scholarly journals Variable Proportions of Phylogenetic Clustering and Low Levels of Antiviral Drug Resistance among the Major HBV Sub-Genotypes in the Middle East and North Africa

Pathogens ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1333
Author(s):  
Rabaa Y. Athamneh ◽  
Ayşe Arıkan ◽  
Murat Sayan ◽  
Azmi Mahafzah ◽  
Malik Sallam
Keyword(s):  
Drug Resistance ◽  
Phylogenetic Analysis ◽  
Saudi Arabia ◽  
Middle East ◽  
North Africa ◽  
Antiviral Drug ◽  
Ratio Test ◽  
Phylogenetic Clustering ◽  
Mena Countries ◽  
Antiviral Drug Resistance

Hepatitis B virus (HBV) infection remains a major public health threat in the Middle East and North Africa (MENA). Phylogenetic analysis of HBV can be helpful to study the putative transmission links and patterns of inter-country spread of the virus. The objectives of the current study were to analyze the HBV genotype/sub-genotype (SGT) distribution, reverse transcriptase (RT), and surface (S) gene mutations and to investigate the domestic transmission of HBV in the MENA. All HBV molecular sequences collected in the MENA were retrieved from GenBank as of 30 April 2021. Determination of genotypes/SGT, RT, and S mutations were based on the Geno2pheno (hbv) 2.0 online tool. For the most prevalent HBV SGTs, maximum likelihood phylogenetic analysis was conducted to identify the putative phylogenetic clusters, with approximate Shimodaira–Hasegawa-like likelihood ratio test values ≥ 0.90, and genetic distance cut-off values ≤ 0.025 substitutions/site as implemented in Cluster Picker. The total number of HBV sequences used for genotype/SGT determination was 4352 that represented a total of 20 MENA countries, with a majority from Iran (n = 2103, 48.3%), Saudi Arabia (n = 503, 11.6%), Tunisia (n = 395, 9.1%), and Turkey (n = 267, 6.1%). Genotype D dominated infections in the MENA (86.6%), followed by genotype A (4.1%), with SGT D1 as the most common in 14 MENA countries and SGT D7 dominance in the Maghreb. The highest prevalence of antiviral drug resistance was observed against lamivudine (4.5%) and telbivudine (4.3%). The proportion of domestic phylogenetic clustering was the highest for SGT D7 (61.9%), followed by SGT D2 (28.2%) and genotype E (25.7%). The largest fraction of domestic clusters with evidence of inter-country spread within the MENA was seen in SGT D7 (81.3%). Small networks (containing 3-14 sequences) dominated among domestic phylogenetic clusters. Specific patterns of HBV genetic diversity were seen in the MENA with SGT D1 dominance in the Levant, Iran, and Turkey; SGT D7 dominance in the Maghreb; and extensive diversity in Saudi Arabia and Egypt. A low prevalence of lamivudine, telbivudine, and entecavir drug resistance was observed in the region, with almost an absence of resistance to tenofovir and adefovir. Variable proportions of phylogenetic clustering indicated prominent domestic transmission of SGT D7 (particularly in the Maghreb) and relatively high levels of virus mobility in SGT D1.

scholarly journals Chapter 9: Russia’s Agri-Food Trade with the Middle East and North Africa

2021 ◽  
pp. 253-277
Author(s):  
Maximilian Heigermoser ◽  
Tinoush Jamali Jaghdani ◽  
Linde Götz
Keyword(s):  
Saudi Arabia ◽  
Middle East ◽  
North Africa ◽  
Food Products ◽  
Political Conflict ◽  
Food Trade ◽  
Mena Countries ◽  
Intergovernmental Cooperation ◽  
Gulf Country ◽  
Food Imports

AbstractThe Middle East and North Africa (MENA) region is the top destination for Russian food exports, grains in particular. Focusing on Turkey, Egypt, Iran, and Saudi Arabia, this chapter shows that Russia’s food trade with MENA countries is strongly affected by bilateral political relations. Russia banned most food imports from Turkey over a political conflict in 2016. In the same year, improved intergovernmental cooperation with Saudi Arabia resulted in a diversification of Russia’s food exports to the Gulf country, and in 2019, Iran’s accession to the Eurasian Economic Union (EAEU) led to increasing food trade with Russia. Food imports in MENA countries are usually managed by powerful state trading enterprises (STEs), which recurrently disapprove food products originating from Russia based on non-adherence to food quality standards. Our analysis shows that Russia is successfully working to open additional destination markets, while simultaneously impeding imports of food products that it aims to produce domestically.

scholarly journals A chronicle of SARS-CoV-2: Seasonality, environmental fate, transport, inactivation, and antiviral drug resistance

2020 ◽  
pp. 124043 ◽  
Author(s):  
Manish Kumar ◽  
Payal Mazumder ◽  
Sanjeeb Mohapatra ◽  
Alok Kumar Thakur ◽  
Kiran Dhangar ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Environmental Fate ◽  
Antiviral Drug ◽  
Antiviral Drug Resistance

Party systems and ideological cleavages in the Middle East and North Africa

2020 ◽  
pp. 135406881989429
Author(s):  
Abdullah Aydogan
Keyword(s):  
Middle East ◽  
North Africa ◽  
Political Party ◽  
Party Systems ◽  
Party Competition ◽  
Right Wing ◽  
Left Wing ◽  
Mena Region ◽  
Quantitative Evidence ◽  
Mena Countries

Previous studies have contrasted the political party systems in the Middle East and North Africa (MENA) with those in more democratic countries, raising three important points: (1) the religious–secular dimension, rather than the economic or social left–right, explains the underlying political party competition; (2) left-wing politics is relatively weaker than right-wing politics; and (3) parties that are traditionally known as rightist take left-leaning positions on numerous issue dimensions, and vice versa. Even though this particular literature on party politics in the MENA has greatly improved our understanding of political dynamics in the region, these studies have either lacked quantitative evidence to support these points or their evidence was limited to single-country cases. This study aims to address this issue by analyzing original expert survey data of the ideological positions of political parties in the MENA region. Results show that in addition to the religious–secular dimension, the economic left–right divide and the pace of political reforms are highly important dimensions. The study also provides numerous examples showing that the policy stances of leftist and rightist parties are significantly reversed when MENA countries are compared with more developed democracies.

Food security in selected Middle East and North Africa (MENA) countries: an inter-country comparison

Food Security ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 531-540 ◽  
Author(s):  
Nasrin Omidvar ◽  
Davod Ahmadi ◽  
Kate Sinclair ◽  
Hugo Melgar-Quiñonez
Keyword(s):  
Food Security ◽  
Middle East ◽  
North Africa ◽  
Mena Countries ◽  
Country Comparison

scholarly journals Prevalence of Antiviral Drug Resistance in Untreated Patients with Cytomegalovirus Retinitis

2000 ◽  
Vol 182 (4) ◽  
pp. 1234-1238 ◽  
Author(s):  
Weiqun Liu ◽  
Carol Shum ◽  
Daniel F. Martin ◽  
Baruch D. Kuppermann ◽  
Anthony J. H. Hall ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Antiviral Drug ◽  
Cytomegalovirus Retinitis ◽  
Antiviral Drug Resistance

China and the Revolutions in the Middle East and North Africa

2011 ◽  
Vol 3 (1-2) ◽  
pp. 192-203 ◽  
Author(s):  
Randall Peerenboom
Keyword(s):  
Social Justice ◽  
Middle East ◽  
North Africa ◽  
Authoritarian Regimes ◽  
Northern Africa ◽  
Mena Countries ◽  
Turn On ◽  
Potential Sources ◽  
The Government

The 2011 revolutions in the Middle East and Northern Africa (MENA) led to considerable hope for some people that China would experience a similar political uprising, as well as considerable anxiety for the ruling regime. The government’s immediate response was to downplay the risk of a similar event occurring in China by distinguishing between China and MENA, while at the same time cracking down on activists and other potential sources of instability—including attempts to organize popular revolutionary protests in China. Although the government has so far managed to avoid a similar uprising, neither response has been entirely successful. Despite a number of significant diff erences between China and MENA countries, there are enough commonalities to justify concerns about political instability. Moreover, relying on repression alone is not a long-term solution to the justified demands of Chinese citizens for political reforms and social justice. Whether China will ultimately be able to avoid the fate of authoritarian regimes in MENA countries will turn on its ability to overcome a series of structural challenges while preventing sudden and unpredictable events, like those that gave rise to the Arab revolutions, from spinning out of control.

scholarly journals Diet, Genetics, and Disease: A Focus on the Middle East and North Africa Region

2012 ◽  
Vol 2012 ◽  
pp. 1-19 ◽  
Author(s):  
Akl C. Fahed ◽  
Abdul-Karim M. El-Hage-Sleiman ◽  
Theresa I. Farhat ◽  
Georges M. Nemer
Keyword(s):  
Middle East ◽  
Chronic Diseases ◽  
North Africa ◽  
Genetic Factors ◽  
Future Research ◽  
Micronutrient Deficiencies ◽  
Mena Region ◽  
Mena Countries ◽  
Nutritional Genomics

The Middle East and North Africa (MENA) region suffers a drastic change from a traditional diet to an industrialized diet. This has led to an unparalleled increase in the prevalence of chronic diseases. This review discusses the role of nutritional genomics, or the dietary signature, in these dietary and disease changes in the MENA. The diet-genetics-disease relation is discussed in detail. Selected disease categories in the MENA are discussed starting with a review of their epidemiology in the different MENA countries, followed by an examination of the known genetic factors that have been reported in the disease discussed, whether inside or outside the MENA. Several diet-genetics-disease relationships in the MENA may be contributing to the increased prevalence of civilization disorders of metabolism and micronutrient deficiencies. Future research in the field of nutritional genomics in the MENA is needed to better define these relationships.

scholarly journals Environmental Performance and Economic Growth in Middle East and North Africa Countries

2019 ◽  
Vol 9 (24) ◽  
Author(s):  
Hichem Dkhili
Keyword(s):  
Economic Growth ◽  
Middle East ◽  
North Africa ◽  
Environmental Performance ◽  
Middle Eastern ◽  
Smooth Transition ◽  
African Countries ◽  
Mena Region ◽  
Mena Countries ◽  
The Impact

Background. Studies on environmental performance/quality and economic growth show inconclusive results. Objective. The aim of the present study is to assess the non-linear relationship between environmental performance and economic growth in the Middle East and North Africa (MENA) region from 2002–2018. Methods. A sample of fourteen (14) MENA countries was used in the present analysis. However, due to important differences between countries in this region, the whole sample was divided into two sub-samples; nine Middle Eastern countries (MEAS) and five North African countries (NAF). We performed the panel smooth transition regression model as an econometric approach. Discussion. Empirical results indicate a threshold effect in the environmental performance and economic growth relationship. The threshold value differs from one group of countries to another. More specifically, we found that the impact of environmental performance and economic growth is positive and significant only if a certain threshold level has been attained. Until then, the effect remains negative. Conclusions. The findings of the present study are of great importance for policymakers since they determine the optimal level of environmental performance required to act positively on the level of economic growth. MENA countries should seek to improve their environmental performance index in order to grow output. Competing Interests. The authors declare no competing financial interests.

scholarly journals Empowering Women, Developing Society: Female Education in the Middle East and North Africa

1970 ◽  
pp. 4-11
Author(s):  
Faraneh Roudi-Fahimi ◽  
Valentine M. Moghadam
Keyword(s):  
Middle East ◽  
Secondary School ◽  
North Africa ◽  
Well Being ◽  
Access To Education ◽  
School Enrolment ◽  
Mena Countries ◽  
The Past ◽  
Secondary School Enrolment ◽  
And Gender

Education is a key part of strategies to improve individuals' well-being and societies' economic and social development. In the Middle East and North Africa (MENA) (countries and territories included in the Middle East and North Africa as defined here are listed in Table 1), access to education has improved dramatically over the past few decades, and there have been a number of encouraging trends in girls' and women's education (see Figure 1). Primary school enrolment is high or universal in most MENA countries, and gender gaps in secondary school enrolment have already disappeared in several countries. Women in MENA countries are also more likely to enrol in universities than they were in the past.

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