scholarly journals Serenoa Repens (Saw Palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part III

Uro ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 155-179
Author(s):  
Stephen B. Strum
Keyword(s):  
Clinical Trials ◽  
World Literature ◽  
English Language ◽  
Serenoa Repens ◽  
Global Literature ◽  
Reductase Inhibitors ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Pharmacologic Agents ◽  
Lower Urinary

Parts I and II of this three-part series indicated how a global review of both English-language and non-English language papers, plus a focus on a lipidosterolic extract of Serenoa repens (LSESr) having a standardized fatty acid profile, have together engendered new insights about the biological activity of LSESr vs. LUTS. In this last part, data from the world literature is presented that confirms that LSESr efficacy is the predominant finding in clinical trials. Despite two placebo-controlled clinical trials performed in the U.S. that failed to confirm a benefit of LSESr vs. placebo in LUTS, the global body of the peer-reviewed literature attests not only to efficacy but also to safety. Results will be presented of important trials that compare LSESr to alpha-blockers such as tamsulosin (Flomax®) as well as to 5α-reductase inhibitors such as finasteride (Proscar®) that demonstrate consistent findings of near equivalency between LSESr and these pharmacologic agents. Studies relating data indicative of an additive effect or synergy between LSESr and tamsulosin will also be presented. The heightened effectiveness of LSESr in men with severe LUTS vs. moderate LUTS expands the importance of our scrutiny of the global literature concerning LSESr. Of great consequence are the contributions of non-English language peer-reviewed publications that have consistently provided evidence of LSESr efficacy in treating LUTS/BPH. These peer-reviewed articles have shown that the effect of LSESr is not that of a placebo. Finally, a comparison of the LSESr extraction products used in the treatment of LUTS, and a discussion of the milieu factors that affect the natural history of LUTS and influence the outcome of clinical trials, complete this detailed analysis of LSESr vs. LUTS.

scholarly journals Serenoa repens (saw palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part III

2021 ◽  
Author(s):  
Stephen Bruce Strum
Keyword(s):  
Clinical Trials ◽  
World Literature ◽  
English Language ◽  
Series Data ◽  
Serenoa Repens ◽  
Global Literature ◽  
Reductase Inhibitors ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Pharmacologic Agents

Parts I and II of this 3-part series indicated how a global review of both English-language and non-English language papers plus a focus on a lipidosterolic extract of Serenoa repens (LSESr) having a standardized fatty acid profile have together engendered new insights about the biological activity of LSESr vs. LUTS. In this last of a 3-part series, data from the world literature is presented that confirms that LSESr efficacy is the predominant finding in clinical trials. Despite two placebo-controlled clinical trials performed in the U.S. that failed to confirm a benefit of LSESr vs. placebo in LUTS, the global body of the peer-reviewed literature attests not only to efficacy but also to safety. Results will be presented of important trials that compare LSESr to alpha-blockers such as tamsulosin (Flomax®) as well as to 5α-reductase inhibitors such as finasteride (Proscar®) that demonstrate consistent findings of near equivalency between LSESr and these pharmacologic agents. Studies relating data indicative of an additive effect or synergy between LSESr and tamsulosin will be presented as well. The heightened effectiveness of LSESr in men with severe LUTS vs. moderate LUTS expands the importance of our scrutinization of the global literature concerning LSESr. Of great consequence are the contributions of non-English language peer-reviewed publications that have consistently provided evidence of LSESr efficacy in treating LUTS/BPH. These peer-reviewed articles have shown that the effect of LSESr is not that of a placebo. Finally, a comparison of the LSESr extraction products used in the treatment of LUTS, and a discussion of the milieu factors that affect the natural history of LUTS and influence the outcome of clinical trials complete this sedulous analysis of LSESr vs. LUTS.

Primary diffuse large B cell lymphoma (DLBCL) of the prostate presenting with lower urinary tract symptoms (LUTS)

2020 ◽  
Vol 13 (12) ◽  
pp. e236280
Author(s):  
Ayesha Nusrat ◽  
Syed Muhammad Nazim
Keyword(s):  
Urinary Tract ◽  
B Cell ◽  
Lower Urinary Tract ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Large B Cell ◽  
Lower Urinary

Malignant lymphomas of the prostate are very rare tumours and are generally not considered in the clinical or pathological diagnosis of prostatic enlargement. We report a case of a 56-year-old man who presented with long-standing history of low back pain and a 2-month history of voiding lower urinary tract symptoms. He denied any history of urinary retention, trauma, catheterisation or any constitutional symptoms. Examination revealed no lymphadenopathy and hepatosplenomegaly. Digital rectal examination showed an irregular, moderately enlarged nodular prostate. His prostate-specific antigen was 1.54 ng/mL. MRI of the pelvis did not show any focal lesion apart from abnormal signal intensity in the central zone. Bone scan was negative. Transrectal ultrasound-guided prostate biopsy revealed diffuse large B cell lymphoma. Bone marrow biopsy and whole body positron emission tomography/CT were unremarkable. The patient achieved complete remission after receiving six cycles of R-CHOP chemotherapy.

scholarly journals Sexual Dysfunctions Related to Drugs Used in the Management of Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Narrative Review on α-Blockers and 5-Alpha Reductase Inhibitors

Uro ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 82-98
Author(s):  
Antonio La Torre ◽  
Caterina Palleria ◽  
Irene Tamanini ◽  
Andrea Scardigli ◽  
Tommaso Cai ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Benign Prostatic Hyperplasia ◽  
Sexual Dysfunction ◽  
Lower Urinary Tract ◽  
Prostatic Hyperplasia ◽  
Sexual Dysfunctions ◽  
Reductase Inhibitors ◽  
Urinary Tract Symptoms ◽  
5 Alpha Reductase Inhibitors ◽  
Lower Urinary

This is a critical review of the current literature data about sexual dysfunction as a potential side effect related to drugs commonly used for the treatment of Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms. In this narrative review, we analyzed data from the literature related to the development of sexual dysfunctions during the treatment of BPH or LUTS. Both α-blockers and 5-alpha reductase inhibitors (5-ARIs) can induce erectile dysfunction, ejaculatory disorders and a reduction in sexual desire. The sexual side effect profile of these drugs is different. Among the α-blockers, silodosin appears to have the highest incidence of ejaculatory disorders. Persistent sexual side effects after the discontinuation of finasteride have been recently reported; however, further studies are needed to clarify the true incidence and the significance of this finding. However, most of the published studies are affected by a weak methodology and other important limitations, with only a few RCTs available. Therefore, it is desirable that future studies will include validated tools to assess and diagnose the sexual dysfunction induced by these medications, especially for ejaculation and sexual desire disorders.

scholarly journals Laparoscopic removal of a pelvic cyst associated with obstructedmegaureter and dysplastic renal remnant

2013 ◽  
Vol 3 (2) ◽  
pp. 159 ◽  
Author(s):  
Michael L. Pianezza ◽  
Eric P. Estey
Keyword(s):  
Lower Urinary Tract ◽  
Bladder Wall ◽  
Renal Tissue ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
The Right ◽  
Laparoscopic Removal ◽  
Pelvic Cyst ◽  
Surgical Option ◽  
Lower Urinary

We report a case of a 41-year-old man with a solitary functioningleft kidney and history of chronic pelvic discomfort associatedwith lower urinary tract symptoms. Imaging revealed a largecystic structure in the pelvis attached to a dilated tortuous ureteron the right with congenital absence of the right kidney. The patientunderwent laparoscopic removal of the pelvic cyst and dilatedright ureter. Pathological assessment revealed mesonephric remnantsrepresenting dysplastic renal tissue attached to a dilated andobstructed megaureter, extending into the bladder wall and forminga large pelvic cyst. The patient’s symptoms resolved. A laparoscopicapproach represents an excellent surgical option for pelvicpathology.Nous décrivons le cas d’un homme de 41 ans porteur d’un seulrein fonctionnel (gauche) et ayant des antécédents de douleurspelviennes chroniques liées à des symptômes affectant les voiesurinaires inférieures. Les épreuves d’imagerie ont révélé une massekystique volumineuse au niveau du pelvis, une dilatation et unesinuosité urétérales du côté droit et l’absence congénitale derein droit. Le patient a subi une ablation par laparoscopie du kystepelvien et de la section dilatée de l’uretère droit. L’évaluationpathologique a révélé des vestiges mésonéphriques constituésde tissu rénal dysplasique lié à un méga-uretère obstrué avec dilatationkystique se prolongeant dans la paroi vésicale et formant ainsiun kyste pelvien volumineux. Les symptômes du patient ont disparu.Une approche laparoscopique représente une excellenteoption chirurgicale en présence de pathologie pelvienne.

scholarly journals Low grade transitional cell carcinoma of the urethra successfully treated with only intraurethral instillation of Mitomycin-C

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Sharfuddeen A. Mashi ◽  
Sani A. Aji ◽  
Muzzammil Abdullahi ◽  
Bashir Yunusa ◽  
Sani U. Alhassan
Keyword(s):  
Mitomycin C ◽  
Urothelial Cancer ◽  
Transitional Cell ◽  
Significant Risk ◽  
Low Grade ◽  
Short Segment ◽  
Urinary Tract Symptoms ◽  
History Of ◽  
Posterior Urethra ◽  
Lower Urinary

Urethral cancer is very rare disease, accounting for less than 0.5% of incidences of malignancies. Data on its management are scarce due to the rare nature of the cases. We present a 34-year-old man, who presented to our hospital with a month history of hematuria. He had no lower urinary tract symptoms and no significant risk factors for urothelial cancer. He was evaluated and found to have lesions in the posterior urethra on urethrocytoscopy, biopsy of which revealed a low-grade urothelial cancer. He was counselled and had 6 courses of intraurethral instillation of 40mg of Mitomycin-C diluited in 50mL of saline held in the urethra with penile clamp for 30 minutes. The hematuria stopped after the second course, a repeat urethrocystoscopy 6 months after the completion of the chemotherapy, showed resolution of the lesion and repeat biopsy showed no evidence of malignancy. However, the patient developed short segment partial penile urethral stricture that was treated with dilatation. In conclusion, low-grade urothelial cancer of the urethra can be successfully cured with Intraurethral instillation of Mitomycin-C, without prior transurethral resection.

The global process of thinking global literature: from Marx’s Weltliteratur to Sarkozy’s littérature-monde

2019 ◽  
Vol 14 (3) ◽  
pp. 395-412 ◽  
Author(s):  
Jernej Habjan
Keyword(s):  
Cold War ◽  
World Literature ◽  
Third World ◽  
Global Approach ◽  
Global History ◽  
Global Literature ◽  
History Of Research ◽  
Literary Theories ◽  
History Of ◽  
Post War

AbstractThis article outlines the history of research in global literature as a history that is itself global. This kind of global history of the theorization of global literature demands a departure from the existing accounts and their nascent gap between heated theoreticist debates and pacifying historicist anthologies. A global approach to the problematic can bridge this gap because it considers not only what the most influential studies on global literature say, but also where and when they say it. Whether these be Romantic assertions of world literature, post-war pleas for cosmopolitan literature, Cold War polemics about ‘Third World’ literature, or millennial theories of transnational, post-national, planetary, and, indeed, global literature, the article considers not only the object of these studies but also the studies themselves as an object; not only the text but also the context. Hence, a historicization of literary theories of globalization in effect bleeds into a historicization of globalization itself.

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