Systematic Review Comparing the Effectiveness of Robotic verse Laparoscopic Liver Surgery in Colorectal Liver Metastasis (CRLM)

Introduction: Colorectal cancer (CRC) is the third most common cancer in the world. The liver is the most common site of metastasis with 15 to 25% of patients presenting with synchronous colorectal liver metastasis (CRLM). This study is aimed at evaluating the long- and short-term outcomes of laparoscopic and robotic CRLM surgery, and directly comparing their respective effectiveness. Methodology: A literature search was performed and all studies that reported on operative characteristics, oncological outcomes for CRLM, morbidity or mortality and cost-effectiveness on robotic or laparoscopic surgery were included. The study design was in keeping with the PRISMA guidelines. Results: From the initial 606 manuscripts identified, 19 studies were included in the final qualitative analysis. A total of 1340 patients with 1194 LLR (Laparoscopic Liver Resection) and 146 RLR (Robotic Liver Resection) cases were analysed. Within the LLR group, the average tumour size excised was 32.1 mm compared to the RLR group of 33.8 mm. The average operative time in the LLR was 193 min, CI of 95% (147.4 min to 238.6 min) compared to RLR 257 min, CI of 95% (201.5 min to 313.8 min) with a p-value < 0.0001. Estimated blood loss was lower in the RLR group (210 mL) compared with the LLR group (246 mL). Conclusion: Despite the higher operative cost, RLRs do not result in statistically better treatment outcomes, with the exception of lower estimated blood loss and excision of larger CRLMs. Operative time and total complication rate are significantly more favourable with LLRs. Our study has shown that robotic liver surgery is safe and feasible in well-selected patients.

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Safety and Efficacy of Laparoscopic Liver Resection for Colorectal Liver Metastasis With Obesity

The American Surgeon ◽

10.1177/0003134820952448 ◽

2020 ◽

pp. 000313482095244

Author(s):

Yoshihiro Inoue ◽

Masatsugu Ishii ◽

Kensuke Fujii ◽

Kentaro Nihei ◽

Yusuke Suzuki ◽

...

Keyword(s):

Liver Resection ◽

Blood Loss ◽

Laparoscopic Liver Resection ◽

Operative Time ◽

Surgical Site Infections ◽

Obese Patients ◽

Visceral Fat Area ◽

Safety And Efficacy ◽

Estimated Blood Loss ◽

Significant Difference

Introduction Laparoscopic liver resection (LLR) in obese patients has been reported to be particularly challenging owing to technical difficulties and various comorbidities. Methods The safety and efficacy outcomes in 314 patients who underwent laparoscopic or open nonanatomical liver resection for colorectal liver metastases (CRLM) were analyzed retrospectively with respect to the patients’ body mass index (BMI) and visceral fat area (VFA). Results Two hundred and four patients underwent LLR, and 110 patients underwent open liver resection (OLR). The rate of conversion from LLR to OLR was 4.4%, with no significant difference between the BMI and VFA groups ( P = .647 and .136, respectively). In addition, there were no significant differences in terms of operative time and estimated blood loss in LLR ( P = .226 and .368; .772 and .489, respectively). The incidence of Clavien-Dindo grade IIIa or higher complications was not significantly different between the BMI and VFA groups of LLR ( P = .877 and .726, respectively). In obese patients, the operative time and estimated blood loss were significantly shorter and lower, respectively, in LLR than in OLR ( P = .003 and < .001; < .001 and < .001, respectively). There was a significant difference in the incidence of postoperative complications, organ/space surgical site infections, and postoperative bile leakage between the LLR and OLR groups ( P = .017, < .001, and < .001, respectively). Conclusion LLR for obese patients with CRLM can be performed safely using various surgical devices with no major difference in outcomes compared to those in nonobese patients. Moreover, LLR has better safety outcomes than OLR in obese patients.

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Open Partial Nephrectomy with Zero Ischaemia Using a Supra 12th Rib Miniflank Incision: A Minimally Invasive Open Approach for Small Renal Masses

Advances in Urology ◽

10.1155/2021/5569254 ◽

2021 ◽

Vol 2021 ◽

pp. 1-5

Author(s):

Syed Ali Ehsanullah ◽

Abida Sultana ◽

Brian Kelly ◽

Charlotte Dunford ◽

Zaheer Shah

Keyword(s):

Renal Function ◽

Blood Loss ◽

Minimally Invasive ◽

Partial Nephrectomy ◽

Operative Time ◽

Tumour Size ◽

Open Approach ◽

Open Partial Nephrectomy ◽

Estimated Blood Loss ◽

The Mean

Introduction. To assess a minimally invasive open technique for partial nephrectomy with zero ischaemia time. Methods. A review was performed in a prospectively maintained database of a single surgeon series of all patients undergoing partial nephrectomy using a supra 12th rib miniflank incision with zero ischaemia. Data of seventy one patients who underwent a partial nephrectomy over an 82-month period were analyzed. Data analyzed included operative time, estimated blood loss, pre and postoperative renal function, complications, final pathological characteristics, and tumour size. Results. Seventy one partial nephrectomies were performed from February 2009 to October 2015. None were converted to radical nephrectomy. Mean operative time was 72 minutes (range 30–250), and mean estimated blood loss was 608 mls (range 100–2500) with one patient receiving blood transfusion. The mean pre and postoperative haemoglobin levels were 144 and 112 g/l. The mean pre and postoperative creatinine levels were 82 and 103 Umol/L. There were 8 Clavian–Dindo Grade 2 complications and 1 major complication (Clavian IIIa). Histology confirmed 24 benign lesions and 47 malignant lesions, 46 cT1a lesions, 24 cT1b lesions, and 1 cT2 lesion. Median follow-up was 38 months with no local recurrence or progression of disease with 5 patients having a positive margin (7%). Conclusion. Our results demonstrate that a supra 12th miniflank incision open partial nephrectomy with zero ischaemic time for SRMs has satisfactory outcomes with preservation of renal function. A minimally invasive open partial nephrectomy remains an important option for units that cannot offer patients a laparoscopic or a robotic procedure.

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O-L01 Learning curve for laparoscopic liver resection: does it affect survival in colorectal liver metastasis?

British Journal of Surgery ◽

10.1093/bjs/znab429.024 ◽

2021 ◽

Vol 108 (Supplement_9) ◽

Author(s):

Hiba Shanti ◽

Rakesh Raman ◽

Saurav Chakravartty ◽

Ajay P. Belgaumkar ◽

Ameet G. Patel

Keyword(s):

Liver Resection ◽

Liver Metastasis ◽

Blood Loss ◽

Learning Curve ◽

Colorectal Liver Metastasis ◽

Laparoscopic Liver Resection ◽

R0 Resection ◽

Recurrence Free Survival ◽

Term Survival ◽

Free Survival

Abstract Background After Gagner introduced laparoscopic liver resection (LLR) in 1992, it was not until 2004 that the first series with more than ten laparoscopic major liver resections was reported. Furthermore, a multicentre study by Allard et al., in 2015 revealed that laparoscopy was only used in 176 (6.7%) patients out of a total of 2620 patients treated for colorectal liver metastasis (CRLM). This lag time in the establishment of LLR was attributed to the steep learning curve (LC) due to technical complexity and caution about oncological safety. The aim of this study is to assess if the learning curve of LLR has affected survival of patients with CRLM. Methods All consecutive LLR performed by a single surgeon between 2000–2019 were retrospectively analysed. RA-CUSUM for conversion rate and the log regression analysis of the blood loss were used to identify two phases in the learning curve. LC was then applied to CRLM patients and the two subgroups were compared for oncological and survival outcomes. The analysis was repeated with propensity score-matched (PSM) groups Results A total of 286 patients were included in the learning curve analysis. Combining the results from the RA-CUSUM and the blood loss log curve identified two distinct phases in the learning curve. The early phase (EP, n = 68) represented the initial learning experience, and the late phase (LP, n = 218) represented increased competence and the introduction of more challenging cases. The LC was applied to 192 patients with colorectal liver metastasis (EPc n = 45, LPc n = 147). R0 resection was achieved in 93%; 100% in EPc and 90% in LPc (P = .02). The cohort median overall survival (OS) and was 60 months. The median recurrence-free survival (RFS) was 16 months. The 5- year OS and RFS were 51% and 33%, respectively. The overall and recurrence-free survival rates were not compromised by the learning curve; OS (HR: 0.78, 95% CI 0.51-1.2, p = .26), RFS (HR: 0.94, 95 % CI 0.64-1.37, p=.76). Results were replicated after PSM. Conclusions In our experience, the development of a laparoscopic liver resection program can be achieved without adverse effect on the long-term survival in CRLM.

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Recent trends in postoperative mortality after liver resection- A systemic review and metanalysis of studies published in last 5 years and metaregression of various factors affecting 90 days mortality

10.1101/2021.03.26.21254407 ◽

2021 ◽

Cited By ~ 1

Author(s):

Bhavin Vasavada ◽

Hardik Patel

Keyword(s):

Liver Resection ◽

Liver Metastasis ◽

Blood Loss ◽

Colorectal Liver Metastasis ◽

Open Surgery ◽

Major Hepatectomy ◽

Mortality Rates ◽

Systemic Review ◽

Funnel Plot ◽

Open Hepatectomy

AbstractAimThe aim of this systemic review and meta-analysis was to analyse 90 days mortality after liver resection, and also study various factors associated with mortality via univariate and multivariate metaregression.MethodsPubMed, Cochrane library, Embase, google scholar, web of science with keywords like ‘liver resection”; “mortality”;” hepatectomy”. Weighted percentage 90 days mortalities were analysed. univariate metaregression was done by DerSimonian-Liard methods. Major hepatectomy, open surgery, cirrhotic livers, blood loss, hepatectomy for hepatocellular carcinoma, hepatectomy for colorectal liver metastasis were taken as moderators in metaregression analysis. We decided to enter all co-variants in multivariate model to look for mixed effects. Heterogeneity was assessed using the Higgins I2 test, with values of 25%, 50% and 75% indicating low, moderate and high degrees of heterogeneity. Cohort studies were assessed for bias using the Newcastle-Ottawa Scale to assess for the risk of bias. Publication bias was assessed using funnel plot. Funnel plot asymmetry was evaluated by Egger’s test.ResultsTotal 29931 patients’ data who underwent liver resections for various etiologies were pooled from 41 studied included1257 patients died within 90 days post operatively. Weighted 90 days mortality was 3.6% (95% C.I 2.8% −4.4%). However, heterogeneity of the analysis was high with I2 94.625%.(p<0.001). We analysed various covariates like major hepatectomy, Age of the patient, blood loss, open surgery, liver resections done for hepatocellular carcinoma or colorectal liver metastasis and cirrhotic liver to check for their association with heterogeneity in the analysis and hence 90 days mortality. On univariate metaregression analysis major hepatectomy (p<0.001), Open hepatectomy (p<0.001), blood loss (p=0.002) was associated with heterogeneity in the analysis and 90 days mortality. On multivariate metaregression Major hepatectomy(p=0.003) and Open surgery (p=0.012) was independently associated with higher 90 days mortality, and liver resection for colorectal liver metastasis was independently associated with lesser 90 days mortality (z= −4.11,p<0.01). Residual heterogeneity after all factor multivariate metaregression model was none (I2=0,Tau2=0, H2=1) and nonsignificant (p=0.49).ConclusionMajor hepatectomy, open hepatectomy, and cirrhotic background is associated with higher mortality rates and colorectal liver metastasis is associated with lower peri operative mortality rates.

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Operative Time, Age, and Serum Albumin Predict Surgical Morbidity After Laparoscopic Liver Surgery

Surgical Innovation ◽

10.1177/1553350621991223 ◽

2021 ◽

pp. 155335062199122

Author(s):

Daniel Heise ◽

Jan Bednarsch ◽

Andreas Kroh ◽

Sandra Schipper ◽

Roman Eickhoff ◽

...

Keyword(s):

Liver Resection ◽

Liver Surgery ◽

Postoperative Morbidity ◽

Operative Time ◽

Multivariable Analysis ◽

Operation Time ◽

Laparoscopic Liver Surgery ◽

Surgical Morbidity ◽

Perioperative Morbidity ◽

Preoperative Albumin

Background. Laparoscopic liver resection (LLR) has emerged as a considerable alternative to conventional liver surgery. However, the increasing complexity of liver resection raises the incidence of postoperative complications. The aim of this study was to identify risk factors for postoperative morbidity in a monocentric cohort of patients undergoing LLR. Methods. All consecutive patients who underwent LLR between 2015 and 2019 at our institution were analyzed for associations between complications with demographics and clinical and operative characteristics by multivariable logistic regression analyses. Results. Our cohort comprised 156 patients who underwent LLR with a mean age of 60.0 ± 14.4 years. General complications and major perioperative morbidity were observed in 19.9% and 9.6% of the patients, respectively. Multivariable analysis identified age>65 years (HR = 2.56; P = .028) and operation time>180 minutes (HR = 4.44; P = .001) as significant predictors of general complications (Clavien ≥1), while albumin<4.3 g/dl (HR = 3.66; P = .033) and also operative time (HR = 23.72; P = .003) were identified as predictors of major postoperative morbidity (Clavien ≥3). Conclusion. Surgical morbidity is based on patient- (age and preoperative albumin) and procedure-related (operative time) characteristics. Careful patient selection is key to improve postoperative outcomes after LLR.

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Two-stage laparoscopic liver resection for bilateral colorectal liver metastasis

Surgical Endoscopy ◽

10.1007/s00464-009-0859-7 ◽

2010 ◽

Vol 24 (8) ◽

pp. 2044-2047 ◽

Cited By ~ 17

Author(s):

M. A. Machado ◽

F. F. Makdissi ◽

R. C. Surjan ◽

G. T. Kappaz ◽

N. Yamaguchi

Keyword(s):

Liver Resection ◽

Liver Metastasis ◽

Colorectal Liver Metastasis ◽

Laparoscopic Liver Resection ◽

Two Stage

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Retroperitoneal hand-assisted laparoscopic nephrectomy and partial nephrectomy

Surgical Techniques Development ◽

10.4081/std.2013.e3 ◽

2013 ◽

Vol 3 (1) ◽

pp. 3 ◽

Cited By ~ 1

Author(s):

Nosratollah Nezakatzgoo ◽

Janet Colli ◽

Matthew Mutter ◽

Sheg Aranmolate ◽

Robert Wake

Keyword(s):

Partial Nephrectomy ◽

Operative Time ◽

Harmonic Scalpel ◽

Oral Intake ◽

Pathological Examination ◽

Tumor Diameter ◽

Renal Masses ◽

Estimated Blood Loss ◽

Average Operative Time

The purpose of the present paper is to describe our technique and experience with retroperitoneal hand-assisted laparoscopic (HAL) nephrectomies as an alternative to the transperitoneal approach. Eight retroperitoneal HAL nephrectomies and one partial nephrectomy were performed. Several excisional techniques were employed incorporating the Harmonic scalpel or Ligasure device. Hemostatic agents were used to cover the renal defect. Surgical bolsters were sutured to the renal capsule with pleget reinforcements to aid in hemostasis. The average operative time was 210 min and estimated blood loss 110 mL. Mean change in hematocrit was 3 units and creatinine was 1 point. No patient required a transfusion. There were no major complications, with a mean follow-up of fourteen months. On average, patients resumed oral intake in 2 days, and were discharged in 3 days. Pathological examination revealed that two lesions were benign and seven malignant. Tumor diameter averaged 3 cm. There were no positive surgical margins. In conclusion, we have demonstrated the feasibility of retroperitoneal laparoscopic hand-assisted nephrectomy and partial nephrectomy surgery for solid renal masses.

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High WNT6 expression indicates unfavorable survival outcome for patients with colorectal liver metastasis after liver resection

Journal of Cancer ◽

10.7150/jca.32817 ◽

2019 ◽

Vol 10 (12) ◽

pp. 2619-2627 ◽

Cited By ~ 1

Author(s):

Jianhong Peng ◽

Yixin Zhao ◽

Qiuyun Luo ◽

Hao Chen ◽

Wenhua Fan ◽

...

Keyword(s):

Liver Resection ◽

Liver Metastasis ◽

Colorectal Liver Metastasis ◽

Survival Outcome

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A team approach to anterior lumbar spine surgery in the military

Vascular ◽

10.1177/1708538113478757 ◽

2013 ◽

Vol 22 (4) ◽

pp. 246-251 ◽

Cited By ~ 3

Author(s):

Anahita Dua ◽

Jennifer Fox ◽

Bhavin Patel ◽

Eric Martin ◽

Michael Rosner ◽

...

Keyword(s):

Lumbar Spine ◽

Blood Loss ◽

Operative Time ◽

Lumbar Spine Surgery ◽

Team Approach ◽

Disc Space ◽

Estimated Blood Loss ◽

All Cause Mortality ◽

The Military ◽

Median Operative Time

We report a five year military experience with anterior retroperitoneal spine exposure combining vascular and neurosurgical spine teams. From August 2005 through April 2010 (56 months), hospital records from a single institution were retrospectively reviewed. Complications, estimated blood loss, transfusions, operative time and length of stay were documented. Eighty-four patients with lumbar spondylosis underwent primary (63, 75%) or secondary exposure (21, 25%) of a single- (66, 79%) or multilevel disc space (18, 21%). Median operative time and estimated blood loss were 127 minutes (range, 30–331 minutes) and 350 mL (range, 0–2940 mL). The overall complication rate was 23.8%. Postoperative complications included six blood transfusions (7%), three patients with retrograde ejaculation (3.57%) or surgical site infection; two with a prolonged ileus (2.38%) or ventral hernia and one each with a bowel obstruction (1, 1.19%), deep venous thrombosis or lymphocele. All-cause mortality was 1%. In conclusion, a team approach can minimize complications while offering the technical benefits and durability of an anterior approach to the lumbar spine.

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