scholarly journals Safety of metoclopramide in traumatic brain injury patients

2020 ◽  
pp. 512-517
Author(s):  
Said Al Jaadi ◽  
Yahya Al Kindi ◽  
Tariq Al-Saadi
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Side Effect ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Antiemetic Agent ◽  
Presenting Symptoms ◽  
The Central Nervous System ◽  
Multiple Variables ◽  
Cns Side Effects

Background: One in every three related-injury deaths in United State are linked directly to traumatic brain injury (TBI), for which it is considered as a leading cause of death. Traumatic brain injury took place due to severe head assault to a hard object, with headache and vomiting being amongst the most common presenting symptoms. Metoclopramide is an old antiemetic agent that has been used widely for nausea and vomiting in TBI patients. Aim: A systematic review of the literature to investigate the safety of metoclopramide in treating traumatic brain injury patients. Methods: A literature review was conducted in 6 databases, we determine the pertinence of a study to the inclusion criteria by assessing the title, keywords, and abstracts. Five studies were found to be relevant. Data were extracted using multiple variables that were formulated incongruent with the study aim and then further analyzed. Results: The collective sample size was 93 patients with an average of age 38.5 years. 51.6 % were male and 48.6% were females. Most patients received 10 mg metoclopramide IV with a percentage of 77.4%. While only 22.5% received 20 mg IV metoclopramide. Seventy-one patients received metoclopramide alone and 22 received combination therapy.  Headache was the most common reported side effect (46.2 %), followed by anxiety and drowsiness with (39.7%) and (27.9 %); respectively. Fatigue reported in (24.7%), while dystonia was the least common and developed only in 5.3%. Conclusion: Metoclopramide is a common medication used to treat TBI patients in the emergency department. However, the review demonstrated that the central nervous system (CNS) side effect is excepted. Alternative options with lower CNS side effects may be better tried.

scholarly journals Safety of Metoclopramide in Traumatic Brain Injury (TBI) Patients

2020 ◽  
Author(s):  
Said Al Jaadi ◽  
Yahya Al-Kindi ◽  
Tariq Al-Saadi
Keyword(s):  
Side Effect ◽  
Brain Injuries ◽  
Traumatic Brain Injuries ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Antiemetic Agent ◽  
Presenting Symptoms ◽  
The Central Nervous System ◽  
Multiple Variables ◽  
Cns Side Effects

Abstract Introduction Traumatic brain injuries (TBIs) occur due to severe head assault to a hard object, with headache and vomiting being amongst the most common presenting symptoms. Metoclopramide is an old antiemetic agent that has been used widely for nausea and vomiting in TBI patients. Aim A systematic review of the literature to investigate the safety of metoclopramide in treating TBI patients. Methods A literature review was conducted in six databases, where we determined the pertinence of a study to the inclusion criteria by assessing the title, keywords, and abstracts. Five studies were found to be relevant. Data were extracted using multiple variables that were formulated incongruent with the study aim and then further analyzed. Results The collective sample size was 93 patients with an average of age 38.5 years. As much as 51.6% were male and 48.6% were females. Most patients received 10 mg metoclopramide IV with a percentage of 77.4%, while only 22.5% received 20 mg IV metoclopramide. Seventy-one patients received metoclopramide alone and 22 received combination therapy. Headache was the most common reported side effect (46.2%), followed by anxiety and drowsiness with (39.7%) and (27.9%), respectively. Fatigue was reported in 24.7%, while dystonia was the least common and developed in only 5.3% of patients. Conclusion Metoclopramide is a common medication used to treat TBI patients in the emergency department. However, the review demonstrated that the central nervous system (CNS) side effect is excepted. Treatments with lower CNS side effects may be better options.

The outcomes of mindfulness-based interventions for adults who have experienced a traumatic brain injury: A systematic review of the literature

2017 ◽  
Vol 16 (2) ◽  
pp. 9 ◽  
Author(s):  
Sophia Kenuk, MS, CTRS ◽  
Heather R. Porter, PhD, CTRS
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Stress Reduction ◽  
Psychosocial Functioning ◽  
Tai Chi ◽  
Future Research ◽  
Recreational Therapy ◽  
Review Of The Literature ◽  
Inclusion Criteria ◽  
Community Activities

This literature review aims to evaluate the effectiveness of mindfulness-based interventions (MBIs) for adults following a traumatic brain injury. A comprehensive literature search yielded 56 articles, of which 16 met the inclusion criteria. Five different MBIs were identified, including mindfulness-based stress reduction, mindfulness-based cognitive therapy, mindfulness training, yoga, tai chi, and qigong. A total of 88 outcomes in the areas of cognition, home and community activities, physical functioning, psychosocial functioning, and recovery and general health were measured across the studies, of which 66 of the 88 outcomes found significant, positive, or significant and positive mixed results (75 percent) across all of the studies. Although more research is needed, these findings indicate that MBIs hold promise in improving functioning. Recommendations for recreational therapy practice and future research are provided.

scholarly journals Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports

2016 ◽  
Vol 7 (1) ◽  
pp. 78 ◽  
Author(s):  
Vineet Tyagi ◽  
Jason Theobald ◽  
James Barger ◽  
Mark Bustoros ◽  
NSumru Bayin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Case Reports ◽  
Review Of The Literature ◽  
Development Review

scholarly journals Pterins as Diagnostic Markers of Mechanical and Impact-Induced Trauma: A Systematic Review

2019 ◽  
Vol 8 (9) ◽  
pp. 1383 ◽  
Author(s):  
Angus Lindsay ◽  
Gregory Baxter-Parker ◽  
Steven P. Gieseg
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Cardiac Surgery ◽  
Brain Injury ◽  
Liver Resection ◽  
Review Of The Literature ◽  
Multiple Forms ◽  
Concentration Changes ◽  
Exercise Induced

We performed a systematic review of the literature to evaluate pterins as biomarkers of mechanical and impact-induced trauma. MEDLINE and Scopus were searched in March 2019. We included in vivo human studies that measured a pterin in response to mechanical or impact-induced trauma with no underlying prior disease or complication. We included 40 studies with a total of 3829 subjects. Seventy-seven percent of studies measured a significant increase in a pterin, primarily neopterin or total neopterin (neopterin + 7,8-dihydroneopterin). Fifty-one percent of studies measured an increase within 24 h or trauma, while 46% measured increases beyond 48 h. Pterins also showed promise as predictors of post-trauma complications such as sepsis, multi-organ failure and mortality. Exercise-induced trauma and traumatic brain injury caused an immediate increase in neopterin or total neopterin, while patients of multiple trauma had elevated pterin levels that remained above baseline for several days. Pterin concentration changes in response to surgery were variable with patients undergoing cardiac surgery having immediate and sustained pterin increases, while hysterectomy, liver resection or hysterectomy showed no change. This review provides systematic evidence that pterins, in particular neopterin and total neopterin, increase in response to multiple forms of mechanical or impact-induced trauma.

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