scholarly journals Hepatitis C Virus Subtypes Novel 6g-Related Subtype and 6w Could Be Indigenous in Southern Taiwan with Characteristic Geographic Distribution

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1316
Author(s):  
Hung-Da Tung ◽  
Pei-Lun Lee ◽  
Jyh-Jou Chen ◽  
Hsing-Tao Kuo ◽  
Ming-Jen Sheu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Geographic Distribution ◽  
Injection Drug Users ◽  
Drug Users ◽  
Endemic Area ◽  
Nonstructural Protein ◽  
Prevalent Subtype ◽  
Southern Taiwan ◽  
Tainan City

Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major HCV GTs in Taiwan were GT 1b and 2 with very rare GT 6 except in injection drug users (IDUs), and subtype 6a is the main GT 6 subtype among IDUs. Recently, we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. A total of 3022 (1343 men and 1679 women) HCV viremic patients were enrolled. Subtypes of GT 6 were determined by sequencing of core/E1 and nonstructural protein 5B in 322 of 518 GT 6 patients. The overall GT 6 prevalence rate was 17.1% (518/3022), with higher prevalence districts (>25%) located in northern Tainan. A novel 6g-related subtype is the most prevalent subtype (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%). The high GT 6 prevalence in Tainan was mainly due to a novel 6g-related subtype and 6w. These two subtypes could be indigenous in Tainan with characteristic geographic distribution.

scholarly journals Geographic Variation of Indigenous Hepatitis C Virus Subtypes 6g and 6w in an Endemic Area of Southern Taiwan

2021 ◽  
Author(s):  
Hung-Da Tung ◽  
Pei-Lun Lee ◽  
Jyh-Jou Chen ◽  
Hsing-Tao Kuo ◽  
Ming-Jen Sheu ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Southeast Asia ◽  
South China ◽  
Injection Drug User ◽  
Prevalence Rate ◽  
Endemic Area ◽  
Nonstructural Protein ◽  
Southern Taiwan ◽  
Tainan City

Abstract Background and Aims: Hepatitis C virus (HCV) genotype (GT) 6 is the most genetically diverse GT and mainly distributed in Southeast Asia and south China but not Taiwan. Earlier studies showed the major GTs in Taiwan were GT 1b and GT 2 with very rare GT6 except in injection drug user and subtype 6a is the main GT 6 subtype among IDUs. Recently we reported a much higher prevalence (18.3%) of GT 6 in Tainan City, southern Taiwan. This study was designed to clarify the subtypes of GT 6 in this endemic area. Materials and Methods: A total 3022 (1343 men and 1679 women) HCV patients were enrolled. GT 6 subtypes were determined by sequencing of core/E1 and nonstructural protein 5B (NS5B) in 322 of 518 GT 6 patients. Results: The overall GT6 prevalence rate was 17.1% (518/3022) with higher prevalence districts located in northern Tainan. The major GT6 subtypes in Tainan were 6g (81.0%), followed by 6w (10.8%), 6a (7.5%), and 6n (0.7%).Conclusions: The high GT 6 prevalence in Tainan was mainly due to subtype 6g and 6w with characteristic geographic distribution, suggesting subtypes 6g and 6w could be indigenous in Tainan for centuries.

scholarly journals Frequent Hepatitis C Virus Superinfection in Injection Drug Users

2004 ◽  
Vol 190 (8) ◽  
pp. 1396-1403 ◽  
Author(s):  
Belinda L. Herring ◽  
Kimberly Page‐Shafer ◽  
Leslie H. Tobler ◽  
Eric L. Delwart
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug

A Review of Hepatitis C Virus: Prevalence, Genotype, Risk Factors in Pakistan Last Quarter of Century

2021 ◽  
Vol 2 (01) ◽  
pp. 26-30
Author(s):  
Aetsam Bin Masood ◽  
Zain Ul Abideen ◽  
Muhammad Salman Anjums ◽  
Muhammad Irfan
Keyword(s):  
Risk Factors ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Prevalence Rate ◽  
Injection Drug Users ◽  
Drug Users ◽  
Educational Background ◽  
Healthcare Waste ◽  
Awareness Campaigns ◽  
The Government

Hepatitis C virus has infected over 200 million people worldwide and is the most common blood-borne disease. Pakistan has the HCV prevalence rate of over 8%. A literature search has been performed using different keywords in different databases i.e. PubMed, Google Scholar, and NCBI. 6.2% prevalence rate was found in the general population, 4.13% in healthcare workers and a higher prevalence rate was observed in injection drug users and multi transfusion population. Use of injection was very frequent among the Pakistani population, reuse and sharing of syringes have an association with HCV infections. In Pakistan most prevalent genotype of HIV was 3a. Knowledge about HCV and its risk factors also varies with the educational background. Blood donors should be screened for HCV, awareness campaigns about different risk factors should be initiated at the government level, and strict regulation on healthcare waste should be implemented, these might help in preventing its spread to healthy individuals.

scholarly journals Prevalence of hepatitis C virus and HIV infection among injection drug users in two Mexican cities bordering the U.S

2007 ◽  
Vol 49 (3) ◽  
Author(s):  
Emily Faye White ◽  
Richard S. Garfein ◽  
Kimberly C Brouwer ◽  
Remedios Lozada ◽  
Rebeca Ramos ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hiv Infection ◽  
Injection Drug Users ◽  
Drug Users ◽  
Injection Drug ◽  
The U.S
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