scholarly journals Increased Water-Solubility and Maintained Antioxidant Power of Resveratrol by Its Encapsulation in Vitamin E TPGS Micelles: A Potential Nutritional Supplement for Chronic Liver Disease

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1128
Author(s):  
Guendalina Zuccari ◽  
Silvana Alfei ◽  
Alessia Zorzoli ◽  
Danilo Marimpietri ◽  
Federica Turrini ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liver Disease ◽  
Vitamin E ◽  
Chronic Liver Disease ◽  
Well Being ◽  
Chronic Liver ◽  
Glycol Succinate ◽  
Phase Solubility ◽  
Antioxidant Power ◽  
Phase Solubility Study

Children affected by chronic liver disease exhibit impaired neurocognitive development and growth due to the low absorption and digestion of nutrients. Furthermore, malnutrition is an adverse prognostic factor in liver transplantation as it is associated with an increase in morbidity and mortality. D-α-tocopheryl-polyethylene-glycol-succinate (TPGS) is currently administered per os as a vitamin E source to improve children’s survival and well-being; however, TPGS alone does not reverse spinocerebellar degeneration and lipid peroxidation. To potentiate the effects of TPGS, we loaded micelles with resveratrol (RES), a natural polyphenol, with antioxidant and antiinflammatory activities, which has demonstrated protective action in the liver. Firstly, we investigated the suitability of TPGS to encapsulate RES in micelles by means of a phase-solubility study, then RES-TPGS formulations were prepared via solvent casting and solvent diffusion evaporation methods. RES-TPGS colloidal dispersions showed small mean diameters (12 nm), low polydispersity, and quite neutral Zeta potentials. The formulations showed a sustained drug release and a good drug loading capacity, further confirmed by infrared spectroscopy and differential scanning calorimetry. RES-TPGSs exhibited unaltered antioxidant activity compared to pristine RES via the DPPH assay and a significant reduction in toxicity compared to empty TPGS on HaCaT cells. Thus, RES-TPGS micelles may overcome the challenges of current liver disease therapy by providing more protective effects thanks to the antioxidant activity of RES and by reducing the surfactant toxicity on normal cells.

Vitamin E deficiency in adults with chronic liver disease

1985 ◽  
Vol 41 (1) ◽  
pp. 66-72 ◽  
Author(s):  
R J Sokol ◽  
W F Balistreri ◽  
J H Hoofnagle ◽  
E A Jones
Keyword(s):  
Liver Disease ◽  
Vitamin E ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Vitamin E Deficiency

scholarly journals Self-Efficacy Among Indonesian Chronic Liver Disease Patients

2020 ◽  
Vol 14 (2) ◽  
Author(s):  
Apriliani Siburian ◽  
Ching Fen Chang
Keyword(s):  
Liver Disease ◽  
Chronic Disease ◽  
Chronic Liver Disease ◽  
Self Efficacy ◽  
Well Being ◽  
Chronic Fatigue ◽  
Developed Countries ◽  
Chronic Liver ◽  
Cross Sectional ◽  
Loss Of Appetite

Chronic Liver Diseases are among the most extensive diseases globally and are related to significant morbidity and mortality. Although physical well-being has long been the primary goal of medical care, as chronic disease becomes more prevalent in developed countries, there has been a greater focus on patients' emotional and social well-being. This study aimed to describe the self-efficacy among chronic liver disease patients in North Sumatra, Indonesia. This study uses a cross-sectional design. The study assessed 102 chronic liver disease patients from two hospitals using the Chronic Disease Self-Efficacy Scales Indonesian version. The participants had moderate self-efficacy (58.8%), followed by high self-efficacy (38.2%). The majority of the patients in this study had moderate self-efficacy because many individuals with chronic liver disease suffer chronic fatigue, abdominal pain and swelling, itchy skin, nausea or vomiting, loss of appetite, and other symptoms that affect self-efficacy.  Health professionals should strengthen patients' self-efficacy by engaging in positive activities and enhancing their coping skills

scholarly journals Is vitamin E beneficial in chronic liver disease?

Hepatology ◽  
2007 ◽  
Vol 46 (2) ◽  
pp. 288-290 ◽  
Author(s):  
Ingrid Hickman ◽  
Graeme Macdonald
Keyword(s):  
Liver Disease ◽  
Vitamin E ◽  
Chronic Liver Disease ◽  
Chronic Liver

scholarly journals Chronic Liver Disease Lowering Physical and Mental Health Dimensions

2021 ◽  
Vol 24 (3) ◽  
pp. 149-156
Author(s):  
Apriliani Siburian ◽  
Ching Fen Chang
Keyword(s):  
Quality Of Life ◽  
Mental Health ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Short Form ◽  
Well Being ◽  
Chronic Liver ◽  
Physical And Mental Health ◽  
Short Form 36

The most prevalent diseases within the world related to major illness and mortality are chronic liver diseases. The developing pervasiveness of chronic liver disease has resulted in increased interest in health-related quality of life, which incorporates the physical well-being of a patient and his emotional and social well-being. This study aimed to define the quality of life of patients with chronic liver disease. This study used the Quality-of-Life Short Form 36 Indonesian version to examine 102 patients with chronic liver disease from two hospitals with a descriptive design. The quality of life of the patients was comparatively low (M ± SD: physical, 42.4 ± 18.33; mental, 48.44 ± 17.19). On both the physical and mental health dimensions of quality of life, the patients in this study scored less than 50 on a scale of 0 to 100, with low scores indicating the low quality of life both physically and mentally. Improving quality of life necessitates a multidisciplinary strategy that combines physical and mental health screening and management. Surrounding support will encourage adaptive coping mechanisms to manage the illness for improving quality of life. AbstrakPenyakit Hati Kronis Menurunkan Dimensi Kesehatan Fisik dan Mental. Penyakit yang paling umum di dunia yang berhubungan dengan penyakit utama dan kematian adalah penyakit hati kronis. Penyebaran penyakit hati kronis yang berkembang telah menghasilkan peningkatan minat pada kualitas hidup yang berhubungan dengan kesehatan, yang mencakup kesejahteraan fisik pasien dan kesejahteraan emosional dan sosialnya. Tujuan dari penelitian ini adalah untuk menjabarkan kualitas hidup pasien penyakit hati kronis. Penelitian ini menggunakan Quality-of-Life Short Form 36 versi Bahasa Indonesia untuk mengumpulkan data dari 102 pasien dari dua rumah sakit melalui desain deskriptif. Penelitian ini menunjukkan bahwa kualitas hidup pasien relatif rendah (M ± SD: fisik, 42,4 ± 18,33; mental, 48,44 ± 17,19). Pada kedua dimensi kualitas hidup yaitu kesehatan fisik dan mental, pasien dalam penelitian ini mendapat nilai kurang dari 50 pada skala 0 hingga 100, dengan nilai rendah menunjukkan kualitas hidup rendah baik fisik maupun mental. Peningkatkan kualitas hidup pasien memerlukan strategi multidisiplin yang menggabungkan skrining dan manajemen kesehatan fisik dan mental. Dukungan lingkungan akan mendorong mekanisme koping yang adaptif untuk mengelola penyakit dalam meningkatkan kualitas hidup.Kata Kunci: Indonesia, kualitas hidup, penyakit hati kronis, sirosis

Genetic predictors of spontaneous viral elimination or chronic liver disease in hepatitis C infection

2001 ◽  
Vol 120 (5) ◽  
pp. A7-A7
Author(s):  
S ROSS ◽  
S MASCHERETTI ◽  
H HINRICHSEN ◽  
P BUGGISCH ◽  
U FOELSCH ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hepatitis C Infection ◽  
Genetic Predictors
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