scholarly journals Mucoadhesion and Mucopenetration of Cannabidiol (CBD)-Loaded Mesoporous Carrier Systems for Buccal Drug Delivery

2021 ◽  
Vol 89 (3) ◽  
pp. 35
Author(s):  
Ulrike Söpper ◽  
Anja Hoffmann ◽  
Rolf Daniels
Keyword(s):  
Drug Delivery ◽  
Propylene Glycol ◽  
Fold Increase ◽  
Carrier System ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Penetration Ability ◽  
Effective Delivery ◽  
Mucosal Absorption ◽  
Carrier Systems

Transmucosal drug delivery represents a promising noninvasive option when drugs are employed which have a low oral bioavailability like CBD. However, this concept can only be successful as long as the formulation provides sufficient buccal retention and mucosal penetration. In this study, mucoadhesive carrier systems were evaluated consisting of CBD-loaded silica (Aeroperl 300) carriers, mucoadhesive polymers (Hypromellose (HPMC), chitosan and carbomer) and propylene glycol as a penetration enhancer. Mucoadhesive effect, drug release and penetration ability were evaluated for each carrier system. The results show that the addition of HPMC and carbomer substantially improve mucoadhesion compared to pure CBD, with an increase of 16-fold and 20-fold, respectively. However, due to their strong swelling, HPMC and carbomer hinder the penetration of CBD and rely on co-administration of propylene glycol as an enhancer to achieve sufficient mucosal absorption. Chitosan, on the other hand, achieves an 8-fold increase in mucoadhesion and enhances the amount of CBD absorbed by three times compared to pure CBD. Thus, chitosan represents a promising polymer to combine both effects. Considering the results, the development of silica-based buccal drug delivery systems is a promising approach for the effective delivery of CBD.

The use of mucoadhesive polymers in buccal drug delivery

2005 ◽  
Vol 57 (11) ◽  
pp. 1666-1691 ◽  
Author(s):  
N SALAMATMILLER ◽  
M CHITTCHANG ◽  
T JOHNSTON
Keyword(s):  
Drug Delivery ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery

Nanoemulsion as a Nano Carrier System in Drug Delivery: A Review

2021 ◽  
Vol 14 (2) ◽  
pp. 5353-5363
Author(s):  
Dharmendra Jain ◽  
Nagesh Dewangan ◽  
Dhalendra Kothale, ◽  
Utsav Verma
Keyword(s):  
Drug Delivery ◽  
Phase Inversion ◽  
Microbial Contamination ◽  
Colloidal Dispersions ◽  
Carrier System ◽  
Hydrophilic Drug ◽  
Globule Size ◽  
Effective Delivery ◽  
Diagnostic Agent ◽  
The Stability

Nanoemulsions are colloidal dispersions having smaller globule size that ranges from 20-600 nm. They are clear transparent and kinetically stable formulations commonly available in the form of creams, shampoos, gels, sprays and aerosols. Nanoemulsions are nano carrier drug delivery system for the protection of drugs from severe environmental conditions like pH, oxidation and hydrolysis. Nanoemulsions are normally contains oil phase, aqueous phase, surfactants and co-surfactants. Different methods are employed for the preparations of nanoemulsions are high pressure homogenization, microfluidization, ultrasonication, spontaneous emulsifi- cation, membrane emulsification, phase inversion temperature and solvent displacement method. The stability of the nanoemulsions has the ability to protect the dosage unit microbial contamination physically and chemically. They can be administered via nasal route, orally, topically, transdermally and also used as prophylactically in bio-terrorism attack and as diagnostic agent. They can be used for the delivery of various types of drugs like vaccines, DNA encoded drugs, antibiotics and vitamins. Various patents on nanoemulsions are also discussed. Nanoemulsions are nano carrier system with safe and effective delivery of lipophilic and hydrophilic drug and also used in targeting.

Current Status of Mucoadhesive Gel Systems for Buccal Drug Delivery

2021 ◽  
Vol 27 ◽  
Author(s):  
Neslihan Üstündağ Okur ◽  
Ece Özcan Bülbül ◽  
Ayşe Pınar Yağcılar ◽  
Panoraia I. Siafaka
Keyword(s):  
Drug Delivery ◽  
Research Field ◽  
Current Status ◽  
Colloidal Systems ◽  
Mucoadhesive Polymers ◽  
Thermal Gelation ◽  
Buccal Drug Delivery ◽  
Gelation Behavior ◽  
Gel Phase

Background: Buccal drug delivery is a fascinating research field. Gel-based formulations present potent characteristics as buccal systems since they have great physicochemical properties. Methods: Among the various gels, in situ gels that are viscous colloidal systems consisted of polymers when physiological conditions change (pH, temperature, ion activation) shift to the gel phase. These systems can improve bioavailability. Other systems such as nanogels or emulgels can be also applied for buccal delivery with promising results. Polymeric gel-based systems can be produced by natural, semisynthetic, and synthetic polymers. Their main advantage is that the active molecules can be released in a sustained and controllable manner. Several gels based on chitosan are produced for the entrapment of drugs demonstrating efficient retention time and bioavailability, due to chitosan mucoadhesion. Besides polysaccharides, poloxamers and Carbopol are also used in buccal gels due to their high swelling ability and reversed thermal gelation behavior. Results: Herein, the authors focused on the current development of mucoadhesive gel systems used in buccal drug delivery. After explaining buccal drug delivery and mucoadhesion, various studies with hydrogels, in situ gels, and nanogels were analyzed as buccal gel systems. Various mucoadhesive gel studies with mucoadhesive polymers have been studied and summarized. This review is presented as valuable guidance to scientists in formulating buccal mucoadhesive drug delivery systems. Conclusions: This review aimed to assist researchers working on buccal drug delivery by summarizing buccal drug delivery, mucoadhesion, and buccal mucoadhesive gel systems recently found in the literature.

Recent progress in mucoadhesive polymers for buccal drug delivery applications

2020 ◽  
pp. 213-240
Author(s):  
Manu Sharma ◽  
Aishwarya Rathore ◽  
Sheelu Sharma ◽  
Veera Sadhu ◽  
Kakarla Raghava Reddy ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Recent Progress ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Drug Delivery Applications

Recent Developments and Potential of Mucoadhesive Buccal Drug Delivery System for Oro-mucosal Disorders

2020 ◽  
Vol 2 (1) ◽  
pp. 12-28
Author(s):  
Deepak Sharma ◽  
Rajeev Garg
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Absorption ◽  
Target Site ◽  
Limited Area ◽  
Epithelial Surface ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Recent Developments

Background: The drug delivery across buccal mucosa is a very interesting option for the treatment of various oro-mucosal disorders such as aphthous stomatitis, periodontitis, gingivitis, toothache, periodontitis, and sjorgensen syndrome. But it is quite difficult because of target site movements, limited area for drug absorption, drinking of fluids, intake of food and saliva flow at regular intervals, contributing to poor retention and sub-therapeutic level of drug at the target site. Due to this, the mucoadhesive buccal drug delivery system has gained a great deal of attention among the various scientists and researchers over the last two decades. Methods: Mucoadhesion is a process of attachment between the natural or synthetic macromolecule and mucosal epithelial surface with the aid of interfacial attractive forces. The process of mucoadhesion has been extensively encouraged by the utilization of mucoadhesive polymers within the formulation that on contact with salivary fluid swells and adheres to buccal epithelium membrane, thus prolonging the drug release, retention time and improving therapeutic performance in case of oral diseases. The present review tries to cover the basic anatomy and structure of oral mucosa, pathways of drug absorption, the theory of mucoadhesion, mechanisms involved in mucoadhesion and various factors affecting mucoadhesion. Results: It highlights the properties of mucoadhesive polymers in drug delivery along with various dosage forms such as mucoadhesive tablets, films, patches, gels, and pastes. Furthermore, it also sheds light on the recent developments made in the field of mucoadhesive buccal drug delivery system that reflects the potential of this system for the effective treatment of oro-mucosal disorders. Conclusion: It can be concluded that the mucoadhesive buccal drug delivery system has great potential in the near future for treating oro-mucosal disorders.

scholarly journals An Advanced Review on Resealed Erythrocytes

2019 ◽  
Vol 7 (6) ◽  
pp. 55-61
Author(s):  
Gousia S. Begum ◽  
Mustafa D
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Loading ◽  
Bioactive Molecules ◽  
Specific Drug ◽  
Site Specific ◽  
Enzyme Replacement ◽  
Effective Delivery ◽  
Novel Drug ◽  
Carrier Systems

Now a days there are numerous applications have been proposed for the use of resealed erythrocytes as carrier for drugs, enzyme replacement therapy etc. Until other carrier systems come of age, resealed erythrocytes technology will remain an active field for the further research. The use of resealed erythrocytes shows potential for a safe and effective delivery of various bioactive molecules for effective targeting. In coming future, erythrocyte based drug delivery system with their capability to afford controlled and site specific drug delivery have been developed for disease management. Erythrocyte carriers are “Nano devices in the field of Nanotechnology”. A large amount of valuable work is needed so as to utilize the potentials of erythrocytes in passive as well as active targeting of drugs in diseases like cancer. At present erythrocytes are most effective carriers in novel drug delivery systems considering their tremendous potential. Hence the present article is reviewed about method of drug loading, evaluation and applications of RSE.

scholarly journals AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

2021 ◽  
pp. 66-74
Author(s):  
LEELA LAKSHMI V. ◽  
UMASHANKAR M. S. ◽  
ALAGUSUNDARAM M.
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Mucoadhesive Polymers ◽  
Buccal Drug Delivery ◽  
Delivery Mechanism ◽  
Mucosal Drug Delivery ◽  
Systemic Drug Delivery ◽  
Systemic Drug

Buccal drug delivery system (BDDS) has won a variety of exposure and traction as it possesses plenty of advantages and benefits as evaluate to different mucosal drug delivery systems. Buccal path for systemic drug delivery, the use of mucoadhesive polymers twill significantly increase the efficacy of many tablets, has been of outstanding interest over the previous couple of decades. This article affords a precise of BDDS mechanisms, consisting of a composition of the oral mucosa, delivery mechanism, numerous forms of BDDS, formulation, assessment and application of BDDS. Additionally, this text affords a precis over the patents, advertised products and destiny factors of BDDS. In this evaluation article, we've got tried to assemble the maximum significant reports (1988 to 2021) of formulation, assessment, application, patents of BDDS. This review will help pharmaceutical researchers to clarify the potential of BDDS to overcome the various existing drug delivery dispute like the efficiency of absorption, permeability and bioavailability of drugs.

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