scholarly journals Gene Regulation of Biofilm-Associated Functional Amyloids

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 490
Author(s):  
Khushal Khambhati ◽  
Jaykumar Patel ◽  
Vijaylaxmi Saxena ◽  
Parvathy A ◽  
Neha Jain
Keyword(s):  
Environmental Factors ◽  
Bacterial Communities ◽  
Genetic Regulation ◽  
Bacterial Cells ◽  
Regulation Of Expression ◽  
Form Of Life ◽  
Stringent Control ◽  
Factors Influencing ◽  
Functional Amyloids ◽  
Biofilm Matrix

Biofilms are bacterial communities encased in a rigid yet dynamic extracellular matrix. The sociobiology of bacterial communities within a biofilm is astonishing, with environmental factors playing a crucial role in determining the switch from planktonic to a sessile form of life. The mechanism of biofilm biogenesis is an intriguingly complex phenomenon governed by the tight regulation of expression of various biofilm-matrix components. One of the major constituents of the biofilm matrix is proteinaceous polymers called amyloids. Since the discovery, the significance of biofilm-associated amyloids in adhesion, aggregation, protection, and infection development has been much appreciated. The amyloid expression and assembly is regulated spatio-temporarily within the bacterial cells to perform a diverse function. This review provides a comprehensive account of the genetic regulation associated with the expression of amyloids in bacteria. The stringent control ensures optimal utilization of amyloid scaffold during biofilm biogenesis. We conclude the review by summarizing environmental factors influencing the expression and regulation of amyloids.

scholarly journals Anti-Biofilm Molecules Targeting Functional Amyloids

Antibiotics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 795
Author(s):  
Leticia Matilla-Cuenca ◽  
Alejandro Toledo-Arana ◽  
Jaione Valle
Keyword(s):  
Biofilm Formation ◽  
Therapeutic Strategy ◽  
Research Area ◽  
Therapeutic Strategies ◽  
Structural Components ◽  
Significant Issue ◽  
Wide Range ◽  
Effective Therapeutic Strategy ◽  
Functional Amyloids ◽  
Biofilm Matrix

The choice of an effective therapeutic strategy in the treatment of biofilm-related infections is a significant issue. Amyloids, which have been historically related to human diseases, are now considered to be prevailing structural components of the biofilm matrix in a wide range of bacteria. This assumption creates the potential for an exciting research area, in which functional amyloids are considered to be attractive targets for drug development to dissemble biofilm structures. The present review describes the best-characterized bacterial functional amyloids and focuses on anti-biofilm agents that target intrinsic and facultative amyloids. This study provides a better understanding of the different modes of actions of the anti-amyloid molecules to inhibit biofilm formation. This information can be further exploited to improve the therapeutic strategies to combat biofilm-related infections.

scholarly journals Environmental factors influencing the number of mosquitoes captured by C0_2 traps at residential areas in Tokyo and neighboring cities, Japan

2005 ◽  
Vol 56 (Supplement) ◽  
pp. 48
Author(s):  
N Nihei ◽  
T Tsuda ◽  
H Kurahashi ◽  
Y Higa ◽  
O Komagata ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Residential Areas ◽  
Factors Influencing

scholarly journals Evaluating socio‐economic and environmental factors influencing farm‐level water scarcity in Punjab, Pakistan

2020 ◽  
Author(s):  
Muhammad Awais Ali Khan ◽  
Khalid Mahmood Ch. ◽  
Ijaz Ashraf ◽  
Muhammad Tahir Siddiqui ◽  
Jerry W. Knox
Keyword(s):  
Environmental Factors ◽  
Water Scarcity ◽  
Farm Level ◽  
Factors Influencing

Bacterial presence in polar regions associated with environment modification by chemical compounds including contaminants

2017 ◽  
Vol 25 (4) ◽  
pp. 481-491 ◽  
Author(s):  
Klaudia Kosek ◽  
Katarzyna Jankowska ◽  
Żaneta Polkowska
Keyword(s):  
Bacterial Communities ◽  
Chemical Compounds ◽  
Freshwater Ecosystems ◽  
Trophic Levels ◽  
Polar Regions ◽  
Bacterial Cells ◽  
Chemical Contamination ◽  
Climate Conditions ◽  
Biological Communities ◽  
Long Time

Microbes are omnipresent and diverse members of all biological communities. In marine and freshwater ecosystems, microorganisms form the base of the food chain supporting higher trophic levels. Even though microbes are generally thought to live in warm regions of Earth, many of them develop in cold climates. Polar regions remain relatively protected from widespread anthropogenic disturbances, which is a consequence of thier remoteness and extreme climate conditions. For a long time these regions were considered to be free from chemical contamination until scientists discovered a presence of pollutants there. Chemical contamination may induce serious disorders in the integrity of polar ecosystems influencing the growth of bacterial communities. Xenobiotics including persistent organic pollutants are transported thousands of kilometers by the air and ocean currents, and they are deposed in high-latitude regions and accumulate in all elements of the environment including bacterial communities. It is important to determine their concentration levels in bacterial cells to assess the possibility of contaminants becoming transferred to higher trophic levels; however, some species of bacteria are capable of metabolizing xenobiotics, which makes them less toxic or even removes them from the environment.

Sign in / Sign up

Export Citation Format

Share Document