scholarly journals The Long-Term Clinical Course of Canine Degenerative Myelopathy and Therapeutic Potential of Curcumin

2021 ◽  
Vol 8 (9) ◽  
pp. 192
Author(s):  
Yui Kobatake ◽  
Kohei Nakata ◽  
Hiroki Sakai ◽  
Jun Sasaki ◽  
Osamu Yamato ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Clinical Course ◽  
Therapeutic Potential ◽  
Late Onset ◽  
Respiratory Disorder ◽  
Limited Information ◽  
Respiratory Impairment ◽  
Degenerative Myelopathy ◽  
End Stage

Canine degenerative myelopathy (DM), recognized as a spontaneous model of amyotrophic lateral sclerosis, is known as a late-onset progressive degenerative disease of the spinal cord. Because of the progressive nature of DM, many dogs are elected to be euthanized, resulting in limited information on the end-stage clinical presentation. We investigated the long-term clinical course from diagnosis to natural death to further deepen our understanding of the entire clinical picture of this disease. Because curcumin was administered in some cases, the therapeutic effect of curcumin on DM was also examined. Forty dogs included in this study were client-owned Pembroke Welsh Corgis with a definitive diagnosis of DM by necropsy and histopathology. Dogs were excluded from this study if they died from another disease or were elected to be euthanized. Information on the long-term clinical symptoms of DM was investigated based on a questionnaire, which was collected from the dog owners. Urinary incontinence and respiratory disorder were observed in most dogs, as was respiratory impairment-correlated death. In contrast, signs consistent with brainstem dysfunction were noticed at the terminal stage in a small portion of dogs. Although further studies with more cases are needed, the results of this study suggest that administration of curcumin is effective in slowing the progression of DM.

scholarly journals Allele-specific antisense oligonucleotide therapy for dominantly inherited hearing impairment DFNA9

2020 ◽  
Author(s):  
Erik de Vrieze ◽  
Jolien Peijnenborg ◽  
Jorge Cañas Martin ◽  
Aniek Martens ◽  
Jaap Oostrik ◽  
...  
Keyword(s):  
Hearing Impairment ◽  
Single Molecule ◽  
Clinical Symptoms ◽  
Therapeutic Potential ◽  
Late Onset ◽  
Cell Model ◽  
Transgenic Cell ◽  
Allele Specific ◽  
Antisense Oligonucleotide Therapy

AbstractThe c.151C>T founder mutation in COCH is a frequent cause of late onset, dominantly inherited hearing impairment and vestibular dysfunction (DFNA9) in the Dutch/Belgian population. The initial clinical symptoms only manifest between the 3rd and 5th decade of life, which leaves ample time for therapeutic intervention. The dominant inheritance pattern and established non-haploinsufficiency disease mechanism indicate that suppressing translation of mutant COCH transcripts has high therapeutic potential. Single-Molecule Real-Time (SMRT) sequencing resulted in the identification of 11 variants with a low population-frequency (< 10%), that are specific to the c.151C>T mutant COCH allele. Proof of concept was obtained that gapmer antisense oligonucleotides (AONs), directed against the c.151C>T mutation or mutant allele-specific intronic variants, are able to specifically induce mutant COCH transcript degradation when delivered to transgenic cells expressing COCH minigenes. Sequence optimization of the AONs against the c.151C>T mutation resulted in a lead molecule that reduced the levels of mutant COCH transcripts by ~60% in a transgenic cell model, without affecting wildtype COCH transcript levels. With the proven safety of AONs in humans, and rapid advancements in inner ear drug delivery, our in-vitro studies indicate that AONs offer a promising treatment modality for DFNA9.

scholarly journals Symptomatic relapse and long-term sequelae of COVID-19 in a previously healthy 30-year-old man

2020 ◽  
Vol 13 (12) ◽  
pp. e239825
Author(s):  
Hatem Abdallah ◽  
Florence Porterfield ◽  
David Fajgenbaum
Keyword(s):  
Natural History ◽  
Clinical Symptoms ◽  
Clinical Course ◽  
Antibody Testing ◽  
Initial Infection ◽  
Viral Shedding ◽  
Long Period ◽  
Igm Antibody ◽  
Symptomatic Relapse

Much has been reported on the clinical course of severe COVID-19, but less is known about the natural history and sequalae of mildly symptomatic cases and the prospects of reinfection or recurrence of symptoms. We report a case of a patient with mildly symptomatic PCR-confirmed COVID-19 who, after being symptom-free for 2 weeks, redeveloped symptoms and was found to be PCR-positive again >4 weeks from original testing. Surprisingly, IgG and IgM antibody testing was negative 2 months after reinfection. Although no negative testing was performed between the two symptomatic bouts, this case raises the possibility of reinfection after controlling the virus and highlights the long period with which a patient can shed virus and experience symptoms after initial infection. Characterising variations in clinical symptoms and length of viral shedding after improvement is essential for informing recommendations on patients safely resuming contact with others.

Hepatitis C Therapy with Long Term Remission after Renal Transplantation

2002 ◽  
Vol 25 (12) ◽  
pp. 1189-1193 ◽  
Author(s):  
S. Bunnapradist ◽  
F. Fabrizi ◽  
J. Vierling ◽  
P. Martin ◽  
A. Moudgil ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Hepatitis C ◽  
Antiviral Agents ◽  
Hcv Infection ◽  
Induction Phase ◽  
Limited Information ◽  
Post Transplantation ◽  
Stage Renal Disease ◽  
End Stage

Hepatitis C virus infection (HCV) is common in patients with end-stage renal disease (ESRD) and long observation periods have shown the detrimental effect of HCV infection on patient and graft survival after renal transplantation. At present, interferon is the most important agent for the treatment of hepatitis C in ESRD; however, limited information exists concerning the long-term response of patients who undergo renal transplantation after successful antiviral therapy. We describe the evolution of HCV infection in a dialysis patient with hepatitis C who was successfully treated with interferon alpha and then underwent renal transplantation. He received aggressive immunosuppression during the induction phase and for allograft rejection; however, regular screening showed complete absence of biochemical and virological relapse of HCV over a 6-year post-transplantation period. We conclude that interferon can offer excellent response in selected dialysis patients with hepatitis C. Alternative strategies with newer antiviral agents are currently under active investigation.

scholarly journals Long COVID-19 Pulmonary Sequelae and Management Considerations

2021 ◽  
Vol 11 (9) ◽  
pp. 838
Author(s):  
Afroditi K. Boutou ◽  
Andreas Asimakos ◽  
Eleni Kortianou ◽  
Ioannis Vogiatzis ◽  
Argyris Tzouvelekis
Keyword(s):  
Clinical Symptoms ◽  
Therapeutic Potential ◽  
Acute Infection ◽  
Rehabilitation Program ◽  
Therapeutic Interventions ◽  
Health Crisis ◽  
Multiple Organs ◽  
Current State ◽  
Pulmonary Manifestations

The human coronavirus 2019 disease (COVID-19) and the associated acute respiratory distress syndrome (ARDS) are responsible for the worst global health crisis of the last century. Similarly, to previous coronaviruses leading to past pandemics, including severe acute respiratory syndrome (SARS) and middle east respiratory syndrome (MERS), a growing body of evidence support that a substantial minority of patients surviving the acute phase of the disease present with long-term sequelae lasting for up to 6 months following acute infection. The clinical spectrum of these manifestations is widespread across multiple organs and consists of the long-COVID-19 syndrome. The aim of the current review is to summarize the current state of knowledge on the pulmonary manifestations of the long COVID-19 syndrome including clinical symptoms, parenchymal, and functional abnormalities, as well as highlight epidemiology, risk factors, and follow-up strategies for early identification and timely therapeutic interventions. The literature data on management considerations including the role of corticosteroids and antifibrotic treatment, as well as the therapeutic potential of a structured and personalized pulmonary rehabilitation program are detailed and discussed.

Frequency of Gastrointestinal Diseases in Patients with End-Stage Renal Disease Treated with Long Term Dialysis

2018 ◽  
Vol 2 (2) ◽  
pp. 105-112
Author(s):  
Lutfi Zylbeari ◽  
Zamira Bexheti ◽  
Gazmend Zylbeari ◽  
Ferizate Haxhirexha ◽  
Kastriot Haxhirexha
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Gastrointestinal Diseases ◽  
Stage Renal Disease ◽  
End Stage

Integrating Focusing and Differentiation: A Therapeutic Path for Couples in Intimate Relationships

2018 ◽  
Vol 3 ◽  
Author(s):  
Evi Zohar
Keyword(s):  
Couples Therapy ◽  
Therapeutic Potential ◽  
Well Being ◽  
Point Of View ◽  
The Body ◽  
Self Awareness ◽  
Emotional Healing ◽  
Felt Sense ◽  
Inner World

Continuing the workshop I've given in the WPC Paris (2017), this article elaborates my discussion of the way I interlace Focusing with Differentiation Based Couples Therapy (Megged, 2017) under the systemic view, in order to facilitate processes of change and healing in working with intimate couples. This article presents the theory and rationale of integrating Differentiation (Bowen, 1978; Schnarch, 2009; Megged, 2017) and Focusing (Gendlin, 1981) approaches, and its therapeutic potential in couple's therapy. It is written from the point of view of a practicing professional in order to illustrate the experiential nature and dynamics of the suggested therapeutic path. Differentiation is a key to mutuality. It offers a solution to the central struggle of any long term intimate relationship: balancing two basic life forces - the drive for individuality and the drive for togetherness (Schnarch, 2009). Focusing is a body-oriented process of self-awareness and emotional healing, in which one learns to pay attention to the body and the ‘Felt Sense’, in order to unfold the implicit, keep it in motion at the precise pace it needs for carrying the next step forward (Gendlin, 1996). Combining Focusing and Differentiation perspectives can cultivate the kind of relationship where a conflict can be constructively and successfully held in the inner world of each partner, while taking into consideration the others' well-being. This creates the possibility for two people to build a mutual emotional field, open to changes, permeable and resilient.

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