Formation of Uni-Lamellar Vesicles in Mixtures of DPPC with PEO-b-PCL Amphiphilic Diblock Copolymers

The ability of mixtures of 1.2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and the amphiphilic diblock copolymers poly (ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) to stabilize uni-lamellar nano-vesicles is reported. Small angle neutron scattering (SANS) is used to define their size distribution and bilayer structure and resolve the copresence of aggregates and clusters in solution. The vesicles have a broad size distribution which is compatible with bilayer membranes of relatively low bending stiffness. Their mean diameter increases moderately with temperature and their number density and mass is higher in the case of the diblock copolymer with the larger hydrophobic block. Bayesian analysis is performed in order to justify the use of the particular SANS fitting model and confirm the reliability of the extracted parameters. This study shows that amphiphilic block copolymers can be effectively used to prepare mixed lipid-block copolymer vesicles with controlled lamellarity and a significant potential as nanocarriers for drug delivery.

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Synthesis, characterization and association behavior of linear-dendritic amphiphilic diblock copolymers based on poly(ethylene oxide) and a dendron derived from 2,2′-bis(hydroxymethyl)propionic acid

Polymer Chemistry ◽

10.1039/c4py01385a ◽

2015 ◽

Vol 6 (12) ◽

pp. 2274-2282 ◽

Cited By ~ 14

Author(s):

Weiwei Zhang ◽

Weiwei Jiang ◽

Delong Zhang ◽

Guangyue Bai ◽

Pengxiao Lou ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Oxide ◽

Propionic Acid ◽

Diblock Copolymers ◽

Association Behavior ◽

Poly Ethylene Oxide ◽

Amphiphilic Diblock Copolymers ◽

Poly Ethylene

Two new amphiphilic linear-dendritic block copolymers have been synthesized and characterized. And their association behaviors have also been studied.

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Synthesis and Self-Assembly Behavior of Chiral Amphiphilic Diblock Copolymers Bearing L-Phenylalanine

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.345.334 ◽

2011 ◽

Vol 345 ◽

pp. 334-337

Author(s):

Yong Zhou ◽

Bing Liu

Keyword(s):

Amino Acid ◽

Self Assembly ◽

Diblock Copolymers ◽

Dihydrogen Phosphate ◽

Sodium Dihydrogen Phosphate ◽

Poly Ethylene Oxide ◽

Amphiphilic Diblock Copolymers ◽

Assembly Behavior ◽

Poly Ethylene ◽

Sodium Dihydrogen

Novel chiral amphiphilic diblock copolymers bearing L-phenylalanine was synthesized using a “click” reaction of N3-L-phenylalanine and MPEO-b-PGPE. The structure and composition of copolymers were characterized by 1H-NMR and elemental analysis. Additionally, the self-assembly behavior of these chiral copolymers was investigated in sodium dihydrogen phosphate buffer (pH 4.5): the CMC of copolymer MPEO-b-PGTP determined by the measurement of surface tension was 2.1 mg/mL; the size and morphology of the micelles were studied using TEM; the specific optical rotation ([α]25D) of the micellar solutions was also measured; the result indicated that the copolymers can form chiral micelles in sodium dihydrogen phosphate buffer (pH =4.5).In recent years, the synthesis, structure and properties of optically active polymer have been paid attention by scientists owing to its potential applications in chiral separation, asymmetric adsorption, chiral synthesis[1]. The amphiphilic block polymers bearing amino acid possess not only the characteristics of the conventional amphiphilic block copolymer, but also good optically activity and biocompatibility. So it can be employed as nanoreactors for asymmetrical catalysis and materials for drug delivery. But there have been few reports published on the synthesis of chiral amphiphilic copolymers bearing amino acid. Sutthira Sutthasupa reported the synthesis of amino acid-based norbornene block copolymer with ester and carboxyl groups as hydrophobic and hydrophilic units[2]. O’Reilly group synthesized the amino acid-based chiral amphiphilic block copolymers using RAFT technique, and elucidated its self-assembly into spherical micelles with optically active hydrophobic core[3]. In the present work, chiral amphiphilic diblock copolymers bearing L-phenylalanine (L-Phe) pendants poly(ethylene oxide)-b-poly (glycidyl triazolyl-L-phenylalanine) (MPEO-b-PGTP) have been synthesized by the modification of poly(ethylene oxide)-b-poly (propargyl glycidyl ether) (MPEO-b-PGPE) with L-phenylalanine.

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Block Copolymer Nanosystems Encapsulating Magnetic Nanoparticles and Drug

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2020.17682 ◽

2020 ◽

Vol 20 (7) ◽

pp. 3981-3988 ◽

Cited By ~ 1

Author(s):

E. Vlassi ◽

A. Papagiannopoulos ◽

A. Sergides ◽

S. Pispas

Keyword(s):

Magnetic Nanoparticles ◽

Ethylene Oxide ◽

Diblock Copolymers ◽

Serum Proteins ◽

Aqueous Media ◽

Self Assembling ◽

Bio Imaging ◽

Poly Ethylene Oxide ◽

Amphiphilic Diblock Copolymers ◽

Poly Ethylene

The goal of this study was to investigate the solution behavior of nanosystems composed of self-assembling amphiphilic diblock copolymers, poly(ethylene oxide-b-phenyl oxazoline) and poly(isoprene-b-ethylene oxide) (PEO-b-PPhOx and PI-b-PEO), with encapsulated iron oxide nanoparticles (γ-Fe2O3). The hybrid nanosystems were tested in aqueous solution, under physiological conditions and in mixtures with serum proteins. Light scattering methods were used to probe changes in size and mass of the formed aggregates in different solution conditions and as a function of storage time. The developed stable hybrid systems with encapsulated magnetic nanoparticles were able to entrap the anti-inflammatory drug, indomethacin. This work demonstrates versatile nanosystems with metal oxide characteristics for bio-imaging and the potential for drug delivery in aqueous media.

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Novel poly(ethylene oxide monomethyl ether)-b-poly(ε-caprolactone) diblock copolymers containing a pH-acid labile ketal group as a block linkage

Polymer Chemistry ◽

10.1039/c4py00114a ◽

2014 ◽

Vol 5 (12) ◽

pp. 3884-3893 ◽

Cited By ~ 21

Author(s):

S. Petrova ◽

E. Jäger ◽

R. Konefał ◽

A. Jäger ◽

C. G. Venturini ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Oxide ◽

Diblock Copolymers ◽

Degradation Products ◽

Monomethyl Ether ◽

Amphiphilic Block Copolymers ◽

Physiological Conditions ◽

Poly Ethylene Oxide ◽

Poly Ethylene ◽

Acid Labile

Acidic physiological conditions trigger degradation of amphiphilic block copolymers containing a ketal group as a block linkage into biocompatible degradation products.

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Synthesis of new amphiphilic diblock copolymers containing poly(ethylene oxide) and poly(?-olefin)

Journal of Polymer Science Part A Polymer Chemistry ◽

10.1002/pola.10427 ◽

2002 ◽

Vol 40 (20) ◽

pp. 3416-3425 ◽

Cited By ~ 34

Author(s):

Yingying Lu ◽

Youliang Hu ◽

Z. M. Wang ◽

E. Manias ◽

T. C. Chung

Keyword(s):

Ethylene Oxide ◽

Diblock Copolymers ◽

Poly Ethylene Oxide ◽

Amphiphilic Diblock Copolymers ◽

Poly Ethylene

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Synthesis and self-association in aqueous media of poly(ethylene oxide)/poly(ethyl glycidyl carbamate) amphiphilic block copolymers

Polymer ◽

10.1016/j.polymer.2006.05.030 ◽

2006 ◽

Vol 47 (14) ◽

pp. 4905-4915 ◽

Cited By ~ 36

Author(s):

Philip Dimitrov ◽

Alicja Utrata-Wesołek ◽

Stanislav Rangelov ◽

Wojciech Wałach ◽

Barbara Trzebicka ◽

...

Keyword(s):

Block Copolymers ◽

Ethylene Oxide ◽

Aqueous Media ◽

Amphiphilic Block Copolymers ◽

Poly Ethylene Oxide ◽

Self Association ◽

Poly Ethylene ◽

Glycidyl Carbamate

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Amphiphilic Diblock Copolymers of Poly(glycidol) with Biodegradable Polyester/Polycarbonate. Organocatalytic One-Pot ROP and Self-Assembling Property

Polymer Chemistry ◽

10.1039/d1py01026c ◽

2021 ◽

Author(s):

Tingyu He ◽

Atsushi Narumi ◽

Yanqiu Wang ◽

Liang Xu ◽

Shin-ichiro Sato ◽

...

Keyword(s):

Block Copolymers ◽

Diblock Copolymers ◽

Amphiphilic Block Copolymers ◽

Synthetic Method ◽

Biodegradable Polyester ◽

One Pot ◽

Self Assembling ◽

Amphiphilic Diblock Copolymers

A synthetic method for a series of poly(glycidol) (PG)-based amphiphilic block copolymers is presented with an emphasis on the catalyst switch method from an organic superbase (t-Bu-P4) to another with...

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