scholarly journals Time-of-Flight Imaging at 10 ps Resolution with an ICCD Camera

Sensors ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 180 ◽  
Author(s):  
Lucrezia Cester ◽  
Ashley Lyons ◽  
Maria Chiara Braidotti ◽  
Daniele Faccio

ICCD cameras can record low light events with extreme temporal resolution. Thus, they are used in a variety of bio-medical applications for single photon time of flight measurements and LIDAR measurements. In this paper, we present a method which allows improvement of the temporal resolution of ICCD cameras down to 10 ps (from the native 200 ps of our model), thus placing ICCD cameras at a better temporal resolution than SPAD cameras and in direct competition with streak cameras. The higher temporal resolution can serve for better tracking and visualization of the information carried in time-of-flight measurements.


2020 ◽  
pp. 1-1
Author(s):  
Francois Piron ◽  
Daniel Morrison ◽  
Mehmet R. Yuce ◽  
Jean-Michel Redoute


Author(s):  
Ashley Lyons ◽  
Alessandro Boccolini ◽  
Francesco Tonolini ◽  
Audrey Repetti ◽  
Zhouye Chen ◽  
...  


2012 ◽  
Vol 39 (10) ◽  
pp. 1470-1475
Author(s):  
Guo-Bin TAN ◽  
Wei GAO ◽  
Zheng-Xu HUANG ◽  
Yi HONG ◽  
Zhong FU ◽  
...  


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
C. Callenberg ◽  
A. Lyons ◽  
D. den Brok ◽  
A. Fatima ◽  
A. Turpin ◽  
...  

AbstractImaging across both the full transverse spatial and temporal dimensions of a scene with high precision in all three coordinates is key to applications ranging from LIDAR to fluorescence lifetime imaging. However, compromises that sacrifice, for example, spatial resolution at the expense of temporal resolution are often required, in particular when the full 3-dimensional data cube is required in short acquisition times. We introduce a sensor fusion approach that combines data having low-spatial resolution but high temporal precision gathered with a single-photon-avalanche-diode (SPAD) array with data that has high spatial but no temporal resolution, such as that acquired with a standard CMOS camera. Our method, based on blurring the image on the SPAD array and computational sensor fusion, reconstructs time-resolved images at significantly higher spatial resolution than the SPAD input, upsampling numerical data by a factor $$12 \times 12$$ 12 × 12 , and demonstrating up to $$4 \times 4$$ 4 × 4 upsampling of experimental data. We demonstrate the technique for both LIDAR applications and FLIM of fluorescent cancer cells. This technique paves the way to high spatial resolution SPAD imaging or, equivalently, FLIM imaging with conventional microscopes at frame rates accelerated by more than an order of magnitude.



2021 ◽  
Vol 11 (6) ◽  
pp. 2773
Author(s):  
Hiroaki Yokota ◽  
Atsuhito Fukasawa ◽  
Minako Hirano ◽  
Toru Ide

Over the years, fluorescence microscopy has evolved and has become a necessary element of life science studies. Microscopy has elucidated biological processes in live cells and organisms, and also enabled tracking of biomolecules in real time. Development of highly sensitive photodetectors and light sources, in addition to the evolution of various illumination methods and fluorophores, has helped microscopy acquire single-molecule fluorescence sensitivity, enabling single-molecule fluorescence imaging and detection. Low-light photodetectors used in microscopy are classified into two categories: point photodetectors and wide-field photodetectors. Although point photodetectors, notably photomultiplier tubes (PMTs), have been commonly used in laser scanning microscopy (LSM) with a confocal illumination setup, wide-field photodetectors, such as electron-multiplying charge-coupled devices (EMCCDs) and scientific complementary metal-oxide-semiconductor (sCMOS) cameras have been used in fluorescence imaging. This review focuses on the former low-light point photodetectors and presents their fluorescence microscopy applications and recent progress. These photodetectors include conventional PMTs, single photon avalanche diodes (SPADs), hybrid photodetectors (HPDs), in addition to newly emerging photodetectors, such as silicon photomultipliers (SiPMs) (also known as multi-pixel photon counters (MPPCs)) and superconducting nanowire single photon detectors (SSPDs). In particular, this review shows distinctive features of HPD and application of HPD to wide-field single-molecule fluorescence detection.



Author(s):  
C. Oprea ◽  
I. Pirnog ◽  
I. Marcu ◽  
M. Udrea


1980 ◽  
Vol 169 (1) ◽  
pp. 185-198 ◽  
Author(s):  
S. Cierjacks ◽  
F. Hinterberger ◽  
G. Schmalz ◽  
D. Erbe ◽  
P.v. Rossen ◽  
...  


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