is associated with metabolic disorders (type 2 diabetes, obesity and hyperlipidemia) grouped together as the metabolic syndrome (MetS). It is now regarded as the hepatic manifestation of this syndrome and is closely linked to insulin resistance (IR).The presence of NAFLD predicts the development of type 2 diabetes independent of established risk factors. NAFLD patients should therefore be screened for diabetes, including by the Oral Glucose Tolerance Test (OGTT) if there any abnormalities of fasting blood glucose (FBG) and given appropriate lifestyle advice. Early diagnosis with the institution of lifestyle measures could help prevent or retard the onset of these metabolic disorders. Type 2 diabetes causes more severe non-alcoholic steatohepatitis (NASH), and patients with diabetes have an increased risk for cirrhosis and the development of hepatocellular carcinoma (HCC)

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Non-Alcoholic fatty liver disease in type 2 diabetes mellitus: A dangerous duo.

The Professional Medical Journal ◽

10.29309/tpmj/2022.29.01.6263 ◽

2021 ◽

Vol 29 (01) ◽

pp. 77-81

Author(s):

Zainab Zaib ◽

Sabir Khan Khattak ◽

Asim Ali Shah ◽

Ayesha Akhtar

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

P Value ◽

Alcoholic Fatty Liver ◽

Increased Risk

Objective: To determine the frequency of nonalcoholic fatty liver disease in type 2 diabetes mellitus. Study Design: Cross sectional study. Setting: Department of Medicine Ayub Teaching Hospital Abbottabad. Period: August 2018 to Feb 2019. Material & Methods: A total of 153 patients, who were diagnosed case of diabetes were studied for the presence of NAFLD. Ultrasound abdomen was used to detect NAFLD. Data was recorded on a pro forma and analyzed using SPSS 20 version. Results: Out of 153 patients, there were 73 males (45.8%) whiles 83 females (54.2%). Patients were aged 30 – 80 years with mean ± SD as 54.60± 11.277 years. The mean duration of diabetes was 7.18±6.95 years. In our study 54.9 % (84) of the patients were having fatty liver on U/S scan, 35.3% have abnormal lipid profile and 35.3 % (54) were hypertensive, out of which 59.3% (32) were having fatty liver on scan with P value of 0.424. Conclusions: Type 2 diabetes patients have increased risk of development of NAFLD, prevalence being 54.9%. Post-menopausal females and those with dyslipidemia have more risk of developing of NAFLD among diabetics.

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