The Prognostic Significance of ErbB1 (EGFR) Expressions in Patients with Curative Resection for Colorectal Cancers

Purpose The prognosis of patients with colorectal cancer has sometimes proved uncertain; thus, the prognostic significance of immune criteria was compared with that of the tumor extension criteria using the American Joint Committee on Cancer/International Union Against Cancer–TNM (AJCC/UICC-TNM) staging system. Patients and Methods We studied the intratumoral immune infiltrates in the center of the tumor and in the invasive margin of 599 specimens of stage I to IV colorectal cancers from two independent cohorts. We analyzed these findings in relation to the degree of tumor extension and to the frequency of recurrence. Results Growth of the primary tumor and metastatic spread were associated with decreased intratumoral immune T-cell densities. Sixty percent of patients with high densities of CD8+ cytotoxic T-lymphocyte infiltrate presented with stage Tis/T1 tumor, whereas no patients with low densities presented with such early-stage tumor. In patients who did not relapse, the density of CD8 infiltrates was inversely correlated with T stage. In contrast, in patients whose tumor recurred, the number of CD8 cells was low regardless of the T stage of the tumor. Univariate analysis showed that the immune score was significantly associated with differences in disease-free, disease-specific, and overall survival (hazard ratio [HR], 0.64, 0.60, and 0.70, respectively; P < .005). Time-dependent receiver operating characteristic curve analysis illustrated the predictive accuracy of the immune parameters (c-index = 65.3%, time-dependent c-index [Cτ] = 66.5%). A final stepwise model for Cox multivariate analysis supports the advantage of the immune score (HR, 0.64; P < .001; Cτ = 67.9%) compared with histopathologic features in predicting recurrence as well as survival. Conclusion Assessment of CD8+ cytotoxic T lymphocytes in combined tumor regions provides an indicator of tumor recurrence beyond that predicted by AJCC/UICC-TNM staging.

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The prognostic significance of lymph node metastasis and intrapancreatic perineural invasion in pancreatic cancer after curative resection

Surgery Today ◽

10.1007/bf02482964 ◽

1999 ◽

Vol 29 (1) ◽

pp. 16-22 ◽

Cited By ~ 100

Author(s):

Hideo Ozaki ◽

Takehisa Hiraoka ◽

Ryuji Mizumoto ◽

Seiki Matsuno ◽

Yoshiro Matsumoto ◽

...

Keyword(s):

Pancreatic Cancer ◽

Lymph Node ◽

Lymph Node Metastasis ◽

Curative Resection ◽

Perineural Invasion ◽

Prognostic Significance ◽

Node Metastasis

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Clinicopathological correlates and prognostic significance of glutathione S-transferase Pi expression in 468 patients after potentially curative resection of node-positive colonic cancer

Histopathology ◽

10.1111/j.1365-2559.2011.04044.x ◽

2011 ◽

Vol 59 (6) ◽

pp. 1057-1070 ◽

Cited By ~ 10

Author(s):

King L Tan ◽

Lucy Jankova ◽

Charles Chan ◽

Caroline L-S Fung ◽

Candice Clarke ◽

...

Keyword(s):

Curative Resection ◽

Colonic Cancer ◽

Prognostic Significance ◽

Glutathione S Transferase ◽

Node Positive

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Prognostic significance of tumor-infiltrating lymphocytes (TILs) in patients with early-stage triple-negative breast cancer (TNBC) treated with curative resection alone

Annals of Oncology ◽

10.1093/annonc/mdx655.014 ◽

2017 ◽

Vol 28 ◽

pp. x19-x20 ◽

Cited By ~ 1

Author(s):

J.H. Park ◽

H.J. Lee ◽

J-H Ahn ◽

J.E. Kim ◽

K.H. Jung ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Curative Resection ◽

Triple Negative ◽

Early Stage ◽

Prognostic Significance ◽

Tumor Infiltrating Lymphocytes ◽

Infiltrating Lymphocytes

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Kallikrein-related peptidases and associated microRNAs as promising prognostic biomarkers in gastrointestinal malignancies

Biological Chemistry ◽

10.1515/hsz-2017-0342 ◽

2018 ◽

Vol 399 (8) ◽

pp. 821-836 ◽

Cited By ~ 6

Author(s):

Panagiotis G. Adamopoulos ◽

Panagiotis Tsiakanikas ◽

Andreas Scorilas

Keyword(s):

Wide Spectrum ◽

Prognostic Significance ◽

Prognostic Biomarkers ◽

Colorectal Cancers ◽

Gi Tract ◽

Aberrant Expression ◽

Gastrointestinal Malignancies ◽

Expression Levels ◽

Related Mortality

AbstractGastrointestinal (GI) malignancies represent a wide spectrum of diseases of the GI tract and its accessory digestive organs, including esophageal (EC), gastric (GC), hepatocellular, pancreatic (PC) and colorectal cancers (CRC). Malignancies of the GI system are responsible for nearly 30% of cancer-related morbidity and approximately 40% of cancer-related mortality, worldwide. For this reason, the discovery of novel prognostic biomarkers that can efficiently provide a better prognosis, risk assessment and prediction of treatment response is an imperative need. Human kallikrein-related peptidases (KLKs) are a subgroup of trypsin and chymotrypsin-like serine peptidases that have emerged as promising prognosticators for many human types of cancer, being aberrantly expressed in cancerous tissues. The aberrant expression ofKLKsin human malignancies is often regulated byKLK/microRNAs (miRNAs) interactions, as many miRNAs have been found to targetKLKsand therefore alter their expression levels. The biomarker utility ofKLKshas been elucidated not only in endocrine-related human malignancies, including those of the prostate and breast, but also in GI malignancies. The main purpose of this review is to summarize the existing information regarding the prognostic significance of KLKs in major types of GI malignancies and highlight the regulatory role of miRNAs on the expression levels ofKLKsin these types of cancer.

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Clinical significance of the preoperative main pancreatic duct dilation and neutrophil-to-lymphocyte ratio in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection

BMC Endocrine Disorders ◽

10.1186/s12902-019-0454-4 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 1

Author(s):

Bo Zhou ◽

Canyang Zhan ◽

Jie Xiang ◽

Yuan Ding ◽

Sheng Yan

Keyword(s):

Pancreatic Duct ◽

Neuroendocrine Tumors ◽

Main Pancreatic Duct ◽

Curative Resection ◽

Who Classification ◽

Prognostic Significance ◽

Small Sample ◽

Neutrophil To Lymphocyte Ratio ◽

Pancreatic Neuroendocrine Tumors ◽

Lymphocyte Ratio

Abstract Background The present study aimed to investigate the prognostic significance of preoperative main pancreatic duct dilation and the neutrophil-to-lymphocyte ratio (PD-NLR) in pancreatic neuroendocrine tumors (PNETs) of the head after curative resection. Methods Sixty-four consecutive PNETs of the head that underwent curative resection were included in the study. Preoperative main pancreatic duct dilation (PD) was defined as a pancreatic duct dilation greater than 3 mm before surgery. Patients with both PD and an elevated NLR (> 3.13), with PD or elevated NLR, or neither of these characteristics were allocated a PD-NLR score of 2, 1, or 0, respectively. Univariate, multivariate and Kaplan-Meier analyses were used to calculate overall survival (OS) and disease-free survival (DFS). Results Preoperative PD-NLR score was correlated with tumor size (P = 0.005), T-stage (P = 0.016), lymph node metastasis (P < 0.001), distant metastasis (P = 0.005), type of hormone production (P = 0.006), perineural invasion (P = 0.014), and WHO classification (P < 0.001). Patients with a high PD-NLR score had a significantly poor OS and DFS relative to those with a low PD-NLR score (P < 0.001). In the multivariate analysis, PD-NLR score was an independent predictor of OS and DFS for PNET of the head (both P < 0.05). In the analyses of the various subgroups, preoperative PD-NLR score was also a predictor of OS and DFS. Additionally, the survival predictive capability of PD-NLR score was superior to that of WHO classification. Conclusions Despite the retrospective nature and small sample size of the present study, the results suggest that preoperative PD-NLR score can serve as an independent prognostic marker of early survival in patients with PNETs of the head undergoing curative resection. Further large prospective studies are necessary to validate our findings.

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