scholarly journals Use of Slaughterhouses as Sentinel Points for Genomic Surveillance of Foot-and-Mouth Disease Virus in Southern Vietnam

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2203
Author(s):  
Umanga Gunasekara ◽  
Miranda R. Bertram ◽  
Do H. Dung ◽  
Bui H. Hoang ◽  
Nguyen T. Phuong ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Principal Component ◽  
Mouth Disease ◽  
Serum Samples ◽  
Southern Vietnam ◽  
Serotype O ◽  
Healthy Cattle ◽  
Mouth Disease Virus ◽  
Foot And Mouth

The genetic diversity of foot-and-mouth disease virus (FMDV) poses a challenge to the successful control of the disease, and it is important to identify the emergence of different strains in endemic settings. The objective of this study was to evaluate the sampling of clinically healthy livestock at slaughterhouses as a strategy for genomic FMDV surveillance. Serum samples (n = 11,875) and oropharyngeal fluid (OPF) samples (n = 5045) were collected from clinically healthy cattle and buffalo on farms in eight provinces in southern and northern Vietnam (2015–2019) to characterize viral diversity. Outbreak sequences were collected between 2009 and 2019. In two slaughterhouses in southern Vietnam, 1200 serum and OPF samples were collected from clinically healthy cattle and buffalo (2017 to 2019) as a pilot study on the use of slaughterhouses as sentinel points in surveillance. FMDV VP1 sequences were analyzed using discriminant principal component analysis and time-scaled phylodynamic trees. Six of seven serotype-O and -A clusters circulating in southern Vietnam between 2017–2019 were detected at least once in slaughterhouses, sometimes pre-dating outbreak sequences associated with the same cluster by 4–6 months. Routine sampling at slaughterhouses may provide a timely and efficient strategy for genomic surveillance to identify circulating and emerging FMDV strains.

scholarly journals First Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Sublineage Ind2001e from Southern Vietnam

2019 ◽  
Vol 8 (10) ◽  
Author(s):  
Rachel M. Palinski ◽  
Miranda R. Bertram ◽  
Le T. Vu ◽  
Steven J. Pauszek ◽  
Ethan J. Hartwig ◽  
...  
Keyword(s):  
Disease Virus ◽  
Tissue Sample ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Epithelial Tissue ◽  
Southern Vietnam ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

We report the polyprotein coding sequence of the newly defined Ind2001e sublineage of foot-and-mouth disease virus (FMDV) serotype O, isolated from a bovine epithelial tissue sample collected in 2017 in Kon Tum Province, Vietnam. This discovery updates FMDV diversity in Vietnam, has implications for FMDV epidemiology, and influences future vaccine selections.

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

A vaccine-matching assessment of different genetic variants of serotype O foot-and-mouth disease virus isolated in Ethiopia between 2011 and 2014

2020 ◽  
Vol 165 (8) ◽  
pp. 1749-1757
Author(s):  
Yeneneh Tesfaye ◽  
Fazlurrahman Khan ◽  
Martha Yami ◽  
Jemma Wadsworth ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genetic Variants ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Isotype-specific antibody responses to foot-and-mouth disease virus in sera and secretions of ‘carrier’ and ‘non-carrier’ cattle

1996 ◽  
Vol 117 (2) ◽  
pp. 349-360 ◽  
Author(s):  
J. S. Salt ◽  
G. Mulcahy ◽  
R. P. Kitching
Keyword(s):  
Disease Virus ◽  
Specific Antibody ◽  
Statistical Significance ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Antibody Responses ◽  
Upper Respiratory Tract ◽  
Serum Samples ◽  
Mouth Disease Virus ◽  
Foot And Mouth

SummaryIsotype-specific antibody responses to foot-and-mouth disease virus (FMDV) were measured in the sera and upper respiratory tract secretions of vaccinated and susceptible cattle challenged with FMDV by direct contact or by intranasal inoculation. A comparison was made between cattle that eliminated FMDV and those that developed and maintained a persistent infection. Serological and mucosal antibody responses were detected in all animals after challenge. IgA and 1gM were detected before the development of IgG1and IgG2responses. 1gM was not detected in vaccinated cattle. Challenge with FMDV elicited a prolonged biphasic secretory antibody response in FMDV ‘carrier’ animals only. The response was detected as FMDVspecific IgA in both mucosal secretions and serum samples, which gained statistical significance (P< 0·05) by 5 weeks after challenge. This observation could represent the basis of a test to differentiate vaccinated and/or recovered convalescent cattle from FMDV ‘carriers’.

Selection and characterization of an acid-resistant mutant of serotype O foot-and-mouth disease virus

2013 ◽  
Vol 159 (4) ◽  
pp. 657-667 ◽  
Author(s):  
Te Liang ◽  
Decheng Yang ◽  
Mengmeng Liu ◽  
Chao Sun ◽  
Fang Wang ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Resistant Mutant ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Genome Sequence of Foot-and-Mouth Disease Virus of Serotype O Lineage Ind-2001d Isolated from Cattle in Mongolia in 2015

2017 ◽  
Vol 5 (45) ◽  
Author(s):  
Tatsuya Nishi ◽  
Gerelmaa Ulziibat ◽  
Buyantogtokh Khanui ◽  
Odonchimeg Myagmarsuren ◽  
Kazuki Morioka ◽  
...  
Keyword(s):  
Southeast Asia ◽  
Disease Virus ◽  
Genome Sequence ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Whole Genome Sequence ◽  
Whole Genome ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth

ABSTRACT We report the whole-genome sequence of the foot-and-mouth disease virus (FMDV) O/MOG/BU/2-7/2015 isolated in Mongolia in 2015. This virus is closely related to isolates identified in Southeast Asia in 2015 and is classified under the O/ME-SA/Ind-2001d lineage. This is the first detection of an FMDV of this lineage in Mongolia.

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