scholarly journals Optimal Control of a Cell-to-Cell Fractional-Order Model with Periodic Immune Response for HCV

Symmetry ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2121
Author(s):  
Xue Yang ◽  
Yongmei Su ◽  
Huijia Li ◽  
Xinjian Zhuo
Keyword(s):  
Optimal Control ◽  
Immune Response ◽  
Combination Therapy ◽  
Fractional Order ◽  
Control Strategies ◽  
Order Model ◽  
Reproduction Numbers ◽  
A Cell ◽  
The Relationship ◽  
Two Equilibria

In this paper, a Caputo fractional-order HCV Periodic immune response model with saturation incidence, cell-to-cell and drug control was proposed. We derive two different basic reproductive numbers and their relation with infection-free equilibrium and the immune-exhausted equilibrium. Moreover, there exists some symmetry in the relationship between the two equilibria and the basic reproduction numbers. We obtain the global stability of the infection-free equilibrium by using Lyapunov function and the local stability of the immune-exhausted equilibrium. The optimal control problem is also considered and two control strategies are given; one is for ITX5061 monotherapy, the other is for ITX5061 and DAAs combination therapy. Matlab numerical simulation shows that combination therapy has lower objective function value; therefore, it is worth trying to use combination therapy to treat HCV infection.

Implementation of fractional optimal control problems in real-world applications

2020 ◽  
Vol 23 (6) ◽  
pp. 1783-1796
Author(s):  
Neelam Singha
Keyword(s):  
Optimal Control ◽  
Fractional Order ◽  
Adomian Decomposition Method ◽  
Necessary Optimality Conditions ◽  
Order Model ◽  
Fractional Optimal Control ◽  
Adomian Decomposition ◽  
Real World Applications ◽  
Fractional Optimal Control Problems ◽  
And Control

Abstract In this article, we aim to analyze a mathematical model of tumor growth as a problem of fractional optimal control. The considered fractional-order model describes the interaction of effector-immune cells and tumor cells, including combined chemo-immunotherapy. We deduce the necessary optimality conditions together with implementing the Adomian decomposition method on the suggested fractional-order optimal control problem. The key motive is to perform numerical simulations that shall facilitate us in understanding the behavior of state and control variables. Further, the graphical interpretation of solutions effectively validates the applicability of the present analysis to investigate the growth of cancer cells in the presence of medical treatment.

scholarly journals Optimal control of acute myeloid leukaemia

2018 ◽  
Author(s):  
Jesse A Sharp ◽  
Alexander P Browning ◽  
Tarunendu Mapder ◽  
Kevin Burrage ◽  
Matthew J Simpson
Keyword(s):  
Optimal Control ◽  
Immune Response ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Cell Model ◽  
Control Strategies ◽  
Treatment Strategies ◽  
Numerical Convergence ◽  
Stem Cell Model ◽  
Acute Myeloid

AbstractAcute myeloid leukaemia (AML) is a blood cancer affecting haematopoietic stem cells. AML is routinely treated with chemotherapy, and so it is of great interest to develop optimal chemotherapy treatment strategies. In this work, we incorporate an immune response into a stem cell model of AML, since we find that previous models lacking an immune response are inappropriate for deriving optimal control strategies. Using optimal control theory, we produce continuous controls and bang-bang controls, corresponding to a range of objectives and parameter choices. Through example calculations, we provide a practical approach to applying optimal control using Pontryagin’s Maximum Principle. In particular, we describe and explore factors that have a profound influence on numerical convergence. We find that the convergence behaviour is sensitive to the method of control updating, the nature of the control, and to the relative weighting of terms in the objective function. All codes we use to implement optimal control are made available.

Model Predictive Control of General Fractional Order Systems Using a General Purpose Optimal Control Problem Solver: RIOTS

2019 ◽  
Author(s):  
Sina Dehghan ◽  
Tiebiao Zhao ◽  
YangQuan Chen ◽  
Taymaz Homayouni
Keyword(s):  
Optimal Control ◽  
Model Predictive Control ◽  
Fractional Order ◽  
Predictive Control ◽  
Order System ◽  
Problem Solver ◽  
Fractional Order Systems ◽  
Application Process ◽  
Order Model ◽  
Integer Order

Abstract RIOTS is a Matlab toolbox capable of solving a very general form of integer order optimal control problems. In this paper, we present an approach for implementing Model Predictive Control (MPC) to control a general form of fractional order systems using RIOTS toolbox. This approach is based on time-response-invariant approximation of fractional order system with an integer order model to be used as the internal model in MPC. The implementation of this approach is demonstrated to control a coupled MIMO commensurate fractional order model. Moreover, the performance and its application process is compared to examples reported in the literature.

scholarly journals Consensus of Fractional-Order Multiagent Systems with Double Integral and Time Delay

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Jun Liu ◽  
Wei Chen ◽  
Kaiyu Qin ◽  
Ping Li
Keyword(s):  
Time Delay ◽  
Fractional Order ◽  
Network Topology ◽  
Proof Of Concept ◽  
State Variables ◽  
Double Integral ◽  
Order Model ◽  
Fractional Order Model ◽  
The Relationship ◽  
Double Integrator

This paper is devoted to the consensus problems for a fractional-order multiagent system (FOMAS) with double integral and time delay, the dynamics of which are double-integrator fractional-order model, where there are two state variables in each agent. The consensus problems are investigated for two types of the double-integrator FOMAS with time delay: the double-integrator FOMAS with time delay whose network topology is undirected topology and the double-integrator FOMAS with time delay whose network topology is directed topology with a spanning tree in this paper. Based on graph theory, Laplace transform, and frequency-domain theory of the fractional-order operator, two maximum tolerable delays are obtained to ensure that the two types of the double-integrator FOMAS with time delay can asymptotically reach consensus. Furthermore, it is proven that the results are also suitable for integer-order dynamical model. Finally, the relationship between the speed of convergence and time delay is revealed, and simulation results are presented as a proof of concept.

Optimal Campaign Strategies in Fractional-Order Smoking Dynamics

2014 ◽  
Vol 69 (5-6) ◽  
pp. 225-231 ◽  
Author(s):  
Anwar Zeb ◽  
Gul Zaman ◽  
Il Hyo Jung ◽  
Madad Khan
Keyword(s):  
Optimal Control ◽  
Maximum Principle ◽  
Optimal Control Problem ◽  
Control Problem ◽  
Fractional Order ◽  
Necessary Conditions ◽  
Order Model ◽  
Campaign Strategies ◽  
Education Campaign ◽  
Fractional Order Model

This paper deals with the optimal control problem in the giving up smoking model of fractional order. For the eradication of smoking in a community, we introduce three control variables in the form of education campaign, anti-smoking gum, and anti-nicotive drugs/medicine in the proposed fractional order model. We discuss the necessary conditions for the optimality of a general fractional optimal control problem whose fractional derivative is described in the Caputo sense. In order to do this, we minimize the number of potential and occasional smokers and maximize the number of ex-smokers. We use Pontryagin’s maximum principle to characterize the optimal levels of the three controls. The resulting optimality system is solved numerically by MATLAB.

Dynamic Study of SIQR-B Fractional-Order Epidemic Model of Cholera with Optimal Control Strategies in Mayo-Tsanaga Department of Cameroon Far North Region

2020 ◽  
Vol 15 (04) ◽  
pp. 237-273
Author(s):  
Tchule Nguiwa ◽  
Mibaile Justin ◽  
Djaouda Moussa ◽  
Gambo Betchewe ◽  
Alidou Mohamadou
Keyword(s):  
Optimal Control ◽  
Fractional Order ◽  
Control Strategies ◽  
Dynamical Behavior ◽  
Contamination Rate ◽  
Asymptotically Stable ◽  
Invariant Region ◽  
Globally Asymptotically Stable ◽  
Positive Orthant ◽  
Disease Free

In this paper, we investigated the dynamical behavior of a fractional-order model of the cholera epidemic in Mayo-Tsanaga Department. We extended the model of Lemos-Paião et al. [A. P. Lemos-Paião, C. J. Silva and D. F. M. Torres, J. Comput. Appl. Math. 16, 427 (2016)] by incorporating the contact rate [Formula: see text] by handling cholera death and optimal control strategies such as vaccination [Formula: see text], water sanitation [Formula: see text]. We provide a theoretical study of the model. We derive the basic reproduction number [Formula: see text] which determines the extinction and the persistence of the infection. We show that the disease-free equilibrium is globally asymptotically stable whenever [Formula: see text], while when [Formula: see text], the disease-free equilibrium is unstable and there exists a unique endemic equilibrium point which is locally asymptotically stable on a positively invariant region of the positive orthant. Using the sensitivity analysis, we find that the parameter related to vaccination and therapeutic treatment is more influencing the model. Theoretical results are supported by numerical simulations, which further suggest use of vaccination in endemic area. In case of a lack of necessary funding to fight again cholera, Figure 6 revealed that efforts should focus to keep contamination rate [Formula: see text] (susceptible-to-cholera death) in other to die out the disease.

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