scholarly journals Association of changes in norepinephrine and serotonin transporter expression with the long-term behavioral effects of antidepressant drugs

2008 ◽  
Author(s):  
Zaorui Zhao
Keyword(s):  
Serotonin Transporter ◽  
Antidepressant Drugs ◽  
Behavioral Effects ◽  
Transporter Expression

scholarly journals Association of Changes in Norepinephrine and Serotonin Transporter Expression with the Long-Term Behavioral Effects of Antidepressant Drugs

2008 ◽  
Vol 34 (6) ◽  
pp. 1467-1481 ◽  
Author(s):  
Zaorui Zhao ◽  
Han-Ting Zhang ◽  
Elianna Bootzin ◽  
Mark J Millan ◽  
James M O'Donnell
Keyword(s):  
Serotonin Transporter ◽  
Antidepressant Drugs ◽  
Behavioral Effects ◽  
Transporter Expression

Long term neurological and behavioral effects of graded perinatal asphyxia in the rat

Life Sciences ◽  
2000 ◽  
Vol 66 (10) ◽  
pp. 947-962 ◽  
Author(s):  
Harald Hoeger ◽  
Mario Engelmann ◽  
Guenther Bernert ◽  
Rainer Seidl ◽  
Hermann Bubna-Littitz ◽  
...  
Keyword(s):  
Perinatal Asphyxia ◽  
Behavioral Effects

Short and long-term motor and behavioral effects of diazoxide and dimethyl sulfoxide administration in the mouse after traumatic brain injury

2013 ◽  
Vol 108 ◽  
pp. 66-73 ◽  
Author(s):  
Craig S. Budinich ◽  
Laura B. Tucker ◽  
Dennell Lowe ◽  
John G. Rosenberger ◽  
Joseph T. McCabe
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Dimethyl Sulfoxide ◽  
Behavioral Effects ◽  
Short And Long Term

Immediate and long-term behavioral effects of a single nicotine injection in adolescent and adult rats

2007 ◽  
Vol 29 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Jennifer M. Brielmaier ◽  
Craig G. McDonald ◽  
Robert F. Smith
Keyword(s):  
Behavioral Effects ◽  
Adult Rats

Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis

Toxicology ◽  
2013 ◽  
Vol 310 ◽  
pp. 29-38 ◽  
Author(s):  
Farah Koraïchi ◽  
Lilia Inoubli ◽  
Nadjem Lakhdari ◽  
Léo Meunier ◽  
Aurélie Vega ◽  
...  
Keyword(s):  
Abc Transporter ◽  
Neonatal Exposure ◽  
Transporter Expression

Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: Similarities to autism spectrum disorders

2014 ◽  
Vol 263 ◽  
pp. 60-69 ◽  
Author(s):  
Z. Merali ◽  
J. Presti-Torres ◽  
J.C. MacKay ◽  
J. Johnstone ◽  
L. Du ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Behavioral Effects ◽  
Peptide Receptors ◽  
Gastrin Releasing Peptide ◽  
Spectrum Disorders

scholarly journals An Investigation of the Long and Short Term Behavioral Effects of General Anesthesia on Pediatric Dental Patients With Autism

2021 ◽  
Vol 2 ◽  
Author(s):  
Janine Tran ◽  
Jung-Wei Chen ◽  
Larry Trapp ◽  
Laura McCormack
Keyword(s):  
General Anesthesia ◽  
Sleep Disturbances ◽  
Activity Level ◽  
Behavioral Effects ◽  
Healthy Children ◽  
Post Discharge ◽  
Dental Surgery ◽  
Dental Patients ◽  
Post Surgery

Purpose: The purpose of this study was to compare the incidence of short and long term adverse behavioral effects of general anesthesia (GA) in healthy vs. moderate to severe autistic (ASD) children.Methods: Forty healthy and 37 ASD children, aged 3–17 years, undergoing GA for dental surgery participated in this study. Their anesthesia records were reviewed, and their parents answered telephone surveys to assess activity level, sleep disturbances, gastrointestinal disturbances, central nervous system effects, and respiratory depression. Three follow-up surveys were taken 8 h, 24 h, and 3 months post-surgery.Results: Four hundred fifty-five incidences of adverse behavioral effects occurred within 8 h post-surgery. Significantly more ASD patients had difficulty walking (P = 0.016) and nausea (P = 0.030), while more healthy children snored in the car ride home (P = 0.036) and talked about the dental surgery (P = 0.027). Three months post-discharge, sixASD patients acted in a way that concerned caregivers compared to 0 healthy patients, (P = 0.008). Incidence of adverse behavioral effects significantly decreased from 8 to 24 h overall.Conclusions: Most behavioral effects occur within 8 h post-surgery. There are potential long term adverse behavioral effects in ASD children from GA, but the chance is low and generally not long lasting.

scholarly journals The Developmental Role of Serotonin: A Comparison of Short- and Long-term Blockade of the Serotonin Transporter on Behavioural Outcomes in Adulthood

2021 ◽  
Author(s):  
◽  
Amy O'Connell
Keyword(s):  
Animal Model ◽  
Serotonin Transporter ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Critical Periods ◽  
Significant Group ◽  
Fluoxetine Treatment ◽  
Short And Long Term

<p>Serotonin is an important neurotransmitter that regulates a range of processes within the brain and is implicated in several psychiatric disorders. In addition, serotonin acts as a developmental signal during critical periods of prenatal development, influencing processes such as neuronal proliferation, migration, and synaptogenesis (Gaspar et al., 2003). The serotonin transporter (5- HTT) plays a key role in regulating extracellular serotonin levels and is the main target of selective-serotonin reuptake inhibitors (SSRIs), a class of drugs that have anti-anxiety and anti- depressive activity. SSRIs cause an acute increase in extracellular serotonin and are commonly prescribed as a treatment for depression and anxiety during pregnancy (Tran & Robb, 2015). Given that these drugs alter serotonin transmission and can pass to the developing fetus via the placenta, it is vital that the outcomes of prenatal SSRI exposure are investigated. In humans, a genetic variant of the gene that codes for the 5-HTT (SLC6A4) has been linked to increased risk for developing depression and anxiety (Caspi et al., 2003). The functional consequences of this genetic polymorphism are life-long alterations in 5-HTT activity, resulting in increased extracellular levels of serotonin (Nakamura et al., 2000). Given prenatal SSRI exposure results in a time-locked blockade of 5-HTT during critical periods of development, it follows that alterations in serotonin during development might similarly result in enhanced risk for depression and anxiety later in life. Outcomes in children prenatally exposed to SSRIs are difficult to study due to confounds of pre- existing maternal depression. Therefore, the current thesis presents two experiments that aimed to further investigate the role of altered extracellular serotonin levels during development in an animal model. Experiment one aimed to develop a method of voluntary oral administration of the SSRI fluoxetine to pregnant rat dams. This method was then applied in experiment two to create a time-locked blockade of 5-HTT during critical periods of development in an animal model of life-long 5-HTT blockade. The aim of experiment two was to directly assess the contribution of short- and long-term 5-HTT blockade on anxiety and depression phenotypes in adult male offspring. In addition, maternal behaviour was assessed to determine whether fluoxetine treatment had an influence on mother-pup interactions that could confound results. To test for anxiety and depression phenotypes, the novel affective disorder test (ADT) was used to assess anxiety behaviour and the deficits in anticipatory pleasure indicative of anhedonia. In the current study, fluoxetine treatment did not have an effect on litter outcomes or mother-pup interactions. Crucially, no significant group differences were found indicating that neither short- nor long- term blockade of 5-HTT resulted in increased anxiety- or depressive-like behaviours in the current experiment. However, limitations with methodological design limit the translatability of these results to the broader literature, and validation of the ADT is required before these results can be generalised beyond this thesis.</p>

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