scholarly journals Synthesis and Characterization of a Fe3O4@PNIPAM-Chitosan Nanocomposite and Its Potential Application in Vincristine Delivery

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1704
Author(s):  
Cynthia N. Hernández-Téllez ◽  
Ana G. Luque-Alcaraz ◽  
Maribel Plascencia-Jatomea ◽  
Hiram J. Higuera-Valenzuela ◽  
Mabeth Burgos-Hernández ◽  
...  
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Release Kinetics ◽  
Magnetic Core ◽  
Systematic Evaluation ◽  
Solution Temperature ◽  
Core Shell ◽  
Particle Size And Morphology ◽  
Size And Morphology ◽  
Thermomagnetic Properties ◽  
Release Model

In this research, we conducted a systematic evaluation of the synthesis parameters of a multi-responsive core-shell nanocomposite (Fe3O4 nanoparticles coated by poly(N-isopropylacrylamide) (PNIPAM) in the presence of chitosan (CS) (Fe3O4@PNIPAM-CS). Scanning electron microscopy (SEM) was used to follow the size and morphology of the nanocomposite. The functionalization and the coating of Fe3O4 nanoparticles (Nps) were evaluated by the ζ-potential evolution and Fourier Transform infrared spectroscopy (FTIR). The nanocomposite exhibited a collapsed structure when the temperature was driven above the lower critical solution temperature (LCST), determined by dynamic light scattering (DLS). The LCST was successfully shifted from 33 to 39 °C, which opens the possibility of using it in physiological systems. A magnetometry test was performed to confirm the superparamagnetic behavior at room temperature. The obtained systems allow the possibility to control specific properties, such as particle size and morphology. Finally, we performed vincristine sulfate loading and release tests. Mathematical analysis reveals a two-stage structural-relaxation release model beyond the LCST. In contrast, a temperature of 25 °C promotes the diffusional release model. As a result, a more in-depth comprehension of the release kinetics was achieved. The synthesis and study of a magnetic core-shell nanoplatform offer a smart material as an alternative targeted release therapy due to its thermomagnetic properties.

scholarly journals Novel magnetic core-shell polypyrrole-Fe3O4 nanoparticles functionalized by peptides or albumin

ARKIVOC ◽  
2010 ◽  
Vol 2010 (10) ◽  
pp. 185-198 ◽  
Author(s):  
Alexandrina Nan ◽  
Izabell Craciunescu ◽  
Rodica Turcu ◽  
Ioan Bratu ◽  
Cristian Leostean ◽  
...  
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Magnetic Core ◽  
Core Shell

scholarly journals Novel magnetic core–shell Ce–Ti@Fe3O4 nanoparticles as an adsorbent for water contaminants removal

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 56913-56917 ◽  
Author(s):  
Ahmad A. Markeb ◽  
Laura A. Ordosgoitia ◽  
Amanda Alonso ◽  
Antoni Sánchez ◽  
Xavier Font
Keyword(s):  
Fe3o4 Nanoparticles ◽  
Magnetic Core ◽  
Core Shell ◽  
Experimental Conditions ◽  
Water Contaminants ◽  
Contaminants Removal ◽  
Cerium Titanate

Magnetic core–shell Ce–Ti@Fe3O4 nanoparticles were synthesized by coating cerium titanate on magnetite under mild experimental conditions.

Direct manipulation of particle size and morphology of ordered mesoporous silica by flow synthesis

RSC Advances ◽  
2015 ◽  
Vol 5 (18) ◽  
pp. 13331-13340 ◽  
Author(s):  
T. N. Ng ◽  
X. Q. Chen ◽  
K. L. Yeung
Keyword(s):  
Particle Size ◽  
Mesoporous Silica ◽  
Hollow Spheres ◽  
Ordered Mesoporous Silica ◽  
Direct Manipulation ◽  
Flow Synthesis ◽  
Precise Control ◽  
Ordered Mesoporous ◽  
Particle Size And Morphology ◽  
Size And Morphology

Flow-synthesis of mesoporous silica allows deliberate and precise control over the size and shapes and enables the preparation of complex microstructures (i.e., hollow spheres).

Designing active mats based on cellulose acetate/polycaprolactone core/shell structures with different release kinetics

2021 ◽  
Vol 261 ◽  
pp. 117849 ◽  
Author(s):  
Adrián Rojas ◽  
Eliezer Velásquez ◽  
Constanza Piña ◽  
María José Galotto ◽  
Carol López de Dicastillo
Keyword(s):  
Cellulose Acetate ◽  
Release Kinetics ◽  
Shell Structures ◽  
Core Shell

scholarly journals Fabrication of copper(II)-coated magnetic core-shell nanoparticles Fe3O4@SiO2-2-aminobenzohydrazide and investigation of its catalytic application in the synthesis of 1,2,3-triazole compounds

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
H. Rajabi-Moghaddam ◽  
M. R. Naimi-Jamal ◽  
M. Tajbakhsh
Keyword(s):  
High Efficiency ◽  
Click Reaction ◽  
Magnetic Core ◽  
Core Shell ◽  
Isatoic Anhydride ◽  
Shell Nanoparticles ◽  
Triazole Derivatives ◽  
Catalytic Application ◽  
Ft Ir ◽  
Core Shell Nanoparticles

AbstractIn the present work, an attempt has been made to synthesize the 1,2,3-triazole derivatives resulting from the click reaction, in a mild and green environment using the new copper(II)-coated magnetic core–shell nanoparticles Fe3O4@SiO2 modified by isatoic anhydride. The structure of the catalyst has been determined by XRD, FE-SEM, TGA, VSM, EDS, and FT-IR analyzes. The high efficiency and the ability to be recovered and reused for at least up to 6 consecutive runs are some superior properties of the catalyst.

scholarly journals Supercritical Carbon Dioxide as a Green Alternative to Achieve Drug Complexation with Cyclodextrins

2021 ◽  
Vol 14 (6) ◽  
pp. 562
Author(s):  
Mauro Banchero
Keyword(s):  
Release Kinetics ◽  
Drug Bioavailability ◽  
Residual Content ◽  
Supercritical Solvent ◽  
Cyclodextrin Complexation ◽  
Supercritical Fluid Technology ◽  
Conventional Drug ◽  
Size And Morphology ◽  
Solvent Residue ◽  
Complexation Mechanism

Cyclodextrins are widely used in pharmaceutics to enhance the bioavailability of many drugs. Conventional drug/cyclodextrin complexation techniques suffer from many drawbacks, such as a high residual content of toxic solvents in the formulations, the degradation of heat labile drugs and the difficulty in controlling the size and morphology of the product particles. These can be overcome by supercritical fluid technology thanks to the outstanding properties of supercritical CO2 (scCO2) such as its mild critical point, its tunable solvent power, and the absence of solvent residue after depressurization. In this work the use of scCO2 as an unconventional medium to achieve the complexation with native and substituted cyclodextrins of over 50 drugs, which belong to different classes, are reviewed. This can be achieved with different approaches such as the “supercritical solvent impregnation” and “particle-formation” techniques. The different techniques are discussed to point out how they affect the complexation mechanism and efficiency, the physical state of the drug as well as the particle size distribution and morphology, which finally condition the release kinetics and drug bioavailability. When applicable, the results obtained for the same drug with various cyclodextrins, or different complexation techniques are compared with those obtained with conventional approaches.

Preparation of High-Purity Ultrafine α-Al2O3 by Solid-State Reaction at Room Temperature

2008 ◽  
Vol 368-372 ◽  
pp. 683-685
Author(s):  
Cheng Wei Hao ◽  
Bo Lin Wu ◽  
Ji Yan Li
Keyword(s):  
Solid State ◽  
High Purity ◽  
Solid State Reaction ◽  
Room Temperature ◽  
Raw Materials ◽  
Phase Particle ◽  
Phase Transformation Temperature ◽  
Particle Size And Morphology ◽  
Size And Morphology ◽  
Α Al2o3

Ammonium aluminium carbonate hydroxide (AACH), with a small quantity of γ-AlOOH, was synthesized through solid-state reaction at room temperature using AlCl3·6H2O and NH4HCO3 as raw materials and polyethylene glycol (PEG-10000) as the dispersant. After calcined at 1100°C for 1.5h, α-Al2O3 powders with primary particle sizes of 20~30nm were obtained. The crystal phase, particle size and morphology of the high-purity ultrafine α-Al2O3 were characterized. The results showed that a small quantity of γ-AlOOH in the AACH decomposed and formed crystal seeds. The presence of crystal seeds reduced the nucleation activation energy and therefore reduced the phase transformation temperature.

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