scholarly journals Highly Efficient Synthesis of Type B Gelatin and Low Molecular Weight Chitosan Nanoparticles: Potential Applications as Bioactive Molecule Carriers and Cell-Penetrating Agents

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4078
Author(s):  
Cristina Gonzalez-Melo ◽  
Andres J. Garcia-Brand ◽  
Valentina Quezada ◽  
Luis H. Reyes ◽  
Carolina Muñoz-Camargo ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Chitosan Nanoparticles ◽  
Synthesis Method ◽  
Low Molecular Weight ◽  
Type B ◽  
Efficient Synthesis ◽  
Gelatin Nanoparticles ◽  
Highly Efficient ◽  
Cell Penetrating ◽  
Bioactive Molecule

Gelatin and chitosan nanoparticles have been widely used in pharmaceutical, biomedical, and nanofood applications due to their high biocompatibility and biodegradability. This study proposed a highly efficient synthesis method for type B gelatin and low-molecular-weight (LMW) chitosan nanoparticles. Gelatin nanoparticles (GNPs) were synthesized by the double desolvation method and the chitosan nanoparticles (CNPs) by the ionic gelation method. The sizes of the obtained CNPs and GNPs (373 ± 71 nm and 244 ± 67 nm, respectively) and zeta potential (+36.60 ± 3.25 mV and −13.42 ± 1.16 mV, respectively) were determined via dynamic light scattering. Morphology and size were verified utilizing SEM and TEM images. Finally, their biocompatibility was tested to assure their potential applicability as bioactive molecule carriers and cell-penetrating agents.

Low molecular weight protamine (LMWP): A nontoxic protamine substitute and an effective cell-penetrating peptide

2014 ◽  
Vol 193 ◽  
pp. 63-73 ◽  
Author(s):  
Huining He ◽  
Junxiao Ye ◽  
Ergang Liu ◽  
Qiuling Liang ◽  
Quan Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Cell Penetrating

scholarly journals Effects of low-molecular-weight organic acids on the dissolution of hydroxyapatite nanoparticles

2016 ◽  
Vol 3 (4) ◽  
pp. 768-779 ◽  
Author(s):  
Dengjun Wang ◽  
Yunsong Xie ◽  
Deb P. Jaisi ◽  
Yan Jin
Keyword(s):  
Molecular Weight ◽  
Organic Acids ◽  
Environmentally Benign ◽  
Low Molecular Weight ◽  
Hydroxyapatite Nanoparticles ◽  
Modern Agriculture ◽  
Highly Efficient

Hydroxyapatite nanoparticles (HANPs) have recently been advocated as a highly efficient and environmentally benign ‘green’ phosphorus (P) nanofertilizer in modern agriculture.

The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine

Biomaterials ◽  
2010 ◽  
Vol 31 (6) ◽  
pp. 1429-1443 ◽  
Author(s):  
Young-Suk Choi ◽  
Jue Yeon Lee ◽  
Jin Sook Suh ◽  
Young-Min Kwon ◽  
Seung-Jin Lee ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Cell Penetrating Peptide ◽  
Low Molecular Weight ◽  
Systemic Delivery ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Low molecular weight glycerol derived coatings on magnetic nanoparticles: role of initiator, temperature, rate of monomer addition, enhanced biocompatibility and stability

RSC Advances ◽  
2021 ◽  
Vol 11 (63) ◽  
pp. 40140-40147
Author(s):  
Simon Doswald ◽  
Wendelin Jan Stark
Keyword(s):  
Molecular Weight ◽  
Magnetic Nanoparticles ◽  
Low Molecular Weight ◽  
Coating Process ◽  
Highly Efficient ◽  
Temperature Rate

A highly efficient coating process of magnetic nanoparticles with hyperbranched polyglycidol was investigated and the resulting particles were tested towards their biocompatible capabilities.

scholarly journals Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1681 ◽  
Author(s):  
Janaína Artem Ataide ◽  
Eloah Favero Gérios ◽  
Letícia Caramori Cefali ◽  
Ana Rita Fernandes ◽  
Maria do Céu Teixeira ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Physicochemical Properties ◽  
Enzyme Stability ◽  
Proteolytic Enzymes ◽  
Chitosan Nanoparticles ◽  
Low Molecular Weight ◽  
Chitosan Oligosaccharide ◽  
Nanoparticle Suspension ◽  
Accelerated Stability ◽  
Low Molecular Weight Chitosan

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all cases, particle size and zeta potential decreased, and polydispersity index increased after bromelain addition. Bromelain encapsulation was higher than 84% and 79% for protein content and enzymatic activity, respectively, with low molecular weight chitosan presenting the highest encapsulation efficiency. Nanoparticle suspension was also tested for accelerated stability and rheological behavior. For the chitosan–bromelain nanoparticles, an instability index below 0.3 was recorded and, in general, the loading of bromelain in chitosan nanoparticles decreased the cohesiveness of the final suspension.

Chloride-promoted Pd-catalyzed direct C–H arylation for highly efficient phosphine-free synthesis of π-conjugated polymers

2015 ◽  
Vol 6 (28) ◽  
pp. 5036-5039 ◽  
Author(s):  
Shotaro Hayashi ◽  
Toshio Koizumi
Keyword(s):  
Molecular Weight ◽  
Conjugated Polymers ◽  
High Molecular Weight ◽  
Efficient Synthesis ◽  
Highly Efficient

We have successfully demonstrated a chloride-promoted Pd-catalyzed phosphine-free direct C–H arylation for highly efficient synthesis of high molecular weight π-conjugated polymers.

Efficient synthesis of the nonamannoside residue of high mannose glycoproteins

2005 ◽  
Vol 83 (6-7) ◽  
pp. 693-701 ◽  
Author(s):  
Lu Jiang ◽  
Tak Hang Chan
Keyword(s):  
Molecular Weight ◽  
Polyethylene Glycol ◽  
Key Words ◽  
Building Blocks ◽  
Polymer Support ◽  
Low Molecular Weight ◽  
Oligosaccharide Synthesis ◽  
Efficient Synthesis ◽  
Solution Synthesis ◽  
High Mannose

An efficient synthesis of the nonamannoside residue 1 of high mannose glycoproteins was achieved using an oligomer-supported solution synthesis with low-molecular-weight polyethylene glycol as the anchor. The synthesis required only five coupling steps from only two monosaccharide building blocks with an overall yield of 12%.Key words: nonamannoside, oligosaccharide synthesis, soluble polymer support synthesis, glycoproteins.

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