scholarly journals Aligned Scaffolds with Biomolecular Gradients for Regenerative Medicine

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 341 ◽  
Author(s):  
Xiaoran Li ◽  
Zhenni Chen ◽  
Haimin Zhang ◽  
Yan Zhuang ◽  
He Shen ◽  
...  
Keyword(s):  
3D Printing ◽  
Regenerative Medicine ◽  
Tissue Regeneration ◽  
Freeze Drying ◽  
Complex Structure ◽  
Biological Processes ◽  
Future Perspectives ◽  
Printing Technology ◽  
3D Printing Technology

Aligned topography and biomolecular gradients exist in various native tissues and play pivotal roles in a set of biological processes. Scaffolds that recapitulate the complex structure and microenvironment show great potential in promoting tissue regeneration and repair. We begin with a discussion on the fabrication of aligned scaffolds, followed by how biomolecular gradients can be immobilized on aligned scaffolds. In particular, we emphasize how electrospinning, freeze drying, and 3D printing technology can accomplish aligned topography and biomolecular gradients flexibly and robustly. We then highlight several applications of aligned scaffolds and biomolecular gradients in regenerative medicine including nerve, tendon/ligament, and tendon/ligament-to-bone insertion regeneration. Finally, we finish with conclusions and future perspectives on the use of aligned scaffolds with biomolecular gradients in regenerative medicine.

scholarly journals Optimization of Hybrid Ink Formulation and IPL Sintering Process for Ink-Jet 3D Printing

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1295
Author(s):  
Jae-Young Lee ◽  
Cheong-Soo Choi ◽  
Kwang-Taek Hwang ◽  
Kyu-Sung Han ◽  
Jin-Ho Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
Complex Structure ◽  
Operating Conditions ◽  
Conductive Layer ◽  
Sintering Process ◽  
Insulation Layer ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Ink Jet ◽  
Multiple Materials

Ink-jet 3D printing technology facilitates the use of various materials of ink on each ink-jet head and simultaneous printing of multiple materials. It is suitable for manufacturing to process a complex multifunctional structure such as sensors and printed circuit boards. In this study, a complex structure of a SiO2 insulation layer and a conductive Cu layer was fabricated with photo-curable nano SiO2 ink and Intense Pulsed Light (IPL)-sinterable Cu nano ink using multi-material ink-jet 3D printing technology. A precise photo-cured SiO2 insulation layer was designed by optimizing the operating conditions and the ink rheological properties, and the resistance of the insulation layer was 2.43 × 1013 Ω·cm. On the photo-cured SiO2 insulation layer, a Cu conductive layer was printed by controlling droplet distance. The sintering of the IPL-sinterable nano Cu ink was performed using an IPL sintering process, and electrical and mechanical properties were confirmed according to the annealing temperature and applied voltage. Then, Cu conductive layer was annealed at 100 °C to remove the solvent, and IPL sintered at 700 V. The Cu conductive layer of the complex structure had an electrical property of 29 µΩ·cm and an adhesive property with SiO2 insulation layer of 5B.

scholarly journals 3D Bioprinting at the Frontier of Regenerative Medicine, Pharmaceutical, and Food Industries

2021 ◽  
Vol 2 ◽  
Author(s):  
Qasem Ramadan ◽  
Mohammed Zourob
Keyword(s):  
Tissue Engineering ◽  
3D Printing ◽  
Regenerative Medicine ◽  
Production Process ◽  
Paradigm Shift ◽  
3D Bioprinting ◽  
Printing Technology ◽  
Food Industries ◽  
3D Printing Technology ◽  
Key Driver

3D printing technology has emerged as a key driver behind an ongoing paradigm shift in the production process of various industrial domains. The integration of 3D printing into tissue engineering, by utilizing life cells which are encapsulated in specific natural or synthetic biomaterials (e.g., hydrogels) as bioinks, is paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries. Here, we present a synthesis of the available 3D bioprinting technology from what is found and what has been achieved in various applications and discussed the capabilities and limitations encountered in this technology.

scholarly journals 3D printing technology to control BMP-2 and VEGF delivery spatially and temporally to promote large-volume bone regeneration

2015 ◽  
Vol 3 (27) ◽  
pp. 5415-5425 ◽  
Author(s):  
Ju Young Park ◽  
Jin-Hyung Shim ◽  
Song-Ah Choi ◽  
Jinah Jang ◽  
Myungshin Kim ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Large Volume ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Engineered Tissue ◽  
Tissue Structures

When large engineered tissue structures are used to achieve tissue regeneration, formation of vasculature is an essential process.

scholarly journals 3D Printing Approach in Dentistry: The Future for Personalized Oral Soft Tissue Regeneration

2020 ◽  
Vol 9 (7) ◽  
pp. 2238
Author(s):  
Dobrila Nesic ◽  
Birgit M. Schaefer ◽  
Yue Sun ◽  
Nikola Saulacic ◽  
Irena Sailer
Keyword(s):  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Soft Tissue Regeneration ◽  
Periodontal Tissues ◽  
Surgical Guides ◽  
3D Printed ◽  
Oral Soft Tissue

Three-dimensional (3D) printing technology allows the production of an individualized 3D object based on a material of choice, a specific computer-aided design and precise manufacturing. Developments in digital technology, smart biomaterials and advanced cell culturing, combined with 3D printing, provide promising grounds for patient-tailored treatments. In dentistry, the “digital workflow” comprising intraoral scanning for data acquisition, object design and 3D printing, is already in use for manufacturing of surgical guides, dental models and reconstructions. 3D printing, however, remains un-investigated for oral mucosa/gingiva. This scoping literature review provides an overview of the 3D printing technology and its applications in regenerative medicine to then describe 3D printing in dentistry for the production of surgical guides, educational models and the biological reconstructions of periodontal tissues from laboratory to a clinical case. The biomaterials suitable for oral soft tissues printing are outlined. The current treatments and their limitations for oral soft tissue regeneration are presented, including “off the shelf” products and the blood concentrate (PRF). Finally, tissue engineered gingival equivalents are described as the basis for future 3D-printed oral soft tissue constructs. The existing knowledge exploring different approaches could be applied to produce patient-tailored 3D-printed oral soft tissue graft with an appropriate inner architecture and outer shape, leading to a functional as well as aesthetically satisfying outcome.

Visualization of the complex structure and stress field inside rock by means of 3D printing technology

2014 ◽  
Vol 59 (36) ◽  
pp. 5354-5365 ◽  
Author(s):  
Yang Ju ◽  
Heping Xie ◽  
Zemin Zheng ◽  
Jinbo Lu ◽  
Lingtao Mao ◽  
...  
Keyword(s):  
3D Printing ◽  
Stress Field ◽  
Complex Structure ◽  
Printing Technology ◽  
3D Printing Technology

scholarly journals Application of 3D Printing in Implantable Medical Devices

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Zhenzhen Wang ◽  
Yan Yang
Keyword(s):  
3D Printing ◽  
Medical Devices ◽  
Complex Structure ◽  
Development Trend ◽  
Implantable Medical Device ◽  
Implantable Medical Devices ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Material Utilization

3D printing technology is widely used in the field of implantable medical device in recent decades because of its advantages in high precision, complex structure, and high material utilization. Based on the characteristics of 3D printing technology, this paper reviews the manufacturing process, materials, and some typical products of 3D printing implantable medical devices and analyzes and summarizes the development trend of 3D printed implantable medical devices.

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