scholarly journals Clinical Implications of Difference in Antigenicity of Different Botulinum Neurotoxin Type A Preparations: Clinical Take-Home Messages from Our Research Pool and Literature

Toxins ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 499 ◽  
Author(s):  
Sara Samadzadeh ◽  
Beyza Ürer ◽  
Raphaela Brauns ◽  
Dietmar Rosenthal ◽  
John-Ih Lee ◽  
...  
Keyword(s):  
Botulinum Toxin Type A ◽  
Neutralizing Antibody ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Cross Sectional Study ◽  
Clinical Aspects ◽  
Sectional Study ◽  
Cross Sectional ◽  
Best Response ◽  
Protein Load

The three different botulinum toxin type A (BoNT/A) preparations being licensed in Europe and the U.S. differ in protein content, which seems to be a major factor influencing the antigenicity of BoNT/A. In the present study, several arguments out of our research pool were collected to demonstrate that the clinical response and antigenicity were different for the three BoNT/A preparations: some results of (1) a cross-sectional study on clinical outcome and antibody formation of 212 patients with cervical dystonia (CD) being treated between 2 and 22 years; (2) another cross-sectional study on the clinical aspects and neutralizing antibody (NAB) induction of 63 patients having developed partial secondary treatment under abobotulinum (aboBoNT/A) onabotulinumtoxin (onaBoNT/A) who were switched to incobotulinumtoxin (incoBoNT/A) in comparison to 32 patients being exclusively treated with incoBoNT/A. These results imply that (1) the presence of NAB cannot be concluded from the course of treatment, that (2) an increase in the dose and variability of outcome with treatment duration indicates the ongoing induction of NABs over time, that (3) the higher protein load of BoNT/A goes along with a higher incidence and prevalence of NAB induction and that (4) the best response to a BoNT/A is also dependent on the protein load of the preparation.

scholarly journals A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm

2016 ◽  
Vol 367 ◽  
pp. 56-62 ◽  
Author(s):  
John Fezza ◽  
John Burns ◽  
Julie Woodward ◽  
Daniel Truong ◽  
Thomas Hedges ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Cross Sectional

scholarly journals Clinical aspects and the quality of life among women with endometriosis and infertility: a cross-sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Marina Pessoa de Farias Rodrigues ◽  
Fabia Lima Vilarino ◽  
Alessandra de Souza Barbeiro Munhoz ◽  
Laércio da Silva Paiva ◽  
Luiz Vinicius de Alcantara Sousa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cross Sectional Study ◽  
Clinical Aspects ◽  
Sectional Study ◽  
Cross Sectional

Symptomatic remission and social/vocational functioning in outpatients with schizophrenia: Prevalence and associations in a cross-sectional study

2007 ◽  
Vol 22 (8) ◽  
pp. 490-498 ◽  
Author(s):  
Luis San ◽  
Antonio Ciudad ◽  
Enrique Álvarez ◽  
Julio Bobes ◽  
Inmaculada Gilaberte
Keyword(s):  
Clinical Remission ◽  
Social Cognitive ◽  
Cross Sectional Study ◽  
Clinical Aspects ◽  
Global Assessment Of Functioning ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vocational Functioning ◽  
Symptomatic Remission ◽  
Operational Criteria

AbstractPurposeProgress in therapeutic options for schizophrenia has revived long-term expectations of researchers, practitioners and patients. At present, definitions of therapeutic outcome include both maintained symptomatic remission and appropriate functioning in a conceptual framework that targets patient's recovery as the ultimate goal. We aimed to know the prevalence and clinical features of patients with schizophrenia achieving these outcomes.MethodsA multi-centre, cross-sectional study was performed in more than 100 mental health facilities within Spain. Recently published consensus-based operational criteria for symptomatic remission and the Global Assessment of Functioning scale were used to evaluate outcomes. Other clinical aspects like depressive symptoms, social cognition, premorbid adjustment and patients' attitudes to medication were also evaluated.ResultsData from 1010 patients were analysed. Of these, 452 (44.8%) were at clinical remission, but only 103 (10.2%) showed an adequate social and/or vocational functioning. Factors predicting both outcomes were better pre-morbid adjustment (odds ratio, OR = 1.56) and better social cognitive function (OR = 1.14). Other factors, like treatment adherence, current or past psychotherapy and patient's age were not associated to functionality but only to clinical remission. Current substance use and previous rehabilitation were associated to a lower likelihood of symptomatic remission.ConclusionAlthough symptomatic remission in patients with schizophrenia is a realistic and reachable goal, future efforts should be directed to a sustained appropriate functioning in these patients.

A cross-sectional structured survey of patients receiving botulinum toxin type A treatment for blepharospasm

2016 ◽  
Vol 22 ◽  
pp. e138 ◽  
Author(s):  
Daniel Truong ◽  
John Fezza ◽  
John Burns ◽  
Julie Woodward ◽  
Thomas Hedges ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Cross Sectional

scholarly journals RELATIONSHIP BETWEEN ESOPHAGITIS GRADES AND HELICOBACTER PYLORI

2016 ◽  
Vol 29 (3) ◽  
pp. 135-137 ◽  
Author(s):  
Patrícia Fernanda Saboya RIBEIRO ◽  
Luiz Fernandao KUBRUSLY ◽  
Paulo Afonso Nunes NASSIF ◽  
Irma Cláudia Saboya RIBEIRO ◽  
Andressa de Souza BERTOLDI ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Type A ◽  
Cross Sectional Study ◽  
Endoscopic Examination ◽  
Type B ◽  
Gastric Lesions ◽  
Sectional Study ◽  
Cross Sectional ◽  
Urease Test ◽  
Significant Difference

ABSTRACT Background: The Helicobacter pylori infection (HP) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. Aim: To evaluate HP's relationship with esophagitis in patients undergoing upper endoscopy. Methods: Observational, retrospective and cross-sectional study, being evaluated 9576 patients undergoing outpatient endoscopic examination during the period between January and December 2015. Were included patients with any esophageal alteration at the examination; greater than 18; of both genders; independent of the complaint or the reason for the examination, illness or drug use. Were excluded those with active bleeding during the examination and in use of anticoagulants. The variables gender, age, esophagitis and result of the urease test, were studied. For statistical analysis was used the Epi Info software 7.1.5.2. Results: Most of the samples consisted of women and the overall average age was 46.54±16.32 years. The presence of infection was balanced for gender: 1204 (12.56%) women and 952 (13.92%) men. Relating degree of esophagitis HP- and HP+ was observed that the type A was the most common (58.79%, n=1460); 604 (24.32%) had grade B; 334 (13.45%) grade C, and 85 (3.42%) grade D. In the relation between the grade of esophagitis with gender, esophagitis A was predominant in women and present in 929 (63.33%), followed by type B, 282 (46.68%), 136 C (40.71%) and D 30 (35.29%). In men 531 (36.36%) showed type A, 322 (53.31%) B, 198 (59.28%) C, and 55 (64.70%) D. Among the groups 40-50 and over 60 years there was a significant difference in whether have or not have HP+. Conclusion: There is no significant difference between HP infection and the different grades of esophagitis.

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