scholarly journals Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 875
Author(s):  
Ascensión Rueda-Robles ◽  
Teresa Rubio-Tomás ◽  
Julio Plaza-Diaz ◽  
Ana I. Álvarez-Mercado
Keyword(s):  
Negative Impact ◽  
Current Knowledge ◽  
Gastric Disease ◽  
Peptic Ulcers ◽  
Gastric Lesions ◽  
Microbial Dysbiosis ◽  
Disease Outcomes ◽  
H Pylori ◽  
Micronutrient Availability

Helicobacter pylori (H. pylori) is a Gram-negative bacterium that colonizes the stomach and can induce gastric disease and intra-gastric lesions, including chronic gastritis, peptic ulcers, gastric adenocarcinoma, and mucosa-associated lymphoid tissue lymphoma. This bacterium is responsible for long-term complications of gastric disease. The conjunction of host genetics, immune response, bacterial virulence expression, diet, micronutrient availability, and microbiome structure influence the disease outcomes related to chronic H. pylori infection. In this regard, the consumption of unhealthy and unbalanced diets can induce microbial dysbiosis, which infection with H. pylori may contribute to. However, to date, clinical trials have reported controversial results and current knowledge in this field is inconclusive. Here, we review preclinical studies concerning the changes produced in the microbiota that may be related to H. pylori infection, as well as the involvement of diet. We summarize and discuss the last approaches based on the modulation of the microbiota to improve the negative impact of H. pylori infection and their potential translation from bench to bedside.

scholarly journals RECURRENCE RATE OF HELICOBACTER PYLORI IN PATIENTS WITH PEPTIC ULCER FIVE YEARS OR MORE AFTER SUCCESSFUL ERADICATION

2016 ◽  
Vol 53 (3) ◽  
pp. 152-155 ◽  
Author(s):  
Yuri Costa Farago FERNANDES ◽  
Gabriel da Rocha BONATTO ◽  
Mauro Willeman BONATTO
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Recurrence Rate ◽  
Early Recurrence ◽  
Peptic Ulcers ◽  
Ulcer Disease ◽  
Gastroduodenal Mucosa ◽  
H Pylori

ABSTRACT Background Infection with Helicobacter pylori is highly prevalent worldwide, especially in developing countries. Its presence in the gastroduodenal mucosa is related with development of peptic ulcer and other illnesses. The eradication of H. pylori improves mucosal histology in patients with peptic ulcers. Objective This study was aimed to verify if H. pylori recurrence occurs five years or more after confirmed eradication in patients with peptic ulcer. Moreover, we sought to determine the recurrence rate. Methods Retrospective and longitudinal, this study was based on a sample of 201 patients from western Paraná, Brazil. The patients were diagnosed with peptic ulcer disease, in the period of 1990-2000, and followed for five years or more after successful H. pylori eradication. Patients with early recurrence - prior to five years after eradication - were excluded from the sample. Results During an average follow-up of 8 years, 180 patients (89.55%) remained negative, and 21 (10.45%) became positive for H. pylori infection. New ulcers appeared in two-thirds of the patients with H. pylori recurrence. Conclusion The recurrence of H. pylori in patients with peptic ulcer can occur in the long-term - even if the infection had been successfully eradicated and the patients had remained free of recurrence in the first years of follow-up.

scholarly journals Nutrition andHelicobacter pylori: Host Diet and Nutritional Immunity Influence Bacterial Virulence and Disease Outcome

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Kathryn P. Haley ◽  
Jennifer A. Gaddy
Keyword(s):  
Severe Disease ◽  
B Cell Lymphoma ◽  
Nutrition Status ◽  
Invasive Adenocarcinoma ◽  
Nutritional Immunity ◽  
Disease Outcomes ◽  
Increased Risk ◽  
Host Diet ◽  
H Pylori ◽  
Micronutrient Availability

Helicobacter pyloricolonizes the stomachs of greater than 50% of the world’s human population making it arguably one of the most successful bacterial pathogens. ChronicH. pyloricolonization results in gastritis in nearly all patients; however in a subset of people, persistent infection withH. pyloriis associated with an increased risk for more severe disease outcomes including B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma) and invasive adenocarcinoma. Research aimed at elucidating determinants that mediate disease progression has revealed genetic differences in both humans andH. pyloriwhich increase the risk for developing gastric cancer. Furthermore, host diet and nutrition status have been shown to influenceH. pylori-associated disease outcomes. In this review we will discuss howH. pyloriis able to create a replicative niche within the hostile host environment by subverting and modifying the host-generated immune response as well as successfully competing for limited nutrients such as transition metals by deploying an arsenal of metal acquisition proteins and virulence factors. Lastly, we will discuss how micronutrient availability or alterations in the gastric microbiome may exacerbate negative disease outcomes associated withH. pyloricolonization.

scholarly journals Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

1994 ◽  
Vol 179 (5) ◽  
pp. 1653-1658 ◽  
Author(s):  
J L Telford ◽  
P Ghiara ◽  
M Dell'Orco ◽  
M Comanducci ◽  
D Burroni ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Peptic Ulcer ◽  
Gastric Mucosa ◽  
Chronic Infection ◽  
Gastric Disease ◽  
Human Gastric Mucosa ◽  
Gastric Lesions ◽  
Gram Negative ◽  
H Pylori ◽  
Cytotoxin Gene

The gram negative, microaerophilic bacterium Helicobacter pylori colonizes the human gastric mucosa and establishes a chronic infection that is tightly associated with atrophic gastritis, peptic ulcer, and gastric carcinoma. Cloning of the H. pylori cytotoxin gene shows that the protein is synthesized as a 140-kD precursor that is processed to a 94-kD fully active toxin. Oral administration to mice of the purified 94-kD protein caused ulceration and gastric lesions that bear some similarities to the pathology observed in humans. The cloning of the cytotoxin gene and the development of a mouse model of human gastric disease will provide the basis for the understanding of H. pylori pathogenesis and the development of therapeutics and vaccines.

scholarly journals Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development

2010 ◽  
Vol 59 (12) ◽  
pp. 1484-1489 ◽  
Author(s):  
Shinobu Imagawa ◽  
Masanori Ito ◽  
Masaharu Yoshihara ◽  
Hidetaka Eguchi ◽  
Shinji Tanaka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Duodenal Ulcer ◽  
Gastric Acid ◽  
Acid Output ◽  
Rank Test ◽  
Peptic Ulcers ◽  
Log Rank Test ◽  
H Pylori

Few reports have described the cancer prevalence of peptic ulcer patients with long-term follow-up studies. We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa). A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled. These 136 cases [102 males and 34 females; 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment; mean follow-up period of 14.4 years (range 1–30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa. We investigated Helicobacter pylori duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases. Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers. GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up. The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P<0.05). dupA-positive H. pylori was detected not only in DU patients (9/20) but also in GU patients (9/36). Gastric acid output was significantly larger in quantity in patients with dupA-positive H. pylori than in those with dupA-negative H. pylori (P<0.05). The occurrence of GCa was significantly lower in patients with dupA-positive H. pylori and a high BAO level (log-rank test P<0.05). DUs, higher acid output and dupA-positive H. pylori were negatively associated with GCa.

scholarly journals Dynamics of Helicobacter pylori infection as a determinant of progression of gastric precancerous lesions: 16-year follow-up of an eradication trial

Gut ◽  
2017 ◽  
Vol 67 (7) ◽  
pp. 1239-1246 ◽  
Author(s):  
Robertino M Mera ◽  
Luis E Bravo ◽  
M Constanza Camargo ◽  
Juan C Bravo ◽  
Alberto G Delgado ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Linear Models ◽  
Precancerous Lesions ◽  
Gastric Lesions ◽  
Logistic Regression Models ◽  
Risk Of Progression ◽  
H Pylori ◽  
Cumulative Time

ObjectiveTo evaluate the long-term effect of cumulative time exposed to Helicobacter pylori infection on the progression of gastric lesions.Design795 adults with precancerous gastric lesions were randomised to receive anti-H. pylori treatment at baseline. Gastric biopsies were obtained at baseline and at 3, 6, 12 and 16 years. A total of 456 individuals attended the 16-year visit. Cumulative time of H. pylori exposure was calculated as the number of years infected during follow-up. Multivariable logistic regression models were used to estimate the risk of progression to a more advanced diagnosis (versus no change/regression) as well as gastric cancer risk by intestinal metaplasia (IM) subtype. For a more detailed analysis of progression, we also used a histopathology score assessing both severity and extension of the gastric lesions (range 1–6). The score difference between baseline and 16 years was modelled by generalised linear models.ResultsIndividuals who were continuously infected with H. pylori for 16 years had a higher probability of progression to a more advanced diagnosis than those who cleared the infection and remained negative after baseline (p=0.001). Incomplete-type IM was associated with higher risk of progression to cancer than complete-type (OR, 11.3; 95% CI 1.4 to 91.4). The average histopathology score increased by 0.20 units/year (95% CI 0.12 to 0.28) among individuals continuously infected with H. pylori. The effect of cumulative time of infection on progression in the histopathology score was significantly higher for individuals with atrophy (without IM) than for individuals with IM (p<0.001).ConclusionsLong-term exposure to H. pylori infection was associated with progression of precancerous lesions. Individuals infected with H. pylori with these lesions may benefit from eradication, particularly those with atrophic gastritis without IM. Incomplete-type IM may be a useful marker for the identification of individuals at higher risk for cancer.

scholarly journals Long-term fire resilience of the Ericaceous Belt, Bale Mountains, Ethiopia

2019 ◽  
Vol 15 (7) ◽  
pp. 20190357 ◽  
Author(s):  
Graciela Gil-Romera ◽  
Carole Adolf ◽  
Blas M. Benito ◽  
Lucas Bittner ◽  
Maria U. Johansson ◽  
...  
Keyword(s):  
Fire History ◽  
Time Perspective ◽  
Negative Impact ◽  
Current Knowledge ◽  
Landscape Management ◽  
Fire Occurrence ◽  
Controlled Burning ◽  
History Of ◽  
Grazing Systems

Fire is the most frequent disturbance in the Ericaceous Belt ( ca 3000–4300 m.a.s.l.), one of the most important plant communities of tropical African mountains. Through resprouting after fire, Erica establishes a positive fire feedback under certain burning regimes. However, present-day human activity in the Bale Mountains of Ethiopia includes fire and grazing systems that may have a negative impact on the resilience of the ericaceous ecosystem. Current knowledge of Erica –fire relationships is based on studies of modern vegetation, lacking a longer time perspective that can shed light on baseline conditions for the fire feedback. We hypothesize that fire has influenced Erica communities in the Bale Mountains at millennial time-scales. To test this, we (1) identify the fire history of the Bale Mountains through a pollen and charcoal record from Garba Guracha, a lake at 3950 m.a.s.l., and (2) describe the long-term bidirectional feedback between wildfire and Erica, which may control the ecosystem's resilience. Our results support fire occurrence in the area since ca 14 000 years ago, with particularly intense burning during the early Holocene, 10.8–6.0 cal ka BP. We show that a positive feedback between Erica abundance and fire occurrence was in operation throughout the Lateglacial and Holocene, and interpret the Ericaceous Belt of the Ethiopian mountains as a long-term fire resilient ecosystem. We propose that controlled burning should be an integral part of landscape management in the Bale Mountains National Park.

scholarly journals Indicators of trypsin-like activity of mixed saliva after installing the endosseous implants in the presence of gastric ulcer and duodenal ulcer

2019 ◽  
pp. 13-22
Author(s):  
Mariya Kuznetsova ◽  
Anna Nikonova ◽  
Ivan Kuznetsov ◽  
Mariya Sevbitova ◽  
Mariya Timoshina
Keyword(s):  
Enzymatic Activity ◽  
Negative Impact ◽  
Repair Process ◽  
Peptic Ulcers ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Implant Placement ◽  
Mixed Saliva ◽  
Orthopedic Patients

The trypsin-like activity of mixed saliva in orthopedic patients after implant placement was monitored. Proved negative impact on the processes of repair of background somatic pathology (peptic ulcers and 12 duodenal ulcers), justify the application of immunomodulator "Erbisol" as a drug that speeds up the repair processes during implantation. At present, the relevant issues are those related to the development of inflammatory complications at the stage of rehabilitation of patients, especially in the presence of somatic pathology and the study of the tissue complex of the implantation zone. Peptic ulcer disease occupies one of the main places in the structure of lesions of the digestive system. The close interdependence between the pathology of internal organs and the oral cavity is confirmed by numerous observations and studies.Implant placement is accompanied by changes in the enzymatic activity of mixed saliva. The presence of somatic pathology (ulcerative disease of the stomach and 12 duodenal ulcers) often leads to more long-term violations of the enzymatic activity of saliva. The use of the drug "Erbisol" in orthopedic dentistry accelerates the repair process, as evidenced by the earlier periods of normalization of the enzymatic activity of mixed saliva, after the installation of implants.Regular and timely monitoring of the condition of the periarticular tissues, as well as objective diagnosis of early inflammatory complications, are necessary to ensure the reliability and long-term functioning of prosthetic structures installed on implants in the oral cavity.It can be concluded that the purpose of our study was to study the trypsin-like activity (TPA) of mixed saliva after implant placement on the background of somatic pathology.

scholarly journals What Predicts Peptic Ulcer in Patients Referred for Endoscopy?

2019 ◽  
Vol 1 (1) ◽  
pp. 1-8
Author(s):  
Omran Habib ◽  
Rifka Abdul-Wahab
Keyword(s):  
Peptic Ulcer ◽  
Clinical Manifestations ◽  
Diagnostic Techniques ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Peptic Ulcers ◽  
Gastric Lesions ◽  
Information Sheet ◽  
Cross Sectional ◽  
H Pylori

Background: Peptic ulcers and other gastric lesions are significant medical conditions. Endoscopy is one useful diagnostic tool, the use of which is dependent on patient selection. Objectives: This study attempts to explore how predictive selected symptoms may be, along with their characteristics in diagnosing peptic ulcers and other gastric lesions in patients undergoing endoscopy. Methods: A cross-sectional study was conducted with 152 patients referred to the endoscopic unit at Al-Sadr teaching hospital in Basrah. The patients were carefully interviewed to determine clinical and sociodemographic characteristics. They were subjected to endoscopic examination by a specialist physician, and their results were recorded on the same information sheet. Data were analyzed using the Statistical Package for Social Science, version 20. Results: Given the complexity of the risk factors, clinical manifestations and diagnostic techniques, it seems difficult to predict which patients are likely to have peptic ulcers and which are not. In this study, only self-reported stress and H pylori infection were found to significantly predict the likelihood of peptic ulcers among patients subjected to endoscopic examination. Conclusions: Patients subjected to endoscopy are expected to have a variety of gastric lesions, including peptic ulcer. A substantial proportion of these patients were entirely lesion free. Key words: Prediction, peptic ulcer, Basrah, endoscopy

scholarly journals INDICATORS OF TRYPSIN-LIKE ACTIVITY OF MIXED SALIVAAFTER INSTALLING THE ENDOSSEOUS IMPLANTS IN THE PRESENCE OF GASTRIC ULCER AND DUODENAL ULCER

2019 ◽  
Vol 27 (27) ◽  
pp. 13-22
Author(s):  
Mariya KUZNETSOVA ◽  
Anna NIKONOVA ◽  
Ivan KUZNETSOV ◽  
Mariya SEVBITOVA ◽  
Mariya TIMOSHINA
Keyword(s):  
Enzymatic Activity ◽  
Negative Impact ◽  
Repair Process ◽  
Peptic Ulcers ◽  
Duodenal Ulcers ◽  
Ulcer Disease ◽  
Implant Placement ◽  
Mixed Saliva ◽  
Orthopedic Patients

The trypsin-like activity of mixed saliva in orthopedic patients after implant placement was monitored. Proved negative impact on the processes of repair of background somatic pathology (peptic ulcers and 12 duodenal ulcers), justify the application of immunomodulator "Erbisol" as a drug that speeds up the repair processes during implantation. At present, the relevant issues are those related to the development of inflammatory complications at the stage of rehabilitation of patients, especially in the presence of somatic pathology and the study of the tissue complex of the implantation zone. Peptic ulcer disease occupies one of the main places in the structure of lesions of the digestive system. The close interdependence between the pathology of internal organs and the oral cavity is confirmed by numerous observations and studies.Implant placement is accompanied by changes in the enzymatic activity of mixed saliva. The presence of somatic pathology (ulcerative disease of the stomach and 12 duodenal ulcers) often leads to more long-term violations of the enzymatic activity of saliva. The use of the drug "Erbisol" in orthopedic dentistry accelerates the repair process, as evidenced by the earlier periods of normalization of the enzymatic activity of mixed saliva, after the installation of implants.Regular and timely monitoring of the condition of the periarticular tissues, as well as objective diagnosis of early inflammatory complications, are necessary to ensure the reliability and long-term functioning of prosthetic structures installed on implants in the oral cavity.It can be concluded that the purpose of our study was to study the trypsin-like activity (TPA) of mixed saliva after implant placement on the background of somatic pathology.

scholarly journals Transient and Persistent Gastric Microbiome: Adherence of Bacteria in Gastric Cancer and Dyspeptic Patient Biopsies after Washing

2020 ◽  
Vol 9 (6) ◽  
pp. 1882 ◽  
Author(s):  
Malene R. Spiegelhauer ◽  
Juozas Kupcinskas ◽  
Thor B. Johannesen ◽  
Mindaugas Urba ◽  
Jurgita Skieceviciene ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bacterial Diversity ◽  
Large Scale ◽  
Amplicon Sequencing ◽  
Rrna Gene ◽  
Peptic Ulcers ◽  
Gastric Biopsies ◽  
H Pylori ◽  
Gastric Microbiota

Helicobacter pylori is a common colonizer of the human stomach, and long-term colonization has been related to development of atrophic gastritis, peptic ulcers and gastric cancer. The increased gastric pH caused by H. pylori colonization, treatment with antibiotics or proton pump inhibitors (PPI) may allow growth of other bacteria. Previous studies have detected non-Helicobacter bacteria in stomach biopsies, but no conclusion has been made of whether these represent a transient contamination or a persistent microbiota. The aim of this study was to evaluate the transient and persistent bacterial communities of gastric biopsies. The washed or unwashed gastric biopsies were investigated by cultivation and microbiota analysis (16S rRNA gene-targeted amplicon sequencing) for the distribution of H. pylori and other non-Helicobacter bacteria. The number of cultured non-Helicobacter bacteria decreased in the washed biopsies, suggesting that they might be a transient contamination. No significant differences in the bacterial diversity were observed in the microbiome analysis between unwashed and washed biopsies. However, the bacterial diversity in biopsies shown H. pylori-positive and H. pylori-negative were significantly different, implying that H. pylori is the major modulator of the gastric microbiome. Further large-scale studies are required to investigate the transient and persistent gastric microbiota.

Sign in / Sign up

Export Citation Format

Share Document