scholarly journals Serotonin Levels in the Serum of Persons with Onchocerciasis-Associated Epilepsy: A Case-Control Study

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 720
Author(s):  
Melissa Krizia Vieri ◽  
An Hotterbeekx ◽  
Michel Mandro ◽  
Joseph Nelson Siewe Fodjo ◽  
Alfred Dusabimana ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Case Control Study ◽  
Democratic Republic Of Congo ◽  
Underlying Mechanism ◽  
Antibody Detection ◽  
Causal Mechanism ◽  
Serotonin Level ◽  
Epidemiological Evidence ◽  
Serum Serotonin ◽  
Control Study

Onchocerciasis-associated epilepsy (OAE) is a devastating childhood disorder occurring in areas with high Onchocerca volvulus transmission. Despite epidemiological evidence showing the association between O. volvulus and epilepsy, the underlying mechanism remains unknown. Since high levels of serotonin are known to induce seizures, we investigated serotonin levels in persons with OAE and controls selected from the Democratic Republic of Congo. Serum serotonin levels were determined by ELISA in 19 persons with OAE, 32 persons with epilepsy without O. volvulus infection, 18 with O. volvulus infection but without epilepsy, and 35 with neither O. volvulus infection nor epilepsy. O. volvulus infection was diagnosed by skin snip testing and/or OV16 antibody detection. Serum serotonin levels were significantly decreased in persons with OAE compared to persons with O. volvulus infection and no epilepsy. In conclusion, an increased serotonin level is unable to explain the pathogenesis of OAE. Other hypotheses to identify the causal mechanism of OAE will need to be investigated.

scholarly journals The Profile of Glycated Hemoglobin in Non-Diabetic Pregnant Women with Preeclampsia: A Case-Control Study in Kinshasa, the Democratic Republic of Congo

2020 ◽  
Vol 10 (03) ◽  
pp. 365-389
Author(s):  
Guelord Mukiapini Luzolo ◽  
Dophie Tshibuela Beya ◽  
Daddy Kabamba Numbi ◽  
Passy Kimena Nyota ◽  
Placide Cyanga Ngandu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Democratic Republic ◽  
Case Control Study ◽  
Glycated Hemoglobin ◽  
Democratic Republic Of Congo ◽  
Case Control ◽  
Republic Of Congo ◽  
Control Study

Misconceptions about HIV infection in Kinshasa (Democratic Republic of Congo): a case–control study on knowledge, attitudes and practices: Table 1

2014 ◽  
Vol 91 (5) ◽  
pp. 334-337 ◽  
Author(s):  
Silvia Carlos ◽  
Miguel Ángel Martínez-González ◽  
Eduardo Burgueño ◽  
Cristina López-del Burgo ◽  
Miguel Ruíz-Canela ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Democratic Republic ◽  
Case Control Study ◽  
Democratic Republic Of Congo ◽  
Case Control ◽  
Republic Of Congo ◽  
Attitudes And Practices ◽  
Knowledge Attitudes And Practices ◽  
Control Study

scholarly journals Effectiveness of Routine BCG Vaccination on Buruli Ulcer Disease: A Case-Control Study in the Democratic Republic of Congo, Ghana and Togo

2015 ◽  
Vol 9 (1) ◽  
pp. e3457 ◽  
Author(s):  
Richard Odame Phillips ◽  
Delphin Mavinga Phanzu ◽  
Marcus Beissner ◽  
Kossi Badziklou ◽  
Elysée Kalundieko Luzolo ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Case Control Study ◽  
Democratic Republic Of Congo ◽  
Buruli Ulcer ◽  
Case Control ◽  
Republic Of Congo ◽  
Ulcer Disease ◽  
Bcg Vaccination ◽  
Control Study

scholarly journals Risk factors for neonatal sepsis in Lubumbashi, Democratic Republic of Congo: A retrospective case-control study

2021 ◽  
Vol 3 (1) ◽  
pp. 63-70
Author(s):  
Adonis Muganza Nyenga ◽  
◽  
Olivier Mukuku ◽  
Janet Ziazia Sunguza ◽  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Neonatal Sepsis ◽  
Democratic Republic ◽  
Case Control Study ◽  
Democratic Republic Of Congo ◽  
Case Control ◽  
Republic Of Congo ◽  
Tract Infections ◽  
Control Study

Purpose: Neonatal sepsis (NS) is a major cause of neonatal morbidity and mortality, particularly in developing countries. Delays in the identification and treatment of NS are the main contributors to the high mortality. This study aims to identify risk factors for NS in newborns in the two university hospitals in Lubumbashi, in the Democratic Republic of Congo. Methods: This hospital-based case-control study was carried out on 486 mother-newborn pairs using the systematic sampling method during November 2019 to October 2020. Data were analyzed using STATA software (version 15). Binary and multivariable logistic regression analyses were computed to identify the associated factors at 95% CI. Results: A total of 162 cases and 324 controls were included in this study. Multiple logistic regression analysis showed that the possible risk factors for NS in this study were low level of education (AOR = 9.16 [2.23-37.67]), maternal genitourinary tract infections (AOR = 42.59 [17.90-101.37]), premature rupture of membranes (AOR = 19.95 [7.27-54.76]), peripartum fever (AOR = 26.25 [2.31-297.83]), prolonged labor (AOR = 14.16 [3.88-51.71]), cesarean section (AOR = 3.57 [1.48-8.61]), obstructed vaginal delivery (AOR = 13.40 [1.32-136.19]), birth weight <1500 grams (AOR = 70.38 [8.64-572.95]), and between 1500-2500 grams (AOR = 7.90 [3.04-20.52]). Conclusion: The study found that maternal and neonatal factors were strongly associated with the risk of developing NS. The present study suggests the possibility of routine assessment of sepsis in newborns born with the above characteristics.

scholarly journals Risk Factors for Neonatal Sepsis in Lubumbashi, Democratic Republic of Congo: A Retrospective Case-Control Study

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Nyenga AM ◽  
◽  
Mukuku O ◽  
Sunguza JZ ◽  
Assumani AN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Neonatal Sepsis ◽  
Democratic Republic ◽  
Case Control Study ◽  
Democratic Republic Of Congo ◽  
Case Control ◽  
Republic Of Congo ◽  
Tract Infections ◽  
Control Study

Background: Neonatal Sepsis (NS) is a major cause of neonatal morbidity and mortality, particularly in developing countries. Delays in the identification and treatment of NS are the main contributors to the high mortality. This study aims to identify risk factors for NS in newborns in the two university hospitals in Lubumbashi, in the Democratic Republic of Congo. Methods: This hospital-based case-control study was carried out on 486 mother-newborn pairs using the systematic sampling method during November 2019 to October 2020. Data were analyzed using STATA software (version 15). Binary and multivariable logistic regression analyses were computed to identify the associated factors at 95% CI. Results: A total of 162 cases and 324 controls were included in this study. Multiple logistic regression analysis showed that the possible risk factors for NS in this study were low level of education (AOR=9.16 [2.23-37.67]), maternal genitourinary tract infections (AOR=42.59 [17.90-101.37]), premature rupture of membranes (AOR=19.95 [7.27-54.76]), peripartum fever (AOR=26.25 [2.31-297.83]), prolonged labor (AOR=14.16 [3.88-51.71]), cesarean section (AOR=3.57 [1.48-8.61]), obstructed vaginal delivery (AOR=13.40 [1.32- 136.19]), birth weight <1500 grams (AOR=70.38 [8.64-572.95]), and between 1500-2500 grams (AOR=7.90 [3.04-20.52]). Conclusion: The study found that maternal and neonatal factors were strongly associated with the risk of developing NS. The present study suggests the possibility of routine assessment of sepsis in newborns born with the above characteristics.

scholarly journals Factors associated with episiotomy practice in Bukavu, Democratic Republic of the Congo

2018 ◽  
Vol 7 (7) ◽  
pp. 2553
Author(s):  
Ntamulenga Innocent ◽  
Mulongo Mbarambara Philémon ◽  
Imani Prince ◽  
Yatoka Justine ◽  
Mukanire Ntakwinja ◽  
...  
Keyword(s):  
Democratic Republic ◽  
Case Control Study ◽  
Neonatal Resuscitation ◽  
Fetal Distress ◽  
Case Control ◽  
Primary Objective ◽  
Foetal Distress ◽  
Factors Associated ◽  
Republic Of The Congo ◽  
Control Study

Background: The primary objective of the present study is to determine the episiotomy rate and factors associated with practice of episiotomy at the maternities in Bukavu town, South-Kivu, DRC.Methods: A case-control study was carried out the women who underwent the episiotomy (case) and those which did not undergo episiotomy (control) over one 12 months period between January to December 2015. A total of 1878 women had a vaginal delivery at a rate of one case for one control (939 cases and 939 controls) were included. Their medical files were exploited. The factors associated with episiotomy were performed by logistic regression.Results: The rate of episiotomy was 20.4%. It was found that after the logistic regression, the Primiparity (OR = 4,5;95% CI:2,31-4,49), the existence of a foetal distress (OR = 4,2;IC to 95% CI :2,36-5,29), the antecedent of episiotomy (OR = 3,9;95% CI:2,83-7,07), private character of maternity (OR= 3,3; 95% CI :2,12-6,30) and the fact that the childbirth was directed by a doctor (OR = 2,3; 95% CI :1,85-5,08) were strongly associated with the practice of the episiotomy in our medium of study.Conclusions: This study showed UA-S/D ratio and UA-RI>2SD are significant predictors of perinatal deaths and immediate neonatal resuscitation in preeclampsia. Acute fetal distress in labour or neonatal nursery admission could not be predicted.

scholarly journals Metal mining and birth defects: a case-control study in Lubumbashi, Democratic Republic of the Congo

2020 ◽  
Vol 4 (4) ◽  
pp. e158-e167 ◽  
Author(s):  
Daan Van Brusselen ◽  
Tony Kayembe-Kitenge ◽  
Sébastien Mbuyi-Musanzayi ◽  
Toni Lubala Kasole ◽  
Leon Kabamba Ngombe ◽  
...  
Keyword(s):  
Birth Defects ◽  
Democratic Republic ◽  
Case Control Study ◽  
Case Control ◽  
Metal Mining ◽  
Republic Of The Congo ◽  
Control Study

Possible Cefotaxime-Induced Stevens–Johnson Syndrome

2003 ◽  
Vol 37 (6) ◽  
pp. 812-814 ◽  
Author(s):  
Evagelos N Liberopoulos ◽  
George L Liamis ◽  
Moses S Elisaf
Keyword(s):  
Case Control Study ◽  
Causality Assessment ◽  
Clinical Manifestations ◽  
Underlying Mechanism ◽  
Upper Urinary Tract ◽  
Stevens Johnson Syndrome ◽  
Case Summary ◽  
Johnson Syndrome ◽  
Increased Risk ◽  
Control Study

OBJECTIVE: To report a case of possible cefotaxime-induced Stevens–Johnson syndrome (SJS). CASE SUMMARY: A 72-year-old woman with an upper urinary tract infection developed erosions and blisters on the skin and the mucous membranes, as well as fever and prostration, soon after the administration of cefotaxime. This presentation is consistent with the features of SJS. Resolution of the clinical manifestations was observed after discontinuation of the drug; all other drugs, infections, or immunologic disorders that could have caused this syndrome were carefully excluded. An objective causality assessment revealed that SJS was possibly associated with the use of cefotaxime. DISCUSSION: Although cephalosporins have been associated with an increased risk for SJS and cefotaxime has been suspected of being associated with SJS in a previous case–control study, this is the first full report for cefotaxime-related SJS in the literature. An immunologically mediated reaction may be the underlying mechanism. CONCLUSIONS: Although cefotaxime administration seems to be the underlying cause of the SJS observed in our patient, establishment of a definite causal relationship requires additional cases and supportive data.

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