scholarly journals Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 757
Author(s):  
Leydy Lorena Mendoza-Tobar ◽  
Ivonne Alejandra Meza-Cabrera ◽  
Juan C. Sepúlveda-Arias ◽  
Jimmy Alexander Guerrero-Vargas
Keyword(s):  
Nervous System ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Scientific Knowledge ◽  
Multiple Organ ◽  
Autonomous Nervous System ◽  
Histopathological Alterations ◽  
Scorpion Venoms ◽  
Histopathological Evaluation ◽  
Biomedical Interest

Among other scorpion species, Colombia has two genera of the Buthidae family Centruroides and Tityus, considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: Centruroides margaritarus, Tityus pachyurus, and T. n. sp. aff. metuendus with biomedical interest were studied. An initial pre-glycemic sample was taken from ICR mice. They were later intraperitoneally inoculated with doses of 35% and 70% of LD50 of total venom. Poisoning signs were observed during a 6-h period to determine the level of scorpionism. After observation, a second glycemic sample was taken, and a histopathological evaluation of different organs was performed. This work revealed that all three venoms showed considerably notorious histopathological alterations in main organs such as heart and lungs; and inducing multiple organ failure, in relation to the glycemia values, only C. margaritatus and T. n. sp. aff. metuendus showed significant changes through manifestation of hyperglycemia. According to the Colombian scorpionism level; signs were mild to severe affecting the autonomous nervous system.

scholarly journals A Case of Japanese Spotted Fever Complicated with Central Nervous System Involvement and Multiple Organ Failure

2012 ◽  
Vol 51 (7) ◽  
pp. 783-786 ◽  
Author(s):  
Ruka Nakata ◽  
Masakatsu Motomura ◽  
Masahiro Tokuda ◽  
Hideki Nakajima ◽  
Tomoko Masuda ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Spotted Fever ◽  
Central Nervous System Involvement ◽  
Multiple Organ ◽  
System Involvement

THE PERIPHERAL NERVOUS SYSTEM IN SEPSIS AND MULTIPLE ORGAN FAILURE

1987 ◽  
Vol 15 (4) ◽  
pp. 447 ◽  
Author(s):  
Charles F. Bolton ◽  
D. W. Zochodne ◽  
N. J. Witt ◽  
J. J. Gilbert ◽  
A. F. Hahn ◽  
...  
Keyword(s):  
Nervous System ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Peripheral Nervous System ◽  
Multiple Organ

scholarly journals The value of neurohumoral regulation in the outcome of multiple organ failure syndrome in sepsis

2020 ◽  
Vol 17 (5) ◽  
pp. 80-86
Author(s):  
M. A. Leontiev ◽  
A. B. Vodova ◽  
S. V. Kravchuk
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Neurohumoral Regulation ◽  
The Central Nervous System ◽  
Quantitative Changes ◽  
Mechanisms Of Development ◽  
And Control

The objective: to present information about potential mechanisms of development of sepsis-associated encephalopathy, and its potential role in sepsis outcome.Neurohumoral regulation is the most important system that integrates many functions of variable values to achieve the final result that is beneficial for the host. The central nervous system (CNS) is the switch and control mechanism responsible for the functioning of this system. The increasing number of studies indicating the relationship between the development of sepsis and occurrence of qualitative and quantitative changes in the central nervous system suggests that it is the degree of damage to neurohumoral regulation mechanisms at the very beginning of the disease can significantly determine the severity of the course and prognosis of the outcome of multiple organ failure syndrome in sepsis.

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

scholarly journals High-dose diquat poisoning: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110261
Author(s):  
Yanxia Huang ◽  
Renjing Zhang ◽  
Mei Meng ◽  
Dechang Chen ◽  
Yunxin Deng
Keyword(s):  
Renal Failure ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
High Dose ◽  
Severe Respiratory Failure ◽  
Aggressive Treatment ◽  
Lung Lesions ◽  
Pulmonary Lesions ◽  
New Treatment

Diquat is a widely used herbicide that is substituted for paraquat. With paraquat off the market, cases of diquat poisoning have been gradually increasing. The kidney is the most frequently impaired organ in diquat poisoning. Few cases of multiple organ failure caused by diquat have been reported. We herein describe a 30-year-old man who orally ingested about 160 mL of enriched diquat. Despite aggressive treatment, the patient’s condition progressed to multiple organ failure and death. The pulmonary lesions in this patient were different from those previously reported. This patient did not die of renal failure but of severe respiratory failure. He exhibited three different stages of pulmonary disease. The lung lesions in this case were unique. We hope that doctors will pay more attention to the lung lesions in patients with diquat poisoning in future and find new treatment methods to save the lives of such patients.

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