scholarly journals Case Reports of Situs Inversus Totalis and Dextrocardia in Sprague Dawley Rats

2019 ◽  
Vol 6 (3) ◽  
pp. 67
Author(s):  
Reynaldo Oliva Hernández ◽  
Jordan D. Lewicky ◽  
Nya L. Fraleigh ◽  
Hoang-Thanh Le
Keyword(s):  
Situs Inversus ◽  
Case Reports ◽  
Health Sciences ◽  
Situs Inversus Totalis ◽  
Anatomical Location ◽  
Sprague Dawley ◽  
Vaccine Research ◽  
Internal Organs ◽  
Sprague Dawley Rats ◽  
Congenital Condition

Situs inversus totalis is a condition where there is a transposition of all internal organs from their normal anatomical location. This infrequent and rare congenital condition has been described in several species of mammals. Dextorcardia is a series of conditions associated with an abnormal congenital positioning of the heart, and is often associated with situs inversus totalis. Here we report a case of situs inversus totalis and two cases of dextrocardia identified in Sprague Dawley rats during gross necropsy evaluations at both the Health Sciences North Research Institute (HSNRI) in Canada and Finlay Institute of Vaccine Research and Production in Cuba. The intent of this report is to share our findings and aid in the accumulation of data on these rare conditions.

scholarly journals Case Report on Situs Inversus Totalis in Two Sprague-Dawley Rats.

1995 ◽  
Vol 44 (4) ◽  
pp. 341-345 ◽  
Author(s):  
Kazumi SHIRAIWA ◽  
Atsushi WATANABE ◽  
Norihiro SATO ◽  
Midori NITO ◽  
Youshiro KOBAYASHI
Keyword(s):  
Case Report ◽  
Situs Inversus ◽  
Situs Inversus Totalis ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Situs Inversus Totalis

2001 ◽  
Vol 20 (1) ◽  
pp. 63-67 ◽  
Author(s):  
Janie Spoon
Keyword(s):  
Situs Inversus ◽  
Vena Cava ◽  
Situs Inversus Totalis ◽  
Mirror Image ◽  
The Body ◽  
Radiographic Examination ◽  
Internal Organs ◽  
Radiographic Findings ◽  
Situs Solitus ◽  
The Right

EXTERNALLY, THE HUMAN BODY appears symmetric; if a line is drawn down the middle of the body, each side appears identical. However, this is not true of the internal anatomy. For example, there is one heart, which lies in the left chest, one liver, in the right abdomen, and one stomach, in the left abdomen. The term situs refers to the position or location of an organ, specifically, the position of the atria and abdominal viscera in relation to the midline of the body.1 There are three types of situs: solitus, inversus, and ambiguous. Situs solitus refers to the normal arrangement of organs, with the right atrium, liver, gallbladder, trilobed lung, and inferior vena cava on the right side and the left atrium, stomach, spleen, bilobed lung, and descending aorta on the left side (Figures 1–3). Situs inversus totalis refers to a mirror image reversal of the normal position of the internal organs (Figures 4 and 5). 1 The incidence of situs inversus totalis is 1 in every 8,000 to 25,000 births, and the condition is most often diagnosed by radiographic examination.2Situs ambiguous, often referred to as heterotaxia, is the random arrangement of the internal organs and is associated with splenic abnormalities and congenital heart disease.3 The purpose of this column is to discuss the embryology, pathophysiology, and diagnosis of situs inversus totalis and to review a case study with radiographic findings.

scholarly journals Angiographic Embolization of a Postpartum Vulvovaginal Hematoma in a Patient with Situs Inversus Totalis: An Effective Second-Line Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Elias M. Dahdouh ◽  
Jacques Balayla ◽  
Johanne Dubé
Keyword(s):  
Situs Inversus ◽  
Primary Treatment ◽  
Situs Inversus Totalis ◽  
Invasive Technique ◽  
Angiographic Embolization ◽  
Internal Organs ◽  
Artery Ligation ◽  
Incision And Drainage ◽  
Obstetrical Complication ◽  
Life Threatening

Situs inversus totalis is a rare congenital anomaly where asymmetrical positioning of internal organs may affect the surgical and radiological management of certain conditions. Vulvovaginal hematoma is a life-threatening complication of vaginal delivery whose primary treatment usually consists of incision and drainage of the hematoma and ligation of the responsible vessels, followed by wound packing. Failure of these measures to control the bleeding was previously considered as an indication for laparotomy to perform bilateral hypogastric artery ligation and, if needed, a hysterectomy. Relative to major abdominal surgery, selective percutaneous angiographic embolization offers considerable advantages and significant less morbidity. Indeed, angiographic embolization is routinely used as a measure to control refractory pelvic bleeding, though the literature and experience in women with situs inversus totalis are scarce. In this paper, we report a case of postpartum vulvovaginal hematoma in a patient with situs inversus, refractory to conventional treatment, where arteriographic embolization was successfully used to control the bleeding. The management of this obstetrical complication and the use of this minimally invasive technique are also reviewed. To the best of our knowledge, this is the first report in the literature describing the feasibility of this technique in a patient with situs inversus totalis.

scholarly journals Effectiveness and selectivity of a heroin conjugate vaccine to attenuate heroin, 6-acetylmorphine, and morphine antinociception in rats: Comparison with naltrexone

2019 ◽  
Author(s):  
Kathryn L. Schwienteck ◽  
Steven Blake ◽  
Paul T. Bremer ◽  
Justin L. Poklis ◽  
E. Andrew Townsend ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Vaccine Effectiveness ◽  
Dose Effect ◽  
Sprague Dawley ◽  
Vaccine Research ◽  
Opioid Dose ◽  
Sprague Dawley Rats ◽  
Before And After ◽  
Naltrexone Treatment ◽  
Empirical Framework

AbstractBackgroundOne emerging strategy to address the opioid crisis includes opioid-targeted immunopharmacotherapies. This study compared effectiveness of a heroin-tetanus toxoid (TT) conjugate vaccine to antagonize heroin, 6-acetylmorphine (6-AM), morphine, and fentanyl antinociception in rats.MethodsAdult male and female Sprague Dawley rats received three doses of active or control vaccine at weeks 0, 2, and 4. Vaccine pharmacological selectivity was assessed by comparing opioid dose-effect curves in 50°C warm-water tail-withdrawal procedure before and after active or control heroin-TT vaccine. Route of administration [subcutaneous (SC) vs. intravenous [IV)] was also examined as a determinant of vaccine effectiveness. Continuous naltrexone treatment (0.0032-0.032 mg/kg/h) effects on heroin, 6-AM, and morphine antinociceptive potency was also determined as a benchmark for minimal vaccine effectiveness.ResultsThe heroin-TT vaccine decreased potency of SC heroin (5-fold), IV heroin (3-fold), and IV 6-AM (3-fold) for several weeks without affecting IV morphine or SC and IV fentanyl potency. The control vaccine did not alter potency of any opioid. Naltrexone dose-dependently decreased antinociceptive potency of SC heroin, and treatment with 0.01 mg/kg/h naltrexone produced similar, approximate 8-fold decreases in potencies of SC and IV heroin, IV 6-AM, and IV morphine. The combination of naltrexone and active vaccine was more effective than naltrexone alone to antagonize SC heroin but not IV heroin.ConclusionsThe heroin-TT vaccine formulation examined is less effective, but more selective, than chronic naltrexone to attenuate heroin antinociception in rats. Furthermore, these results provide an empirical framework for future preclinical opioid vaccine research to benchmark effectiveness against naltrexone.

scholarly journals Right Hemihepatectomy via an Anterior Approach for Hepatocellular Carcinoma in a Situs Inversus Totalis Patient

2020 ◽  
Vol 14 (1) ◽  
pp. 91-97
Author(s):  
Rong-Dang Fu ◽  
Jie-Yuan Li ◽  
Xiao-Hong Zhang ◽  
Huan-Wei Chen
Keyword(s):  
Hepatocellular Carcinoma ◽  
Situs Inversus ◽  
Anterior Approach ◽  
Middle Hepatic Vein ◽  
Situs Inversus Totalis ◽  
Mirror Image ◽  
Right Hemihepatectomy ◽  
Glissonian Approach ◽  
Congenital Condition ◽  
Chest X Ray

Situs inversus totalis (SIT) is a rare congenital condition in which the usual position of the organs is reversed from left to right as a mirror image of the normal situation. Due to the abnormal transposition, this represents a technical challenge for the surgeon. In the present study, right hemihepatectomy via the anterior approach was performed for a 68-year-old hepatocellular carcinoma (HCC) patient with SIT. SIT was diagnosed by chest X-ray and computed tomography. The tumors were located in segments VIII and VI of the liver, and there was no metastasis to the lymph nodes and distant organs. Hemihepatic vascular inflow occlusion was performed using the selective intra-Glissonian approach. The middle hepatic vein was preserved under the guidance with intraoperative ultrasonography. The present case suggests that right hemihepatectomy via the anterior approach may be a safe, feasible, and effective procedure for HCC patients with SIT.

Situs Inversus Totalis in a Dog With a Chronic Diaphragmatic Hernia

2009 ◽  
Vol 45 (5) ◽  
pp. 245-248 ◽  
Author(s):  
Tige H. Witsberger ◽  
David I. Dismukes ◽  
Efrat Y. Kelmer
Keyword(s):  
Case Report ◽  
Diaphragmatic Hernia ◽  
Situs Inversus ◽  
Situs Inversus Totalis ◽  
Mirror Image ◽  
Doberman Pinscher ◽  
Clinically Normal ◽  
Normal Orientation ◽  
Congenital Condition ◽  
Thoracic And Abdominal

Situs inversus totalis is a rare, congenital condition that is characterized by the development of the thoracic and abdominal viscera in a mirror image to their normal orientation. This case report describes the condition in a 4-year-old, spayed female Doberman pinscher that was evaluated for dyspnea following sedation. Radiography confirmed a diaphragmatic hernia. Situs inversus was discovered during surgical correction. The diaphragmatic rent was repaired, and the dog was clinically normal at recheck 13 months after surgery.

scholarly journals Gallbladder Adenosquamous Cancer With Situs Inversus Totalis: A Case Report and Literature Review

2021 ◽  
Author(s):  
JunMing Huang ◽  
Hanjin Yang ◽  
Meng Wang ◽  
Xinyu Zhao ◽  
Shiyi Shao ◽  
...  
Keyword(s):  
Gallbladder Cancer ◽  
Situs Inversus ◽  
Adenosquamous Carcinoma ◽  
Squamous Carcinoma ◽  
Radical Resection ◽  
Situs Inversus Totalis ◽  
Internal Organs ◽  
En Bloc ◽  
Regional Node ◽  
Adenosquamous Cancer

Abstract Background: Situs inversus totalis (SIT) is a rare genetic congenital disease, characterized by complete right-left inversion of all the internal organs. We herein describe a meaningful case which was diagnosed as gallbladder adenosquamous carcinoma, a rare histology type of gallbladder cancer, with SIT. Case presrntaton: A 59-year-old Chinese woman was admitted for persistent epigastric distention and intermittent abdominal pain. The abdominal CT scan revealed a huge mass at the gallbladder bottom, involving the adjacent transverse colon and liver. En-bloc radical resection of the gallbladder cancer, including partial colonectomy and hepatectomy with regional node dissection, followed by colocolostomy and Roux-en-Y choledochojejunostomy, was successfully performed Pathology analysis indicated an adenosquamous carcinoma with positive adenocarcinoma marker (CK7, CK19) and squamous carcinoma markers (CK5/6, P63). Conclusion: The SIT anomaly might increase the risk of malignancies by sharing genome mutations, suggesting the importance of surveillance in the SIT settings.

scholarly journals Laparoscopic Approach In Patient With Situs Inversus Totalis And Colelithiasis: A Case Report

10.3823/2523 ◽  
2017 ◽  
Vol 10 ◽  
Author(s):  
Deborah Marques Centeno ◽  
Tiago Galan França ◽  
Acacio Augusto Centeno ◽  
Marcos Antonio neves Noronha ◽  
Carolina Ribeiro Mainardi ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Case Report ◽  
Situs Inversus ◽  
Surgical Intervention ◽  
Laparoscopic Approach ◽  
Situs Inversus Totalis ◽  
Complete Evaluation ◽  
Previous Diagnosis ◽  
Congenital Condition ◽  
Normal Health

Title: Laparoscopic Approach in Patient with Situs Inversus Totalis and Colelithiasis: a Case Report. Background: Situs Inversus Totalis is a rare clinical condition that gives a mirror aspect to the position of the organs. It is a congenital condition and though it does not affect normal health or longevity, it may be a challenge in cases requiring surgical intervention. Case: The authors report a case of cholelithiasis in a patient with previous diagnosis of Situs Inversus Totalis. The patient presented abdominal pain, related to eating and associated with nausea and vomiting. After the image exams, it was performed the surgical procedure, without intercurrences. Conclusion:Situs Inversus Totalis is a challenge for surgical approach because of the mirrored configuration of the organs, which can lead to misdiagnosis. Using image exams anda complete evaluation of the patient helps the correct management in caso of surgical procedures, and consequently influence in the prognosis.

scholarly journals Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Fahmi Kaid ◽  
A. M. Alabsi ◽  
Nashwan Alafifi ◽  
Rola Ali-Saeed ◽  
May Ameen Al-koshab ◽  
...  
Keyword(s):  
Normal Control ◽  
Scientific Data ◽  
Control Group ◽  
Sprague Dawley ◽  
Internal Organs ◽  
Sprague Dawley Rats ◽  
Hematological Effects ◽  
Acute Study ◽  
Isolated Compound ◽  
Higher Doses

Goniothalamin (GTN) is an isolated compound from several plants of the genus Goniothalamus, and its anticancer effect against several cancers was reported. However, there is no scientific data about effects of its higher doses on internal organs. Accordingly, this study aimed to evaluate the acute and subacute effects of higher doses of GTN on the hematology, biochemistry, and histology of selected internal organs of male Sprague-Dawley rats. In acute study, 35 rats were distributed in 5 groups (n=7) which were intraperitoneally (IP) injected with a single dose of either 100, 200, 300, 400, or 500 mg/kg of GTN, while extra 7 rats serve as a normal control. In subacute study, 7 rats were IP-injected with a daily dose of 42 mg/kg of GTN for 14 days, while another 7 rats serve as a normal control group. The normal controls in both studies were IP-injected simultaneously with 2 ml/kg of 10% DMSO in PBS. At the end of both tests, rats were sacrificed to collect blood for hematology and biochemistry and harvest livers, kidneys, lungs, hearts, spleens, and brains for histology. During acute and subacute exposure, no abnormal changes were observed in the hematology, biochemistry, and histology of the internal organs. However, the 300, 400, and 500 mg/kg of GTN during acute exposure were associated with morbidities and mortalities. Ultimately, GTN could be safe up to the dose of 200 mg/kg, and the dose of 42 mg/kg of GTN was tolerated well.

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